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PubMed code 10395489

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078513
PNG
(7,8-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)c(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H4Cl2N4O3/c11-3-1-5-6(2-4(3)12)16-8(9(17)13-5)14-7(15-16)10(18)19/h1-2H,(H,13,17)(H,18,19)
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 74n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Glycine/NMDA receptor in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078527
PNG
(7,9-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES OC(=O)c1nc2n(n1)c1c(Cl)cc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H4Cl2N4O3/c11-3-1-4(12)6-5(2-3)13-9(17)8-14-7(10(18)19)15-16(6)8/h1-2H,(H,13,17)(H,18,19)
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 140n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078519
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H5ClN4O3/c11-4-1-2-6-5(3-4)12-9(16)8-13-7(10(17)18)14-15(6)8/h1-3H,(H,12,16)(H,17,18)
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 170n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078515
PNG
(7-Bromo-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(Br)cc1[nH]c2=O
Show InChI InChI=1S/C10H5BrN4O3/c11-4-1-2-6-5(3-4)12-9(16)8-13-7(10(17)18)14-15(6)8/h1-3H,(H,12,16)(H,17,18)
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 390n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078531
PNG
(4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazol...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F
Show InChI InChI=1S/C11H5F3N4O3/c12-11(13,14)4-1-2-6-5(3-4)15-9(19)8-16-7(10(20)21)17-18(6)8/h1-3H,(H,15,19)(H,20,21)
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 570n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078507
PNG
(7,8-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES CCOC(=O)c1nc2n(n1)c1cc(Cl)c(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H8Cl2N4O3/c1-2-21-12(20)9-16-10-11(19)15-7-3-5(13)6(14)4-8(7)18(10)17-9/h3-4H,2H2,1H3,(H,15,19)
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 710n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078517
PNG
(7-Nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)[N+]([O-])=O
Show InChI InChI=1S/C10H5N5O5/c16-9-8-12-7(10(17)18)13-14(8)6-2-1-4(15(19)20)3-5(6)11-9/h1-3H,(H,11,16)(H,17,18)
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 710n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078533
PNG
((7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]...)
Show SMILES OC(=O)Cc1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C11H7ClN4O3/c12-5-1-2-7-6(3-5)13-11(19)10-14-8(4-9(17)18)15-16(7)10/h1-3H,4H2,(H,13,19)(H,17,18)
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 1.10E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078532
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES ONC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H6ClN5O3/c11-4-1-2-6-5(3-4)12-10(18)8-13-7(9(17)15-19)14-16(6)8/h1-3,19H,(H,12,18)(H,15,17)
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 1.10E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Glycine/NMDA receptor in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078522
PNG
(4-Oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin...)
Show SMILES OC(=O)c1nc2n(n1)c1ccccc1[nH]c2=O
Show InChI InChI=1S/C10H6N4O3/c15-9-8-12-7(10(16)17)13-14(8)6-4-2-1-3-5(6)11-9/h1-4H,(H,11,15)(H,16,17)
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 1.10E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078514
PNG
(4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazol...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F
Show InChI InChI=1S/C13H9F3N4O3/c1-2-23-12(22)9-18-10-11(21)17-7-5-6(13(14,15)16)3-4-8(7)20(10)19-9/h3-5H,2H2,1H3,(H,17,21)
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 1.80E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078525
PNG
(7-Chloro-8-nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(c(Cl)cc1[n-]c2=[OH+])[N+]([O-])=O
Show InChI InChI=1S/C10H4ClN5O5/c11-3-1-4-6(2-5(3)16(20)21)15-8(9(17)12-4)13-7(14-15)10(18)19/h1-2H,(H2,12,17,18,19)
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 2.20E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078508
PNG
(7-Bromo-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccc(Br)cc1[nH]c2=O
Show InChI InChI=1S/C12H9BrN4O3/c1-2-20-12(19)9-15-10-11(18)14-7-5-6(13)3-4-8(7)17(10)16-9/h3-5H,2H2,1H3,(H,14,18)
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 2.60E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078536
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H9ClN4O3/c1-2-20-12(19)9-15-10-11(18)14-7-5-6(13)3-4-8(7)17(10)16-9/h3-5H,2H2,1H3,(H,14,18)
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 3.00E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078510
PNG
(8-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)ccc1[nH]c2=O
Show InChI InChI=1S/C10H5ClN4O3/c11-4-1-2-5-6(3-4)15-8(9(16)12-5)13-7(14-15)10(17)18/h1-3H,(H,12,16)(H,17,18)
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 3.50E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078506
PNG
(8-Chloro-6-nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)cc([N+]([O-])=O)c1[nH]c2=O
Show InChI InChI=1S/C10H4ClN5O5/c11-3-1-4-6(5(2-3)16(20)21)12-9(17)8-13-7(10(18)19)14-15(4)8/h1-2H,(H,12,17)(H,18,19)
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 4.50E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078523
PNG
(7,9-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES CCOC(=O)c1nc2n(n1)c1c(Cl)cc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H8Cl2N4O3/c1-2-21-12(20)9-16-10-11(19)15-7-4-5(13)3-6(14)8(7)18(10)17-9/h3-4H,2H2,1H3,(H,15,19)
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 4.80E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078518
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES Clc1ccc2c(c1)[nH]c(=O)c1nc(nn21)C(=O)Nc1nnn[nH]1
Show InChI InChI=1S/C11H6ClN9O2/c12-4-1-2-6-5(3-4)13-10(23)8-14-7(18-21(6)8)9(22)15-11-16-19-20-17-11/h1-3H,(H,13,23)(H2,15,16,17,19,20,22)
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 5.10E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078535
PNG
(CHEMBL83901 | [(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]...)
Show SMILES COC(=O)CNC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C13H10ClN5O4/c1-23-9(20)5-15-12(21)10-17-11-13(22)16-7-4-6(14)2-3-8(7)19(11)18-10/h2-4H,5H2,1H3,(H,15,21)(H,16,22)
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 5.40E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078526
PNG
((7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]...)
Show SMILES CCOC(=O)Cc1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C13H11ClN4O3/c1-2-21-11(19)6-10-16-12-13(20)15-8-5-7(14)3-4-9(8)18(12)17-10/h3-5H,2,6H2,1H3,(H,15,20)
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 6.50E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078520
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES NC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H6ClN5O2/c11-4-1-2-6-5(3-4)13-10(18)9-14-8(7(12)17)15-16(6)9/h1-3H,(H2,12,17)(H,13,18)
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 7.20E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078512
PNG
(7-Chloro-2-hydroxymethyl-5H-[1,2,4]triazolo[1,5-a]...)
Show SMILES OCc1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H7ClN4O2/c11-5-1-2-7-6(3-5)12-10(17)9-13-8(4-16)14-15(7)9/h1-3,16H,4H2,(H,12,17)
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 7.50E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078521
PNG
(CHEMBL313269 | [(7-Chloro-4-oxo-4,5-dihydro-[1,2,4...)
Show SMILES OC(=O)CNC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H8ClN5O4/c13-5-1-2-7-6(3-5)15-12(22)10-16-9(17-18(7)10)11(21)14-4-8(19)20/h1-3H,4H2,(H,14,21)(H,15,22)(H,19,20)
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 8.80E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078534
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES NNC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H7ClN6O2/c11-4-1-2-6-5(3-4)13-10(19)8-14-7(9(18)15-12)16-17(6)8/h1-3H,12H2,(H,13,19)(H,15,18)
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 9.60E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Glycine/NMDA receptor in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078529
PNG
((7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]...)
Show SMILES Clc1ccc2c(c1)[nH]c(=O)c1nc(CC#N)nn21
Show InChI InChI=1S/C11H6ClN5O/c12-6-1-2-8-7(5-6)14-11(18)10-15-9(3-4-13)16-17(8)10/h1-2,5H,3H2,(H,14,18)
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 9.70E+3n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078530
PNG
(4-Oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccccc1[nH]c2=O
Show InChI InChI=1S/C12H10N4O3/c1-2-19-12(18)9-14-10-11(17)13-7-5-3-4-6-8(7)16(10)15-9/h3-6H,2H2,1H3,(H,13,17)
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 1.67E+4n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078516
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES OCCNC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H10ClN5O3/c13-6-1-2-8-7(5-6)15-12(21)10-16-9(17-18(8)10)11(20)14-3-4-19/h1-2,5,19H,3-4H2,(H,14,20)(H,15,21)
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 2.77E+4n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078511
PNG
(8-Nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(ccc1[n-]c2=[OH+])[N+]([O-])=O
Show InChI InChI=1S/C10H5N5O5/c16-9-8-12-7(10(17)18)13-14(8)6-3-4(15(19)20)1-2-5(6)11-9/h1-3H,(H2,11,16,17,18)
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 7.94E+4n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078528
PNG
(7-Chloro-5-ethyl-4-oxo-4,5-dihydro-[1,2,4]triazolo...)
Show SMILES CCn1c2cc(Cl)ccc2n2nc(nc2c1=O)C(O)=O
Show InChI InChI=1S/C12H9ClN4O3/c1-2-16-8-5-6(13)3-4-7(8)17-10(11(16)18)14-9(15-17)12(19)20/h3-5H,2H2,1H3,(H,19,20)
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 8.80E+4n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078524
PNG
(8-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES CCOC(=O)c1nc2n(n1)c1cc(Cl)ccc1[nH]c2=O
Show InChI InChI=1S/C12H9ClN4O3/c1-2-20-12(19)9-15-10-11(18)14-7-4-3-6(13)5-8(7)17(10)16-9/h3-5H,2H2,1H3,(H,14,18)
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 8.82E+4n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078509
PNG
(7-Amino-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccc(N)cc1[nH]c2=O
Show InChI InChI=1S/C12H11N5O3/c1-2-20-12(19)9-15-10-11(18)14-7-5-6(13)3-4-8(7)17(10)16-9/h3-5H,2,13H2,1H3,(H,14,18)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078506
PNG
(8-Chloro-6-nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)cc([N+]([O-])=O)c1[nH]c2=O
Show InChI InChI=1S/C10H4ClN5O5/c11-3-1-4-6(5(2-3)16(20)21)12-9(17)8-13-7(10(18)19)14-15(4)8/h1-2H,(H,12,17)(H,18,19)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078510
PNG
(8-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)ccc1[nH]c2=O
Show InChI InChI=1S/C10H5ClN4O3/c11-4-1-2-5-6(3-4)15-8(9(16)12-5)13-7(14-15)10(17)18/h1-3H,(H,12,16)(H,17,18)
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n/an/an/an/a 3.25E+4n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078507
PNG
(7,8-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES CCOC(=O)c1nc2n(n1)c1cc(Cl)c(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H8Cl2N4O3/c1-2-21-12(20)9-16-10-11(19)15-7-3-5(13)6(14)4-8(7)18(10)17-9/h3-4H,2H2,1H3,(H,15,19)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078536
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C12H9ClN4O3/c1-2-20-12(19)9-15-10-11(18)14-7-5-6(13)3-4-8(7)17(10)16-9/h3-5H,2H2,1H3,(H,14,18)
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n/an/an/an/a 2.21E+4n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078530
PNG
(4-Oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccccc1[nH]c2=O
Show InChI InChI=1S/C12H10N4O3/c1-2-19-12(18)9-14-10-11(17)13-7-5-3-4-6-8(7)16(10)15-9/h3-6H,2H2,1H3,(H,13,17)
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n/an/an/an/a 6.90E+4n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078528
PNG
(7-Chloro-5-ethyl-4-oxo-4,5-dihydro-[1,2,4]triazolo...)
Show SMILES CCn1c2cc(Cl)ccc2n2nc(nc2c1=O)C(O)=O
Show InChI InChI=1S/C12H9ClN4O3/c1-2-16-8-5-6(13)3-4-7(8)17-10(11(16)18)14-9(15-17)12(19)20/h3-5H,2H2,1H3,(H,19,20)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078517
PNG
(7-Nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)[N+]([O-])=O
Show InChI InChI=1S/C10H5N5O5/c16-9-8-12-7(10(17)18)13-14(8)6-2-1-4(15(19)20)3-5(6)11-9/h1-3H,(H,11,16)(H,17,18)
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n/an/an/an/a 7.80E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078509
PNG
(7-Amino-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES CCOC(=O)c1nc2n(n1)c1ccc(N)cc1[nH]c2=O
Show InChI InChI=1S/C12H11N5O3/c1-2-20-12(19)9-15-10-11(18)14-7-5-6(13)3-4-8(7)17(10)16-9/h3-5H,2,13H2,1H3,(H,14,18)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078513
PNG
(7,8-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(Cl)c(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H4Cl2N4O3/c11-3-1-5-6(2-4(3)12)16-8(9(17)13-5)14-7(15-16)10(18)19/h1-2H,(H,13,17)(H,18,19)
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n/an/an/an/a 300n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the NMDA receptor-ion channel complex was demonstrated by the ability to inhibit the binding of thechannel-blocking agent [3...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078511
PNG
(8-Nitro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES OC(=O)c1nc2n(n1)c1cc(ccc1[n-]c2=[OH+])[N+]([O-])=O
Show InChI InChI=1S/C10H5N5O5/c16-9-8-12-7(10(17)18)13-14(8)6-3-4(15(19)20)1-2-5(6)11-9/h1-3H,(H2,11,16,17,18)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078527
PNG
(7,9-Dichloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5...)
Show SMILES OC(=O)c1nc2n(n1)c1c(Cl)cc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H4Cl2N4O3/c11-3-1-4(12)6-5(2-3)13-9(17)8-14-7(10(18)19)15-16(6)8/h1-2H,(H,13,17)(H,18,19)
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n/an/an/an/a 1.35E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078515
PNG
(7-Bromo-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]qu...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(Br)cc1[nH]c2=O
Show InChI InChI=1S/C10H5BrN4O3/c11-4-1-2-6-5(3-4)12-9(16)8-13-7(10(17)18)14-15(6)8/h1-3H,(H,12,16)(H,17,18)
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n/an/an/an/a 3.70E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078519
PNG
(7-Chloro-4-oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]q...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(Cl)cc1[nH]c2=O
Show InChI InChI=1S/C10H5ClN4O3/c11-4-1-2-6-5(3-4)12-9(16)8-13-7(10(17)18)14-15(6)8/h1-3H,(H,12,16)(H,17,18)
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n/an/an/an/a 2.90E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078522
PNG
(4-Oxo-4,5-dihydro-[1,2,4]triazolo[1,5-a]quinoxalin...)
Show SMILES OC(=O)c1nc2n(n1)c1ccccc1[nH]c2=O
Show InChI InChI=1S/C10H6N4O3/c15-9-8-12-7(10(16)17)13-14(8)6-4-2-1-3-5(6)11-9/h1-4H,(H,11,15)(H,16,17)
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n/an/an/an/a 4.90E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
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n/an/an/an/a 330n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50078531
PNG
(4-Oxo-7-trifluoromethyl-4,5-dihydro-[1,2,4]triazol...)
Show SMILES OC(=O)c1nc2n(n1)c1ccc(cc1[nH]c2=O)C(F)(F)F
Show InChI InChI=1S/C11H5F3N4O3/c12-11(13,14)4-1-2-6-5(3-4)15-9(19)8-16-7(10(20)21)17-18(6)8/h1-3H,(H,15,19)(H,20,21)
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n/an/an/an/a 3.18E+3n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...

J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%