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Patent code US8791123

Compile Data Set for Download or QSAR

Found 504 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127642
PNG
(US10251889, Example 15 | US10758542, Example 15 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29|
Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1
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n/an/a 156n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127648
PNG
(US10251889, Example 21 | US10758542, Example 21 | ...)
Show SMILES Cn1cnc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)c1 |r|
Show InChI InChI=1S/C22H21F2N7O/c1-29-12-15(26-13-29)10-25-22(32)17-11-27-31-8-6-20(28-21(17)31)30-7-2-3-19(30)16-9-14(23)4-5-18(16)24/h4-6,8-9,11-13,19H,2-3,7,10H2,1H3,(H,25,32)/t19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127652
PNG
(US8791123, 25)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCc3cnc[nH]3)c2n1 |r|
Show InChI InChI=1S/C22H21F2N7O/c23-14-3-4-18(24)16(10-14)19-2-1-8-30(19)20-6-9-31-21(29-20)17(12-28-31)22(32)26-7-5-15-11-25-13-27-15/h3-4,6,9-13,19H,1-2,5,7-8H2,(H,25,27)(H,26,32)/t19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127656
PNG
(US10251889, Example 29 | US10758542, Example 29 | ...)
Show SMILES OC[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C20H21F2N5O3/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-24-27)20(30)23-9-13(29)11-28/h3-5,7-8,10,13,17,28-29H,1-2,6,9,11H2,(H,23,30)/t13-,17+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127660
PNG
(US8791123, 33)
Show SMILES OC(=O)C1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F |(4.86,-7.13,;5.95,-6.04,;7.44,-6.44,;5.55,-4.55,;4.06,-4.15,;3.66,-2.67,;4.75,-1.58,;6.24,-1.98,;6.64,-3.46,;4.35,-.09,;2.87,.31,;1.78,-.78,;2.47,1.8,;3.37,3.04,;2.47,4.29,;1,3.81,;-.33,4.58,;-1.66,3.81,;-1.66,2.27,;-.33,1.5,;1,2.27,;-3,1.5,;-3,-.04,;-4.46,-.51,;-5.37,.73,;-4.46,1.98,;-4.86,3.46,;-3.77,4.55,;-4.17,6.04,;-3.08,7.13,;-5.66,6.44,;-6.75,5.35,;-6.35,3.86,;-7.44,2.77,)|
Show InChI InChI=1S/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)
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n/an/a 23.4n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127667
PNG
(US10251889, Example 40 | US10758542, Example 40 | ...)
Show SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H22F3N5O/c1-21(2,12-22)27-20(30)15-11-25-29-9-7-18(26-19(15)29)28-8-3-4-17(28)14-10-13(23)5-6-16(14)24/h5-7,9-11,17H,3-4,8,12H2,1-2H3,(H,27,30)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127687
PNG
(US10251889, Example 60 | US10758542, Example 60 | ...)
Show SMILES CC(CO)(CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-21(11-29,12-30)26-20(31)15-10-24-28-8-6-18(25-19(15)28)27-7-2-3-17(27)14-9-13(22)4-5-16(14)23/h4-6,8-10,17,29-30H,2-3,7,11-12H2,1H3,(H,26,31)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127696
PNG
(US8791123, 69)
Show SMILES CC(C)(NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1)C#N
Show InChI InChI=1S/C20H20FN7O/c1-20(2,12-22)26-19(29)15-11-24-28-7-5-17(25-18(15)28)27-6-3-4-16(27)13-8-14(21)10-23-9-13/h5,7-11,16H,3-4,6H2,1-2H3,(H,26,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127702
PNG
(US10251889, Example 75 | US10758542, Example 75 | ...)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r|
Show InChI InChI=1S/C18H18FN5O2/c1-26-22-18(25)14-11-20-24-9-7-16(21-17(14)24)23-8-3-6-15(23)12-4-2-5-13(19)10-12/h2,4-5,7,9-11,15H,3,6,8H2,1H3,(H,22,25)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127703
PNG
(US10251889, Example 76 | US10758542, Example 76 | ...)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cc(OCCN2CCOCC2)c1 |r|
Show InChI InChI=1S/C23H27FN6O3/c24-17-12-16(13-18(14-17)33-11-8-28-6-9-32-10-7-28)20-2-1-4-29(20)21-3-5-30-23(27-21)19(15-26-30)22(25)31/h3,5,12-15,20H,1-2,4,6-11H2,(H2,25,31)/t20-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127716
PNG
(US10251889, Example 89 | US10758542, Example 89 | ...)
Show SMILES COCCOc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(N)=O)c2n1 |r|
Show InChI InChI=1S/C20H22FN5O3/c1-28-9-10-29-17-5-4-13(21)11-14(17)16-3-2-7-25(16)18-6-8-26-20(24-18)15(12-23-26)19(22)27/h4-6,8,11-12,16H,2-3,7,9-10H2,1H3,(H2,22,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127719
PNG
(US10251889, Example 92 | US10758542, Example 92 | ...)
Show SMILES CC1(O)CN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C20H21FN6O2/c1-20(29)11-25(12-20)19(28)15-10-23-27-6-4-17(24-18(15)27)26-5-2-3-16(26)13-7-14(21)9-22-8-13/h4,6-10,16,29H,2-3,5,11-12H2,1H3/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127723
PNG
(US10251889, Example 96 | US10758542, Example 96 | ...)
Show SMILES COC1CN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C20H21FN6O2/c1-29-15-11-25(12-15)20(28)16-10-23-27-6-4-18(24-19(16)27)26-5-2-3-17(26)13-7-14(21)9-22-8-13/h4,6-10,15,17H,2-3,5,11-12H2,1H3/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127725
PNG
(US10251889, Example 98 | US10758542, Example 98 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(CC3)C(F)(F)F)c2n1 |r|
Show InChI InChI=1S/C20H18F4N6O/c21-13-8-12(9-25-10-13)15-2-1-6-29(15)16-3-7-30-17(27-16)14(11-26-30)18(31)28-19(4-5-19)20(22,23)24/h3,7-11,15H,1-2,4-6H2,(H,28,31)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127737
PNG
(US10251889, Example 110 | US10758542, Example 110 ...)
Show SMILES C[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 |r|
Show InChI InChI=1S/C19H21FN6O2/c1-12(27)8-22-19(28)15-11-23-26-6-4-17(24-18(15)26)25-5-2-3-16(25)13-7-14(20)10-21-9-13/h4,6-7,9-12,16,27H,2-3,5,8H2,1H3,(H,22,28)/t12-,16?/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127752
PNG
(US10758542, Example 125 | US8791123, 125 | US97824...)
Show SMILES CC(C)(CO)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H25FN6O2/c1-21(2,13-29)12-24-20(30)16-11-25-28-7-5-18(26-19(16)28)27-6-3-4-17(27)14-8-15(22)10-23-9-14/h5,7-11,17,29H,3-4,6,12-13H2,1-2H3,(H,24,30)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127758
PNG
(US10758542, Example 131 | US8791123, 131 | US97824...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCC(F)(F)F)c2n1 |r|
Show InChI InChI=1S/C18H16F4N6O/c19-12-6-11(7-23-8-12)14-2-1-4-27(14)15-3-5-28-16(26-15)13(9-25-28)17(29)24-10-18(20,21)22/h3,5-9,14H,1-2,4,10H2,(H,24,29)/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127760
PNG
(US10758542, Example 133 | US8791123, 133 | US97824...)
Show SMILES O[C@@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127761
PNG
(US8791123, 134 | US9782415, Example 134 | US979672...)
Show SMILES FC(F)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C18H17F3N6O/c19-12-6-11(7-22-8-12)14-2-1-4-26(14)16-3-5-27-17(25-16)13(9-24-27)18(28)23-10-15(20)21/h3,5-9,14-15H,1-2,4,10H2,(H,23,28)/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127762
PNG
(US10758542, Example 135 | US8791123, 135 | US97824...)
Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127774
PNG
(US10251889, Example 147 | US10758542, Example 147 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N3CC(C)(O)C3)c2n1 |r|
Show InChI InChI=1S/C21H23FN6O3/c1-21(30)11-26(12-21)20(29)15-10-24-28-7-5-17(25-18(15)28)27-6-3-4-16(27)14-8-13(22)9-23-19(14)31-2/h5,7-10,16,30H,3-4,6,11-12H2,1-2H3/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127778
PNG
(US10251889, Example 151 | US10758542, Example 151 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCCO)c2n1 |r|
Show InChI InChI=1S/C21H25FN6O3/c1-31-21-15(11-14(22)12-24-21)17-5-4-8-27(17)18-6-9-28-19(26-18)16(13-25-28)20(30)23-7-2-3-10-29/h6,9,11-13,17,29H,2-5,7-8,10H2,1H3,(H,23,30)/t17-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127782
PNG
(US10251889, Example 155 | US10758542, Example 155 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCO)c2n1 |r|
Show InChI InChI=1S/C19H21FN6O3/c1-29-19-13(9-12(20)10-22-19)15-3-2-6-25(15)16-4-7-26-17(24-16)14(11-23-26)18(28)21-5-8-27/h4,7,9-11,15,27H,2-3,5-6,8H2,1H3,(H,21,28)/t15-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127802
PNG
(US10251889, Example 175 | US10758542, Example 175 ...)
Show SMILES C[C@H](O)[C@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-12(30)17(11-29)25-21(31)15-10-24-28-8-6-19(26-20(15)28)27-7-2-3-18(27)14-9-13(22)4-5-16(14)23/h4-6,8-10,12,17-18,29-30H,2-3,7,11H2,1H3,(H,25,31)/t12-,17-,18?/m0/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127807
PNG
(US10251889, Example 180 | US10758542, Example 180 ...)
Show SMILES CC(C)(C)[C@@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H27F2N5O2/c1-23(2,3)19(13-31)27-22(32)16-12-26-30-10-8-20(28-21(16)30)29-9-4-5-18(29)15-11-14(24)6-7-17(15)25/h6-8,10-12,18-19,31H,4-5,9,13H2,1-3H3,(H,27,32)/t18-,19-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127831
PNG
(US10251889, Example 204 | US10758542, Example 204 ...)
Show SMILES CC1(C)OCC(COc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC4)c3n2)O1 |r|
Show InChI InChI=1S/C26H30FN5O4/c1-26(2)35-15-18(36-26)14-34-22-8-5-16(27)12-19(22)21-4-3-10-31(21)23-9-11-32-24(30-23)20(13-28-32)25(33)29-17-6-7-17/h5,8-9,11-13,17-18,21H,3-4,6-7,10,14-15H2,1-2H3,(H,29,33)/t18?,21-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127839
PNG
(US8791123, 212 | US8791123, 213)
Show SMILES CC(NC(=O)c1cnn2ccc(nc12)N1C(CO)CCC1c1cncc(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H20F4N6O2/c1-11(20(22,23)24)27-19(32)15-9-26-29-5-4-17(28-18(15)29)30-14(10-31)2-3-16(30)12-6-13(21)8-25-7-12/h4-9,11,14,16,31H,2-3,10H2,1H3,(H,27,32)
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127842
PNG
(US10251889, Example 215 | US10758542, Example 215 ...)
Show SMILES CC(C)NC(=O)c1cnn2ccc(nc12)N1[C@H](CO)CC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C20H23FN6O2/c1-12(2)24-20(29)16-10-23-26-6-5-18(25-19(16)26)27-15(11-28)3-4-17(27)13-7-14(21)9-22-8-13/h5-10,12,15,17,28H,3-4,11H2,1-2H3,(H,24,29)/t15-,17+/m0/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127858
PNG
(US10251889, Example 231 | US10758542, Example 231 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)Nc4cccnc4)c3n2)c1=O |r|
Show InChI InChI=1S/C22H20FN7O2/c1-28-13-14(23)10-16(22(28)32)18-5-3-8-29(18)19-6-9-30-20(27-19)17(12-25-30)21(31)26-15-4-2-7-24-11-15/h2,4,6-7,9-13,18H,3,5,8H2,1H3,(H,26,31)/t18-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127859
PNG
(US10251889, Example 232 | US10758542, Example 232 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NCC4CC4)c3n2)c1=O |r|
Show InChI InChI=1S/C21H23FN6O2/c1-26-12-14(22)9-15(21(26)30)17-3-2-7-27(17)18-6-8-28-19(25-18)16(11-24-28)20(29)23-10-13-4-5-13/h6,8-9,11-13,17H,2-5,7,10H2,1H3,(H,23,29)/t17-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127808
PNG
(US8791123, 181 | US9782415, Example 181)
Show SMILES Cc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C20H21FN6O/c1-12-15(9-13(21)10-22-12)17-3-2-7-26(17)18-6-8-27-19(25-18)16(11-23-27)20(28)24-14-4-5-14/h6,8-11,14,17H,2-5,7H2,1H3,(H,24,28)/t17-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127817
PNG
(US10758542, Example 190 | US8791123, 190 | US97824...)
Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1
Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM127725
PNG
(US10251889, Example 98 | US10758542, Example 98 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(CC3)C(F)(F)F)c2n1 |r|
Show InChI InChI=1S/C20H18F4N6O/c21-13-8-12(9-25-10-13)15-2-1-6-29(15)16-3-7-30-17(27-16)14(11-26-30)18(31)28-19(4-5-19)20(22,23)24/h3,7-11,15H,1-2,4-6H2,(H,28,31)/t15-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM127679
PNG
(US10251889, Example 52 | US10758542, Example 52 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C19H19FN6O/c20-13-8-12(9-21-10-13)16-2-1-6-25(16)17-5-7-26-18(24-17)15(11-22-26)19(27)23-14-3-4-14/h5,7-11,14,16H,1-4,6H2,(H,23,27)/t16-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM127767
PNG
(US10251889, Example 140 | US10758542, Example 140 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1 |r,wD:9.9,27.29,(-7.78,2.63,;-6.29,2.23,;-5.21,3.32,;-5.6,4.81,;-4.51,5.9,;-3.03,5.5,;-1.94,6.59,;-2.63,4.01,;-3.72,2.92,;-3.32,1.43,;-4.22,.19,;-3.32,-1.06,;-1.85,-.58,;-1.85,.96,;-.52,1.73,;-.52,3.27,;.81,4.04,;2.15,3.27,;3.61,3.74,;4.52,2.5,;3.61,1.25,;4.01,-.24,;2.92,-1.33,;5.5,-.64,;5.9,-2.12,;7.38,-2.52,;7.78,-4.01,;6.69,-5.1,;7.09,-6.59,;5.21,-4.7,;4.81,-3.21,;2.15,1.73,;.81,.96,)|
Show InChI InChI=1S/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/m1/s1
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Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM127733
PNG
(US10251889, Example 106 | US10758542, Example 106 ...)
Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1
Show InChI InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM127808
PNG
(US8791123, 181 | US9782415, Example 181)
Show SMILES Cc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C20H21FN6O/c1-12-15(9-13(21)10-22-12)17-3-2-7-26(17)18-6-8-27-19(25-18)16(11-23-27)20(28)24-14-4-5-14/h6,8-11,14,17H,2-5,7H2,1H3,(H,24,28)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM127821
PNG
(US10251889, Example 195 | US10758542, Example 194 ...)
Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1 |r,wD:26.28,(-7.38,2.87,;-6.05,3.64,;-6.05,5.18,;-4.72,5.95,;-3.38,5.18,;-2.05,5.95,;-3.38,3.64,;-4.72,2.87,;-4.72,1.33,;-5.96,.42,;-5.49,-1.04,;-3.95,-1.04,;-3.47,.42,;-2.14,1.19,;-2.14,2.73,;-.8,3.5,;.53,2.73,;1.99,3.21,;2.9,1.96,;1.99,.72,;2.76,-.62,;1.99,-1.95,;4.3,-.62,;5.07,-1.95,;6.61,-1.95,;7.38,-3.28,;6.61,-4.62,;7.38,-5.95,;5.07,-4.62,;4.3,-3.28,;.53,1.19,;-.8,.42,)|
Show InChI InChI=1S/C23H27FN6O2/c1-14-18(11-15(24)12-25-14)20-3-2-9-29(20)21-8-10-30-22(28-21)19(13-26-30)23(32)27-16-4-6-17(31)7-5-16/h8,10-13,16-17,20,31H,2-7,9H2,1H3,(H,27,32)/t16?,17-,20?
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array Biopharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127669
PNG
(US10251889, Example 42 | US10758542, Example 42 | ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1C[C@H](O)C[C@@H]1c1cccc(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O2/c1-21(2,3)25-20(29)16-11-23-27-8-7-18(24-19(16)27)26-12-15(28)10-17(26)13-5-4-6-14(22)9-13/h4-9,11,15,17,28H,10,12H2,1-3H3,(H,25,29)/t15-,17-/m1/s1
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n/an/a 48.3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127678
PNG
(US8791123, 51)
Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.1,wD:24.28,1.0,(5.55,-6.59,;5.95,-5.1,;7.04,-6.19,;7.04,-4.01,;6.64,-2.52,;5.15,-2.12,;4.06,-3.21,;4.46,-4.7,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)|
Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1
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n/an/a 1.18n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127682
PNG
(US8791123, 55 | US8791123, 56)
Show SMILES OCC(O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1CO
Show InChI InChI=1S/C21H24FN5O4/c22-14-4-3-13(11-28)16(8-14)18-2-1-6-26(18)19-5-7-27-20(25-19)17(10-24-27)21(31)23-9-15(30)12-29/h3-5,7-8,10,15,18,28-30H,1-2,6,9,11-12H2,(H,23,31)
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n/an/a 1n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127685
PNG
(US10251889, Example 58 | US10758542, Example 58 | ...)
Show SMILES CC(C)(N)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H24F2N6O/c1-21(2,24)12-25-20(30)15-11-26-29-9-7-18(27-19(15)29)28-8-3-4-17(28)14-10-13(22)5-6-16(14)23/h5-7,9-11,17H,3-4,8,12,24H2,1-2H3,(H,25,30)/t17-/m1/s1
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n/an/a 9.40n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127686
PNG
(US10251889, Example 59 | US10758542, Example 59 | ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CC(F)(F)C[C@@H]1c1cccc(F)c1 |r|
Show InChI InChI=1S/C21H22F3N5O/c1-20(2,3)27-19(30)15-11-25-29-8-7-17(26-18(15)29)28-12-21(23,24)10-16(28)13-5-4-6-14(22)9-13/h4-9,11,16H,10,12H2,1-3H3,(H,27,30)/t16-/m1/s1
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US Patent
n/an/a 16.9n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127688
PNG
(US10251889, Example 61 | US10758542, Example 61 | ...)
Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1
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n/an/a 1.95n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127692
PNG
(US10251889, Example 65 | US10758542, Example 65 | ...)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C18H17F2N5O2/c1-27-23-18(26)13-10-21-25-8-6-16(22-17(13)25)24-7-2-3-15(24)12-9-11(19)4-5-14(12)20/h4-6,8-10,15H,2-3,7H2,1H3,(H,23,26)/t15-/m1/s1
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n/an/a 0.600n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127694
PNG
(US10251889, Example 67 | US10758542, Example 67 | ...)
Show SMILES CC1(C)CC[C@@H](N1c1ccn2ncc(C(N)=O)c2n1)c1cc(F)ccc1F |r|
Show InChI InChI=1S/C19H19F2N5O/c1-19(2)7-5-15(12-9-11(20)3-4-14(12)21)26(19)16-6-8-25-18(24-16)13(10-23-25)17(22)27/h3-4,6,8-10,15H,5,7H2,1-2H3,(H2,22,27)/t15-/m1/s1
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n/an/a 5.10n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127698
PNG
(US10251889, Example 71 | US10758542, Example 71 | ...)
Show SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C20H22F2N6O/c1-20(2,12-21)26-19(29)15-11-24-28-7-5-17(25-18(15)28)27-6-3-4-16(27)13-8-14(22)10-23-9-13/h5,7-11,16H,3-4,6,12H2,1-2H3,(H,26,29)/t16-/m1/s1
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n/an/a 8.65n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127703
PNG
(US10251889, Example 76 | US10758542, Example 76 | ...)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cc(OCCN2CCOCC2)c1 |r|
Show InChI InChI=1S/C23H27FN6O3/c24-17-12-16(13-18(14-17)33-11-8-28-6-9-32-10-7-28)20-2-1-4-29(20)21-3-5-30-23(27-21)19(15-26-30)22(25)31/h3,5,12-15,20H,1-2,4,6-11H2,(H2,25,31)/t20-/m1/s1
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n/an/a 90.0n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127704
PNG
(US10251889, Example 77 | US10758542, Example 77 | ...)
Show SMILES COCCOc1cc(F)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C23H26FN5O3/c1-31-9-10-32-18-12-15(11-16(24)13-18)20-3-2-7-28(20)21-6-8-29-22(27-21)19(14-25-29)23(30)26-17-4-5-17/h6,8,11-14,17,20H,2-5,7,9-10H2,1H3,(H,26,30)/t20-/m1/s1
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n/an/a 5.37n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127721
PNG
(US10251889, Example 94 | US10758542, Example 94 | ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N3CCCC3)c2n1 |r|
Show InChI InChI=1S/C20H21FN6O/c21-15-10-14(11-22-12-15)17-4-3-8-26(17)18-5-9-27-19(24-18)16(13-23-27)20(28)25-6-1-2-7-25/h5,9-13,17H,1-4,6-8H2/t17-/m1/s1
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n/an/a 568n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%