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Patent code US9527851

Compile Data Set for Download or QSAR

Found 260 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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US Patent
n/an/a 71n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260481
PNG
(US10428074, Example 56 | US9527851, 56 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 75n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260517
PNG
(US10428074, Example 134 | US9527851, 134 | US95278...)
Show SMILES COC(=O)CN1C[C@H]2[C@H](CN(C)c3ncnc4[nH]ccc34)[C@H]2C1 |r|
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n/an/a 164n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260462
PNG
(US10428074, Example 21 | US9527851, 21 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CNS(C)(=O)=O)c1ncnc2[nH]ccc12 |r|
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n/an/a 17n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260476
PNG
(US10428074, Example 41 | US9527851, 41 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 80n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260492
PNG
(US10428074, Example 81 | US9527851, 81 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)c1ccccc1)c1ncnc2[nH]ccc12 |r|
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US Patent
n/an/a 113n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260494
PNG
(US10428074, Example 83 | US9527851, 83 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C(C)(C)O)c1ncnc2[nH]ccc12 |r|
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n/an/a 50n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260498
PNG
(US10428074, Example 92 | US9527851, 92 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)CO)c1ncnc2[nH]ccc12 |r|
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n/an/a 131n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 3n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 4n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260507
PNG
(US9527851, 113 | US9527851, example 113)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ccnc3[nH]ccc23)n1 |r|
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n/an/a 178n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260508
PNG
(US10428074, Example 114 | US9527851, 114 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12 |r|
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n/an/a 140n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
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n/an/a 31n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202295
PNG
(2-hydroxy-1-((3as,5r,6ar/3as,5r,6ar)-3a-methyl-5-(...)
Show SMILES CN([C@H]1C[C@@H]2CN(C[C@]2(C)C1)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12 |r|
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n/an/a 30n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260461
PNG
(US10428074, Example 19 | US9527851, 19 | US9527851...)
Show SMILES C[C@@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 48n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202309
PNG
(2-hydroxy-1-((3ar,5r,6as)-5-(methyl(7h-pyrrolo[2,3...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12 |r|
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n/an/a 21n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260466
PNG
(US10428074, Example 26 | US9527851, 26 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 46n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260474
PNG
(US10428074, Example 39 | US9527851, 39 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12 |r|
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n/an/a 34n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 98n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260482
PNG
(US10428074, Example 61 | US9527851, 61 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)no1)c1ncnc2[nH]ccc12 |r|
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n/an/a 128n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260491
PNG
(US10428074, Example 80 | US9527851, 80 | US9527851...)
Show SMILES CNC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 127n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260496
PNG
(US10428074, Example 85 | US9527851, 85 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Cc1nn[nH]n1)c1ncnc2[nH]ccc12 |r|
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n/an/a 80n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 0.200n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260522
PNG
(US10428074, Example 151 | US9527851, 151 | US95278...)
Show SMILES CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
PDB

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US Patent
n/an/a 106n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202320
PNG
(1-((4as,7ar)-6-(methyl(7h-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES CN(Cc1ccccc1)C1C[C@H]2CCN(C[C@H]2C1)C(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C21H32N2O2/c1-21(2,3)25-20(24)23-11-10-17-12-19(13-18(17)15-23)22(4)14-16-8-6-5-7-9-16/h5-9,17-19H,10-15H2,1-4H3/t17-,18-,19?/m1/s1
PDB

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n/an/a 16n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260472
PNG
(US10428074, Example 37 | US9527851, 37 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r|
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US Patent
n/an/a 72n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260481
PNG
(US10428074, Example 56 | US9527851, 56 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 32n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202344
PNG
(US10428074, Example 65 | US9527851, example 65)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)ns1)c1ncnc2[nH]ccc12 |r|
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n/an/a 179n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260488
PNG
(US10428074, Example 73 | US9527851, 73 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r|
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n/an/a 47n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260490
PNG
(US10428074, Example 75 | US9527851, 75 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12 |r|
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n/an/a 156n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM202291
PNG
(2-hydroxy-1-((3ar,5s,6as)-5-(methyl(7h-pyrrolo[2,3...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OO)c1ncnc2[nH]ccc12 |r|
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n/an/a 11n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260473
PNG
(US10428074, Example 38 | US9527851, 38 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
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n/an/a 40n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260514
PNG
(US9527851, 128 | US9527851, example 128)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r|
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n/an/a 4n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260520
PNG
(US9527851, 148 | US9527851, example 148)
Show SMILES CN(C1CC2CNC(=O)CC2C1)c1ncnc2[nH]ccc12
PDB

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n/an/a 71n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260453
PNG
(US10428074, Example 6 | US9527851, 6 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r|
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n/an/a 11n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.300n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260479
PNG
(US9527851, 50)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12 |r|
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n/an/a 201n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260505
PNG
(US10428074, Example 111 | US9527851, 111 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12 |r|
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n/an/a 101n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260514
PNG
(US9527851, 128 | US9527851, example 128)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r|
PDB

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n/an/a 4n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260521
PNG
(US10428074, Example 150 | US9527851, 150 | US95278...)
Show SMILES CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r|
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n/an/a 148n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 98n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260495
PNG
(US10428074, Example 84 | US9527851, 84 | US9527851...)
Show SMILES CCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 73n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260508
PNG
(US10428074, Example 114 | US9527851, 114 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12 |r|
PDB

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n/an/a 2n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 1n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260463
PNG
(US10428074, Example 22 | US9527851, 22 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 54n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260471
PNG
(US10428074, Example 36 | US9527851, 36)
Show SMILES COC(=O)N1CC[C@H]2CC(C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 75n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260474
PNG
(US10428074, Example 39 | US9527851, 39 | US9527851...)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 113n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 31n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260488
PNG
(US10428074, Example 73 | US9527851, 73 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 47n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260497
PNG
(US10428074, Example 86 | US9527851, 86 | US9527851...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 52n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 260 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%