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Patent code US8791123

Compile Data Set for Download or QSAR

Found 504 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127648
PNG
(US10251889, Example 21 | US10758542, Example 21 | ...)
Show SMILES Cn1cnc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)c1 |r|
Show InChI InChI=1S/C22H21F2N7O/c1-29-12-15(26-13-29)10-25-22(32)17-11-27-31-8-6-20(28-21(17)31)30-7-2-3-19(30)16-9-14(23)4-5-18(16)24/h4-6,8-9,11-13,19H,2-3,7,10H2,1H3,(H,25,32)/t19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127658
PNG
(US10251889, Example 31 | US10758542, Example 31 | ...)
Show SMILES OC1CN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C20H19F2N5O2/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(24-18)15(9-23-27)20(29)25-10-13(28)11-25/h3-5,7-9,13,17,28H,1-2,6,10-11H2/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127659
PNG
(US10251889, Example 32 | US10758542, Example 32 | ...)
Show SMILES CC1(O)CN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c1-21(30)11-26(12-21)20(29)15-10-24-28-8-6-18(25-19(15)28)27-7-2-3-17(27)14-9-13(22)4-5-16(14)23/h4-6,8-10,17,30H,2-3,7,11-12H2,1H3/t17-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127666
PNG
(US8791123, 39)
Show SMILES Fc1ccc(F)c(c1)C1CCCN1c1ccn2ncc(C(=O)NCC#N)c2n1
Show InChI InChI=1S/C19H16F2N6O/c20-12-3-4-15(21)13(10-12)16-2-1-8-26(16)17-5-9-27-18(25-17)14(11-24-27)19(28)23-7-6-22/h3-5,9-11,16H,1-2,7-8H2,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127671
PNG
(US8791123, 44)
Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)
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n/an/a 388n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127674
PNG
(US8791123, 47)
Show SMILES NS(=O)(=O)CCNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O3S/c20-12-3-4-15(21)13(10-12)16-2-1-7-26(16)17-5-8-27-18(25-17)14(11-24-27)19(28)23-6-9-31(22,29)30/h3-5,8,10-11,16H,1-2,6-7,9H2,(H,23,28)(H2,22,29,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127679
PNG
(US10251889, Example 52 | US10758542, Example 52 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C19H19FN6O/c20-13-8-12(9-21-10-13)16-2-1-6-25(16)17-5-7-26-18(24-17)15(11-22-26)19(27)23-14-3-4-14/h5,7-11,14,16H,1-4,6H2,(H,23,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127680
PNG
(US10251889, Example 53 | US10758542, Example 53 | ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C20H23FN6O/c1-20(2,3)25-19(28)15-12-23-27-8-6-17(24-18(15)27)26-7-4-5-16(26)13-9-14(21)11-22-10-13/h6,8-12,16H,4-5,7H2,1-3H3,(H,25,28)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127689
PNG
(US10251889, Example 62 | US10758542, Example 62 | ...)
Show SMILES OC[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H21F4N5O3/c22-12-3-4-16(21(23,24)25)14(8-12)17-2-1-6-29(17)18-5-7-30-19(28-18)15(10-27-30)20(33)26-9-13(32)11-31/h3-5,7-8,10,13,17,31-32H,1-2,6,9,11H2,(H,26,33)/t13-,17+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127694
PNG
(US10251889, Example 67 | US10758542, Example 67 | ...)
Show SMILES CC1(C)CC[C@@H](N1c1ccn2ncc(C(N)=O)c2n1)c1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H19F2N5O/c1-19(2)7-5-15(12-9-11(20)3-4-14(12)21)26(19)16-6-8-25-18(24-16)13(10-23-25)17(22)27/h3-4,6,8-10,15H,5,7H2,1-2H3,(H2,22,27)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127699
PNG
(US10251889, Example 72 | US10758542, Example 72 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCOCC3)c2n1 |r|
Show InChI InChI=1S/C21H23FN6O2/c22-15-10-14(11-23-12-15)18-2-1-6-27(18)19-3-7-28-20(26-19)17(13-24-28)21(29)25-16-4-8-30-9-5-16/h3,7,10-13,16,18H,1-2,4-6,8-9H2,(H,25,29)/t18-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127700
PNG
(US10251889, Example 73 | US10758542, Example 73 | ...)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C17H17FN6O2/c1-26-22-17(25)13-10-20-24-6-4-15(21-16(13)24)23-5-2-3-14(23)11-7-12(18)9-19-8-11/h4,6-10,14H,2-3,5H2,1H3,(H,22,25)/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127701
PNG
(US10251889, Example 74 | US10758542, Example 74 | ...)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r|
Show InChI InChI=1S/C17H16FN5O/c18-12-4-1-3-11(9-12)14-5-2-7-22(14)15-6-8-23-17(21-15)13(10-20-23)16(19)24/h1,3-4,6,8-10,14H,2,5,7H2,(H2,19,24)/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127710
PNG
(US8791123, 83)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)cnc1CO
Show InChI InChI=1S/C18H19FN6O3/c1-28-23-18(27)13-9-21-25-6-4-16(22-17(13)25)24-5-2-3-15(24)12-7-11(19)8-20-14(12)10-26/h4,6-9,15,26H,2-3,5,10H2,1H3,(H,23,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127725
PNG
(US10251889, Example 98 | US10758542, Example 98 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(CC3)C(F)(F)F)c2n1 |r|
Show InChI InChI=1S/C20H18F4N6O/c21-13-8-12(9-25-10-13)15-2-1-6-29(15)16-3-7-30-17(27-16)14(11-26-30)18(31)28-19(4-5-19)20(22,23)24/h3,7-11,15H,1-2,4-6H2,(H,28,31)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127726
PNG
(US10251889, Example 100 | US10758542, Example 100 ...)
Show SMILES O[C@H]1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r,wD:23.27,1.0,(7.01,-5.81,;6.24,-4.48,;7.01,-3.14,;6.24,-1.81,;4.7,-1.81,;3.93,-3.14,;4.7,-4.48,;3.93,-.47,;5.02,.61,;6.5,.22,;4.62,2.1,;5.52,3.35,;4.62,4.59,;3.15,4.12,;1.82,4.89,;.49,4.12,;.49,2.58,;1.82,1.81,;3.15,2.58,;-.85,1.81,;-.37,.34,;-1.62,-.56,;-2.86,.34,;-2.39,1.81,;-3.16,3.14,;-2.39,4.48,;-3.16,5.81,;-4.7,5.81,;-5.47,4.48,;-7.01,4.48,;-4.7,3.14,)|
Show InChI InChI=1S/C22H25FN6O2/c23-15-10-14(11-24-12-15)19-2-1-8-28(19)20-7-9-29-21(27-20)18(13-25-29)22(31)26-16-3-5-17(30)6-4-16/h7,9-13,16-17,19,30H,1-6,8H2,(H,26,31)/t16?,17-,19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127733
PNG
(US10251889, Example 106 | US10758542, Example 106 ...)
Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1
Show InChI InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127737
PNG
(US10251889, Example 110 | US10758542, Example 110 ...)
Show SMILES C[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 |r|
Show InChI InChI=1S/C19H21FN6O2/c1-12(27)8-22-19(28)15-11-23-26-6-4-17(24-18(15)26)25-5-2-3-16(25)13-7-14(20)10-21-9-13/h4,6-7,9-12,16,27H,2-3,5,8H2,1H3,(H,22,28)/t12-,16?/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127738
PNG
(US10251889, Example 111 | US10758542, Example 111 ...)
Show SMILES CC(C)(O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1
Show InChI InChI=1S/C20H23FN6O2/c1-20(2,29)12-23-19(28)15-11-24-27-7-5-17(25-18(15)27)26-6-3-4-16(26)13-8-14(21)10-22-9-13/h5,7-11,16,29H,3-4,6,12H2,1-2H3,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127741
PNG
(US10251889, Example 114 | US10758542, Example 114 ...)
Show SMILES CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1
Show InChI InChI=1S/C17H17FN6O/c1-19-17(25)13-10-21-24-6-4-15(22-16(13)24)23-5-2-3-14(23)11-7-12(18)9-20-8-11/h4,6-10,14H,2-3,5H2,1H3,(H,19,25)
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127747
PNG
(US10251889, Example 120 | US10758542, Example 120 ...)
Show SMILES O[C@H]1CCCC1NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16?,17?,18-/m0/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127749
PNG
(US10251889, Example 122 | US10758542, Example 122 ...)
Show SMILES CC(C)[C@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H25FN6O2/c1-13(2)17(12-29)25-21(30)16-11-24-28-7-5-19(26-20(16)28)27-6-3-4-18(27)14-8-15(22)10-23-9-14/h5,7-11,13,17-18,29H,3-4,6,12H2,1-2H3,(H,25,30)/t17-,18?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127760
PNG
(US10758542, Example 133 | US8791123, 133 | US97824...)
Show SMILES O[C@@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127763
PNG
(US10251889, Example 136 | US10758542, Example 136 ...)
Show SMILES O[C@@H]1CCCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C22H25FN6O2/c23-15-10-14(11-24-12-15)18-5-3-8-28(18)20-7-9-29-21(27-20)16(13-25-29)22(31)26-17-4-1-2-6-19(17)30/h7,9-13,17-19,30H,1-6,8H2,(H,26,31)/t17-,18-,19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127774
PNG
(US10251889, Example 147 | US10758542, Example 147 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N3CC(C)(O)C3)c2n1 |r|
Show InChI InChI=1S/C21H23FN6O3/c1-21(30)11-26(12-21)20(29)15-10-24-28-7-5-17(25-18(15)28)27-6-3-4-16(27)14-8-13(22)9-23-19(14)31-2/h5,7-10,16,30H,3-4,6,11-12H2,1-2H3/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127784
PNG
(US10251889, Example 157 | US10758542, Example 157 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC[C@@H](C)O)c2n1 |r|
Show InChI InChI=1S/C20H23FN6O3/c1-12(28)9-22-19(29)15-11-24-27-7-5-17(25-18(15)27)26-6-3-4-16(26)14-8-13(21)10-23-20(14)30-2/h5,7-8,10-12,16,28H,3-4,6,9H2,1-2H3,(H,22,29)/t12-,16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127787
PNG
(US10251889, Example 160 | US10758542, Example 160 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC(CO)CO)c2n1 |r|
Show InChI InChI=1S/C20H23FN6O4/c1-31-20-14(7-12(21)8-22-20)16-3-2-5-26(16)17-4-6-27-18(25-17)15(9-23-27)19(30)24-13(10-28)11-29/h4,6-9,13,16,28-29H,2-3,5,10-11H2,1H3,(H,24,30)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127794
PNG
(US10251889, Example 167 | US10758542, Example 167 ...)
Show SMILES C[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C20H21F2N5O2/c1-12(28)10-23-20(29)15-11-24-27-8-6-18(25-19(15)27)26-7-2-3-17(26)14-9-13(21)4-5-16(14)22/h4-6,8-9,11-12,17,28H,2-3,7,10H2,1H3,(H,23,29)/t12-,17?/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127796
PNG
(US10251889, Example 169 | US10758542, Example 169 ...)
Show SMILES O[C@H]1CC[C@@H](C1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H23F2N5O2/c23-13-3-6-18(24)16(10-13)19-2-1-8-28(19)20-7-9-29-21(27-20)17(12-25-29)22(31)26-14-4-5-15(30)11-14/h3,6-7,9-10,12,14-15,19,30H,1-2,4-5,8,11H2,(H,26,31)/t14-,15-,19+/m0/s1
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n/an/a 759n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127814
PNG
(US10251889, Example 187 | US10758542, Example 187 ...)
Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(N)=O)c2n1
Show InChI InChI=1S/C17H17FN6O/c1-10-12(7-11(18)8-20-10)14-3-2-5-23(14)15-4-6-24-17(22-15)13(9-21-24)16(19)25/h4,6-9,14H,2-3,5H2,1H3,(H2,19,25)
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127825
PNG
(US10251889, Example 198 | US10758542, Example 198 ...)
Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@H]3CN4CCC3CC4)c2n1 |r,wU:23.24,(-8.26,.87,;-6.93,1.64,;-6.93,3.18,;-5.59,3.95,;-4.26,3.18,;-2.93,3.95,;-4.26,1.64,;-5.59,.87,;-5.59,-.67,;-6.84,-1.58,;-6.36,-3.04,;-4.82,-3.04,;-4.35,-1.58,;-3.02,-.81,;-3.02,.73,;-1.68,1.5,;-.35,.73,;1.12,1.21,;2.02,-.04,;1.12,-1.28,;1.89,-2.62,;1.12,-3.95,;3.22,-3.39,;4.55,-2.62,;5.36,-1.4,;6.99,-.68,;6.99,1.03,;6.13,-.11,;6.13,-2.12,;7.46,-2.72,;8.26,-1.4,;-.35,-.81,;-1.68,-1.58,)|
Show InChI InChI=1S/C24H28FN7O/c1-15-18(11-17(25)12-26-15)21-3-2-7-31(21)22-6-10-32-23(29-22)19(13-27-32)24(33)28-20-14-30-8-4-16(20)5-9-30/h6,10-13,16,20-21H,2-5,7-9,14H2,1H3,(H,28,33)/t20-,21?/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127833
PNG
(US10251889, Example 206 | US10758542, Example 206 ...)
Show SMILES CC1(C)OCC(COc2cc(F)cc(c2)[C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC4)c3n2)O1 |r|
Show InChI InChI=1S/C26H30FN5O4/c1-26(2)35-15-20(36-26)14-34-19-11-16(10-17(27)12-19)22-4-3-8-31(22)23-7-9-32-24(30-23)21(13-28-32)25(33)29-18-5-6-18/h7,9-13,18,20,22H,3-6,8,14-15H2,1-2H3,(H,29,33)/t20?,22-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127855
PNG
(US10251889, Example 228 | US10758542, Example 228 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC4)c3n2)c1=O |r|
Show InChI InChI=1S/C20H21FN6O2/c1-25-11-12(21)9-14(20(25)29)16-3-2-7-26(16)17-6-8-27-18(24-17)15(10-22-27)19(28)23-13-4-5-13/h6,8-11,13,16H,2-5,7H2,1H3,(H,23,28)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127859
PNG
(US10251889, Example 232 | US10758542, Example 232 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NCC4CC4)c3n2)c1=O |r|
Show InChI InChI=1S/C21H23FN6O2/c1-26-12-14(22)9-15(21(26)30)17-3-2-7-27(17)18-6-8-28-19(25-18)16(11-24-28)20(29)23-10-13-4-5-13/h6,8-9,11-13,17H,2-5,7,10H2,1H3,(H,23,29)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127863
PNG
(US10251889, Example 236 | US10758542, Example 236 ...)
Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cn(C)c1=O)C1CC1 |r|
Show InChI InChI=1S/C22H25FN6O2/c1-13(14-5-6-14)25-21(30)17-11-24-29-9-7-19(26-20(17)29)28-8-3-4-18(28)16-10-15(23)12-27(2)22(16)31/h7,9-14,18H,3-6,8H2,1-2H3,(H,25,30)/t13-,18+/m0/s1
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n/an/a 419n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127864
PNG
(US10251889, Example 237 | US10758542, Example 237 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4(C)CC4)c3n2)c1=O |r|
Show InChI InChI=1S/C21H23FN6O2/c1-21(6-7-21)25-19(29)15-11-23-28-9-5-17(24-18(15)28)27-8-3-4-16(27)14-10-13(22)12-26(2)20(14)30/h5,9-12,16H,3-4,6-8H2,1-2H3,(H,25,29)/t16-/m1/s1
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n/an/a 616n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127866
PNG
(US10251889, Example 239 | US8791123, 239 | US97824...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)Nc4ccc(F)cn4)c3n2)c1=O |r|
Show InChI InChI=1S/C22H19F2N7O2/c1-29-12-14(24)9-15(22(29)33)17-3-2-7-30(17)19-6-8-31-20(28-19)16(11-26-31)21(32)27-18-5-4-13(23)10-25-18/h4-6,8-12,17H,2-3,7H2,1H3,(H,25,27,32)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127679
PNG
(US10251889, Example 52 | US10758542, Example 52 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C19H19FN6O/c20-13-8-12(9-21-10-13)16-2-1-6-25(16)17-5-7-26-18(24-17)15(11-22-26)19(27)23-14-3-4-14/h5,7-11,14,16H,1-4,6H2,(H,23,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127808
PNG
(US8791123, 181 | US9782415, Example 181)
Show SMILES Cc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C20H21FN6O/c1-12-15(9-13(21)10-22-12)17-3-2-7-26(17)18-6-8-27-19(25-18)16(11-23-27)20(28)24-14-4-5-14/h6,8-11,14,17H,2-5,7H2,1H3,(H,24,28)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127750
PNG
(US10251889, Example 123 | US10758542, Example 123 ...)
Show SMILES C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1 |r|
Show InChI InChI=1S/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127821
PNG
(US10251889, Example 195 | US10758542, Example 194 ...)
Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1 |r,wD:26.28,(-7.38,2.87,;-6.05,3.64,;-6.05,5.18,;-4.72,5.95,;-3.38,5.18,;-2.05,5.95,;-3.38,3.64,;-4.72,2.87,;-4.72,1.33,;-5.96,.42,;-5.49,-1.04,;-3.95,-1.04,;-3.47,.42,;-2.14,1.19,;-2.14,2.73,;-.8,3.5,;.53,2.73,;1.99,3.21,;2.9,1.96,;1.99,.72,;2.76,-.62,;1.99,-1.95,;4.3,-.62,;5.07,-1.95,;6.61,-1.95,;7.38,-3.28,;6.61,-4.62,;7.38,-5.95,;5.07,-4.62,;4.3,-3.28,;.53,1.19,;-.8,.42,)|
Show InChI InChI=1S/C23H27FN6O2/c1-14-18(11-15(24)12-25-14)20-3-2-9-29(20)21-8-10-30-22(28-21)19(13-26-30)23(32)27-16-4-6-17(31)7-5-16/h8,10-13,16-17,20,31H,2-7,9H2,1H3,(H,27,32)/t16?,17-,20?
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM127733
PNG
(US10251889, Example 106 | US10758542, Example 106 ...)
Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1
Show InChI InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM127720
PNG
(US10251889, Example 93 | US10758542, Example 93 | ...)
Show SMILES CC(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C19H21FN6O/c1-12(2)23-19(27)15-11-22-26-7-5-17(24-18(15)26)25-6-3-4-16(25)13-8-14(20)10-21-9-13/h5,7-12,16H,3-4,6H2,1-2H3,(H,23,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM127733
PNG
(US10251889, Example 106 | US10758542, Example 106 ...)
Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1
Show InChI InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127630
PNG
(US10251889, Example 3 | US10758542, Example 3 | US...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/m1/s1
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n/an/a 2.30n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127635
PNG
(US10251889, Example 8 | US10758542, Example 8 | US...)
Show SMILES CC(C)(CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H23F2N5O2/c1-21(2,12-29)26-20(30)15-11-24-28-9-7-18(25-19(15)28)27-8-3-4-17(27)14-10-13(22)5-6-16(14)23/h5-7,9-11,17,29H,3-4,8,12H2,1-2H3,(H,26,30)/t17-/m1/s1
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n/an/a 1.10n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127636
PNG
(US10251889, Example 9 | US10758542, Example 9 | US...)
Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1
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n/an/a 3.45n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127649
PNG
(US10251889, Example 22 | US10758542, Example 22 | ...)
Show SMILES Cn1cc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cn1 |r|
Show InChI InChI=1S/C22H21F2N7O/c1-29-13-14(11-26-29)10-25-22(32)17-12-27-31-8-6-20(28-21(17)31)30-7-2-3-19(30)16-9-15(23)4-5-18(16)24/h4-6,8-9,11-13,19H,2-3,7,10H2,1H3,(H,25,32)/t19-/m1/s1
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n/an/a 2.10n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127654
PNG
(US10251889, Example 27 | US10758542, Example 27 | ...)
Show SMILES CN(C)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H19F2N5O/c1-24(2)19(27)14-11-22-26-9-7-17(23-18(14)26)25-8-3-4-16(25)13-10-12(20)5-6-15(13)21/h5-7,9-11,16H,3-4,8H2,1-2H3/t16-/m1/s1
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n/an/a 215n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127658
PNG
(US10251889, Example 31 | US10758542, Example 31 | ...)
Show SMILES OC1CN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C20H19F2N5O2/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(24-18)15(9-23-27)20(29)25-10-13(28)11-25/h3-5,7-9,13,17,28H,1-2,6,10-11H2/t17-/m1/s1
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n/an/a 10.6n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%