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PubMed code 14684321

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50130461
PNG
(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
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PubMed
 1.60n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137539
PNG
(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-fur...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cc(F)cc3F)nc12
Show InChI InChI=1S/C20H18F3N3O2/c1-26-6-4-11(5-7-26)13-10-28-16-2-3-17(24-19(13)16)25-20(27)18-14(22)8-12(21)9-15(18)23/h2-3,8-11H,4-7H2,1H3,(H,24,25,27)
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 2.30n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137540
PNG
(2-Chloro-6-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cccc3Cl)nc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-9-7-12(8-10-25)13-11-27-16-5-6-17(23-19(13)16)24-20(26)18-14(21)3-2-4-15(18)22/h2-6,11-12H,7-10H2,1H3,(H,23,24,26)
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 2.90n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137538
PNG
(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3Cl)nc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-8-6-12(7-9-25)15-11-27-17-4-5-18(23-19(15)17)24-20(26)14-3-2-13(22)10-16(14)21/h2-5,10-12H,6-9H2,1H3,(H,23,24,26)
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 3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137541
PNG
(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C20H20FN3O2/c1-24-10-8-13(9-11-24)16-12-26-17-6-7-18(22-19(16)17)23-20(25)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,22,23,25)
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 3.10n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50130443
PNG
(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo...)
Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C20H21FN4O/c1-25-10-8-13(9-11-25)16-12-22-17-6-7-18(23-19(16)17)24-20(26)14-2-4-15(21)5-3-14/h2-7,12-13,22H,8-11H2,1H3,(H,23,24,26)
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 7.60n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137542
PNG
(CHEMBL178066 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Show SMILES CN(C)CCc1c(C)[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
Show InChI InChI=1S/C20H22FN3O/c1-13-17(10-11-24(2)3)18-12-16(8-9-19(18)22-13)23-20(25)14-4-6-15(21)7-5-14/h4-9,12,22H,10-11H2,1-3H3,(H,23,25)
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 8.20n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137537
PNG
(CHEMBL369391 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Show SMILES CN(C)CCc1c(C)oc2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C19H20FN3O2/c1-12-15(10-11-23(2)3)18-16(25-12)8-9-17(21-18)22-19(24)13-4-6-14(20)7-5-13/h4-9H,10-11H2,1-3H3,(H,21,22,24)
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 14n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137538
PNG
(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3Cl)nc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-8-6-12(7-9-25)15-11-27-17-4-5-18(23-19(15)17)24-20(26)14-3-2-13(22)10-16(14)21/h2-5,10-12H,6-9H2,1H3,(H,23,24,26)
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n/an/an/an/a 277n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137541
PNG
(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3)nc12
Show InChI InChI=1S/C20H20FN3O2/c1-24-10-8-13(9-11-24)16-12-26-17-6-7-18(22-19(16)17)23-20(25)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,22,23,25)
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n/an/an/an/a 66n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137539
PNG
(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-fur...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cc(F)cc3F)nc12
Show InChI InChI=1S/C20H18F3N3O2/c1-26-6-4-11(5-7-26)13-10-28-16-2-3-17(24-19(13)16)25-20(27)18-14(22)8-12(21)9-15(18)23/h2-3,8-11H,4-7H2,1H3,(H,24,25,27)
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n/an/an/an/a 92n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1F


(Homo sapiens (Human))		BDBM50137540
PNG
(2-Chloro-6-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cccc3Cl)nc12
Show InChI InChI=1S/C20H19ClFN3O2/c1-25-9-7-12(8-10-25)13-11-27-16-5-6-17(23-19(13)16)24-20(26)18-14(21)3-2-4-15(18)22/h2-6,11-12H,7-10H2,1H3,(H,23,24,26)
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n/an/an/an/a 69n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor

Bioorg Med Chem Lett 14: 167-70 (2003)


BindingDB Entry DOI: 10.7270/Q2S46RCF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%