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Patent code US9181266

Compile Data Set for Download or QSAR

Found 321 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191172
PNG
(US9181266, 41)
Show SMILES C[C@H](C1CC1)N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1 |r|
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US Patent
n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191176
PNG
(US9181266, 45)
Show SMILES FC(F)CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H27F3N4O4/c25-17-3-1-15(2-4-17)23(33)16-5-8-30(9-6-16)13-22(32)31(11-20(26)27)12-21-28-19-7-10-35-14-18(19)24(34)29-21/h1-4,16,20H,5-14H2,(H,28,29,34)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191181
PNG
(US9181266, 50)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC(F)F)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H30F2N4O5/c1-35-18-4-2-16(3-5-18)24(33)17-6-9-30(10-7-17)14-23(32)31(12-21(26)27)13-22-28-20-8-11-36-15-19(20)25(34)29-22/h2-5,17,21H,6-15H2,1H3,(H,28,29,34)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191185
PNG
(US9181266, 54)
Show SMILES COCCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C26H34N4O6/c1-34-14-12-30(15-23-27-22-9-13-36-17-21(22)26(33)28-23)24(31)16-29-10-7-19(8-11-29)25(32)18-3-5-20(35-2)6-4-18/h3-6,19H,7-17H2,1-2H3,(H,27,28,33)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191209
PNG
(US9181266, 78)
Show SMILES CC#CCOc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C30H36N4O5/c1-2-3-15-39-24-8-6-22(7-9-24)29(36)23-10-13-33(14-11-23)19-28(35)34(17-21-4-5-21)18-27-31-26-12-16-38-20-25(26)30(37)32-27/h6-9,21,23H,4-5,10-20H2,1H3,(H,31,32,37)
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n/an/a 1.47E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191215
PNG
(US9181266, 84)
Show SMILES CCCOc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H32N4O5/c1-2-12-34-19-5-3-17(4-6-19)24(31)18-7-10-29(11-8-18)15-23(30)26-14-22-27-21-9-13-33-16-20(21)25(32)28-22/h3-6,18H,2,7-16H2,1H3,(H,26,30)(H,27,28,32)
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n/an/a 4.80E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191222
PNG
(US9181266, 91)
Show SMILES O=C(CN1CCC(CC1)C(=O)c1ccc2OCCc2c1)NCc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C24H28N4O5/c29-22(25-12-21-26-19-6-9-32-14-18(19)24(31)27-21)13-28-7-3-15(4-8-28)23(30)17-1-2-20-16(11-17)5-10-33-20/h1-2,11,15H,3-10,12-14H2,(H,25,29)(H,26,27,31)
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n/an/a 1.67E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM191224
PNG
(US9181266, 93)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C24H30N4O5/c1-15-11-17(3-4-20(15)32-2)23(30)16-5-8-28(9-6-16)13-22(29)25-12-21-26-19-7-10-33-14-18(19)24(31)27-21/h3-4,11,16H,5-10,12-14H2,1-2H3,(H,25,29)(H,26,27,31)
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n/an/a 1.71E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM50439800
PNG
(CHEMBL2419697 | US9181266, 1)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C22H25FN4O4/c23-16-3-1-14(2-4-16)21(29)15-5-8-27(9-6-15)12-20(28)24-11-19-25-18-7-10-31-13-17(18)22(30)26-19/h1-4,15H,5-13H2,(H,24,28)(H,25,26,30)
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n/an/a 3.10E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191142
PNG
(US9181266, 3)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H32N4O5/c1-16(2)34-19-5-3-17(4-6-19)24(31)18-7-10-29(11-8-18)14-23(30)26-13-22-27-21-9-12-33-15-20(21)25(32)28-22/h3-6,16,18H,7-15H2,1-2H3,(H,26,30)(H,27,28,32)
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n/an/a 2.10E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191150
PNG
(US9181266, 12)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc(C)c(C)c(=O)[nH]2)CC1
Show InChI InChI=1S/C22H28N4O4/c1-14-15(2)24-19(25-22(14)29)12-23-20(27)13-26-10-8-17(9-11-26)21(28)16-4-6-18(30-3)7-5-16/h4-7,17H,8-13H2,1-3H3,(H,23,27)(H,24,25,29)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM50439799
PNG
(CHEMBL2419698 | US9181266, 13)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2cccs2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C27H29FN4O4S/c28-20-5-3-18(4-6-20)26(34)19-7-10-31(11-8-19)16-25(33)32(14-21-2-1-13-37-21)15-24-29-23-9-12-36-17-22(23)27(35)30-24/h1-6,13,19H,7-12,14-17H2,(H,29,30,35)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191154
PNG
(US9181266, 17)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2nc3ccccc3s2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C30H30FN5O4S/c31-21-7-5-19(6-8-21)29(38)20-9-12-35(13-10-20)17-28(37)36(16-27-33-24-3-1-2-4-25(24)41-27)15-26-32-23-11-14-40-18-22(23)30(39)34-26/h1-8,20H,9-18H2,(H,32,34,39)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM50439795
PNG
(CHEMBL2419702 | US9181266, 34)
Show SMILES CCCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C25H31FN4O4/c1-2-10-30(14-22-27-21-9-13-34-16-20(21)25(33)28-22)23(31)15-29-11-7-18(8-12-29)24(32)17-3-5-19(26)6-4-17/h3-6,18H,2,7-16H2,1H3,(H,27,28,33)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191172
PNG
(US9181266, 41)
Show SMILES C[C@H](C1CC1)N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1 |r|
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191176
PNG
(US9181266, 45)
Show SMILES FC(F)CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H27F3N4O4/c25-17-3-1-15(2-4-17)23(33)16-5-8-30(9-6-16)13-22(32)31(11-20(26)27)12-21-28-19-7-10-35-14-18(19)24(34)29-21/h1-4,16,20H,5-14H2,(H,28,29,34)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191181
PNG
(US9181266, 50)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC(F)F)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H30F2N4O5/c1-35-18-4-2-16(3-5-18)24(33)17-6-9-30(10-7-17)14-23(32)31(12-21(26)27)13-22-28-20-8-11-36-15-19(20)25(34)29-22/h2-5,17,21H,6-15H2,1H3,(H,28,29,34)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191192
PNG
(US9181266, 61)
Show SMILES Fc1ccc2C(=O)C3(Cc2c1)CCN(CC(=O)NCc1nc2CCOCc2c(=O)[nH]1)CC3
Show InChI InChI=1S/C23H25FN4O4/c24-15-1-2-16-14(9-15)10-23(21(16)30)4-6-28(7-5-23)12-20(29)25-11-19-26-18-3-8-32-13-17(18)22(31)27-19/h1-2,9H,3-8,10-13H2,(H,25,29)(H,26,27,31)
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n/an/a>1.90E+4n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191198
PNG
(US9181266, 67)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C23H28N4O5/c1-31-17-4-2-15(3-5-17)22(29)16-6-9-27(10-7-16)13-21(28)24-12-20-25-19-8-11-32-14-18(19)23(30)26-20/h2-5,16H,6-14H2,1H3,(H,24,28)(H,25,26,30)
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n/an/a 3.64E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191215
PNG
(US9181266, 84)
Show SMILES CCCOc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H32N4O5/c1-2-12-34-19-5-3-17(4-6-19)24(31)18-7-10-29(11-8-18)15-23(30)26-14-22-27-21-9-13-33-16-20(21)25(32)28-22/h3-6,18H,2,7-16H2,1H3,(H,26,30)(H,27,28,32)
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n/an/a 2.13E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191218
PNG
(US9181266, 87)
Show SMILES O=C(CN1CCC(CC1)C(=O)c1ccc(OC2CCOCC2)cc1)NCc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C27H34N4O6/c32-25(28-15-24-29-23-9-14-36-17-22(23)27(34)30-24)16-31-10-5-19(6-11-31)26(33)18-1-3-20(4-2-18)37-21-7-12-35-13-8-21/h1-4,19,21H,5-17H2,(H,28,32)(H,29,30,34)
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n/an/a 2.84E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM191219
PNG
(US9181266, 88)
Show SMILES COCCOc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H32N4O6/c1-33-12-13-35-19-4-2-17(3-5-19)24(31)18-6-9-29(10-7-18)15-23(30)26-14-22-27-21-8-11-34-16-20(21)25(32)28-22/h2-5,18H,6-16H2,1H3,(H,26,30)(H,27,28,32)
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n/an/a 2.37E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191144
PNG
(US9181266, 6)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCCCCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C25H32N4O4/c1-33-19-9-7-17(8-10-19)24(31)18-11-13-29(14-12-18)16-23(30)26-15-22-27-21-6-4-2-3-5-20(21)25(32)28-22/h7-10,18H,2-6,11-16H2,1H3,(H,26,30)(H,27,28,32)
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n/an/a 575n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191146
PNG
(US9181266, 8)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C28H36N4O4/c1-36-22-10-8-20(9-11-22)27(34)21-12-14-31(15-13-21)18-26(33)32(16-19-6-7-19)17-25-29-24-5-3-2-4-23(24)28(35)30-25/h8-11,19,21H,2-7,12-18H2,1H3,(H,29,30,35)
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n/an/a 31n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191149
PNG
(US9181266, 11)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C23H28N4O4/c1-31-17-7-5-15(6-8-17)22(29)16-9-11-27(12-10-16)14-21(28)24-13-20-25-19-4-2-3-18(19)23(30)26-20/h5-8,16H,2-4,9-14H2,1H3,(H,24,28)(H,25,26,30)
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n/an/a 28.5n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191157
PNG
(US9181266, 20)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccncc2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C28H30FN5O4/c29-22-3-1-20(2-4-22)27(36)21-7-12-33(13-8-21)17-26(35)34(15-19-5-10-30-11-6-19)16-25-31-24-9-14-38-18-23(24)28(37)32-25/h1-6,10-11,21H,7-9,12-18H2,(H,31,32,37)
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n/an/a 845n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191171
PNG
(US9181266, 40)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2nc3CCOCc3c(=O)[nH]2)Cc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C29H29F3N4O4/c30-21-4-1-18(2-5-21)28(38)19-7-10-35(11-8-19)16-27(37)36(14-20-3-6-22(31)13-24(20)32)15-26-33-25-9-12-40-17-23(25)29(39)34-26/h1-6,13,19H,7-12,14-17H2,(H,33,34,39)
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n/an/a 77n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191172
PNG
(US9181266, 41)
Show SMILES C[C@H](C1CC1)N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1 |r|
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n/an/a 16n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191175
PNG
(US9181266, 44)
Show SMILES FCCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H28F2N4O4/c25-8-11-30(13-21-27-20-7-12-34-15-19(20)24(33)28-21)22(31)14-29-9-5-17(6-10-29)23(32)16-1-3-18(26)4-2-16/h1-4,17H,5-15H2,(H,27,28,33)
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n/an/a 72n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191182
PNG
(US9181266, 51)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CC(=O)NCc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C22H24FN5O4/c23-14-1-2-15-18(9-14)32-27-21(15)13-3-6-28(7-4-13)11-20(29)24-10-19-25-17-5-8-31-12-16(17)22(30)26-19/h1-2,9,13H,3-8,10-12H2,(H,24,29)(H,25,26,30)
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n/an/a 207n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191192
PNG
(US9181266, 61)
Show SMILES Fc1ccc2C(=O)C3(Cc2c1)CCN(CC(=O)NCc1nc2CCOCc2c(=O)[nH]1)CC3
Show InChI InChI=1S/C23H25FN4O4/c24-15-1-2-16-14(9-15)10-23(21(16)30)4-6-28(7-5-23)12-20(29)25-11-19-26-18-3-8-32-13-17(18)22(31)27-19/h1-2,9H,3-8,10-13H2,(H,25,29)(H,26,27,31)
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n/an/a 25n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191202
PNG
(US9181266, 71)
Show SMILES FC(F)CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C25H27F5N4O5/c26-20(27)11-34(12-21-31-19-7-10-38-14-18(19)24(37)32-21)22(35)13-33-8-5-16(6-9-33)23(36)15-1-3-17(4-2-15)39-25(28,29)30/h1-4,16,20H,5-14H2,(H,31,32,37)
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n/an/a 43n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))		BDBM191210
PNG
(US9181266, 79)
Show SMILES O=C(CN1CCC(CC1)C(=O)N1CCc2ccccc2C1)NCc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O4/c31-23(26-13-22-27-21-8-12-34-16-20(21)24(32)28-22)15-29-9-5-18(6-10-29)25(33)30-11-7-17-3-1-2-4-19(17)14-30/h1-4,18H,5-16H2,(H,26,31)(H,27,28,32)
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n/an/a 3.02E+3n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191145
PNG
(US9181266, 7)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C29H38N4O4/c1-37-23-11-9-21(10-12-23)28(35)22-13-15-32(16-14-22)19-27(34)33(17-20-7-8-20)18-26-30-25-6-4-2-3-5-24(25)29(36)31-26/h9-12,20,22H,2-8,13-19H2,1H3,(H,30,31,36)
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n/an/a 371n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191146
PNG
(US9181266, 8)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C28H36N4O4/c1-36-22-10-8-20(9-11-22)27(34)21-12-14-31(15-13-21)18-26(33)32(16-19-6-7-19)17-25-29-24-5-3-2-4-23(24)28(35)30-25/h8-11,19,21H,2-7,12-18H2,1H3,(H,29,30,35)
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n/an/a 16n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191147
PNG
(US9181266, 9)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)NCc2nc3CCCCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C24H30N4O4/c1-32-18-8-6-16(7-9-18)23(30)17-10-12-28(13-11-17)15-22(29)25-14-21-26-20-5-3-2-4-19(20)24(31)27-21/h6-9,17H,2-5,10-15H2,1H3,(H,25,29)(H,26,27,31)
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n/an/a 14n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191152
PNG
(US9181266, 15)
Show SMILES Fc1ccc(CN(Cc2nc3CCOCc3c(=O)[nH]2)C(=O)CN2CCC(CC2)C(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C29H30F2N4O4/c30-22-5-1-19(2-6-22)15-35(16-26-32-25-11-14-39-18-24(25)29(38)33-26)27(36)17-34-12-9-21(10-13-34)28(37)20-3-7-23(31)8-4-20/h1-8,21H,9-18H2,(H,32,33,38)
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n/an/a 32n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191154
PNG
(US9181266, 17)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2nc3ccccc3s2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C30H30FN5O4S/c31-21-7-5-19(6-8-21)29(38)20-9-12-35(13-10-20)17-28(37)36(16-27-33-24-3-1-2-4-25(24)41-27)15-26-32-23-11-14-40-18-22(23)30(39)34-26/h1-8,20H,9-18H2,(H,32,34,39)
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n/an/a 18n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191157
PNG
(US9181266, 20)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccncc2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C28H30FN5O4/c29-22-3-1-20(2-4-22)27(36)21-7-12-33(13-8-21)17-26(35)34(15-19-5-10-30-11-6-19)16-25-31-24-9-14-38-18-23(24)28(37)32-25/h1-6,10-11,21H,7-9,12-18H2,(H,31,32,37)
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n/an/a 206n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM50439797
PNG
(CHEMBL2419700 | US9181266, 22)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccccn2)Cc2nc3CCOCc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C28H30FN5O4/c29-21-6-4-19(5-7-21)27(36)20-8-12-33(13-9-20)17-26(35)34(15-22-3-1-2-11-30-22)16-25-31-24-10-14-38-18-23(24)28(37)32-25/h1-7,11,20H,8-10,12-18H2,(H,31,32,37)
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n/an/a 31n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191164
PNG
(US9181266, 31)
Show SMILES CC[C@H](C)N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1 |r|
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n/an/a 13n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191167
PNG
(US9181266, 35)
Show SMILES C[C@H](N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1)c1ccc(F)cc1 |r|
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n/an/a 68n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191173
PNG
(US9181266, 42)
Show SMILES C[C@@H](C1CC1)N(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1 |r|
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n/an/a 10n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191176
PNG
(US9181266, 45)
Show SMILES FC(F)CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H27F3N4O4/c25-17-3-1-15(2-4-17)23(33)16-5-8-30(9-6-16)13-22(32)31(11-20(26)27)12-21-28-19-7-10-35-14-18(19)24(34)29-21/h1-4,16,20H,5-14H2,(H,28,29,34)
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n/an/a 10.2n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191183
PNG
(US9181266, 52)
Show SMILES O=C(CN1CCC(CC1)c1nnc(o1)-c1ccccc1)NCc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C23H26N6O4/c30-20(24-12-19-25-18-8-11-32-14-17(18)21(31)26-19)13-29-9-6-16(7-10-29)23-28-27-22(33-23)15-4-2-1-3-5-15/h1-5,16H,6-14H2,(H,24,30)(H,25,26,31)
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n/an/a 170n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191184
PNG
(US9181266, 53)
Show SMILES COCCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C26H32N6O5/c1-35-14-12-32(15-22-27-21-9-13-36-17-20(21)24(34)28-22)23(33)16-31-10-7-19(8-11-31)26-30-29-25(37-26)18-5-3-2-4-6-18/h2-6,19H,7-17H2,1H3,(H,27,28,34)
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n/an/a 142n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191185
PNG
(US9181266, 54)
Show SMILES COCCN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C26H34N4O6/c1-34-14-12-30(15-23-27-22-9-13-36-17-21(22)26(33)28-23)24(31)16-29-10-7-19(8-11-29)25(32)18-3-5-20(35-2)6-4-18/h3-6,19H,7-17H2,1-2H3,(H,27,28,33)
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n/an/a 14n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191192
PNG
(US9181266, 61)
Show SMILES Fc1ccc2C(=O)C3(Cc2c1)CCN(CC(=O)NCc1nc2CCOCc2c(=O)[nH]1)CC3
Show InChI InChI=1S/C23H25FN4O4/c24-15-1-2-16-14(9-15)10-23(21(16)30)4-6-28(7-5-23)12-20(29)25-11-19-26-18-3-8-32-13-17(18)22(31)27-19/h1-2,9H,3-8,10-13H2,(H,25,29)(H,26,27,31)
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n/an/a 8n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191206
PNG
(US9181266, 75)
Show SMILES FC(F)CN(Cc1nc2CCOCc2c(=O)[nH]1)C(=O)CN1CCC(CC1)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H27F5N4O4/c26-20(27)11-34(12-21-31-19-7-10-38-14-18(19)24(37)32-21)22(35)13-33-8-5-16(6-9-33)23(36)15-1-3-17(4-2-15)25(28,29)30/h1-4,16,20H,5-14H2,(H,31,32,37)
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n/an/a 17n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM191210
PNG
(US9181266, 79)
Show SMILES O=C(CN1CCC(CC1)C(=O)N1CCc2ccccc2C1)NCc1nc2CCOCc2c(=O)[nH]1
Show InChI InChI=1S/C25H31N5O4/c31-23(26-13-22-27-21-8-12-34-16-20(21)24(32)28-22)15-29-9-5-18(6-10-29)25(33)30-11-7-17-3-1-2-4-19(17)14-30/h1-4,18H,5-16H2,(H,26,31)(H,27,28,32)
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n/an/a 815n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...

US Patent US9181266 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XTF
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%