Found 776 hits Enz. Inhib. hit(s) with Target = 'Macrophage migration inhibitory factor (MIF)' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648297
(1-(3-methoxy-4-(((5-(thiophen-2-yl)- 1,3,4-oxadiaz...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)N1CCCC(C1)C(O)=O | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| MCE PC cid PC sid UniChem
| | n/a | n/a | 6.92 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648295
(3'-methoxy-4'-((5-(thiophen-2-yl)- 1,3,4-oxadiazol...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)C1=CCC(CC1)C(O)=O |t:24| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 7.24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50327348
(3-(3-hydroxybenzyl)-6-methylbenzo[d]oxazol-2(3H)-o...)Show InChI InChI=1S/C15H13NO3/c1-10-5-6-13-14(7-10)19-15(18)16(13)9-11-3-2-4-12(17)8-11/h2-8,17H,9H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MIF tautomerase |
Bioorg Med Chem Lett 20: 5811-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.129 BindingDB Entry DOI: 10.7270/Q29Z955S |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648298
(2-((3-metboxy-4-((5-(thiophen-2-yl)- 1,3,4-oxadiaz...)Show SMILES COc1cc(NC(C)(C)C(O)=O)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 9.55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50327346
(3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-o...)Show InChI InChI=1S/C15H13NO3/c1-10-5-6-14-13(7-10)16(15(18)19-14)9-11-3-2-4-12(17)8-11/h2-8,17H,9H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MIF tautomerase |
Bioorg Med Chem Lett 20: 5811-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.129 BindingDB Entry DOI: 10.7270/Q29Z955S |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648281
(4-(2-hydroxyethoxy)-2-methoxy-N- (5-(thiophen-2-yl...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648291
(4-(3-(2H-tetrazol-5-yl)propyl)-2- methoxy-N-(5-(th...)Show SMILES COc1cc(CCCc2nn[nH]n2)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 11.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648286
(4-((2H-tetrazol-5-yl)methoxy)-2- methoxy-N-(5-(thi...)Show SMILES COc1cc(OCc2nn[nH]n2)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 12.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648296
((3-methoxy-4-((5-(thiophen-2-yl)- 1,3,4-oxadiazol-...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)N1CCCC1C(O)=O | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648293
(Cis-4-(3-methoxy-4-((5-(thiophen-2- yl)-1,3,4-oxad...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)C1CC[C@@H](CC1)C(O)=O |r,wU:24.30,(-.11,-2.98,;-.51,-1.49,;.58,-.4,;2.07,-.8,;3.16,.29,;2.76,1.78,;1.27,2.18,;.18,1.09,;-1.3,1.49,;-1.7,2.98,;-2.39,.4,;-3.88,.8,;-4.36,2.26,;-5.9,2.26,;-6.37,.8,;-5.13,-.11,;-7.71,.03,;-8.95,.93,;-10.2,.03,;-9.72,-1.44,;-8.18,-1.44,;4.65,-.11,;5.04,-1.59,;6.53,-1.99,;7.62,-.9,;7.22,.58,;5.74,.98,;9.11,-1.3,;10.2,-.21,;9.51,-2.79,)| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 18.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648260
(2,4-dimethoxy-N-(5-(thiophen-3-yl)- 1,3,4-oxadiazo...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 18.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648289
(4-(3-cyanopropyl)-2-methoxy-N-(5- (thiophen-2-yl)-...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 20.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648267
(2,4-dimethoxy-N-(5-(thiophen-2-yl)- 1,3,4-oxadiazo...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 22.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648282
(4-(2-(benzyloxy)ethoxy)-2-methoxy- N-(5-(thiophen-...)Show SMILES COc1cc(OCCOCc2ccccc2)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 23.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648285
(2-(3-methoxy-4-((5-(thiophen-2-yl)- 1,3,4-oxadiazo...)Show SMILES COc1cc(OC(C)(C)C(O)=O)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 25.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648283
(2-(3-methoxy-4-((5-(thiophen-2-yl)- 1,3,4-oxadiazo...)Show SMILES COc1cc(OCC(O)=O)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 28.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648287
(2-methoxy-4-((2-((5-methyl-2-oxo- 1,3-dioxol-4-yl)...)Show SMILES COc1cc(OCc2nnn(Cc3oc(=O)oc3C)n2)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648303
(2-methoxy-4-morpholino-N-(5- (thiophen-2-yl)-1,3,4...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)N1CCOCC1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 36.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648294
(Trans-4-(3-methoxy-4-((5-(thiophen- 2-yl)-1,3,4-ox...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)C1CC[C@@H](CC1)C(O)=O |r,wD:24.30,(-.11,-2.98,;-.51,-1.49,;.58,-.4,;2.07,-.8,;3.16,.29,;2.76,1.78,;1.27,2.18,;.18,1.09,;-1.3,1.49,;-1.7,2.98,;-2.39,.4,;-3.88,.8,;-4.36,2.26,;-5.9,2.26,;-6.37,.8,;-5.13,-.11,;-7.71,.03,;-8.95,.93,;-10.2,.03,;-9.72,-1.44,;-8.18,-1.44,;4.65,-.11,;5.74,.98,;7.22,.58,;7.62,-.9,;6.53,-1.99,;5.04,-1.59,;9.11,-1.3,;10.2,-.21,;9.51,-2.79,)| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human His-tagged MIF tautomerization expressed in Escherichia coli BL21 (DE3) using D-dopachrome as substrate after 10 mins... |
J Med Chem 61: 8104-8119 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00589 BindingDB Entry DOI: 10.7270/Q2KS6V5P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50095997
(3',4',7-trihydroxyisoflavone | CHEMBL13486)Show InChI InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity expressed in Escherichia coli BL21 (DE3) using 4-hydroxyphenyl pyruvic acid as substrate |
Bioorg Med Chem Lett 26: 2764-2767 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.074 BindingDB Entry DOI: 10.7270/Q24X59PR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50313986
(3-(3,4-dihydroxyphenyl)-4H-chromen-4-one | CHEMBL1...)Show InChI InChI=1S/C15H10O4/c16-12-6-5-9(7-13(12)17)11-8-19-14-4-2-1-3-10(14)15(11)18/h1-8,16-17H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description Inhibition of MIF |
Bioorg Med Chem Lett 20: 1821-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.009 BindingDB Entry DOI: 10.7270/Q2D79BJG |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648300
(2-methoxy-4-morpholino-N-(5- (thiazol-5-yl)-1,3,4-...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cncs1)N1CCOCC1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 46.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648288
(2-methoxy-4-((1-((5-methyl-2-oxo- 1,3-dioxol-4-yl)...)Show SMILES COc1cc(OCc2nnnn2Cc2oc(=O)oc2C)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326574
(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)Show InChI InChI=1S/C15H10N2O2S/c18-15(13-7-4-10-20-13)19-14-9-8-12(16-17-14)11-5-2-1-3-6-11/h1-10H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326574
(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)Show InChI InChI=1S/C15H10N2O2S/c18-15(13-7-4-10-20-13)19-14-9-8-12(16-17-14)11-5-2-1-3-6-11/h1-10H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648299
(4-(6-oxa-3-azabicyclo[3.1.1]heptan- 3-yl)-2-methox...)Show SMILES COc1cc(ccc1C(=O)Nc1nnc(o1)-c1cccs1)N1CC2CC(C1)O2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 51.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648264
(2,4-dimethoxy-N-(5-(thiazol-5-yl)- 1,3,4-oxadiazol...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 67.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM33627
((1,3-benzoxazol-2-ylthio)formic acid butyl ester |...)Show InChI InChI=1S/C12H13NO3S/c1-2-3-8-15-12(14)17-11-13-9-6-4-5-7-10(9)16-11/h4-7H,2-3,8H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648280
(4-hydroxy-2-methoxy-N-(5- (thiophen-2-yl)-1,3,4-ox...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 81.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50167982
(CHEMBL3797982)Show InChI InChI=1S/C13H10N2O2/c16-11-5-4-9(7-12(11)17)10-8-14-13-3-1-2-6-15(10)13/h1-8,16-17H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of MIF (unknown origin) tautomerase activity using dopachrome as substrate |
Bioorg Med Chem Lett 26: 2764-2767 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.074 BindingDB Entry DOI: 10.7270/Q24X59PR |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50209085
(3-fluoro-4-hydroxybenzaldehyde (4-methoxyphenyl)hy...)Show InChI InChI=1S/C14H13FN2O2/c1-19-12-5-3-11(4-6-12)17-16-9-10-2-7-14(18)13(15)8-10/h2-8,18H,9H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
and The New York School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of MIF tautomerase activity by spectrophotometric assay |
J Med Chem 50: 1993-7 (2007)
Article DOI: 10.1021/jm061477+ BindingDB Entry DOI: 10.7270/Q23X869D |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM33627
((1,3-benzoxazol-2-ylthio)formic acid butyl ester |...)Show InChI InChI=1S/C12H13NO3S/c1-2-3-8-15-12(14)17-11-13-9-6-4-5-7-10(9)16-11/h4-7H,2-3,8H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648284
(4-(2-(dimethylamino)ethoxy)-2- methoxy-N-(5-(thiop...)Show SMILES COc1cc(OCCN(C)C)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648279
(4-(benzyloxy)-2-methoxy-N-(5- (thiophen-2-yl)-1,3,...)Show SMILES COc1cc(OCc2ccccc2)ccc1C(=O)Nc1nnc(o1)-c1cccs1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50209081
(3-chloro-4-hydroxybenzaldehyde (4-methoxyphenyl)hy...)Show InChI InChI=1S/C14H13ClN2O2/c1-19-12-5-3-11(4-6-12)17-16-9-10-2-7-14(18)13(15)8-10/h2-8,18H,9H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
and The New York School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of MIF tautomerase activity by spectrophotometric assay |
J Med Chem 50: 1993-7 (2007)
Article DOI: 10.1021/jm061477+ BindingDB Entry DOI: 10.7270/Q23X869D |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50203072
(3-isothiocyanatoprop-1-ene | Allyl isothiocyanate ...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago
Curated by ChEMBL
| Assay Description Inhibition of macrophage migration inhibitory factor tautomerase activity in human Jurkat T cells using L-dopachrome methyl ester as substrate incuba... |
Eur J Med Chem 93: 501-10 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.012 BindingDB Entry DOI: 10.7270/Q26Q1ZZ7 |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648266
(N-(5-(3-fluorothiophen-2-yl)-1,3,4- oxadiazol-2-yl...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 288 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326573
(1-Phenyl-3-(2-thiazolyl)-2-thiourea | 1-phenyl-3-(...)Show InChI InChI=1S/C9H8N4S2/c14-8(12-9-13-10-6-15-9)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50209089
(3-bromo-4-hydroxybenzaldehyde (4-methoxyphenyl)hyd...)Show InChI InChI=1S/C14H13BrN2O2/c1-19-12-5-3-11(4-6-12)17-16-9-10-2-7-14(18)13(15)8-10/h2-8,18H,9H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
and The New York School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of MIF tautomerase activity by spectrophotometric assay |
J Med Chem 50: 1993-7 (2007)
Article DOI: 10.1021/jm061477+ BindingDB Entry DOI: 10.7270/Q23X869D |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM92515
(RDR 03785, 11)Show SMILES Oc1cc2OCOc2cc1C(N1CCOCC1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H18F3NO4/c20-19(21,22)13-3-1-12(2-4-13)18(23-5-7-25-8-6-23)14-9-16-17(10-15(14)24)27-11-26-16/h1-4,9-10,18,24H,5-8,11H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Covalent inhibition of MIF (unknown origin) tautomerase activity using 4-hydroxyphenyl pyruvic acid as substrate |
Bioorg Med Chem Lett 26: 2764-2767 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.074 BindingDB Entry DOI: 10.7270/Q24X59PR |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50458539
(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)Show SMILES [Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[#6]-[#8]-c1cc(ccc1\[#7]=[#7]\c1ccc2c(cc(c(-[#7])c2c1-[#8])S([#8-])(=O)=O)S([#8-])(=O)=O)-c1ccc(\[#7]=[#7]\c2ccc3c(cc(c(-[#7])c3c2-[#8])S([#8-])(=O)=O)S([#8-])(=O)=O)c(-[#8]-[#6])c1 Show InChI InChI=1S/C34H28N6O16S4/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)/p-4/b39-37+,40-38+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant biotinylated human MIF tautomerase activity expressed in Escherichia coli BL21 DE3 assessed as reduction in tautomerization... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.9b00351 BindingDB Entry DOI: 10.7270/Q2CJ8J3J |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50458547
(CHEMBL4203719)Show InChI InChI=1S/C20H16N2O2S/c23-18-12-10-17(11-13-18)21-20(25)22-19(24)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-13,23H,(H2,21,22,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of MIF (unknown origin) tautomerase activity using dopa as substrate |
J Med Chem 61: 8104-8119 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00589 BindingDB Entry DOI: 10.7270/Q2KS6V5P |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50180758
(4-((pyridin-4-ylthio)methyl)benzene-1,2-diol | CHE...)Show InChI InChI=1S/C12H11NO2S/c14-11-2-1-9(7-12(11)15)8-16-10-3-5-13-6-4-10/h1-7,14-15H,8H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Advanced Industrial Science and Technology (AIST)
Curated by ChEMBL
| Assay Description Inhibition of MIF |
J Med Chem 49: 523-33 (2006)
Article DOI: 10.1021/jm050480a BindingDB Entry DOI: 10.7270/Q2HD7V63 |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50458539
(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)Show SMILES [Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[#6]-[#8]-c1cc(ccc1\[#7]=[#7]\c1ccc2c(cc(c(-[#7])c2c1-[#8])S([#8-])(=O)=O)S([#8-])(=O)=O)-c1ccc(\[#7]=[#7]\c2ccc3c(cc(c(-[#7])c3c2-[#8])S([#8-])(=O)=O)S([#8-])(=O)=O)c(-[#8]-[#6])c1 Show InChI InChI=1S/C34H28N6O16S4/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)/p-4/b39-37+,40-38+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MIF expressed in Escherichia coli BL21 DE3 binding to recombinant soluble human CD74 receptor ectodomain (73 to 232 r... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.9b00351 BindingDB Entry DOI: 10.7270/Q2CJ8J3J |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50167987
(CHEMBL3799453)Show InChI InChI=1S/C13H9FN2O3/c14-11-6-9(3-4-12(11)17)7-16-19-13(18)10-2-1-5-15-8-10/h1-8,17H/b16-7+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of MIF (unknown origin) tautomerase activity using dopachrome as substrate |
Bioorg Med Chem Lett 26: 2764-2767 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.074 BindingDB Entry DOI: 10.7270/Q24X59PR |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326573
(1-Phenyl-3-(2-thiazolyl)-2-thiourea | 1-phenyl-3-(...)Show InChI InChI=1S/C9H8N4S2/c14-8(12-9-13-10-6-15-9)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010 BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50553880
(CHEMBL4761710) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01160 BindingDB Entry DOI: 10.7270/Q2KW5KPR |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50209090
(4-hydroxybenzaldehyde (4-methoxyphenyl)hydrazone |...)Show InChI InChI=1S/C14H14N2O2/c1-18-14-8-4-12(5-9-14)16-15-10-11-2-6-13(17)7-3-11/h2-9,17H,10H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
and The New York School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of MIF tautomerase activity by spectrophotometric assay |
J Med Chem 50: 1993-7 (2007)
Article DOI: 10.1021/jm061477+ BindingDB Entry DOI: 10.7270/Q23X869D |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM648304
(2,4-dimethoxy-N-((5-(thiophen-2-yl)- 1,3,4-oxadiaz...) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |