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TargetMonoglyceride lipase
LigandBDBM50160284
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1566110 (CHEMBL3791994)
IC50 10.0±n/a nM
Citation Brindisi, MMaramai, SGemma, SBrogi, SGrillo, ADi Cesare Mannelli, LGabellieri, ELamponi, SSaponara, SGorelli, BTedesco, DBonfiglio, TLandry, CJung, KMArmirotti, ALuongo, LLigresti, APiscitelli, FBertucci, CDehouck, MPCampiani, GMaione, SGhelardini, CPittaluga, APiomelli, DDi Marzo, VButini, S Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem59:2612-32 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monoglyceride lipase
Name:Monoglyceride lipase
Synonyms:MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:Enzyme
Mol. Mass.:33505.38
Organism:Rattus norvegicus (Rat)
Description:Q8R431
Residue:303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLG
HSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRID
SSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGAR
CLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50160284
n/a
NameBDBM50160284
Synonyms:CHEMBL3785379
TypeSmall organic molecule
Emp. Form.C24H22FN5O4
Mol. Mass.463.461
SMILESFc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1 |r|
Structure
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