Found 30 hits of ki data for polymerid = 3592 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50552984
(CHEMBL1410976)Show SMILES COc1cc(C=C2C(=O)OC(OC2=O)c2ccccc2)cc(Br)c1O | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal hexa-His-tagged human SIRT1 (156 to 664 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociatio... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00559 BindingDB Entry DOI: 10.7270/Q2VQ3698 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50178769
((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)Show InChI InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 114 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Uncompetitive inhibition of His6-tagged SIRT1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant measured ever... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00017 BindingDB Entry DOI: 10.7270/Q2MK6HQZ |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576050
(CHEMBL4858009)Show SMILES NC(=O)C1CN(Cc2ccccc2[N+]([O-])=O)c2ccccc2O1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 285 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Uncompetitive inhibition of His6-tagged SIRT1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant measured ever... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00017 BindingDB Entry DOI: 10.7270/Q2MK6HQZ |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576055
(CHEMBL4855963) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Uncompetitive inhibition of His6-tagged SIRT1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant measured ever... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00017 BindingDB Entry DOI: 10.7270/Q2MK6HQZ |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50044816
(CHEMBL1576457)Show InChI InChI=1S/C12H7N5OS/c1-2-6-13-8(4-1)11-16-17-10(9-5-3-7-18-9)14-15-12(17)19-11/h1-7H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse... |
Bioorg Med Chem Lett 24: 3050-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50552984
(CHEMBL1410976)Show SMILES COc1cc(C=C2C(=O)OC(OC2=O)c2ccccc2)cc(Br)c1O | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal hexa-His-tagged human SIRT1 F273L mutant (156 to 664 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissocia... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00559 BindingDB Entry DOI: 10.7270/Q2VQ3698 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50552984
(CHEMBL1410976)Show SMILES COc1cc(C=C2C(=O)OC(OC2=O)c2ccccc2)cc(Br)c1O | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal hexa-His-tagged human SIRT1 I347A mutant (156 to 664 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissocia... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00559 BindingDB Entry DOI: 10.7270/Q2VQ3698 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50425971
(CHEMBL2314710)Show InChI InChI=1S/C15H10O5/c16-8-1-3-13(18)11(6-8)15(19)12-7-20-14-4-2-9(17)5-10(12)14/h1-7,16-18H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Mixed-type inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using NAD+ as ... |
Eur J Med Chem 60: 441-50 (2013)
Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50552984
(CHEMBL1410976)Show SMILES COc1cc(C=C2C(=O)OC(OC2=O)c2ccccc2)cc(Br)c1O | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal hexa-His-tagged human SIRT1 N346A mutant (156 to 664 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissocia... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00559 BindingDB Entry DOI: 10.7270/Q2VQ3698 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50168921
(CHEMBL3806257)Show InChI InChI=1S/C19H16N4O3/c20-18(24)15-9-17(11-22-10-15)26-12-13-2-1-3-16(8-13)23-19(25)14-4-6-21-7-5-14/h1-11H,12H2,(H2,20,24)(H,23,25) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll... |
J Med Chem 59: 2928-41 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50168905
(CHEMBL3805692)Show SMILES NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)N3CCOCC3)c2)c1 Show InChI InChI=1S/C24H24N4O4/c25-23(29)19-13-22(15-26-14-19)32-16-17-2-1-3-20(12-17)27-24(30)18-4-6-21(7-5-18)28-8-10-31-11-9-28/h1-7,12-15H,8-11,16H2,(H2,25,29)(H,27,30) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll... |
J Med Chem 59: 2928-41 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50463739
(CHEMBL4237803)Show InChI InChI=1S/C17H21N3O5/c1-25-12-8-6-11(7-9-12)19-15-14(16(22)17(15)23)18-10-4-2-3-5-13(21)20-24/h6-9,18-19,24H,2-5,10H2,1H3,(H,20,21) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nestle Skin Health R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method |
Bioorg Med Chem Lett 28: 2985-2992 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.029 BindingDB Entry DOI: 10.7270/Q2M0484T |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50463743
(CHEMBL4241370)Show SMILES CC(C)(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O Show InChI InChI=1S/C19H22F3N3O4/c1-18(2,10-4-3-5-13(26)25-29)24-15-14(16(27)17(15)28)23-12-8-6-11(7-9-12)19(20,21)22/h6-9,23-24,29H,3-5,10H2,1-2H3,(H,25,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nestle Skin Health R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method |
Bioorg Med Chem Lett 28: 2985-2992 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.029 BindingDB Entry DOI: 10.7270/Q2M0484T |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50463738
(CHEMBL4244764)Show SMILES CC(Nc1c(NCCCCCC(=O)NO)c(=O)c1=O)C12CC3CC(CC(C3)C1)C2 |THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25| Show InChI InChI=1S/C22H33N3O4/c1-13(22-10-14-7-15(11-22)9-16(8-14)12-22)24-19-18(20(27)21(19)28)23-6-4-2-3-5-17(26)25-29/h13-16,23-24,29H,2-12H2,1H3,(H,25,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nestle Skin Health R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method |
Bioorg Med Chem Lett 28: 2985-2992 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.029 BindingDB Entry DOI: 10.7270/Q2M0484T |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50105327
(JNJ-26481585 | Quisinostat)Show SMILES Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12 Show InChI InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nestle Skin Health R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method |
Bioorg Med Chem Lett 28: 2985-2992 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.029 BindingDB Entry DOI: 10.7270/Q2M0484T |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1 Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+ | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nestle Skin Health R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method |
Bioorg Med Chem Lett 28: 2985-2992 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.029 BindingDB Entry DOI: 10.7270/Q2M0484T |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50552984
(CHEMBL1410976)Show SMILES COc1cc(C=C2C(=O)OC(OC2=O)c2ccccc2)cc(Br)c1O | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal hexa-His-tagged human SIRT1 F414A mutant (156 to 664 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissocia... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00559 BindingDB Entry DOI: 10.7270/Q2VQ3698 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50168918
(CHEMBL3806063)Show InChI InChI=1S/C19H16N4O3/c20-18(24)15-8-17(11-22-10-15)26-12-13-3-1-5-16(7-13)23-19(25)14-4-2-6-21-9-14/h1-11H,12H2,(H2,20,24)(H,23,25) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll... |
J Med Chem 59: 2928-41 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50044816
(CHEMBL1576457)Show InChI InChI=1S/C12H7N5OS/c1-2-6-13-8(4-1)11-16-17-10(9-5-3-7-18-9)14-15-12(17)19-11/h1-7H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 F414A mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit... |
Bioorg Med Chem Lett 24: 3050-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576690
(CHEMBL4873772)Show SMILES O=C(NCCOCCOCCOCCNC(=O)c1cccc(c1)-c1cccnc1)c1cccc(c1)-c1cccnc1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50044816
(CHEMBL1576457)Show InChI InChI=1S/C12H7N5OS/c1-2-6-13-8(4-1)11-16-17-10(9-5-3-7-18-9)14-15-12(17)19-11/h1-7H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 I347A mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit... |
Bioorg Med Chem Lett 24: 3050-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576687
(CHEMBL4855531)Show SMILES O=C(CNCCCCCCNC(=O)C1CC(=O)c2ccccc12)C1CC2CCC1C2 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50044816
(CHEMBL1576457)Show InChI InChI=1S/C12H7N5OS/c1-2-6-13-8(4-1)11-16-17-10(9-5-3-7-18-9)14-15-12(17)19-11/h1-7H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 F273L mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit... |
Bioorg Med Chem Lett 24: 3050-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576701
(CHEMBL4867959)Show SMILES O=C(NCCCCCCNC(=O)c1cccc(c1)-c1cccnc1)c1cccc(c1)-c1cccnc1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 7.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576689
(CHEMBL4872893)Show SMILES COc1cc(CC(=O)NCCCCCCNC(=O)c2cccc(c2)-c2cccnc2)cc(OC)c1OC | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50168493
(CHEMBL3805479)Show SMILES NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)-c3cccs3)c2)c1 Show InChI InChI=1S/C24H19N3O3S/c25-23(28)19-12-21(14-26-13-19)30-15-16-3-1-4-20(11-16)27-24(29)18-8-6-17(7-9-18)22-5-2-10-31-22/h1-14H,15H2,(H2,25,28)(H,27,29) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll... |
J Med Chem 59: 2928-41 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576711
(CHEMBL4857381)Show SMILES O=C(CNCc1ccc(CNC(=O)C2CC(=O)c3ccccc23)cc1)C1CC2CCC1C2 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576713
(CHEMBL4871121)Show SMILES O=C(CNCCOCCOCCNC(=O)C1CC(=O)c2ccccc12)C1CC2CCC1C2 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.83E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576712
(CHEMBL4853759)Show SMILES O=C(CNCCCNC(=O)C1CC(=O)c2ccccc12)C1CC2CCC1C2 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 2.02E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576714
(CHEMBL4858422)Show SMILES O=C(CNCCOCCOCCOCCNC(=O)C1CC(=O)c2ccccc12)C1CC2CCC1C2 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 6.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT1 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |