Compile Data Set for Download or QSAR

Found 227 hits of ic50 data for polymerid = 4873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50065646 (CHEMBL3087181) Show SMILES O=C(N1CCC(CC1)C(c1ccc2OCOc2c1)c1ccc2OCOc2c1)n1cncn1 Show InChI InChI=1S/C23H22N4O5/c28-23(27-12-24-11-25-27)26-7-5-15(6-8-26)22(16-1-3-18-20(9-16)31-13-29-18)17-2-4-19-21(10-17)32-14-30-19/h1-4,9-12,15,22H,5-8,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.214	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat MAGL				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50160284 (CHEMBL3785379) Show SMILES Fc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C24H22FN5O4/c25-17-4-1-15(2-5-17)21-22(16-3-6-19-20(11-16)34-14-33-19)30(23(21)31)18-7-9-28(10-8-18)24(32)29-13-26-12-27-29/h1-6,11-13,18,21-22H,7-10,14H2/t21-,22-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
University of Siena Curated by ChEMBL					Assay Description Inhibition of rat MAGL				J Med Chem 59: 2612-32 (2016) Article DOI: 10.1021/acs.jmedchem.5b01812 BindingDB Entry DOI: 10.7270/Q21R6SC7
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50450752 (CHEMBL4216513) Show SMILES O=[#6](-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc2-[#8]-[#6]-[#8]-c2c1)-c1ccc2-[#8]-[#6]-[#8]-c2c1)-n1cncn1 Show InChI InChI=1S/C23H20N4O5/c28-23(27-12-24-11-25-27)26-7-5-15(6-8-26)22(16-1-3-18-20(9-16)31-13-29-18)17-2-4-19-21(10-17)32-14-30-19/h1-4,9-12H,5-8,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.269	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat MAGL				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50102829 (CHEMBL3356956) Show SMILES O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)n1cncn1 Show InChI InChI=1S/C20H21N5O/c26-20(25-16-21-15-22-25)24-13-11-23(12-14-24)19(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,15-16,19H,11-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.589	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat MAGL				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50099618 (CHEMBL1232635) Show SMILES Fc1ccc(cc1)C(N1CCN(CC1)C(=O)n1cncn1)c1ccc(F)cc1 Show InChI InChI=1S/C20H19F2N5O/c21-17-5-1-15(2-6-17)19(16-3-7-18(22)8-4-16)25-9-11-26(12-10-25)20(28)27-14-23-13-24-27/h1-8,13-14,19H,9-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of rat MAGL				J Med Chem 63: 5783-5796 (2020) Article DOI: 10.1021/acs.jmedchem.9b02137 BindingDB Entry DOI: 10.7270/Q2GQ7288
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50099618 (CHEMBL1232635) Show SMILES Fc1ccc(cc1)C(N1CCN(CC1)C(=O)n1cncn1)c1ccc(F)cc1 Show InChI InChI=1S/C20H19F2N5O/c21-17-5-1-15(2-6-17)19(16-3-7-18(22)8-4-16)25-9-11-26(12-10-25)20(28)27-14-23-13-24-27/h1-8,13-14,19H,9-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat MAGL				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50160284 (CHEMBL3785379) Show SMILES Fc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1 |r| Show InChI InChI=1S/C24H22FN5O4/c25-17-4-1-15(2-5-17)21-22(16-3-6-19-20(11-16)34-14-33-19)30(23(21)31)18-7-9-28(10-8-18)24(32)29-13-26-12-27-29/h1-6,11-13,18,21-22H,7-10,14H2/t21-,22-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
University of Siena Curated by ChEMBL					Assay Description Inhibition of MAGL in rat brain membranes preincubated for 20 mins followed by fluorophosphonate-rhodamine addition measured after 30 mins by competi...				J Med Chem 59: 2612-32 (2016) Article DOI: 10.1021/acs.jmedchem.5b01812 BindingDB Entry DOI: 10.7270/Q21R6SC7
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514172 (CHEMBL4536072) Show SMILES O=c1n(NCCCCCNn2sc3ccccc3c2=O)sc2ccccc12 Show InChI InChI=1S/C19H20N4O2S2/c24-18-14-8-2-4-10-16(14)26-22(18)20-12-6-1-7-13-21-23-19(25)15-9-3-5-11-17(15)27-23/h2-5,8-11,20-21H,1,6-7,12-13H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM179950 (US9133148, 3a) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)C(F)(F)F Show InChI InChI=1S/C21H20F6N2O3/c22-20(23,24)18(21(25,26)27)32-19(30)29-11-9-28(10-12-29)14-15-5-4-8-17(13-15)31-16-6-2-1-3-7-16/h1-8,13,18H,9-12,14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assay				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514166 (CHEMBL4448448) Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12 Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514173 (CHEMBL4463191) Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12 Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50359050 (CHEMBL1922513) Show SMILES CCCCCCCCn1sc2ccccc2c1=O Show InChI InChI=1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of recombinant rat N-terminal histidine tagged MAGL expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells preincubated for 10 mins fol...				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520895 (CHEMBL4472033) Show SMILES O=C(Oc1cc(ccn1)C#N)N1CCC(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H23N3O2/c26-18-19-11-14-27-23(17-19)30-25(29)28-15-12-22(13-16-28)24(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-11,14,17,22,24H,12-13,15-16H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514167 (CHEMBL4560077) Show SMILES O=c1n(CCc2cccc3ccccc23)sc2ccccc12 Show InChI InChI=1S/C19H15NOS/c21-19-17-10-3-4-11-18(17)22-20(19)13-12-15-8-5-7-14-6-1-2-9-16(14)15/h1-11H,12-13H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM60622 (BDBM50300355 | US11753371, Compound JZL-184 | US91...) Show SMILES OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1 Show InChI InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of rat MAGL expressed in monkey COS7 cells				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520905 (CHEMBL4437385) Show SMILES Clc1ccc(cc1)C(C1CCN(CC1)C(=O)Oc1cccc(c1)C#N)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H22Cl2N2O2/c27-22-8-4-19(5-9-22)25(20-6-10-23(28)11-7-20)21-12-14-30(15-13-21)26(31)32-24-3-1-2-18(16-24)17-29/h1-11,16,21,25H,12-15H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50435396 (CHEMBL2391916) Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12 Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520885 (CHEMBL4521157) Show SMILES O=C(Oc1cccc(c1)C#N)N1CCC(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C26H24N2O2/c27-19-20-8-7-13-24(18-20)30-26(29)28-16-14-23(15-17-28)25(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-13,18,23,25H,14-17H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM179929 (US9133148, 1a) Show SMILES OC(C1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)(c1ccc2OCOc2c1)c1ccc2OCOc2c1 Show InChI InChI=1S/C24H21F6NO7/c25-23(26,27)20(24(28,29)30)38-21(32)31-7-5-13(6-8-31)22(33,14-1-3-16-18(9-14)36-11-34-16)15-2-4-17-19(10-15)37-12-35-17/h1-4,9-10,13,20,33H,5-8,11-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assay				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50450761 (CHEMBL4202705) Show SMILES CCCCCCCC\C=C/CCCCCCCCn1sccc1=O Show InChI InChI=1S/C21H37NOS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-21(23)18-20-24-22/h9-10,18,20H,2-8,11-17,19H2,1H3/b10-9-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of recombinant rat N-terminal histidine tagged MAGL expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells preincubated for 10 mins fol...				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514173 (CHEMBL4463191) Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12 Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520890 (CHEMBL4445089) Show SMILES O=C(Oc1cccc(c1)C#N)N1CCN(CC1)C1c2ccccc2-c2ccccc12 Show InChI InChI=1S/C25H21N3O2/c26-17-18-6-5-7-19(16-18)30-25(29)28-14-12-27(13-15-28)24-22-10-3-1-8-20(22)21-9-2-4-11-23(21)24/h1-11,16,24H,12-15H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514173 (CHEMBL4463191) Show SMILES O=c1n(NCc2ccccc2)sc2ccccc12 Show InChI InChI=1S/C14H12N2OS/c17-14-12-8-4-5-9-13(12)18-16(14)15-10-11-6-2-1-3-7-11/h1-9,15H,10H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514170 (CHEMBL4515209) Show SMILES O=c1n(CCc2ccc3ccccc3c2)sc2ccccc12 Show InChI InChI=1S/C19H15NOS/c21-19-17-7-3-4-8-18(17)22-20(19)12-11-14-9-10-15-5-1-2-6-16(15)13-14/h1-10,13H,11-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514182 (CHEMBL3219170) Show SMILES O=c1n(sc2ccccc12)C1CCCCC1 Show InChI InChI=1S/C13H15NOS/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50359050 (CHEMBL1922513) Show SMILES CCCCCCCCn1sc2ccccc2c1=O Show InChI InChI=1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of rat recombinant N-terminal his-tagged MAGL expressed in Escherichia coli DH5alpha assessed as 2-oleoylglycerol hydrolysis after 10 mins...				Bioorg Med Chem Lett 21: 7321-4 (2011) Article DOI: 10.1016/j.bmcl.2011.10.026 BindingDB Entry DOI: 10.7270/Q2B27VPC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50359050 (CHEMBL1922513) Show SMILES CCCCCCCCn1sc2ccccc2c1=O Show InChI InChI=1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM61908 (2-methyl-1,2-benzothiazol-3-one | KUC103657N | acs...) Show SMILES Cn1sc2ccccc2c1=O Show InChI InChI=1S/C8H7NOS/c1-9-8(10)6-4-2-3-5-7(6)11-9/h2-5H,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50435396 (CHEMBL2391916) Show SMILES O=c1n(CCc2ccccc2)sc2ccccc12 Show InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520896 (CHEMBL4463729) Show SMILES O=C(Oc1cccc(n1)C#N)N1CCC(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H23N3O2/c26-18-22-12-7-13-23(27-22)30-25(29)28-16-14-21(15-17-28)24(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h1-13,21,24H,14-17H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514166 (CHEMBL4448448) Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12 Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL C208A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50359049 (CHEMBL1922512) Show SMILES CCCCCCCCN1SCCC1=O Show InChI InChI=1S/C11H21NOS/c1-2-3-4-5-6-7-9-12-11(13)8-10-14-12/h2-10H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of rat recombinant N-terminal his-tagged MAGL expressed in Escherichia coli DH5alpha assessed as 2-oleoylglycerol hydrolysis after 10 mins...				Bioorg Med Chem Lett 21: 7321-4 (2011) Article DOI: 10.1016/j.bmcl.2011.10.026 BindingDB Entry DOI: 10.7270/Q2B27VPC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM66023 (2-octyl-1,2-thiazol-3-one | 2-octyl-3-isothiazolon...) Show SMILES CCCCCCCCn1sccc1=O Show InChI InChI=1S/C11H19NOS/c1-2-3-4-5-6-7-9-12-11(13)8-10-14-12/h8,10H,2-7,9H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of recombinant rat N-terminal histidine tagged MAGL expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells preincubated for 10 mins fol...				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM81363 (Pristimerin) Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=c5c(cc(O)c(O)c5=C)[C@]4(C)CC[C@@]3(C)C2C1 |r,c:16,t:14| Show InChI InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,31-32H,1,10-15,17H2,2-7H3/t23?,26-,27-,28+,29-,30+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	37
University of California Irvine					Assay Description Purified recombinant rat MGL was prepared and enzyme activity was assayed.				Chem Biol 16: 1045-52 (2009) Article DOI: 10.1016/j.chembiol.2009.09.012 BindingDB Entry DOI: 10.7270/Q2HH6HJ3
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50481947 (CHEBI:8416 | GNF-Pf-476 | PRISTIMERIN | Pristimeri...) Show SMILES [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)OC |r,c:24,t:14,16,19| Show InChI InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23-,26-,27-,28+,29-,30+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant rat MAGL by LC-MS analysis				Citation and Details Article DOI: 10.1016/j.bmcl.2021.127986 BindingDB Entry DOI: 10.7270/Q2D222D0
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50450775 (CHEMBL4207055 | med.21724, Compound 142) Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(C)=C(O)C(=O)C=C5[C@]4(C)CC[C@@]3(C)C2C1 |r,c:24,t:14,16,19| Show InChI InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23?,26-,27-,28+,29-,30+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of recombinant rat MAGL expressed in Escherichia coli using 2-AG as substrate				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514180 (CHEMBL4439900) Show SMILES COC(=O)c1ccc(CNn2sc3ccccc3c2=O)cc1 Show InChI InChI=1S/C16H14N2O3S/c1-21-16(20)12-8-6-11(7-9-12)10-17-18-15(19)13-4-2-3-5-14(13)22-18/h2-9,17H,10H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520901 (CHEMBL4472005) Show SMILES COc1cc(OC(=O)N2CCC(CC2)C(c2ccccc2)c2ccccc2)cc(c1)C#N Show InChI InChI=1S/C27H26N2O3/c1-31-24-16-20(19-28)17-25(18-24)32-27(30)29-14-12-23(13-15-29)26(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-11,16-18,23,26H,12-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520904 (CHEMBL4541769) Show SMILES Fc1ccc(cc1)C(N1CCN(CC1)C(=O)Oc1cccc(c1)C#N)c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N3O2/c26-21-8-4-19(5-9-21)24(20-6-10-22(27)11-7-20)29-12-14-30(15-13-29)25(31)32-23-3-1-2-18(16-23)17-28/h1-11,16,24H,12-15H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520894 (CHEMBL4540953) Show SMILES Oc1cc(OC(=O)N2CCC(CC2)C(c2ccccc2)c2ccccc2)cc(c1)C#N Show InChI InChI=1S/C26H24N2O3/c27-18-19-15-23(29)17-24(16-19)31-26(30)28-13-11-22(12-14-28)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-10,15-17,22,25,29H,11-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520888 (CHEMBL4473440) Show SMILES Fc1cc(OC(=O)N2CCC(CC2)C(c2ccccc2)c2ccccc2)cc(c1)C#N Show InChI InChI=1S/C26H23FN2O2/c27-23-15-19(18-28)16-24(17-23)31-26(30)29-13-11-22(12-14-29)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-10,15-17,22,25H,11-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520898 (CHEMBL4435037) Show SMILES O=C(Oc1cccc(c1)C#N)N1CCN(CC1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H23N3O2/c26-19-20-8-7-13-23(18-20)30-25(29)28-16-14-27(15-17-28)24(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-13,18,24H,14-17H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520892 (CHEMBL4548730) Show SMILES Fc1ccc(cc1OC(=O)N1CCC(CC1)C(c1ccccc1)c1ccccc1)C#N Show InChI InChI=1S/C26H23FN2O2/c27-23-12-11-19(18-28)17-24(23)31-26(30)29-15-13-22(14-16-29)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-12,17,22,25H,13-16H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514166 (CHEMBL4448448) Show SMILES O=c1n(NCCCCCCNn2sc3ccccc3c2=O)sc2ccccc12 Show InChI InChI=1S/C20H22N4O2S2/c25-19-15-9-3-5-11-17(15)27-23(19)21-13-7-1-2-8-14-22-24-20(26)16-10-4-6-12-18(16)28-24/h3-6,9-12,21-22H,1-2,7-8,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL C201A mutant expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520887 (CHEMBL4565696) Show SMILES O=C(Oc1cccc(c1)C#N)N1CCC(CC1)OC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C26H24N2O3/c27-19-20-8-7-13-24(18-20)31-26(29)28-16-14-23(15-17-28)30-25(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-13,18,23,25H,14-17H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50514179 (CHEMBL4558017) Show SMILES Oc1ccc2sn(CCc3ccccc3)c(=O)c2c1 Show InChI InChI=1S/C15H13NO2S/c17-12-6-7-14-13(10-12)15(18)16(19-14)9-8-11-4-2-1-3-5-11/h1-7,10,17H,8-9H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...				J Med Chem 63: 1261-1280 (2020) Article DOI: 10.1021/acs.jmedchem.9b01679 BindingDB Entry DOI: 10.7270/Q2377D2G
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM60419 (BDBM50295658 | NAM) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCN1C(=O)C=CC1=O |c:23| Show InChI InChI=1S/C24H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-23(26)20-21-24(25)27/h6-7,9-10,12-13,15-16,20-21H,2-5,8,11,14,17-19,22H2,1H3/b7-6-,10-9-,13-12-,16-15-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of MAGL in rat cerebellar membranes				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM60419 (BDBM50295658 | NAM) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCN1C(=O)C=CC1=O |c:23| Show InChI InChI=1S/C24H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-23(26)20-21-24(25)27/h6-7,9-10,12-13,15-16,20-21H,2-5,8,11,14,17-19,22H2,1H3/b7-6-,10-9-,13-12-,16-15-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical and Pharmaceutical Sciences, University of Ferrara , 44121 Ferrara, Italy. Curated by ChEMBL					Assay Description Inhibition of MAGL from Wistar rat brain using 2-monooleoyl[1,2,3-H]glycerol as substrate				J Med Chem 61: 1340-1354 (2018) Article DOI: 10.1021/acs.jmedchem.7b01845 BindingDB Entry DOI: 10.7270/Q2JM2D3V
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM60419 (BDBM50295658 | NAM) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCN1C(=O)C=CC1=O |c:23| Show InChI InChI=1S/C24H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-23(26)20-21-24(25)27/h6-7,9-10,12-13,15-16,20-21H,2-5,8,11,14,17-19,22H2,1H3/b7-6-,10-9-,13-12-,16-15-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat cerebellar membranes MAGL-like activity preincubated for 30 mins followed by 2-AG substrate addition after 90 mins by HPLC analysis				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Rattus norvegicus (Rat))	BDBM50520891 (CHEMBL4557262) Show SMILES O=C(Oc1cccc(c1)C#N)N1CCN(CC1)C1CC1 Show InChI InChI=1S/C15H17N3O2/c16-11-12-2-1-3-14(10-12)20-15(19)18-8-6-17(7-9-18)13-4-5-13/h1-3,10,13H,4-9H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
MAK Scientific LLC Curated by ChEMBL					Assay Description Inhibition of purified rat MGL using AHMMCE as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured at 15 mins inte...				Bioorg Med Chem 27: 55-64 (2019) Article DOI: 10.1016/j.bmc.2018.11.003 BindingDB Entry DOI: 10.7270/Q2XD153X
					More data for this Ligand-Target Pair

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