Affinity Data by PubMed id=12519058

PubMed code 12519058

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122764 (2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...) Show SMILES Nc1[nH+]ccn1Cc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM20079 (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...) Show SMILES Clc1c(CN2CCCC2=N)[nH]c(=O)[nH]c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122771 (2-Amino-1-(5-chloro-2,6-dioxo-1,2,3,6-tetrahydro-p...) Show SMILES Nc1[nH+]ccn1Cc1[nH]c(=O)[nH]c(=O)c1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122768 (2-Amino-1-(2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-...) Show SMILES Nc1[nH+]ccn1Cc1cc(=O)[nH]c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122770 (6-Amino-5-bromo-1H-pyrimidine-2,4-dione \| 6-Amino-...) Show SMILES Nc1[nH]c(=O)[nH]c(=O)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122765 (6-(2-Nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122767 (5-Chloro-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50122766 (5-Bromo-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Compound was evaluated for its inhibitory activity against recombinant purified E. coli Thymidine Phosphorylase				J Med Chem 46: 207-9 (2003) Article DOI: 10.1021/jm020964w BindingDB Entry DOI: 10.7270/Q24X574R
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%