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Patent code US8791123

Compile Data Set for Download or QSAR

Found 504 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127628
PNG
(US10251889, Example 1 | US10758542, Example 1 | US...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H23F2N5O/c1-21(2,3)26-20(29)15-12-24-28-10-8-18(25-19(15)28)27-9-4-5-17(27)14-11-13(22)6-7-16(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H,26,29)/t17-/m1/s1
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n/an/a 0.700n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127629
PNG
(US10251889, Example 2 | US10758542, Example 2 | US...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3ccccn3)c2n1 |r|
Show InChI InChI=1S/C22H18F2N6O/c23-14-6-7-17(24)15(12-14)18-4-3-10-29(18)20-8-11-30-21(28-20)16(13-26-30)22(31)27-19-5-1-2-9-25-19/h1-2,5-9,11-13,18H,3-4,10H2,(H,25,27,31)/t18-/m1/s1
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n/an/a 0.700n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127636
PNG
(US10251889, Example 9 | US10758542, Example 9 | US...)
Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1
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n/an/a 3.45n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127642
PNG
(US10251889, Example 15 | US10758542, Example 15 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29|
Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1
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n/an/a 0.600n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127645
PNG
(US10251889, Example 18 | US10758542, Example 18 | ...)
Show SMILES O[C@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18+/m0/s1
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n/an/a 38.3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127647
PNG
(US10251889, Example 20 | US10758542, Example 20 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCOCC3)c2n1 |r|
Show InChI InChI=1S/C22H23F2N5O2/c23-14-3-4-18(24)16(12-14)19-2-1-8-28(19)20-5-9-29-21(27-20)17(13-25-29)22(30)26-15-6-10-31-11-7-15/h3-5,9,12-13,15,19H,1-2,6-8,10-11H2,(H,26,30)/t19-/m1/s1
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n/an/a 0.600n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127648
PNG
(US10251889, Example 21 | US10758542, Example 21 | ...)
Show SMILES Cn1cnc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)c1 |r|
Show InChI InChI=1S/C22H21F2N7O/c1-29-12-15(26-13-29)10-25-22(32)17-11-27-31-8-6-20(28-21(17)31)30-7-2-3-19(30)16-9-14(23)4-5-18(16)24/h4-6,8-9,11-13,19H,2-3,7,10H2,1H3,(H,25,32)/t19-/m1/s1
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n/an/a 2.95n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127651
PNG
(US10251889, Example 24 | US10758542, Example 24 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCNC3=O)c2n1 |r|
Show InChI InChI=1S/C22H23F2N7O2/c23-14-3-4-17(24)15(12-14)18-2-1-8-30(18)19-5-9-31-20(28-19)16(13-27-31)21(32)25-6-10-29-11-7-26-22(29)33/h3-5,9,12-13,18H,1-2,6-8,10-11H2,(H,25,32)(H,26,33)/t18-/m1/s1
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n/an/a 3.60n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127653
PNG
(US10251889, Example 26 | US10758542, Example 26 | ...)
Show SMILES OC[C@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C20H21F2N5O3/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-24-27)20(30)23-9-13(29)11-28/h3-5,7-8,10,13,17,28-29H,1-2,6,9,11H2,(H,23,30)/t13-,17-/m1/s1
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n/an/a 1.30n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127665
PNG
(US8791123, 38)
Show SMILES CC(C)(NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F)C#N
Show InChI InChI=1S/C21H20F2N6O/c1-21(2,12-24)27-20(30)15-11-25-29-9-7-18(26-19(15)29)28-8-3-4-17(28)14-10-13(22)5-6-16(14)23/h5-7,9-11,17H,3-4,8H2,1-2H3,(H,27,30)
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n/an/a 1.30n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127668
PNG
(US10251889, Example 41 | US10758542, Example 41 | ...)
Show SMILES O[C@@H]1C[C@@H](N(C1)c1ccn2ncc(C(=O)NC3CC3)c2n1)c1cccc(F)c1 |r|
Show InChI InChI=1S/C20H20FN5O2/c21-13-3-1-2-12(8-13)17-9-15(27)11-25(17)18-6-7-26-19(24-18)16(10-22-26)20(28)23-14-4-5-14/h1-3,6-8,10,14-15,17,27H,4-5,9,11H2,(H,23,28)/t15-,17-/m1/s1
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n/an/a 28.9n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127684
PNG
(US8791123, 57)
Show SMILES CC(C)(CNS(C)(=O)=O)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C22H26F2N6O3S/c1-22(2,13-26-34(3,32)33)28-21(31)16-12-25-30-10-8-19(27-20(16)30)29-9-4-5-18(29)15-11-14(23)6-7-17(15)24/h6-8,10-12,18,26H,4-5,9,13H2,1-3H3,(H,28,31)
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n/an/a 3.93n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127687
PNG
(US10251889, Example 60 | US10758542, Example 60 | ...)
Show SMILES CC(CO)(CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-21(11-29,12-30)26-20(31)15-10-24-28-8-6-18(25-19(15)28)27-7-2-3-17(27)14-9-13(22)4-5-16(14)23/h4-6,8-10,17,29-30H,2-3,7,11-12H2,1H3,(H,26,31)/t17-/m1/s1
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n/an/a 2.25n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127697
PNG
(US8791123, 70)
Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1
Show InChI InChI=1S/C22H26FN7O3S/c1-34(32,33)28-8-4-17(5-9-28)26-22(31)18-14-25-30-10-6-20(27-21(18)30)29-7-2-3-19(29)15-11-16(23)13-24-12-15/h6,10-14,17,19H,2-5,7-9H2,1H3,(H,26,31)
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n/an/a 23.9n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127707
PNG
(US8791123, 80)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)cnc1CO
Show InChI InChI=1S/C21H25FN6O2/c1-21(2,3)26-20(30)15-11-24-28-8-6-18(25-19(15)28)27-7-4-5-17(27)14-9-13(22)10-23-16(14)12-29/h6,8-11,17,29H,4-5,7,12H2,1-3H3,(H,26,30)
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n/an/a 1.80n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127708
PNG
(US8791123, 81)
Show SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)cnc1CO
Show InChI InChI=1S/C21H24F2N6O2/c1-21(2,12-22)27-20(31)15-10-25-29-7-5-18(26-19(15)29)28-6-3-4-17(28)14-8-13(23)9-24-16(14)11-30/h5,7-10,17,30H,3-4,6,11-12H2,1-2H3,(H,27,31)
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n/an/a 1.15n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127709
PNG
(US8791123, 82)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)cnc1CO
Show InChI InChI=1S/C17H17FN6O2/c18-10-6-11(13(9-25)20-7-10)14-2-1-4-23(14)15-3-5-24-17(22-15)12(8-21-24)16(19)26/h3,5-8,14,25H,1-2,4,9H2,(H2,19,26)
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n/an/a 2.55n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127710
PNG
(US8791123, 83)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)cnc1CO
Show InChI InChI=1S/C18H19FN6O3/c1-28-23-18(27)13-9-21-25-6-4-16(22-17(13)25)24-5-2-3-15(24)12-7-11(19)8-20-14(12)10-26/h4,6-9,15,26H,2-3,5,10H2,1H3,(H,23,27)
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n/an/a 1.77n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127712
PNG
(US10251889, Example 85 | US10758542, Example 85 | ...)
Show SMILES Fc1cc(OCCN2CCOCC2)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C26H31FN6O3/c27-19-14-18(15-21(16-19)36-13-10-31-8-11-35-12-9-31)23-2-1-6-32(23)24-5-7-33-25(30-24)22(17-28-33)26(34)29-20-3-4-20/h5,7,14-17,20,23H,1-4,6,8-13H2,(H,29,34)/t23-/m1/s1
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n/an/a 9.38n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127714
PNG
(US10251889, Example 87 | US10758542, Example 87 | ...)
Show SMILES Fc1ccc(OCCN2CCOCC2)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C26H31FN6O3/c27-18-3-6-23(36-15-12-31-10-13-35-14-11-31)20(16-18)22-2-1-8-32(22)24-7-9-33-25(30-24)21(17-28-33)26(34)29-19-4-5-19/h3,6-7,9,16-17,19,22H,1-2,4-5,8,10-15H2,(H,29,34)/t22-/m1/s1
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n/an/a 16.1n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127727
PNG
(US8791123, 100)
Show SMILES O[C@H]1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r,wU:1.0,wD:23.27,(7.01,-5.81,;6.24,-4.48,;4.7,-4.48,;3.93,-3.14,;4.7,-1.81,;6.24,-1.81,;7.01,-3.14,;3.93,-.47,;5.02,.61,;6.5,.22,;4.62,2.1,;5.52,3.35,;4.62,4.59,;3.15,4.12,;1.82,4.89,;.49,4.12,;.49,2.58,;1.82,1.81,;3.15,2.58,;-.85,1.81,;-.37,.34,;-1.62,-.56,;-2.86,.34,;-2.39,1.81,;-3.16,3.14,;-2.39,4.48,;-3.16,5.81,;-4.7,5.81,;-5.47,4.48,;-7.01,4.48,;-4.7,3.14,)|
Show InChI InChI=1S/C22H25FN6O2/c23-15-10-14(11-24-12-15)19-2-1-8-28(19)20-7-9-29-21(27-20)18(13-25-29)22(31)26-16-3-5-17(30)6-4-16/h7,9-13,16-17,19,30H,1-6,8H2,(H,26,31)/t16?,17-,19-/m1/s1
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n/an/a 4.70n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127728
PNG
(US10251889, Example 101 | US10758542, Example 101 ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCC3)c2n1 |r|
Show InChI InChI=1S/C20H21FN6O/c21-14-9-13(10-22-11-14)17-5-2-7-26(17)18-6-8-27-19(25-18)16(12-23-27)20(28)24-15-3-1-4-15/h6,8-12,15,17H,1-5,7H2,(H,24,28)/t17-/m1/s1
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n/an/a 11.7n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127733
PNG
(US10251889, Example 106 | US10758542, Example 106 ...)
Show SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)NCC3CC3)c2n1
Show InChI InChI=1S/C20H21FN6O/c21-15-8-14(10-22-11-15)17-2-1-6-26(17)18-5-7-27-19(25-18)16(12-24-27)20(28)23-9-13-3-4-13/h5,7-8,10-13,17H,1-4,6,9H2,(H,23,28)
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n/an/a 7.70n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127774
PNG
(US10251889, Example 147 | US10758542, Example 147 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N3CC(C)(O)C3)c2n1 |r|
Show InChI InChI=1S/C21H23FN6O3/c1-21(30)11-26(12-21)20(29)15-10-24-28-7-5-17(25-18(15)28)27-6-3-4-16(27)14-8-13(22)9-23-19(14)31-2/h5,7-10,16,30H,3-4,6,11-12H2,1-2H3/t16-/m1/s1
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n/an/a 30.8n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127780
PNG
(US10251889, Example 153 | US10758542, Example 153 ...)
Show SMILES CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1OC |r|
Show InChI InChI=1S/C18H19FN6O2/c1-20-17(26)13-10-22-25-7-5-15(23-16(13)25)24-6-3-4-14(24)12-8-11(19)9-21-18(12)27-2/h5,7-10,14H,3-4,6H2,1-2H3,(H,20,26)/t14-/m1/s1
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n/an/a 2.10n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127788
PNG
(US10251889, Example 161 | US10758542, Example 161 ...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3ccc(=O)[nH]c3)c2n1 |r|
Show InChI InChI=1S/C22H20FN7O3/c1-33-22-15(9-13(23)10-25-22)17-3-2-7-29(17)18-6-8-30-20(28-18)16(12-26-30)21(32)27-14-4-5-19(31)24-11-14/h4-6,8-12,17H,2-3,7H2,1H3,(H,24,31)(H,27,32)/t17-/m1/s1
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n/an/a 3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127804
PNG
(US10251889, Example 177 | US10758542, Example 177 ...)
Show SMILES C[C@@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C20H21F2N5O2/c1-12(11-28)24-20(29)15-10-23-27-8-6-18(25-19(15)27)26-7-2-3-17(26)14-9-13(21)4-5-16(14)22/h4-6,8-10,12,17,28H,2-3,7,11H2,1H3,(H,24,29)/t12-,17+/m0/s1
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n/an/a 1.80n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127816
PNG
(US10251889, Example 189 | US10758542, Example 189 ...)
Show SMILES C[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1C |r|
Show InChI InChI=1S/C20H23FN6O2/c1-12(28)9-23-20(29)16-11-24-27-7-5-18(25-19(16)27)26-6-3-4-17(26)15-8-14(21)10-22-13(15)2/h5,7-8,10-12,17,28H,3-4,6,9H2,1-2H3,(H,23,29)/t12-,17-/m1/s1
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n/an/a 76.4n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127826
PNG
(US10251889, Example 199 | US10758542, Example 199 ...)
Show SMILES CCc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1 |r,wD:9.9,27.29,(-8.05,3.64,;-6.72,2.87,;-5.38,3.64,;-5.38,5.18,;-4.05,5.95,;-2.72,5.18,;-1.38,5.95,;-2.72,3.64,;-4.05,2.87,;-4.05,1.33,;-5.3,.42,;-4.82,-1.04,;-3.28,-1.04,;-2.8,.42,;-1.47,1.19,;-1.47,2.73,;-.14,3.5,;1.2,2.73,;2.66,3.21,;3.57,1.96,;2.66,.72,;3.43,-.62,;2.66,-1.95,;4.97,-.62,;5.74,-1.95,;7.28,-1.95,;8.05,-3.28,;7.28,-4.62,;8.05,-5.95,;5.74,-4.62,;4.97,-3.28,;1.2,1.19,;-.14,.42,)|
Show InChI InChI=1S/C24H29FN6O2/c1-2-20-18(12-15(25)13-26-20)21-4-3-10-30(21)22-9-11-31-23(29-22)19(14-27-31)24(33)28-16-5-7-17(32)8-6-16/h9,11-14,16-17,21,32H,2-8,10H2,1H3,(H,28,33)/t16?,17-,21-/m1/s1
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n/an/a 3.60n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127827
PNG
(US10758542, Example 200 | US8791123, 200 | US97824...)
Show SMILES CCc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r|
Show InChI InChI=1S/C23H27FN6O2/c1-2-19-17(10-14(24)12-25-19)20-4-3-8-29(20)21-7-9-30-22(28-21)18(13-26-30)23(32)27-15-5-6-16(31)11-15/h7,9-10,12-13,15-16,20,31H,2-6,8,11H2,1H3,(H,27,32)/t15-,16-,20?/m0/s1
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n/an/a 12.7n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127853
PNG
(US10251889, Example 226 | US10758542, Example 226 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC(C)(C)C)c3n2)c1=O |r|
Show InChI InChI=1S/C21H25FN6O2/c1-21(2,3)25-19(29)15-11-23-28-9-7-17(24-18(15)28)27-8-5-6-16(27)14-10-13(22)12-26(4)20(14)30/h7,9-12,16H,5-6,8H2,1-4H3,(H,25,29)/t16-/m1/s1
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n/an/a 10.5n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127854
PNG
(US10251889, Example 227 | US10758542, Example 227 ...)
Show SMILES CC(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cn(C)c1=O |r|
Show InChI InChI=1S/C20H23FN6O2/c1-12(2)23-19(28)15-10-22-27-8-6-17(24-18(15)27)26-7-4-5-16(26)14-9-13(21)11-25(3)20(14)29/h6,8-12,16H,4-5,7H2,1-3H3,(H,23,28)/t16-/m1/s1
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n/an/a 12.3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127856
PNG
(US10251889, Example 229 | US10758542, Example 229 ...)
Show SMILES Cc1ccc(NC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C)c2=O)cn1 |r|
Show InChI InChI=1S/C23H22FN7O2/c1-14-5-6-16(11-25-14)27-22(32)18-12-26-31-9-7-20(28-21(18)31)30-8-3-4-19(30)17-10-15(24)13-29(2)23(17)33/h5-7,9-13,19H,3-4,8H2,1-2H3,(H,27,32)/t19-/m1/s1
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n/an/a 15.9n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127857
PNG
(US10251889, Example 230 | US10758542, Example 230 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CCC4)c3n2)c1=O |r|
Show InChI InChI=1S/C21H23FN6O2/c1-26-12-13(22)10-15(21(26)30)17-6-3-8-27(17)18-7-9-28-19(25-18)16(11-23-28)20(29)24-14-4-2-5-14/h7,9-12,14,17H,2-6,8H2,1H3,(H,24,29)/t17-/m1/s1
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n/an/a 3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127861
PNG
(US10251889, Example 234 | US10758542, Example 234 ...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)N[C@@H]4CCCC[C@H]4O)c3n2)c1=O |r|
Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-15(23(28)33)18-6-4-9-29(18)20-8-10-30-21(27-20)16(12-25-30)22(32)26-17-5-2-3-7-19(17)31/h8,10-13,17-19,31H,2-7,9H2,1H3,(H,26,32)/t17-,18-,19-/m1/s1
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n/an/a 10.7n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127634
PNG
(US10251889, Example 7 | US10758542, Example 7 | US...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:4.7,wD:23.27,1.0,(6.35,-6.59,;5.95,-5.1,;7.04,-4.01,;6.64,-2.52,;5.15,-2.12,;4.06,-3.21,;4.46,-4.7,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)|
Show InChI InChI=1S/C23H25F2N5O2/c24-14-3-8-19(25)17(12-14)20-2-1-10-29(20)21-9-11-30-22(28-21)18(13-26-30)23(32)27-15-4-6-16(31)7-5-15/h3,8-9,11-13,15-16,20,31H,1-2,4-7,10H2,(H,27,32)/t15-,16-,20-/m1/s1
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n/an/a 0.450n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127641
PNG
(US10251889, Example 14 | US10758542, Example 14 | ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCC3)c2n1 |r|
Show InChI InChI=1S/C21H21F2N5O/c22-13-6-7-17(23)15(11-13)18-5-2-9-27(18)19-8-10-28-20(26-19)16(12-24-28)21(29)25-14-3-1-4-14/h6-8,10-12,14,18H,1-5,9H2,(H,25,29)/t18-/m1/s1
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n/an/a 0.550n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127646
PNG
(US10251889, Example 19 | US10758542, Example 19 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/m1/s1
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n/an/a 74.3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127663
PNG
(US10251889, Example 36 | US10758542, Example 36 | ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O/c1-21(2,3)25-20(28)16-13-23-27-11-9-18(24-19(16)27)26-10-5-8-17(26)14-6-4-7-15(22)12-14/h4,6-7,9,11-13,17H,5,8,10H2,1-3H3,(H,25,28)/t17-/m1/s1
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n/an/a 2.10n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127674
PNG
(US8791123, 47)
Show SMILES NS(=O)(=O)CCNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O3S/c20-12-3-4-15(21)13(10-12)16-2-1-7-26(16)17-5-8-27-18(25-17)14(11-24-27)19(28)23-6-9-31(22,29)30/h3-5,8,10-11,16H,1-2,6-7,9H2,(H,23,28)(H2,22,29,30)
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n/an/a 1.5n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127680
PNG
(US10251889, Example 53 | US10758542, Example 53 | ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r|
Show InChI InChI=1S/C20H23FN6O/c1-20(2,3)25-19(28)15-12-23-27-8-6-17(24-18(15)27)26-7-4-5-16(26)13-9-14(21)11-22-10-13/h6,8-12,16H,4-5,7H2,1-3H3,(H,25,28)/t16-/m1/s1
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n/an/a 10.4n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127695
PNG
(US10251889, Example 68 | US10758542, Example 68 | ...)
Show SMILES CC1(C)CC[C@@H](N1c1ccn2ncc(C(=O)NC3CC3)c2n1)c1cc(F)ccc1F |r|
Show InChI InChI=1S/C22H23F2N5O/c1-22(2)9-7-18(15-11-13(23)3-6-17(15)24)29(22)19-8-10-28-20(27-19)16(12-25-28)21(30)26-14-4-5-14/h3,6,8,10-12,14,18H,4-5,7,9H2,1-2H3,(H,26,30)/t18-/m1/s1
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n/an/a 6.60n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127704
PNG
(US10251889, Example 77 | US10758542, Example 77 | ...)
Show SMILES COCCOc1cc(F)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 |r|
Show InChI InChI=1S/C23H26FN5O3/c1-31-9-10-32-18-12-15(11-16(24)13-18)20-3-2-7-28(20)21-6-8-29-22(27-21)19(14-25-29)23(30)26-17-4-5-17/h6,8,11-14,17,20H,2-5,7,9-10H2,1H3,(H,26,30)/t20-/m1/s1
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n/an/a 5.37n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127726
PNG
(US10251889, Example 100 | US10758542, Example 100 ...)
Show SMILES O[C@H]1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r,wD:23.27,1.0,(7.01,-5.81,;6.24,-4.48,;7.01,-3.14,;6.24,-1.81,;4.7,-1.81,;3.93,-3.14,;4.7,-4.48,;3.93,-.47,;5.02,.61,;6.5,.22,;4.62,2.1,;5.52,3.35,;4.62,4.59,;3.15,4.12,;1.82,4.89,;.49,4.12,;.49,2.58,;1.82,1.81,;3.15,2.58,;-.85,1.81,;-.37,.34,;-1.62,-.56,;-2.86,.34,;-2.39,1.81,;-3.16,3.14,;-2.39,4.48,;-3.16,5.81,;-4.7,5.81,;-5.47,4.48,;-7.01,4.48,;-4.7,3.14,)|
Show InChI InChI=1S/C22H25FN6O2/c23-15-10-14(11-24-12-15)19-2-1-8-28(19)20-7-9-29-21(27-20)18(13-25-29)22(31)26-16-3-5-17(30)6-4-16/h7,9-13,16-17,19,30H,1-6,8H2,(H,26,31)/t16?,17-,19-/m1/s1
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n/an/a 7n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127732
PNG
(US10251889, Example 105 | US10758542, Example 105 ...)
Show SMILES O[C@H]1CC[C@@H](C1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H23FN6O2/c22-14-8-13(10-23-11-14)18-2-1-6-27(18)19-5-7-28-20(26-19)17(12-24-28)21(30)25-15-3-4-16(29)9-15/h5,7-8,10-12,15-16,18,29H,1-4,6,9H2,(H,25,30)/t15-,16-,18?/m0/s1
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n/an/a 25.4n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127741
PNG
(US10251889, Example 114 | US10758542, Example 114 ...)
Show SMILES CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1
Show InChI InChI=1S/C17H17FN6O/c1-19-17(25)13-10-21-24-6-4-15(22-16(13)24)23-5-2-3-14(23)11-7-12(18)9-20-8-11/h4,6-10,14H,2-3,5H2,1H3,(H,19,25)
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n/an/a 29.9n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127744
PNG
(US10251889, Example 117 | US10758542, Example 117 ...)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1
Show InChI InChI=1S/C16H15FN6O/c17-11-6-10(7-19-8-11)13-2-1-4-22(13)14-3-5-23-16(21-14)12(9-20-23)15(18)24/h3,5-9,13H,1-2,4H2,(H2,18,24)
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n/an/a 45n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127749
PNG
(US10251889, Example 122 | US10758542, Example 122 ...)
Show SMILES CC(C)[C@H](CO)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 |r|
Show InChI InChI=1S/C21H25FN6O2/c1-13(2)17(12-29)25-21(30)16-11-24-28-7-5-19(26-20(16)28)27-6-3-4-18(27)14-8-15(22)10-23-9-14/h5,7-11,13,17-18,29H,3-4,6,12H2,1-2H3,(H,25,30)/t17-,18?/m0/s1
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n/an/a 33.2n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127750
PNG
(US10251889, Example 123 | US10758542, Example 123 ...)
Show SMILES C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1 |r|
Show InChI InChI=1S/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18-/m1/s1
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n/an/a 6.40n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127764
PNG
(US10251889, Example 137 | US10758542, Example 137 ...)
Show SMILES Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N3CCCCC3)c2n1 |r|
Show InChI InChI=1S/C21H23FN6O/c22-16-11-15(12-23-13-16)18-5-4-9-27(18)19-6-10-28-20(25-19)17(14-24-28)21(29)26-7-2-1-3-8-26/h6,10-14,18H,1-5,7-9H2/t18-/m1/s1
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n/an/a 794n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...

US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%