Found 62 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50119368
((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167675
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1cccc2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-20-10-19-32(42-34(44)23-30-17-9-16-29-15-7-8-18-31(29)30)36(46)43-25-28(21-26-11-3-1-4-12-26)22-33(43)35(45)41-24-27-13-5-2-6-14-27/h1-9,11-18,28,32-33H,10,19-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t28-,32+,33+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167674
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES COc1ccc(CNC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C(=O)[C@H](CCCNC(N)=N)NC(=O)Cc2cccc3ccccc23)cc1 Show InChI InChI=1S/C38H44N6O4/c1-48-31-18-16-27(17-19-31)24-42-36(46)34-22-28(21-26-9-3-2-4-10-26)25-44(34)37(47)33(15-8-20-41-38(39)40)43-35(45)23-30-13-7-12-29-11-5-6-14-32(29)30/h2-7,9-14,16-19,28,33-34H,8,15,20-25H2,1H3,(H,42,46)(H,43,45)(H4,39,40,41)/t28-,33+,34+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167676
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(4-chloro-phenyl)-ace...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H39ClN6O3/c34-27-15-13-24(14-16-27)20-30(41)39-28(12-7-17-37-33(35)36)32(43)40-22-26(18-23-8-3-1-4-9-23)19-29(40)31(42)38-21-25-10-5-2-6-11-25/h1-6,8-11,13-16,26,28-29H,7,12,17-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t26-,28+,29+/m1/s1 | PDB
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| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167676
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(4-chloro-phenyl)-ace...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H39ClN6O3/c34-27-15-13-24(14-16-27)20-30(41)39-28(12-7-17-37-33(35)36)32(43)40-22-26(18-23-8-3-1-4-9-23)19-29(40)31(42)38-21-25-10-5-2-6-11-25/h1-6,8-11,13-16,26,28-29H,7,12,17-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t26-,28+,29+/m1/s1 | PDB
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| 109 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167688
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32+,33+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167687
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCCc1ccccc1 Show InChI InChI=1S/C37H45N7O3/c38-37(39)41-20-10-18-32(43-34(45)23-29-24-42-31-17-8-7-16-30(29)31)36(47)44-25-28(21-27-13-5-2-6-14-27)22-33(44)35(46)40-19-9-15-26-11-3-1-4-12-26/h1-8,11-14,16-17,24,28,32-33,42H,9-10,15,18-23,25H2,(H,40,46)(H,43,45)(H4,38,39,41)/t28-,32+,33+/m1/s1 | PDB
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| 226 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167690
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C35H41N7O3/c36-35(37)38-17-9-16-30(41-32(43)20-27-22-39-29-15-8-7-14-28(27)29)34(45)42-23-26(18-24-10-3-1-4-11-24)19-31(42)33(44)40-21-25-12-5-2-6-13-25/h1-8,10-15,22,26,30-31,39H,9,16-21,23H2,(H,40,44)(H,41,43)(H4,36,37,38)/t26-,30+,31+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167688
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32+,33+/m1/s1 | PDB
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| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167677
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(3,4-dichloro-phenyl)...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc(Cl)c(Cl)c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H38Cl2N6O3/c34-26-14-13-24(17-27(26)35)19-30(42)40-28(12-7-15-38-33(36)37)32(44)41-21-25(16-22-8-3-1-4-9-22)18-29(41)31(43)39-20-23-10-5-2-6-11-23/h1-6,8-11,13-14,17,25,28-29H,7,12,15-16,18-21H2,(H,39,43)(H,40,42)(H4,36,37,38)/t25-,28+,29+/m1/s1 | PDB
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| 255 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167675
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1cccc2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-20-10-19-32(42-34(44)23-30-17-9-16-29-15-7-8-18-31(29)30)36(46)43-25-28(21-26-11-3-1-4-12-26)22-33(43)35(45)41-24-27-13-5-2-6-14-27/h1-9,11-18,28,32-33H,10,19-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t28-,32+,33+/m1/s1 | PDB
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| 258 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167689
((2S,4R)-1-[(S)-2-(2-Benzo[1,3]dioxol-5-yl-acetylam...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2OCOc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H40N6O5/c35-34(36)37-15-7-12-27(39-31(41)19-25-13-14-29-30(18-25)45-22-44-29)33(43)40-21-26(16-23-8-3-1-4-9-23)17-28(40)32(42)38-20-24-10-5-2-6-11-24/h1-6,8-11,13-14,18,26-28H,7,12,15-17,19-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t26-,27+,28+/m1/s1 | PDB
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| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167693
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(2-chloro-phenyl)-ace...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccccc1Cl)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H39ClN6O3/c34-27-15-8-7-14-26(27)20-30(41)39-28(16-9-17-37-33(35)36)32(43)40-22-25(18-23-10-3-1-4-11-23)19-29(40)31(42)38-21-24-12-5-2-6-13-24/h1-8,10-15,25,28-29H,9,16-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t25-,28+,29+/m1/s1 | PDB
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| 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167689
((2S,4R)-1-[(S)-2-(2-Benzo[1,3]dioxol-5-yl-acetylam...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2OCOc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H40N6O5/c35-34(36)37-15-7-12-27(39-31(41)19-25-13-14-29-30(18-25)45-22-44-29)33(43)40-21-26(16-23-8-3-1-4-9-23)17-28(40)32(42)38-20-24-10-5-2-6-11-24/h1-6,8-11,13-14,18,26-28H,7,12,15-17,19-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t26-,27+,28+/m1/s1 | PDB
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| 333 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167679
((S)-4-Benzyl-1-[5-guanidino-2-((S)-2-naphthalen-2-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1CCN(Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H43N7O3/c38-37(39)40-19-9-16-32(42-34(45)23-29-17-18-30-14-7-8-15-31(30)22-29)36(47)44-21-20-43(25-28-12-5-2-6-13-28)26-33(44)35(46)41-24-27-10-3-1-4-11-27/h1-8,10-15,17-18,22,32-33H,9,16,19-21,23-26H2,(H,41,46)(H,42,45)(H4,38,39,40)/t32-,33-/m0/s1 | PDB
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| 376 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167687
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCCc1ccccc1 Show InChI InChI=1S/C37H45N7O3/c38-37(39)41-20-10-18-32(43-34(45)23-29-24-42-31-17-8-7-16-30(29)31)36(47)44-25-28(21-27-13-5-2-6-14-27)22-33(44)35(46)40-19-9-15-26-11-3-1-4-12-26/h1-8,11-14,16-17,24,28,32-33,42H,9-10,15,18-23,25H2,(H,40,46)(H,43,45)(H4,38,39,41)/t28-,32+,33+/m1/s1 | PDB
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| 527 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167681
((S)-4-Benzoyl-1-[5-guanidino-2-((S)-2-naphthalen-2...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1CCN(C[C@H]1C(=O)NCc1ccccc1)C(=O)c1ccccc1 Show InChI InChI=1S/C37H41N7O4/c38-37(39)40-19-9-16-31(42-33(45)23-27-17-18-28-12-7-8-15-30(28)22-27)36(48)44-21-20-43(35(47)29-13-5-2-6-14-29)25-32(44)34(46)41-24-26-10-3-1-4-11-26/h1-8,10-15,17-18,22,31-32H,9,16,19-21,23-25H2,(H,41,46)(H,42,45)(H4,38,39,40)/t31-,32-/m0/s1 | PDB
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| 649 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167680
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCc1ccccc1 Show InChI InChI=1S/C36H43N7O3/c37-36(38)40-18-9-16-31(42-33(44)22-28-23-41-30-15-8-7-14-29(28)30)35(46)43-24-27(20-26-12-5-2-6-13-26)21-32(43)34(45)39-19-17-25-10-3-1-4-11-25/h1-8,10-15,23,27,31-32,41H,9,16-22,24H2,(H,39,45)(H,42,44)(H4,37,38,40)/t27-,31+,32+/m1/s1 | PDB
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| 667 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167693
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(2-chloro-phenyl)-ace...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccccc1Cl)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H39ClN6O3/c34-27-15-8-7-14-26(27)20-30(41)39-28(16-9-17-37-33(35)36)32(43)40-22-25(18-23-10-3-1-4-11-23)19-29(40)31(42)38-21-24-12-5-2-6-13-24/h1-8,10-15,25,28-29H,9,16-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t25-,28+,29+/m1/s1 | PDB
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| 692 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50119368
((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 | PDB
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| 736 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167674
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES COc1ccc(CNC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C(=O)[C@H](CCCNC(N)=N)NC(=O)Cc2cccc3ccccc23)cc1 Show InChI InChI=1S/C38H44N6O4/c1-48-31-18-16-27(17-19-31)24-42-36(46)34-22-28(21-26-9-3-2-4-10-26)25-44(34)37(47)33(15-8-20-41-38(39)40)43-35(45)23-30-13-7-12-29-11-5-6-14-32(29)30/h2-7,9-14,16-19,28,33-34H,8,15,20-25H2,1H3,(H,42,46)(H,43,45)(H4,39,40,41)/t28-,33+,34+/m1/s1 | PDB
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| 871 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167677
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(3,4-dichloro-phenyl)...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc(Cl)c(Cl)c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H38Cl2N6O3/c34-26-14-13-24(17-27(26)35)19-30(42)40-28(12-7-15-38-33(36)37)32(44)41-21-25(16-22-8-3-1-4-9-22)18-29(41)31(43)39-20-23-10-5-2-6-11-23/h1-6,8-11,13-14,17,25,28-29H,7,12,15-16,18-21H2,(H,39,43)(H,40,42)(H4,36,37,38)/t25-,28+,29+/m1/s1 | PDB
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| 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167686
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)Nc1ccccc1 Show InChI InChI=1S/C34H39N7O3/c35-34(36)37-17-9-16-29(40-31(42)20-25-21-38-28-15-8-7-14-27(25)28)33(44)41-22-24(18-23-10-3-1-4-11-23)19-30(41)32(43)39-26-12-5-2-6-13-26/h1-8,10-15,21,24,29-30,38H,9,16-20,22H2,(H,39,43)(H,40,42)(H4,35,36,37)/t24-,29+,30+/m1/s1 | PDB
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| 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167690
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C35H41N7O3/c36-35(37)38-17-9-16-30(41-32(43)20-27-22-39-29-15-8-7-14-28(27)29)34(45)42-23-26(18-24-10-3-1-4-11-24)19-31(42)33(44)40-21-25-12-5-2-6-13-25/h1-8,10-15,22,26,30-31,39H,9,16-21,23H2,(H,40,44)(H,41,43)(H4,36,37,38)/t26-,30+,31+/m1/s1 | PDB
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| 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167692
((2S,4R)-4-Benzyl-1-((S)-5-guanidino-2-phenylacetyl...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H40N6O3/c34-33(35)36-18-10-17-28(38-30(40)21-25-13-6-2-7-14-25)32(42)39-23-27(19-24-11-4-1-5-12-24)20-29(39)31(41)37-22-26-15-8-3-9-16-26/h1-9,11-16,27-29H,10,17-23H2,(H,37,41)(H,38,40)(H4,34,35,36)/t27-,28+,29+/m1/s1 | PDB
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| 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167680
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCc1ccccc1 Show InChI InChI=1S/C36H43N7O3/c37-36(38)40-18-9-16-31(42-33(44)22-28-23-41-30-15-8-7-14-29(28)30)35(46)43-24-27(20-26-12-5-2-6-13-26)21-32(43)34(45)39-19-17-25-10-3-1-4-11-25/h1-8,10-15,23,27,31-32,41H,9,16-22,24H2,(H,39,45)(H,42,44)(H4,37,38,40)/t27-,31+,32+/m1/s1 | PDB
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| 1.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167692
((2S,4R)-4-Benzyl-1-((S)-5-guanidino-2-phenylacetyl...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H40N6O3/c34-33(35)36-18-10-17-28(38-30(40)21-25-13-6-2-7-14-25)32(42)39-23-27(19-24-11-4-1-5-12-24)20-29(39)31(41)37-22-26-15-8-3-9-16-26/h1-9,11-16,27-29H,10,17-23H2,(H,37,41)(H,38,40)(H4,34,35,36)/t27-,28+,29+/m1/s1 | PDB
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| 1.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167686
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)Nc1ccccc1 Show InChI InChI=1S/C34H39N7O3/c35-34(36)37-17-9-16-29(40-31(42)20-25-21-38-28-15-8-7-14-27(25)28)33(44)41-22-24(18-23-10-3-1-4-11-23)19-30(41)32(43)39-26-12-5-2-6-13-26/h1-8,10-15,21,24,29-30,38H,9,16-20,22H2,(H,39,43)(H,40,42)(H4,35,36,37)/t24-,29+,30+/m1/s1 | PDB
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| 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167678
((2S,4R)-4-Benzyl-1-{(S)-2-[(biphenyl-2-carbonyl)-a...)Show SMILES NC(=N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C38H42N6O3/c39-38(40)41-22-12-21-33(43-35(45)32-20-11-10-19-31(32)30-17-8-3-9-18-30)37(47)44-26-29(23-27-13-4-1-5-14-27)24-34(44)36(46)42-25-28-15-6-2-7-16-28/h1-11,13-20,29,33-34H,12,21-26H2,(H,42,46)(H,43,45)(H4,39,40,41)/t29-,33+,34+/m1/s1 | PDB
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| 2.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167673
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-1H-imidaz...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1cnc[nH]1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C31H40N8O3/c32-31(33)35-15-7-12-26(38-28(40)14-13-25-19-34-21-37-25)30(42)39-20-24(16-22-8-3-1-4-9-22)17-27(39)29(41)36-18-23-10-5-2-6-11-23/h1-6,8-11,19,21,24,26-27H,7,12-18,20H2,(H,34,37)(H,36,41)(H,38,40)(H4,32,33,35)/t24-,26+,27+/m1/s1 | PDB
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| 4.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167685
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-phenyl-pr...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H42N6O3/c35-34(36)37-20-10-17-29(39-31(41)19-18-25-11-4-1-5-12-25)33(43)40-24-28(21-26-13-6-2-7-14-26)22-30(40)32(42)38-23-27-15-8-3-9-16-27/h1-9,11-16,28-30H,10,17-24H2,(H,38,42)(H,39,41)(H4,35,36,37)/t28-,29+,30+/m1/s1 | PDB
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| 4.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167677
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(3,4-dichloro-phenyl)...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc(Cl)c(Cl)c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H38Cl2N6O3/c34-26-14-13-24(17-27(26)35)19-30(42)40-28(12-7-15-38-33(36)37)32(44)41-21-25(16-22-8-3-1-4-9-22)18-29(41)31(43)39-20-23-10-5-2-6-11-23/h1-6,8-11,13-14,17,25,28-29H,7,12,15-16,18-21H2,(H,39,43)(H,40,42)(H4,36,37,38)/t25-,28+,29+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167685
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-phenyl-pr...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H42N6O3/c35-34(36)37-20-10-17-29(39-31(41)19-18-25-11-4-1-5-12-25)33(43)40-24-28(21-26-13-6-2-7-14-26)22-30(40)32(42)38-23-27-15-8-3-9-16-27/h1-9,11-16,28-30H,10,17-24H2,(H,38,42)(H,39,41)(H4,35,36,37)/t28-,29+,30+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167679
((S)-4-Benzyl-1-[5-guanidino-2-((S)-2-naphthalen-2-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1CCN(Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H43N7O3/c38-37(39)40-19-9-16-32(42-34(45)23-29-17-18-30-14-7-8-15-31(30)22-29)36(47)44-21-20-43(25-28-12-5-2-6-13-28)26-33(44)35(46)41-24-27-10-3-1-4-11-27/h1-8,10-15,17-18,22,32-33H,9,16,19-21,23-26H2,(H,41,46)(H,42,45)(H4,38,39,40)/t32-,33-/m0/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167693
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(2-chloro-phenyl)-ace...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccccc1Cl)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H39ClN6O3/c34-27-15-8-7-14-26(27)20-30(41)39-28(16-9-17-37-33(35)36)32(43)40-22-25(18-23-10-3-1-4-11-23)19-29(40)31(42)38-21-24-12-5-2-6-13-24/h1-8,10-15,25,28-29H,9,16-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t25-,28+,29+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167689
((2S,4R)-1-[(S)-2-(2-Benzo[1,3]dioxol-5-yl-acetylam...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2OCOc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H40N6O5/c35-34(36)37-15-7-12-27(39-31(41)19-25-13-14-29-30(18-25)45-22-44-29)33(43)40-21-26(16-23-8-3-1-4-9-23)17-28(40)32(42)38-20-24-10-5-2-6-11-24/h1-6,8-11,13-14,18,26-28H,7,12,15-17,19-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t26-,27+,28+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167682
((2S,4R)-4-Benzyl-1-[(R)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32-,33+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167673
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-1H-imidaz...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1cnc[nH]1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C31H40N8O3/c32-31(33)35-15-7-12-26(38-28(40)14-13-25-19-34-21-37-25)30(42)39-20-24(16-22-8-3-1-4-9-22)17-27(39)29(41)36-18-23-10-5-2-6-11-23/h1-6,8-11,19,21,24,26-27H,7,12-18,20H2,(H,34,37)(H,36,41)(H,38,40)(H4,32,33,35)/t24-,26+,27+/m1/s1 | PDB
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167685
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-phenyl-pr...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H42N6O3/c35-34(36)37-20-10-17-29(39-31(41)19-18-25-11-4-1-5-12-25)33(43)40-24-28(21-26-13-6-2-7-14-26)22-30(40)32(42)38-23-27-15-8-3-9-16-27/h1-9,11-16,28-30H,10,17-24H2,(H,38,42)(H,39,41)(H4,35,36,37)/t28-,29+,30+/m1/s1 | PDB
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167683
((2S,4S)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32-,33-/m0/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167680
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCc1ccccc1 Show InChI InChI=1S/C36H43N7O3/c37-36(38)40-18-9-16-31(42-33(44)22-28-23-41-30-15-8-7-14-29(28)30)35(46)43-24-27(20-26-12-5-2-6-13-26)21-32(43)34(45)39-19-17-25-10-3-1-4-11-25/h1-8,10-15,23,27,31-32,41H,9,16-22,24H2,(H,39,45)(H,42,44)(H4,37,38,40)/t27-,31+,32+/m1/s1 | PDB
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167676
((2S,4R)-4-Benzyl-1-{(S)-2-[2-(4-chloro-phenyl)-ace...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H39ClN6O3/c34-27-15-13-24(14-16-27)20-30(41)39-28(12-7-17-37-33(35)36)32(43)40-22-26(18-23-8-3-1-4-9-23)19-29(40)31(42)38-21-25-10-5-2-6-11-25/h1-6,8-11,13-16,26,28-29H,7,12,17-22H2,(H,38,42)(H,39,41)(H4,35,36,37)/t26-,28+,29+/m1/s1 | PDB
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167687
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCCc1ccccc1 Show InChI InChI=1S/C37H45N7O3/c38-37(39)41-20-10-18-32(43-34(45)23-29-24-42-31-17-8-7-16-30(29)31)36(47)44-25-28(21-27-13-5-2-6-14-27)22-33(44)35(46)40-19-9-15-26-11-3-1-4-12-26/h1-8,11-14,16-17,24,28,32-33,42H,9-10,15,18-23,25H2,(H,40,46)(H,43,45)(H4,38,39,41)/t28-,32+,33+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167674
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES COc1ccc(CNC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C(=O)[C@H](CCCNC(N)=N)NC(=O)Cc2cccc3ccccc23)cc1 Show InChI InChI=1S/C38H44N6O4/c1-48-31-18-16-27(17-19-31)24-42-36(46)34-22-28(21-26-9-3-2-4-10-26)25-44(34)37(47)33(15-8-20-41-38(39)40)43-35(45)23-30-13-7-12-29-11-5-6-14-32(29)30/h2-7,9-14,16-19,28,33-34H,8,15,20-25H2,1H3,(H,42,46)(H,43,45)(H4,39,40,41)/t28-,33+,34+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167688
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32+,33+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167690
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C35H41N7O3/c36-35(37)38-17-9-16-30(41-32(43)20-27-22-39-29-15-8-7-14-28(27)29)34(45)42-23-26(18-24-10-3-1-4-11-24)19-31(42)33(44)40-21-25-12-5-2-6-13-25/h1-8,10-15,22,26,30-31,39H,9,16-21,23H2,(H,40,44)(H,41,43)(H4,36,37,38)/t26-,30+,31+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167692
((2S,4R)-4-Benzyl-1-((S)-5-guanidino-2-phenylacetyl...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C33H40N6O3/c34-33(35)36-18-10-17-28(38-30(40)21-25-13-6-2-7-14-25)32(42)39-23-27(19-24-11-4-1-5-12-24)20-29(39)31(41)37-22-26-15-8-3-9-16-26/h1-9,11-16,27-29H,10,17-23H2,(H,37,41)(H,38,40)(H4,34,35,36)/t27-,28+,29+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167684
((2S,4R)-1-{(S)-2-[3-(2-Aminomethyl-phenyl)-propion...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1C[NH-])C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C35H44N7O3/c36-22-29-15-8-7-14-28(29)17-18-32(43)41-30(16-9-19-39-35(37)38)34(45)42-24-27(20-25-10-3-1-4-11-25)21-31(42)33(44)40-23-26-12-5-2-6-13-26/h1-8,10-15,27,30-31,36H,9,16-24H2,(H,40,44)(H,41,43)(H4,37,38,39)/q-1/t27-,30+,31+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167686
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-1H-indol-...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)Nc1ccccc1 Show InChI InChI=1S/C34H39N7O3/c35-34(36)37-17-9-16-29(40-31(42)20-25-21-38-28-15-8-7-14-27(25)28)33(44)41-22-24(18-23-10-3-1-4-11-23)19-30(41)32(43)39-26-12-5-2-6-13-26/h1-8,10-15,21,24,29-30,38H,9,16-20,22H2,(H,39,43)(H,40,42)(H4,35,36,37)/t24-,29+,30+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167678
((2S,4R)-4-Benzyl-1-{(S)-2-[(biphenyl-2-carbonyl)-a...)Show SMILES NC(=N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C38H42N6O3/c39-38(40)41-22-12-21-33(43-35(45)32-20-11-10-19-31(32)30-17-8-3-9-18-30)37(47)44-26-29(23-27-13-4-1-5-14-27)24-34(44)36(46)42-25-28-15-6-2-7-16-28/h1-11,13-20,29,33-34H,12,21-26H2,(H,42,46)(H,43,45)(H4,39,40,41)/t29-,33+,34+/m1/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167681
((S)-4-Benzoyl-1-[5-guanidino-2-((S)-2-naphthalen-2...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1CCN(C[C@H]1C(=O)NCc1ccccc1)C(=O)c1ccccc1 Show InChI InChI=1S/C37H41N7O4/c38-37(39)40-19-9-16-31(42-33(45)23-27-17-18-28-12-7-8-15-30(28)22-27)36(48)44-21-20-43(35(47)29-13-5-2-6-14-29)25-32(44)34(46)41-24-26-10-3-1-4-11-26/h1-8,10-15,17-18,22,31-32H,9,16,19-21,23-25H2,(H,41,46)(H,42,45)(H4,38,39,40)/t31-,32-/m0/s1 | PDB
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Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50119368
((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 | PDB
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50167675
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1cccc2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-20-10-19-32(42-34(44)23-30-17-9-16-29-15-7-8-18-31(29)30)36(46)43-25-28(21-26-11-3-1-4-12-26)22-33(43)35(45)41-24-27-13-5-2-6-14-27/h1-9,11-18,28,32-33H,10,19-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t28-,32+,33+/m1/s1 | PDB
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 1 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167684
((2S,4R)-1-{(S)-2-[3-(2-Aminomethyl-phenyl)-propion...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1C[NH-])C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C35H44N7O3/c36-22-29-15-8-7-14-28(29)17-18-32(43)41-30(16-9-19-39-35(37)38)34(45)42-24-27(20-25-10-3-1-4-11-25)21-31(42)33(44)40-23-26-12-5-2-6-13-26/h1-8,10-15,27,30-31,36H,9,16-24H2,(H,40,44)(H,41,43)(H4,37,38,39)/q-1/t27-,30+,31+/m1/s1 | PDB
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| 7.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167685
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-phenyl-pr...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H42N6O3/c35-34(36)37-20-10-17-29(39-31(41)19-18-25-11-4-1-5-12-25)33(43)40-24-28(21-26-13-6-2-7-14-26)22-30(40)32(42)38-23-27-15-8-3-9-16-27/h1-9,11-16,28-30H,10,17-24H2,(H,38,42)(H,39,41)(H4,35,36,37)/t28-,29+,30+/m1/s1 | PDB
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| 7.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167685
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-phenyl-pr...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H42N6O3/c35-34(36)37-20-10-17-29(39-31(41)19-18-25-11-4-1-5-12-25)33(43)40-24-28(21-26-13-6-2-7-14-26)22-30(40)32(42)38-23-27-15-8-3-9-16-27/h1-9,11-16,28-30H,10,17-24H2,(H,38,42)(H,39,41)(H4,35,36,37)/t28-,29+,30+/m1/s1 | PDB
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| 8.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167678
((2S,4R)-4-Benzyl-1-{(S)-2-[(biphenyl-2-carbonyl)-a...)Show SMILES NC(=N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C38H42N6O3/c39-38(40)41-22-12-21-33(43-35(45)32-20-11-10-19-31(32)30-17-8-3-9-18-30)37(47)44-26-29(23-27-13-4-1-5-14-27)24-34(44)36(46)42-25-28-15-6-2-7-16-28/h1-11,13-20,29,33-34H,12,21-26H2,(H,42,46)(H,43,45)(H4,39,40,41)/t29-,33+,34+/m1/s1 | PDB
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| 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167684
((2S,4R)-1-{(S)-2-[3-(2-Aminomethyl-phenyl)-propion...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1C[NH-])C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C35H44N7O3/c36-22-29-15-8-7-14-28(29)17-18-32(43)41-30(16-9-19-39-35(37)38)34(45)42-24-27(20-25-10-3-1-4-11-25)21-31(42)33(44)40-23-26-12-5-2-6-13-26/h1-8,10-15,27,30-31,36H,9,16-24H2,(H,40,44)(H,41,43)(H4,37,38,39)/q-1/t27-,30+,31+/m1/s1 | PDB
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| 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50167673
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-1H-imidaz...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1cnc[nH]1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C31H40N8O3/c32-31(33)35-15-7-12-26(38-28(40)14-13-25-19-34-21-37-25)30(42)39-20-24(16-22-8-3-1-4-9-22)17-27(39)29(41)36-18-23-10-5-2-6-11-23/h1-6,8-11,19,21,24,26-27H,7,12-18,20H2,(H,34,37)(H,36,41)(H,38,40)(H4,32,33,35)/t24-,26+,27+/m1/s1 | PDB
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| 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 3 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167685
((2S,4R)-4-Benzyl-1-[(S)-5-guanidino-2-(3-phenyl-pr...)Show SMILES NC(=N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C34H42N6O3/c35-34(36)37-20-10-17-29(39-31(41)19-18-25-11-4-1-5-12-25)33(43)40-24-28(21-26-13-6-2-7-14-26)22-30(40)32(42)38-23-27-15-8-3-9-16-27/h1-9,11-16,28-30H,10,17-24H2,(H,38,42)(H,39,41)(H4,35,36,37)/t28-,29+,30+/m1/s1 | PDB
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| 3.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167683
((2S,4S)-4-Benzyl-1-[(S)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32-,33-/m0/s1 | PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50167682
((2S,4R)-4-Benzyl-1-[(R)-5-guanidino-2-(2-naphthale...)Show SMILES NC(=N)NCCC[C@@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C37H42N6O3/c38-37(39)40-19-9-16-32(42-34(44)23-28-17-18-30-14-7-8-15-31(30)21-28)36(46)43-25-29(20-26-10-3-1-4-11-26)22-33(43)35(45)41-24-27-12-5-2-6-13-27/h1-8,10-15,17-18,21,29,32-33H,9,16,19-20,22-25H2,(H,41,45)(H,42,44)(H4,38,39,40)/t29-,32-,33+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter& Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibitory activity towards human Melanocortin 4 Receptor |
Bioorg Med Chem Lett 15: 2819-23 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.120
BindingDB Entry DOI: 10.7270/Q2F76DBS |
More data for this
Ligand-Target Pair | |
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