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PubMed code 10639288

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3603
PNG
(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Show SMILES CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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n/an/a 0.00800n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3570
PNG
(8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15/h1-8H,(H,18,19)(H,17,20,21)
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n/an/a 0.00800n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3770
PNG
(6-N-(3-bromophenyl)-8-thia-3,5-diazatricyclo[7.4.0...)
Show SMILES Nc1ccc2sc3c(Nc4cccc(Br)c4)ncnc3c2c1
Show InChI InChI=1S/C16H11BrN4S/c17-9-2-1-3-11(6-9)21-16-15-14(19-8-20-16)12-7-10(18)4-5-13(12)22-15/h1-8H,18H2,(H,19,20,21)
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n/an/a 0.270n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3583
PNG
(5-[(3-Bromophenyl)amino]-1H-pyrrolo[3,2-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4[nH]ccc4cc23)c1
Show InChI InChI=1S/C16H11BrN4/c17-11-2-1-3-12(7-11)21-16-13-6-10-4-5-18-14(10)8-15(13)19-9-20-16/h1-9,18H,(H,19,20,21)
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n/an/a 0.390n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3582
PNG
(5-[(3-Bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazo...)
Show SMILES Brc1cccc(Nc2ncnc3cc4[nH]ncc4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-10-2-1-3-11(5-10)20-15-12-4-9-7-19-21-13(9)6-14(12)17-8-18-15/h1-8H,(H,19,21)(H,17,18,20)
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n/an/a 0.440n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3772
PNG
(6-N-(3-bromophenyl)-8-thia-3,5-diazatricyclo[7.4.0...)
Show SMILES Nc1ccc2c(c1)sc1c(Nc3cccc(Br)c3)ncnc21
Show InChI InChI=1S/C16H11BrN4S/c17-9-2-1-3-11(6-9)21-16-15-14(19-8-20-16)12-5-4-10(18)7-13(12)22-15/h1-8H,18H2,(H,19,20,21)
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n/an/a 0.470n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3733
PNG
(2-({6-[(3-methylphenyl)amino]pyrimidin-4-yl}amino)...)
Show SMILES Cc1cccc(Nc2cc(NCCO)ncn2)c1
Show InChI InChI=1S/C13H16N4O/c1-10-3-2-4-11(7-10)17-13-8-12(14-5-6-18)15-9-16-13/h2-4,7-9,18H,5-6H2,1H3,(H2,14,15,16,17)
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n/an/a 1n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3773
PNG
(6-N-(3-bromophenyl)-12-fluoro-8-thia-3,5-diazatric...)
Show SMILES Nc1cc2sc3c(Nc4cccc(Br)c4)ncnc3c2cc1F
Show InChI InChI=1S/C16H10BrFN4S/c17-8-2-1-3-9(4-8)22-16-15-14(20-7-21-16)10-5-11(18)12(19)6-13(10)23-15/h1-7H,19H2,(H,20,21,22)
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n/an/a 1n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3776
PNG
(4-(3-Bromoanilino)-8-methylaminobenzo[b]thieno[3,2...)
Show SMILES CNc1ccc2sc3c(Nc4cccc(Br)c4)ncnc3c2c1
Show InChI InChI=1S/C17H13BrN4S/c1-19-11-5-6-14-13(8-11)15-16(23-14)17(21-9-20-15)22-12-4-2-3-10(18)7-12/h2-9,19H,1H3,(H,20,21,22)
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n/an/a 1.10n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3758
PNG
(N-(3-Bromophenyl)-6-methoxy-1H-pyrimido[4,5-b]indo...)
Show SMILES COc1ccc2[nH]c3ncnc(Nc4cccc(Br)c4)c3c2c1
Show InChI InChI=1S/C17H13BrN4O/c1-23-12-5-6-14-13(8-12)15-16(19-9-20-17(15)22-14)21-11-4-2-3-10(18)7-11/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a 1.20n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3584
PNG
(9-[(3-Bromophenyl)amino]-1H-pyrrolo[2,3-f]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3ccc4cc[nH]c4c23)c1
Show InChI InChI=1S/C16H11BrN4/c17-11-2-1-3-12(8-11)21-16-14-13(19-9-20-16)5-4-10-6-7-18-15(10)14/h1-9,18H,(H,19,20,21)
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n/an/a 1.24n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3762
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 53 | N-(3-brom...)
Show SMILES Brc1cccc(Nc2ncnc3c4ccccc4sc23)c1
Show InChI InChI=1S/C16H10BrN3S/c17-10-4-3-5-11(8-10)20-16-15-14(18-9-19-16)12-6-1-2-7-13(12)21-15/h1-9H,(H,18,19,20)
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n/an/a 1.80n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3768
PNG
(6-N-(3-methylphenyl)-8-thia-3,5-diazatricyclo[7.4....)
Show SMILES Cc1cccc(Nc2ncnc3c4cc(N)ccc4sc23)c1
Show InChI InChI=1S/C17H14N4S/c1-10-3-2-4-12(7-10)21-17-16-15(19-9-20-17)13-8-11(18)5-6-14(13)22-16/h2-9H,18H2,1H3,(H,19,20,21)
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n/an/a 2.10n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3780
PNG
(6-N-(3-bromophenyl)-8-thia-3,5-diazatricyclo[7.4.0...)
Show SMILES Nc1cccc2c1sc1c(Nc3cccc(Br)c3)ncnc21
Show InChI InChI=1S/C16H11BrN4S/c17-9-3-1-4-10(7-9)21-16-15-13(19-8-20-16)11-5-2-6-12(18)14(11)22-15/h1-8H,18H2,(H,19,20,21)
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n/an/a 2.70n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3774
PNG
(6-N-(3-bromophenyl)-11-N-ethyl-12-fluoro-8-thia-3,...)
Show SMILES CCNc1cc2sc3c(Nc4cccc(Br)c4)ncnc3c2cc1F
Show InChI InChI=1S/C18H14BrFN4S/c1-2-21-14-8-15-12(7-13(14)20)16-17(25-15)18(23-9-22-16)24-11-5-3-4-10(19)6-11/h3-9,21H,2H2,1H3,(H,22,23,24)
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n/an/a 7.90n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3767
PNG
(6-N-phenyl-8-thia-3,5-diazatricyclo[7.4.0.0^{2,7}]...)
Show SMILES Nc1ccc2sc3c(Nc4ccccc4)ncnc3c2c1
Show InChI InChI=1S/C16H12N4S/c17-10-6-7-13-12(8-10)14-15(21-13)16(19-9-18-14)20-11-4-2-1-3-5-11/h1-9H,17H2,(H,18,19,20)
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n/an/a 9.40n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3735
PNG
(Anilinopyrimidine deriv. 3 | N-(3-bromophenyl)thie...)
Show SMILES Brc1cccc(Nc2ncnc3ccsc23)c1
Show InChI InChI=1S/C12H8BrN3S/c13-8-2-1-3-9(6-8)16-12-11-10(4-5-17-11)14-7-15-12/h1-7H,(H,14,15,16)
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n/an/a 11n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3764
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 55 | N-(3-meth...)
Show SMILES Cc1cccc(Nc2ncnc3c2sc2ccc(cc32)[N+]([O-])=O)c1
Show InChI InChI=1S/C17H12N4O2S/c1-10-3-2-4-11(7-10)20-17-16-15(18-9-19-17)13-8-12(21(22)23)5-6-14(13)24-16/h2-9H,1H3,(H,18,19,20)
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n/an/a 11n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3766
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 57 | N-(3-brom...)
Show SMILES [O-][N+](=O)c1ccc2sc3c(Nc4cccc(Br)c4)ncnc3c2c1
Show InChI InChI=1S/C16H9BrN4O2S/c17-9-2-1-3-10(6-9)20-16-15-14(18-8-19-16)12-7-11(21(22)23)4-5-13(12)24-15/h1-8H,(H,18,19,20)
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n/an/a 12.3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3778
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 69 | N-(3-brom...)
Show SMILES COc1cccc2c3ncnc(Nc4cccc(Br)c4)c3sc12
Show InChI InChI=1S/C17H12BrN3OS/c1-22-13-7-3-6-12-14-16(23-15(12)13)17(20-9-19-14)21-11-5-2-4-10(18)8-11/h2-9H,1H3,(H,19,20,21)
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n/an/a 12.6n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3777
PNG
(4-(3-Bromoanilino)-8-dimethylaminobenzo[b]thieno[3...)
Show SMILES CN(C)c1ccc2sc3c(Nc4cccc(Br)c4)ncnc3c2c1
Show InChI InChI=1S/C18H15BrN4S/c1-23(2)13-6-7-15-14(9-13)16-17(24-15)18(21-10-20-16)22-12-5-3-4-11(19)8-12/h3-10H,1-2H3,(H,20,21,22)
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n/an/a 19.8n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3781
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 72 | N-(3-brom...)
Show SMILES COc1cccc2sc3c(Nc4cccc(Br)c4)ncnc3c12
Show InChI InChI=1S/C17H12BrN3OS/c1-22-12-6-3-7-13-14(12)15-16(23-13)17(20-9-19-15)21-11-5-2-4-10(18)8-11/h2-9H,1H3,(H,19,20,21)
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n/an/a 20n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3263
PNG
(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Show SMILES Clc1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H10ClN3/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H,(H,16,17,18)
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n/an/a 23n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3577
PNG
(9-[(3-Bromophenyl)amino]-1H-imidazo[4,5-f]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3ccc4[nH]cnc4c23)c1
Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(6-9)21-15-13-11(17-8-20-15)4-5-12-14(13)19-7-18-12/h1-8H,(H,18,19)(H,17,20,21)
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n/an/a 29n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3753
PNG
(N-(3-bromophenyl)-9H-pyrimido[4,5-b]indol-4-amine ...)
Show SMILES Brc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1
Show InChI InChI=1S/C16H11BrN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)
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n/an/a 31n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3736
PNG
(Anilinopyrimidine deriv. 4 | N-(3-bromophenyl)thie...)
Show SMILES Brc1cccc(Nc2ncnc3sccc23)c1
Show InChI InChI=1S/C12H8BrN3S/c13-8-2-1-3-9(6-8)16-11-10-4-5-17-12(10)15-7-14-11/h1-7H,(H,14,15,16)
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n/an/a 35n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3785
PNG
(N-(3-bromophenyl)-3,7-dithia-5,10,12-triazatricycl...)
Show SMILES Brc1cccc(Nc2ncnc3c2sc2ncsc32)c1
Show InChI InChI=1S/C13H7BrN4S2/c14-7-2-1-3-8(4-7)18-12-10-9(15-5-16-12)11-13(20-10)17-6-19-11/h1-6H,(H,15,16,18)
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n/an/a 40n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3769
PNG
(6-N-[3-(trifluoromethyl)phenyl]-8-thia-3,5-diazatr...)
Show SMILES Nc1ccc2sc3c(Nc4cccc(c4)C(F)(F)F)ncnc3c2c1
Show InChI InChI=1S/C17H11F3N4S/c18-17(19,20)9-2-1-3-11(6-9)24-16-15-14(22-8-23-16)12-7-10(21)4-5-13(12)25-15/h1-8H,21H2,(H,22,23,24)
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n/an/a 47n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3771
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 62 | N-(3-brom...)
Show SMILES [O-][N+](=O)c1ccc2c(c1)sc1c(Nc3cccc(Br)c3)ncnc21
Show InChI InChI=1S/C16H9BrN4O2S/c17-9-2-1-3-10(6-9)20-16-15-14(18-8-19-16)12-5-4-11(21(22)23)7-13(12)24-15/h1-8H,(H,18,19,20)
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n/an/a 48n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3763
PNG
(12-nitro-N-phenyl-8-thia-3,5-diazatricyclo[7.4.0.0...)
Show SMILES [O-][N+](=O)c1ccc2sc3c(Nc4ccccc4)ncnc3c2c1
Show InChI InChI=1S/C16H10N4O2S/c21-20(22)11-6-7-13-12(8-11)14-15(23-13)16(18-9-17-14)19-10-4-2-1-3-5-10/h1-9H,(H,17,18,19)
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n/an/a 58n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3744
PNG
(N-(3-bromophenyl)-5H-pyrimido[5,4-b]indol-4-amine ...)
Show SMILES Brc1cccc(Nc2ncnc3c4ccccc4[nH]c23)c1
Show InChI InChI=1S/C16H11BrN4/c17-10-4-3-5-11(8-10)20-16-15-14(18-9-19-16)12-6-1-2-7-13(12)21-15/h1-9,21H,(H,18,19,20)
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n/an/a 72n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3775
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 66 | N-(3-brom...)
Show SMILES COc1ccc2c(c1)sc1c(Nc3cccc(Br)c3)ncnc21
Show InChI InChI=1S/C17H12BrN3OS/c1-22-12-5-6-13-14(8-12)23-16-15(13)19-9-20-17(16)21-11-4-2-3-10(18)7-11/h2-9H,1H3,(H,19,20,21)
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n/an/a 80n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3745
PNG
(N-(3-bromophenyl)-5-methyl-5H-pyrimido[5,4-b]indol...)
Show SMILES Cn1c2ccccc2c2ncnc(Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C17H13BrN4/c1-22-14-8-3-2-7-13(14)15-16(22)17(20-10-19-15)21-12-6-4-5-11(18)9-12/h2-10H,1H3,(H,19,20,21)
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n/an/a 132n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3757
PNG
(4-N-(3-bromophenyl)-9H-pyrimido[4,5-b]indole-2,4-d...)
Show SMILES Nc1nc(Nc2cccc(Br)c2)c2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C16H12BrN5/c17-9-4-3-5-10(8-9)19-14-13-11-6-1-2-7-12(11)20-15(13)22-16(18)21-14/h1-8H,(H4,18,19,20,21,22)
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n/an/a 147n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3779
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 70 | N-(3-brom...)
Show SMILES [O-][N+](=O)c1cccc2c1sc1c(Nc3cccc(Br)c3)ncnc21
Show InChI InChI=1S/C16H9BrN4O2S/c17-9-3-1-4-10(7-9)20-16-15-13(18-8-19-16)11-5-2-6-12(21(22)23)14(11)24-15/h1-8H,(H,18,19,20)
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n/an/a 158n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3760
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 51 | N-benzyl-...)
Show SMILES C(Nc1ncnc2c3ccccc3sc12)c1ccccc1
Show InChI InChI=1S/C17H13N3S/c1-2-6-12(7-3-1)10-18-17-16-15(19-11-20-17)13-8-4-5-9-14(13)21-16/h1-9,11H,10H2,(H,18,19,20)
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n/an/a 191n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3752
PNG
(N-phenyl-9H-pyrimido[4,5-b]indol-4-amine | Pyrimid...)
Show SMILES N(c1ccccc1)c1ncnc2[nH]c3ccccc3c12
Show InChI InChI=1S/C16H12N4/c1-2-6-11(7-3-1)19-15-14-12-8-4-5-9-13(12)20-16(14)18-10-17-15/h1-10H,(H2,17,18,19,20)
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n/an/a 264n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3578
PNG
(6-[(3-Bromophenyl)amino]-1H-imidazo[4,5-h]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3c4nc[nH]c4ccc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(6-9)21-15-11-4-5-12-14(19-7-17-12)13(11)18-8-20-15/h1-8H,(H,17,19)(H,18,20,21)
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n/an/a 272n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3747
PNG
(N-[(1R)-1-phenylethyl]-5H-pyrimido[5,4-b]indol-4-a...)
Show SMILES C[C@@H](Nc1ncnc2c3ccccc3[nH]c12)c1ccccc1 |r|
Show InChI InChI=1S/C18H16N4/c1-12(13-7-3-2-4-8-13)21-18-17-16(19-11-20-18)14-9-5-6-10-15(14)22-17/h2-12,22H,1H3,(H,19,20,21)/t12-/m1/s1
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n/an/a 419n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3782
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 73 | N-(3-brom...)
Show SMILES COc1cc2sc3c(Nc4cccc(Br)c4)ncnc3c2cc1OC
Show InChI InChI=1S/C18H14BrN3O2S/c1-23-13-7-12-15(8-14(13)24-2)25-17-16(12)20-9-21-18(17)22-11-5-3-4-10(19)6-11/h3-9H,1-2H3,(H,20,21,22)
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n/an/a 444n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3765
PNG
(12-nitro-N-[3-(trifluoromethyl)phenyl]-8-thia-3,5-...)
Show SMILES [O-][N+](=O)c1ccc2sc3c(Nc4cccc(c4)C(F)(F)F)ncnc3c2c1
Show InChI InChI=1S/C17H9F3N4O2S/c18-17(19,20)9-2-1-3-10(6-9)23-16-15-14(21-8-22-16)12-7-11(24(25)26)4-5-13(12)27-15/h1-8H,(H,21,22,23)
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n/an/a 460n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3746
PNG
(N-benzyl-5H-pyrimido[5,4-b]indol-4-amine | Pyrimid...)
Show SMILES C(Nc1ncnc2c3ccccc3[nH]c12)c1ccccc1
Show InChI InChI=1S/C17H14N4/c1-2-6-12(7-3-1)10-18-17-16-15(19-11-20-17)13-8-4-5-9-14(13)21-16/h1-9,11,21H,10H2,(H,18,19,20)
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n/an/a 460n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3761
PNG
(Benzothieno[3,2-d]pyrimidine deriv. 52 | CHEMBL103...)
Show SMILES C[C@@H](Nc1ncnc2c3ccccc3sc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H15N3S/c1-12(13-7-3-2-4-8-13)21-18-17-16(19-11-20-18)14-9-5-6-10-15(14)22-17/h2-12H,1H3,(H,19,20,21)/t12-/m1/s1
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n/an/a 538n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3784
PNG
(N-(3-bromophenyl)-8-thia-3,5,10-triazatricyclo[7.4...)
Show SMILES Brc1cccc(Nc2ncnc3c4cccnc4sc23)c1
Show InChI InChI=1S/C15H9BrN4S/c16-9-3-1-4-10(7-9)20-14-13-12(18-8-19-14)11-5-2-6-17-15(11)21-13/h1-8H,(H,18,19,20)
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n/an/a 732n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3786
PNG
(Benzofurano[3,2-d]pyrimidine deriv. 77 | N-(3-brom...)
Show SMILES Brc1cccc(Nc2ncnc3c4ccccc4oc23)c1
Show InChI InChI=1S/C16H10BrN3O/c17-10-4-3-5-11(8-10)20-16-15-14(18-9-19-16)12-6-1-2-7-13(12)21-15/h1-9H,(H,18,19,20)
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n/an/a 740n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3754
PNG
(N-(3-bromophenyl)-9-methyl-9H-pyrimido[4,5-b]indol...)
Show SMILES Cn1c2ccccc2c2c(Nc3cccc(Br)c3)ncnc12
Show InChI InChI=1S/C17H13BrN4/c1-22-14-8-3-2-7-13(14)15-16(19-10-20-17(15)22)21-12-6-4-5-11(18)9-12/h2-10H,1H3,(H,19,20,21)
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n/an/a 742n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3783
PNG
(N-(3-chlorophenyl)-8-thia-3,5,10-triazatricyclo[7....)
Show SMILES Clc1cccc(Nc2ncnc3c4cccnc4sc23)c1
Show InChI InChI=1S/C15H9ClN4S/c16-9-3-1-4-10(7-9)20-14-13-12(18-8-19-14)11-5-2-6-17-15(11)21-13/h1-8H,(H,18,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3743
PNG
(N-Phenyl-5H-pyrimido[5,4-b]indole-4-amine Hydrochl...)
Show SMILES N(c1ccccc1)c1ncnc2c3ccccc3[nH]c12
Show InChI InChI=1S/C16H12N4/c1-2-6-11(7-3-1)19-16-15-14(17-10-18-16)12-8-4-5-9-13(12)20-15/h1-10,20H,(H,17,18,19)
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n/an/a 2.11E+3n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3755
PNG
(N-(3-bromophenyl)-9-[2-(diethylamino)ethyl]-9H-pyr...)
Show SMILES CCN(CC)CCn1c2ccccc2c2c(Nc3cccc(Br)c3)ncnc12
Show InChI InChI=1S/C22H24BrN5/c1-3-27(4-2)12-13-28-19-11-6-5-10-18(19)20-21(24-15-25-22(20)28)26-17-9-7-8-16(23)14-17/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,24,25,26)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3759
PNG
(N-(3-bromophenyl)-9-[2-(diethylamino)ethyl]-6-meth...)
Show SMILES CCN(CC)CCn1c2ccc(OC)cc2c2c(Nc3cccc(Br)c3)ncnc12
Show InChI InChI=1S/C23H26BrN5O/c1-4-28(5-2)11-12-29-20-10-9-18(30-3)14-19(20)21-22(25-15-26-23(21)29)27-17-8-6-7-16(24)13-17/h6-10,13-15H,4-5,11-12H2,1-3H3,(H,25,26,27)
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n/an/a 4.27E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3756
PNG
(N-(3-bromophenyl)-2-methyl-9H-pyrimido[4,5-b]indol...)
Show SMILES Cc1nc(Nc2cccc(Br)c2)c2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H13BrN4/c1-10-19-16(21-12-6-4-5-11(18)9-12)15-13-7-2-3-8-14(13)22-17(15)20-10/h2-9H,1H3,(H2,19,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3751
PNG
(Pyrimido[4,5-b]indole deriv. 42 | dimethyl(2-{9H-p...)
Show SMILES CN(C)CCNc1ncnc2[nH]c3ccccc3c12
Show InChI InChI=1S/C14H17N5/c1-19(2)8-7-15-13-12-10-5-3-4-6-11(10)18-14(12)17-9-16-13/h3-6,9H,7-8H2,1-2H3,(H2,15,16,17,18)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3748
PNG
(N-[(1S)-1-phenylethyl]-5H-pyrimido[5,4-b]indol-4-a...)
Show SMILES C[C@H](Nc1ncnc2c3ccccc3[nH]c12)c1ccccc1 |r|
Show InChI InChI=1S/C18H16N4/c1-12(13-7-3-2-4-8-13)21-18-17-16(19-11-20-18)14-9-5-6-10-15(14)22-17/h2-12,22H,1H3,(H,19,20,21)/t12-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3750
PNG
(Pyrimido[5,4-b]indole deriv. 41 | dimethyl(2-{5H-p...)
Show SMILES CN(C)CCNc1ncnc2c3ccccc3[nH]c12
Show InChI InChI=1S/C14H17N5/c1-19(2)8-7-15-14-13-12(16-9-17-14)10-5-3-4-6-11(10)18-13/h3-6,9,18H,7-8H2,1-2H3,(H,15,16,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3749
PNG
(N-cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine | Pyr...)
Show SMILES C1CCC(CC1)Nc1ncnc2c3ccccc3[nH]c12
Show InChI InChI=1S/C16H18N4/c1-2-6-11(7-3-1)19-16-15-14(17-10-18-16)12-8-4-5-9-13(12)20-15/h4-5,8-11,20H,1-3,6-7H2,(H,17,18,19)
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n/an/a>1.00E+5n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%