Compile Data Set for Download or QSAR

Found 410 hits Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B (NF-kB)'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527568 (US11186588, Example 26) Show SMILES Cc1nnc2N(Cc3ccc(F)nc3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527554 (US11186588, Example 9) Show SMILES Cc1nnc2N(Cc3cccc(F)c3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527550 (US11186588, Example 5) Show SMILES Cc1nnc2N(Cc3ccccn3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:14| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM511480 (US11059789, Example 40 | US11691950, Example 40) Show SMILES CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:15,t:11| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2C82FD9
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527563 (US11186588, Example 21 | US11186588, Example 22) Show SMILES Cc1nnc2N(Cc3cccc(F)n3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527557 (US11186588, Example 12) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1cccc(C)c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527563 (US11186588, Example 21 | US11186588, Example 22) Show SMILES Cc1nnc2N(Cc3cccc(F)n3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527616 (US11186588, Example 92) Show SMILES Cc1nnc2N(Cc3cccnc3)N=C(c3c(C)c(C)sc3-n12)c1ccc(N)cc1 |c:14| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM511481 (US11059789, Example 25 | US11691950, Example 25) Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:11,t:7| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2C82FD9
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527608 (US11186588, Example 81) Show SMILES Cc1nnc2N(Cc3cccnc3N)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM50062648 (2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F Show InChI InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527567 (US11186588, Example 25) Show SMILES Cc1nnc2N(Cc3cccnc3F)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527549 (US11186588, Example 3) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1ccccc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM511482 (US11059789, Example 83 | US11691950, Example 83) Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C[C@H](N)C(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:11,t:7| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2C82FD9
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM511483 (US11059789, Example 66 | US11691950, Example 66) Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)c1ccc(cc1)C(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:11,t:7| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2C82FD9
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM50196926 (CHEMBL438139 | Rocaglamide | US10085988, Compound ...) Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...				J Nat Prod 73: 949-55 (2010) Article DOI: 10.1021/np1002065 BindingDB Entry DOI: 10.7270/Q28S4QWW
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527560 (US11186588, Example 16) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1cccc(Cl)c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	77.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527551 (US11186588, Example 6) Show SMILES COc1cccc(CN2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)c1 |c:9| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	86.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527572 (US11186588, Example 33) Show SMILES COc1cccc(CN2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccccc2)c1 |c:9| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	87.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527610 (US11186588, Example 83 | US11186588, Example 86) Show SMILES COC(=O)c1ncccc1CN1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |c:13| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	95.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527617 (N-(4-(2,3,9-trimethyl-6H-thieno[2,3-e][1,2,4]triaz...) Show SMILES CC(=O)Nc1ccc(cc1)C1=NNc2nnc(C)n2-c2sc(C)c(C)c12 |t:11| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM511484 (US11059789, Example 33 | US11691950, Example 33) Show SMILES CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:14,t:10| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2C82FD9
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527553 (US11186588, Example 8) Show SMILES Cc1nnc2N(Cc3ccccc3F)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527575 (US11186588, Example 38) Show SMILES Cc1nnc2N(Cc3cccnc3Cl)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527609 (US11186588, Example 82) Show SMILES CC(=O)Nc1ncccc1CN1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |c:13| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527561 (US11186588, Example 18) Show SMILES Cc1nnc2N(Cc3cccc(c3)C(F)(F)F)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:18| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527571 (US11186588, Example 31) Show SMILES Cc1nnc2N(Cc3ccccn3)N=C(c3c(C)c(C)sc3-n12)c1ccccc1 |c:14| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527565 (US11186588, Example 23) Show SMILES Cc1nnc2N(Cc3ncccc3F)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM50062645 (3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...) Show SMILES CCCCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F Show InChI InChI=1S/C18H14ClF6N3O3/c1-2-3-4-31-15(30)9-5-10(17(20,21)22)7-11(6-9)27-14(29)12-8-26-16(19)28-13(12)18(23,24)25/h5-8H,2-4H2,1H3,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527555 (US11186588, Example 10) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1ccccc1Cl)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527585 (US11186588, Example 49) Show SMILES COc1ncccc1CN1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |c:11| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527558 (US11186588, Example 13) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1ccc(C)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	233	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527601 (US11186588, Example 73) Show SMILES Cc1sc(NC(=S)N(N)Cc2cccnc2)c(C(=O)c2cccc(Cl)c2)c1C Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	246	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527570 (US11186588, Example 29) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1ccccc1)c1nnc(C)n-21)c1ccccc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	265	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527587 (US11186588, Example 51) Show SMILES COc1ccncc1CN1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |c:11| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	265	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527559 (US11186588, Example 14) Show SMILES Cc1nnc2N(Cc3ccc(cc3)C(F)(F)F)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:18| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	276	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM50062658 (3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...) Show SMILES CCOC(=O)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F Show InChI InChI=1S/C16H10ClF6N3O3/c1-2-29-13(28)7-3-8(15(18,19)20)5-9(4-7)25-12(27)10-6-24-14(17)26-11(10)16(21,22)23/h3-6H,2H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527618 (US11186588, Example 103 | US11186588, Example 99) Show SMILES COc1cncc(CNNC(=O)OC(C)(C)C)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527556 (US11186588, Example 11) Show SMILES Cc1sc-2c(c1C)C(=NN(Cc1ccccc1C)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	291	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527584 (US11186588, Example 48) Show SMILES COc1ccnc(CN2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)c1 |c:9| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	297	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527615 (Synthesis of | US11186588, Example 90) Show SMILES Cc1nnc2N(Cc3cccnc3F)N=C(c3c(C)c(C)sc3-n12)c1ccccc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	298	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527586 (US11186588, Example 50) Show SMILES COc1ccc(CN2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)cn1 |c:8| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	355	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527595 (US11186588, Example 61) Show SMILES Cc1nnc2N(Cc3cccnc3)N=C(c3ccsc3-n12)c1ccc(Cl)cc1 |c:14| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	377	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM50062669 (2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...) Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc1 Show InChI InChI=1S/C13H6ClF6N3O/c14-11-21-5-8(9(23-11)13(18,19)20)10(24)22-7-3-1-6(2-4-7)12(15,16)17/h1-5H,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527574 (US11186588, Example 36) Show SMILES Cc1nnc2N(Cc3ccc(Cl)cn3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:15| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	401	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM527581 (US11186588, Example 45) Show SMILES Cc1nnc2N(Cc3cccs3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:13| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	429	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...				Citation and Details BindingDB Entry DOI: 10.7270/Q21R6TQ4
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM367259 (US10226464, Compound 27) Show SMILES Cc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1F Show InChI InChI=1S/C12H7FN2O3/c1-5-2-9-6(4-8(5)13)3-7-10(16)14-12(17)15-11(7)18-9/h2-4H,1H3,(H,14,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM367260 (US10226464, Compound 28) Show SMILES CCOc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1F Show InChI InChI=1S/C13H9FN2O4/c1-2-19-10-5-9-6(4-8(10)14)3-7-11(17)15-13(18)16-12(7)20-9/h3-5H,2H2,1H3,(H,15,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM367263 (US10226464, Compound 31) Show SMILES CCCCCCOc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1F Show InChI InChI=1S/C17H17FN2O4/c1-2-3-4-5-6-23-14-9-13-10(8-12(14)18)7-11-15(21)19-17(22)20-16(11)24-13/h7-9H,2-6H2,1H3,(H,19,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM367265 (US10226464, Compound 33) Show SMILES CC(C)CCOc1cc2oc3nc(=O)[nH]c(=O)c3cc2cc1F Show InChI InChI=1S/C16H15FN2O4/c1-8(2)3-4-22-13-7-12-9(6-11(13)17)5-10-14(20)18-16(21)19-15(10)23-12/h5-8H,3-4H2,1-2H3,(H,18,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...				Bioorg Med Chem Lett 17: 5384-9 (2007) BindingDB Entry DOI: 10.7270/Q2028TVG
					More data for this Ligand-Target Pair

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