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PubMed code 15801844

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164462
PNG
(2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butyl]-hex...)
Show SMILES O=C1CN(CCCCN2CCN(CC2)c2cccc3ccccc23)C(=O)C2CCCN12
Show InChI InChI=1S/C25H32N4O2/c30-24-19-28(25(31)23-11-6-14-29(23)24)13-4-3-12-26-15-17-27(18-16-26)22-10-5-8-20-7-1-2-9-21(20)22/h1-2,5,7-10,23H,3-4,6,11-19H2
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 0.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016825
PNG
(CHEMBL421130)
Show SMILES O=C1C2CCCN2C(=O)N1CCCCN1CCN(CC1)c1cccc2[nH]cnc12
Show InChI InChI=1S/C21H28N6O2/c28-20-18-7-4-10-26(18)21(29)27(20)9-2-1-8-24-11-13-25(14-12-24)17-6-3-5-16-19(17)23-15-22-16/h3,5-6,15,18H,1-2,4,7-14H2,(H,22,23)
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 1.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50080166
PNG
(2-{4-[4-(1H-Benzoimidazol-4-yl)-piperazin-1-yl]-bu...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc2[nH]cnc12
Show InChI InChI=1S/C21H28N6O2/c28-20-18-7-4-10-26(18)21(29)27(20)9-2-1-8-24-11-13-25(14-12-24)17-6-3-5-16-19(17)23-15-22-16/h3,5-6,15,28H,1-2,4,7-14H2,(H,22,23)
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 1.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016822
PNG
(CHEMBL33150)
Show SMILES O=C1C2CCCN2C(=O)N1CCCCN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C24H30N4O2/c29-23-22-11-6-14-27(22)24(30)28(23)13-4-3-12-25-15-17-26(18-16-25)21-10-5-8-19-7-1-2-9-20(19)21/h1-2,5,7-10,22H,3-4,6,11-18H2
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 2.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50126474
PNG
(2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butyl]-tet...)
Show SMILES Oc1c2CCCn2c(=O)n1CCCCN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C24H30N4O2/c29-23-22-11-6-14-27(22)24(30)28(23)13-4-3-12-25-15-17-26(18-16-25)21-10-5-8-19-7-1-2-9-20(19)21/h1-2,5,7-10,29H,3-4,6,11-18H2
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 2.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164454
PNG
((S)-2-((S)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@H]1CN(CCN1CN1CC(=O)N2CCC[C@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21-/m0/s1
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 2.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016826
PNG
(CHEMBL34288)
Show SMILES O=C1C2CCCCN2C(=O)N1CN1CCN(CC1)c1cccc2OC=COCc12 |c:27|
Show InChI InChI=1S/C21H26N4O4/c26-20-18-4-1-2-7-24(18)21(27)25(20)15-22-8-10-23(11-9-22)17-5-3-6-19-16(17)14-28-12-13-29-19/h3,5-6,12-13,18H,1-2,4,7-11,14-15H2
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 3.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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 4.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50023228
PNG
(CHEMBL33258)
Show SMILES O=C1C2CCCN2C(=O)N1CN1CCN(CC1)c1cccc2[nH]cnc12
Show InChI InChI=1S/C18H22N6O2/c25-17-15-5-2-6-23(15)18(26)24(17)12-21-7-9-22(10-8-21)14-4-1-3-13-16(14)20-11-19-13/h1,3-4,11,15H,2,5-10,12H2,(H,19,20)
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 4.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50126481
PNG
(2-[4-(1H-Benzoimidazol-4-yl)-piperazin-1-ylmethyl]...)
Show SMILES Oc1c2CCCn2c(=O)n1CN1CCN(CC1)c1cccc2[nH]cnc12
Show InChI InChI=1S/C18H22N6O2/c25-17-15-5-2-6-23(15)18(26)24(17)12-21-7-9-22(10-8-21)14-4-1-3-13-16(14)20-11-19-13/h1,3-4,11,25H,2,5-10,12H2,(H,19,20)
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 4.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164455
PNG
((R)-2-[4-((R)-2-Methyl-4-naphthalen-1-yl-piperazin...)
Show SMILES C[C@@H]1CN(CCN1CCCCN1CC(=O)N2CCCC2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H34N4O2/c1-20-18-28(23-11-6-9-21-8-2-3-10-22(21)23)17-16-27(20)13-4-5-14-29-19-25(31)30-15-7-12-24(30)26(29)32/h2-3,6,8-11,20,24H,4-5,7,12-19H2,1H3/t20-,24?/m1/s1
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 4.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164463
PNG
((R)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m1/s1
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 4.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50126477
PNG
(2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-tetrahy...)
Show SMILES Oc1c2CCCCn2c(=O)n1CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C22H26N4O2/c27-21-20-9-3-4-11-25(20)22(28)26(21)16-23-12-14-24(15-13-23)19-10-5-7-17-6-1-2-8-18(17)19/h1-2,5-8,10,27H,3-4,9,11-16H2
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 5.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016824
PNG
(CHEMBL445055)
Show SMILES O=C1C2CCCCN2C(=O)N1CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C22H26N4O2/c27-21-20-9-3-4-11-25(20)22(28)26(21)16-23-12-14-24(15-13-23)19-10-5-7-17-6-1-2-8-18(17)19/h1-2,5-8,10,20H,3-4,9,11-16H2
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 5.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50023227
PNG
(CHEMBL2113057)
Show SMILES O=C1CN(CCCCN2CCN(CC2)c2cccc3OC=COCc23)C(=O)C2CCCN12 |c:21|
Show InChI InChI=1S/C24H32N4O4/c29-23-17-27(24(30)21-6-4-10-28(21)23)9-2-1-8-25-11-13-26(14-12-25)20-5-3-7-22-19(20)18-31-15-16-32-22/h3,5,7,15-16,21H,1-2,4,6,8-14,17-18H2
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 6.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164456
PNG
((S)-2-((R)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@@H]1CN(CCN1CN1CC(=O)N2CCC[C@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21+/m1/s1
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 6.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164458
PNG
((R)-2-((S)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@H]1CN(CCN1CN1CC(=O)N2CCC[C@@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21+/m0/s1
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 6.40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50126475
PNG
(2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hexahyd...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)C2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2
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 6.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164462
PNG
(2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butyl]-hex...)
Show SMILES O=C1CN(CCCCN2CCN(CC2)c2cccc3ccccc23)C(=O)C2CCCN12
Show InChI InChI=1S/C25H32N4O2/c30-24-19-28(25(31)23-11-6-14-29(23)24)13-4-3-12-26-15-17-27(18-16-26)22-10-5-8-20-7-1-2-9-21(20)22/h1-2,5,7-10,23H,3-4,6,11-19H2
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 8n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(RAT)		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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 8.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50023226
PNG
(CHEMBL34287)
Show SMILES O=C1C2CCCCN2C(=O)N1CN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C20H26N4O4/c25-19-16-4-1-2-7-23(16)20(26)24(19)14-21-8-10-22(11-9-21)15-5-3-6-17-18(15)28-13-12-27-17/h3,5-6,16H,1-2,4,7-14H2
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 9.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164457
PNG
((R)-2-((R)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@@H]1CN(CCN1CN1CC(=O)N2CCC[C@@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21-/m1/s1
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 9.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016823
PNG
(CHEMBL430914)
Show SMILES O=C1C2CCCN2C(=O)N1CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C21H24N4O2/c26-20-19-9-4-10-24(19)21(27)25(20)15-22-11-13-23(14-12-22)18-8-3-6-16-5-1-2-7-17(16)18/h1-3,5-8,19H,4,9-15H2
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 10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50126476
PNG
(2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-tetrahy...)
Show SMILES Oc1c2CCCn2c(=O)n1CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C21H24N4O2/c26-20-19-9-4-10-24(19)21(27)25(20)15-22-11-13-23(14-12-22)18-8-3-6-16-5-1-2-7-17(16)18/h1-3,5-8,26H,4,9-15H2
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 10.4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164461
PNG
((S)-2-[4-(9H-5,6-Dioxa-benzocyclohepten-1-yl)-pipe...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3OOC=CCc23)C(=O)[C@@H]2CCCN12 |c:19|
Show InChI InChI=1S/C21H26N4O4/c26-20-14-24(21(27)18-6-2-8-25(18)20)15-22-9-11-23(12-10-22)17-5-1-7-19-16(17)4-3-13-28-29-19/h1,3,5,7,13,18H,2,4,6,8-12,14-15H2/t18-/m0/s1
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 12n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164459
PNG
(2-[4-(9H-5,6-Dioxa-benzocyclohepten-1-yl)-piperazi...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3OOC=CCc23)C(=O)C2CCCN12 |c:19|
Show InChI InChI=1S/C21H26N4O4/c26-20-14-24(21(27)18-6-2-8-25(18)20)15-22-9-11-23(12-10-22)17-5-1-7-19-16(17)4-3-13-28-29-19/h1,3,5,7,13,18H,2,4,6,8-12,14-15H2
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 12n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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 14n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral frontal cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50164453
PNG
((S)-2-[4-((S)-2-Methyl-4-naphthalen-1-yl-piperazin...)
Show SMILES C[C@H]1CN(CCN1CCCCN1CC(=O)N2CCCC2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H34N4O2/c1-20-18-28(23-11-6-9-21-8-2-3-10-22(21)23)17-16-27(20)13-4-5-14-29-19-25(31)30-15-7-12-24(30)26(29)32/h2-3,6,8-11,20,24H,4-5,7,12-19H2,1H3/t20-,24?/m0/s1
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 15n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50016825
PNG
(CHEMBL421130)
Show SMILES O=C1C2CCCN2C(=O)N1CCCCN1CCN(CC1)c1cccc2[nH]cnc12
Show InChI InChI=1S/C21H28N6O2/c28-20-18-7-4-10-26(18)21(29)27(20)9-2-1-8-24-11-13-25(14-12-24)17-6-3-5-16-19(17)23-15-22-16/h3,5-6,15,18H,1-2,4,7-14H2,(H,22,23)
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 19n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164455
PNG
((R)-2-[4-((R)-2-Methyl-4-naphthalen-1-yl-piperazin...)
Show SMILES C[C@@H]1CN(CCN1CCCCN1CC(=O)N2CCCC2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H34N4O2/c1-20-18-28(23-11-6-9-21-8-2-3-10-22(21)23)17-16-27(20)13-4-5-14-29-19-25(31)30-15-7-12-24(30)26(29)32/h2-3,6,8-11,20,24H,4-5,7,12-19H2,1H3/t20-,24?/m1/s1
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 20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50078561
PNG
(CHEMBL1204203 | CHEMBL416266 | Ethanesulfonic acid...)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)N1CCN(CCCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C22H33N5O4S/c1-2-32(30,31)23-18-7-5-8-19(17-18)25-15-13-24(14-16-25)10-3-4-11-27-21(28)20-9-6-12-26(20)22(27)29/h5,7-8,17,23,28H,2-4,6,9-16H2,1H3
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 27n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164453
PNG
((S)-2-[4-((S)-2-Methyl-4-naphthalen-1-yl-piperazin...)
Show SMILES C[C@H]1CN(CCN1CCCCN1CC(=O)N2CCCC2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H34N4O2/c1-20-18-28(23-11-6-9-21-8-2-3-10-22(21)23)17-16-27(20)13-4-5-14-29-19-25(31)30-15-7-12-24(30)26(29)32/h2-3,6,8-11,20,24H,4-5,7,12-19H2,1H3/t20-,24?/m0/s1
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 34n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50016822
PNG
(CHEMBL33150)
Show SMILES O=C1C2CCCN2C(=O)N1CCCCN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C24H30N4O2/c29-23-22-11-6-14-27(22)24(30)28(23)13-4-3-12-25-15-17-26(18-16-25)21-10-5-8-19-7-1-2-9-20(19)21/h1-2,5,7-10,22H,3-4,6,11-18H2
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 65n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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 101n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hyphalamus membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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 192n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-raclopride binding to Dopamine receptor D2 in rat striatum membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50016826
PNG
(CHEMBL34288)
Show SMILES O=C1C2CCCCN2C(=O)N1CN1CCN(CC1)c1cccc2OC=COCc12 |c:27|
Show InChI InChI=1S/C21H26N4O4/c26-20-18-4-1-2-7-24(18)21(27)25(20)15-22-8-10-23(11-9-22)17-5-3-6-19-16(17)14-28-12-13-29-19/h3,5-6,12-13,18H,1-2,4,7-11,14-15H2
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 348n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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 976n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]paroxetine binding to 5-hydroxytryptamine transporter in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164459
PNG
(2-[4-(9H-5,6-Dioxa-benzocyclohepten-1-yl)-piperazi...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3OOC=CCc23)C(=O)C2CCCN12 |c:19|
Show InChI InChI=1S/C21H26N4O4/c26-20-14-24(21(27)18-6-2-8-25(18)20)15-22-9-11-23(12-10-22)17-5-1-7-19-16(17)4-3-13-28-29-19/h1,3,5,7,13,18H,2,4,6,8-12,14-15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50016823
PNG
(CHEMBL430914)
Show SMILES O=C1C2CCCN2C(=O)N1CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C21H24N4O2/c26-20-19-9-4-10-24(19)21(27)25(20)15-22-11-13-23(14-12-22)18-8-3-6-16-5-1-2-7-17(16)18/h1-3,5-8,19H,4,9-15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164454
PNG
((S)-2-((S)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@H]1CN(CCN1CN1CC(=O)N2CCC[C@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50016824
PNG
(CHEMBL445055)
Show SMILES O=C1C2CCCCN2C(=O)N1CN1CCN(CC1)c1cccc2ccccc12
Show InChI InChI=1S/C22H26N4O2/c27-21-20-9-3-4-11-25(20)22(28)26(21)16-23-12-14-24(15-13-23)19-10-5-7-17-6-1-2-8-18(17)19/h1-2,5-8,10,20H,3-4,9,11-16H2
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50023228
PNG
(CHEMBL33258)
Show SMILES O=C1C2CCCN2C(=O)N1CN1CCN(CC1)c1cccc2[nH]cnc12
Show InChI InChI=1S/C18H22N6O2/c25-17-15-5-2-6-23(15)18(26)24(17)12-21-7-9-22(10-8-21)14-4-1-3-13-16(14)20-11-19-13/h1,3-4,11,15H,2,5-10,12H2,(H,19,20)
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164456
PNG
((S)-2-((R)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@@H]1CN(CCN1CN1CC(=O)N2CCC[C@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21+/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164461
PNG
((S)-2-[4-(9H-5,6-Dioxa-benzocyclohepten-1-yl)-pipe...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3OOC=CCc23)C(=O)[C@@H]2CCCN12 |c:19|
Show InChI InChI=1S/C21H26N4O4/c26-20-14-24(21(27)18-6-2-8-25(18)20)15-22-9-11-23(12-10-22)17-5-1-7-19-16(17)4-3-13-28-29-19/h1,3,5,7,13,18H,2,4,6,8-12,14-15H2/t18-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50023226
PNG
(CHEMBL34287)
Show SMILES O=C1C2CCCCN2C(=O)N1CN1CCN(CC1)c1cccc2OCCOc12
Show InChI InChI=1S/C20H26N4O4/c25-19-16-4-1-2-7-23(16)20(26)24(19)14-21-8-10-22(11-9-21)15-5-3-6-17-18(15)28-13-12-27-17/h3,5-6,16H,1-2,4,7-14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50126475
PNG
(2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hexahyd...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)C2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(RAT)		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]GR-113808 binding to 5-hydroxytryptamine 4 receptor of rat striatum membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164458
PNG
((R)-2-((S)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@H]1CN(CCN1CN1CC(=O)N2CCC[C@@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21+/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164457
PNG
((R)-2-((R)-2-Methyl-4-naphthalen-1-yl-piperazin-1-...)
Show SMILES C[C@@H]1CN(CCN1CN1CC(=O)N2CCC[C@@H]2C1=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-14-24(20-9-4-7-18-6-2-3-8-19(18)20)12-13-25(17)16-26-15-22(28)27-11-5-10-21(27)23(26)29/h2-4,6-9,17,21H,5,10-16H2,1H3/t17-,21-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50078561
PNG
(CHEMBL1204203 | CHEMBL416266 | Ethanesulfonic acid...)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)N1CCN(CCCCn2c(O)c3CCCn3c2=O)CC1
Show InChI InChI=1S/C22H33N5O4S/c1-2-32(30,31)23-18-7-5-8-19(17-18)25-15-13-24(14-16-25)10-3-4-11-27-21(28)20-9-6-12-26(20)22(27)29/h5,7-8,17,23,28H,2-4,6,9-16H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50023227
PNG
(CHEMBL2113057)
Show SMILES O=C1CN(CCCCN2CCN(CC2)c2cccc3OC=COCc23)C(=O)C2CCCN12 |c:21|
Show InChI InChI=1S/C24H32N4O4/c29-23-17-27(24(30)21-6-4-10-28(21)23)9-2-1-8-25-11-13-26(14-12-25)20-5-3-7-22-19(20)18-31-15-16-32-22/h3,5,7,15-16,21H,1-2,4,6,8-14,17-18H2
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50164463
PNG
((R)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m1/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat cerebral cortex membranes

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50164450
PNG
((S)-2-(4-Naphthalen-1-yl-piperazin-1-ylmethyl)-hex...)
Show SMILES O=C1CN(CN2CCN(CC2)c2cccc3ccccc23)C(=O)[C@@H]2CCCN12
Show InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2/t20-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells

J Med Chem 48: 2548-2558 (2005)


Article DOI: 10.1021/jm048999e
BindingDB Entry DOI: 10.7270/Q23F4PNB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%