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PubMed code 15922595

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168170
PNG
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES NCCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H27FN4/c24-20-4-2-19(3-5-20)23-21(17-6-11-26-12-7-17)16-22(27-23)18-8-14-28(15-9-18)13-1-10-25/h2-7,11-12,16,18,27H,1,8-10,13-15,25H2
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n/an/a 0.0460n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168185
PNG
(4-[2-(3-Bromo-4-fluoro-phenyl)-5-(1-methyl-piperid...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)c(Br)c1)-c1ccncc1
Show InChI InChI=1S/C21H21BrFN3/c1-26-10-6-15(7-11-26)20-13-17(14-4-8-24-9-5-14)21(25-20)16-2-3-19(23)18(22)12-16/h2-5,8-9,12-13,15,25H,6-7,10-11H2,1H3
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n/an/a 0.150n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168208
PNG
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES NC1(CN2CCC(CC2)c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)CC1
Show InChI InChI=1S/C24H27FN4/c25-20-3-1-19(2-4-20)23-21(17-5-11-27-12-6-17)15-22(28-23)18-7-13-29(14-8-18)16-24(26)9-10-24/h1-6,11-12,15,18,28H,7-10,13-14,16,26H2
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n/an/a 0.240n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168202
PNG
(2-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES NCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C22H25FN4/c23-19-3-1-18(2-4-19)22-20(16-5-10-25-11-6-16)15-21(26-22)17-7-12-27(13-8-17)14-9-24/h1-6,10-11,15,17,26H,7-9,12-14,24H2
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168206
PNG
(4-[5-(1-Ethyl-piperidin-4-yl)-2-(4-fluoro-phenyl)-...)
Show SMILES CCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C22H24FN3/c1-2-26-13-9-17(10-14-26)21-15-20(16-7-11-24-12-8-16)22(25-21)18-3-5-19(23)6-4-18/h3-8,11-12,15,17,25H,2,9-10,13-14H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168187
PNG
(4-{2-(4-Fluoro-phenyl)-5-[1-(1-methyl-azetidin-2-y...)
Show SMILES CN1CCC1CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C25H29FN4/c1-29-13-10-22(29)17-30-14-8-19(9-15-30)24-16-23(18-6-11-27-12-7-18)25(28-24)20-2-4-21(26)5-3-20/h2-7,11-12,16,19,22,28H,8-10,13-15,17H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168192
PNG
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES CC(=O)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H24FN3O/c1-16(28)15-27-12-8-18(9-13-27)22-14-21(17-6-10-25-11-7-17)23(26-22)19-2-4-20(24)5-3-19/h2-7,10-11,14,18,26H,8-9,12-13,15H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168190
PNG
(4-[2-(3-Chloro-4-fluoro-phenyl)-5-(1-methyl-piperi...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)c(Cl)c1)-c1ccncc1
Show InChI InChI=1S/C21H21ClFN3/c1-26-10-6-15(7-11-26)20-13-17(14-4-8-24-9-5-14)21(25-20)16-2-3-19(23)18(22)12-16/h2-5,8-9,12-13,15,25H,6-7,10-11H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168176
PNG
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES OCCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H26FN3O/c24-20-4-2-19(3-5-20)23-21(17-6-10-25-11-7-17)16-22(26-23)18-8-13-27(14-9-18)12-1-15-28/h2-7,10-11,16,18,26,28H,1,8-9,12-15H2
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168171
PNG
(4-(2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3/c1-25-12-8-16(9-13-25)20-14-19(15-6-10-23-11-7-15)21(24-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16,24H,8-9,12-13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168193
PNG
(2-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES OCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C22H24FN3O/c23-19-3-1-18(2-4-19)22-20(16-5-9-24-10-6-16)15-21(25-22)17-7-11-26(12-8-17)13-14-27/h1-6,9-10,15,17,25,27H,7-8,11-14H2
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168207
PNG
(4-[4-(4-Fluoro-phenyl)-2-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O/c1-24-12-8-16(9-13-24)20-23-18(14-2-4-17(21)5-3-14)19(25-20)15-6-10-22-11-7-15/h2-7,10-11,16H,8-9,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168194
PNG
(4-[2-(4-Chloro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(Cl)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22ClN3/c1-25-12-8-16(9-13-25)20-14-19(15-6-10-23-11-7-15)21(24-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16,24H,8-9,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168169
PNG
(4-[2-(4-Fluoro-phenyl)-4-methyl-5-(1-methyl-piperi...)
Show SMILES CN1CCC(CC1)c1[nH]c(c(c1C)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3/c1-15-20(16-7-11-24-12-8-16)22(17-3-5-19(23)6-4-17)25-21(15)18-9-13-26(2)14-10-18/h3-8,11-12,18,25H,9-10,13-14H2,1-2H3
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Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168203
PNG
(4-[4-Chloro-2-(4-fluoro-phenyl)-5-(1-methyl-piperi...)
Show SMILES CN1CCC(CC1)c1[nH]c(c(c1Cl)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H21ClFN3/c1-26-12-8-16(9-13-26)21-19(22)18(14-6-10-24-11-7-14)20(25-21)15-2-4-17(23)5-3-15/h2-7,10-11,16,25H,8-9,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168197
PNG
(4-[5-(4-Fluoro-phenyl)-2-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H21FN4/c1-25-12-8-16(9-13-25)20-23-18(14-2-4-17(21)5-3-14)19(24-20)15-6-10-22-11-7-15/h2-7,10-11,16H,8-9,12-13H2,1H3,(H,23,24)
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168178
PNG
(1-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES OC1(CN2CCC(CC2)c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)CC1
Show InChI InChI=1S/C24H26FN3O/c25-20-3-1-19(2-4-20)23-21(17-5-11-26-12-6-17)15-22(27-23)18-7-13-28(14-8-18)16-24(29)9-10-24/h1-6,11-12,15,18,27,29H,7-10,13-14,16H2
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168205
PNG
(4-[4-Bromo-2-(4-fluoro-phenyl)-5-(1-methyl-piperid...)
Show SMILES CN1CCC(CC1)c1[nH]c(c(c1Br)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H21BrFN3/c1-26-12-8-16(9-13-26)21-19(22)18(14-6-10-24-11-7-14)20(25-21)15-2-4-17(23)5-3-15/h2-7,10-11,16,25H,8-9,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168174
PNG
(4-[4-(4-Fluoro-phenyl)-2-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1nc(c(s1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3S/c1-24-12-8-16(9-13-24)20-23-18(14-2-4-17(21)5-3-14)19(25-20)15-6-10-22-11-7-15/h2-7,10-11,16H,8-9,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168199
PNG
(4-[2-(4-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1C
Show InChI InChI=1S/C22H24FN3/c1-15-14-24-10-7-19(15)20-13-21(16-8-11-26(2)12-9-16)25-22(20)17-3-5-18(23)6-4-17/h3-7,10,13-14,16,25H,8-9,11-12H2,1-2H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168180
PNG
(4-[2-(3,4-Difluoro-phenyl)-5-(1-methyl-piperidin-4...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)c(F)c1)-c1ccncc1
Show InChI InChI=1S/C21H21F2N3/c1-26-10-6-15(7-11-26)20-13-17(14-4-8-24-9-5-14)21(25-20)16-2-3-18(22)19(23)12-16/h2-5,8-9,12-13,15,25H,6-7,10-11H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168196
PNG
(2-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES CC(N)CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H27FN4/c1-16(25)15-28-12-8-18(9-13-28)22-14-21(17-6-10-26-11-7-17)23(27-22)19-2-4-20(24)5-3-19/h2-7,10-11,14,16,18,27H,8-9,12-13,15,25H2,1H3
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n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168201
PNG
(4-[2-(4-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c(o1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H21FN2O/c1-24-12-8-16(9-13-24)20-14-19(15-6-10-23-11-7-15)21(25-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16H,8-9,12-13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168195
PNG
(4-[2-(4-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(C)c1
Show InChI InChI=1S/C22H24FN3/c1-15-13-18(7-10-24-15)20-14-21(16-8-11-26(2)12-9-16)25-22(20)17-3-5-19(23)6-4-17/h3-7,10,13-14,16,25H,8-9,11-12H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168200
PNG
(4-[5-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-pyrrol-...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C21H23N3/c1-24-13-9-17(10-14-24)20-15-19(16-7-11-22-12-8-16)21(23-20)18-5-3-2-4-6-18/h2-8,11-12,15,17,23H,9-10,13-14H2,1H3
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n/an/a 3.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168172
PNG
(4-[2-(4-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c(s1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H21FN2S/c1-24-12-8-16(9-13-24)20-14-19(15-6-10-23-11-7-15)21(25-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16H,8-9,12-13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168204
PNG
(4-[2-(4-Fluoro-phenyl)-5-(1-propyl-piperidin-4-yl)...)
Show SMILES CCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H26FN3/c1-2-13-27-14-9-18(10-15-27)22-16-21(17-7-11-25-12-8-17)23(26-22)19-3-5-20(24)6-4-19/h3-8,11-12,16,18,26H,2,9-10,13-15H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168181
PNG
(4-[2-(3-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1cccc(F)c1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3/c1-25-11-7-16(8-12-25)20-14-19(15-5-9-23-10-6-15)21(24-20)17-3-2-4-18(22)13-17/h2-6,9-10,13-14,16,24H,7-8,11-12H2,1H3
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n/an/a 7.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168198
PNG
(4-[2-Furan-2-yl-5-(1-methyl-piperidin-4-yl)-1H-pyr...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccco1)-c1ccncc1
Show InChI InChI=1S/C19H21N3O/c1-22-10-6-15(7-11-22)17-13-16(14-4-8-20-9-5-14)19(21-17)18-3-2-12-23-18/h2-5,8-9,12-13,15,21H,6-7,10-11H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168179
PNG
(3-[2-(4-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1cccnc1
Show InChI InChI=1S/C21H22FN3/c1-25-11-8-15(9-12-25)20-13-19(17-3-2-10-23-14-17)21(24-20)16-4-6-18(22)7-5-16/h2-7,10,13-15,24H,8-9,11-12H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168175
PNG
(4-[5-(1-Methyl-piperidin-4-yl)-2-thiophen-3-yl-1H-...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccsc1)-c1ccncc1
Show InChI InChI=1S/C19H21N3S/c1-22-9-4-15(5-10-22)18-12-17(14-2-7-20-8-3-14)19(21-18)16-6-11-23-13-16/h2-3,6-8,11-13,15,21H,4-5,9-10H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168177
PNG
(4-[4,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-1-met...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H22F2N2/c1-26-12-10-16(11-13-26)21-14-20(15-2-6-18(23)7-3-15)22(25-21)17-4-8-19(24)9-5-17/h2-9,14,16,25H,10-13H2,1H3
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n/an/a 15.6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168184
PNG
(2-[2-(4-Fluoro-phenyl)-5-(1-methyl-piperidin-4-yl)...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccccn1
Show InChI InChI=1S/C21H22FN3/c1-25-12-9-15(10-13-25)20-14-18(19-4-2-3-11-23-19)21(24-20)16-5-7-17(22)8-6-16/h2-8,11,14-15,24H,9-10,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168189
PNG
(4-[2-Furan-3-yl-5-(1-methyl-piperidin-4-yl)-1H-pyr...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccoc1)-c1ccncc1
Show InChI InChI=1S/C19H21N3O/c1-22-9-4-15(5-10-22)18-12-17(14-2-7-20-8-3-14)19(21-18)16-6-11-23-13-16/h2-3,6-8,11-13,15,21H,4-5,9-10H2,1H3
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Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168168
PNG
(4-[5-(1-Methyl-piperidin-4-yl)-2-thiazol-2-yl-1H-p...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1nccs1)-c1ccncc1
Show InChI InChI=1S/C18H20N4S/c1-22-9-4-14(5-10-22)16-12-15(13-2-6-19-7-3-13)17(21-16)18-20-8-11-23-18/h2-3,6-8,11-12,14,21H,4-5,9-10H2,1H3
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n/an/a 39.7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168183
PNG
(4-[2-(4-Methanesulfonyl-phenyl)-5-(1-methyl-piperi...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(cc1)S(C)(=O)=O)-c1ccncc1
Show InChI InChI=1S/C22H25N3O2S/c1-25-13-9-17(10-14-25)21-15-20(16-7-11-23-12-8-16)22(24-21)18-3-5-19(6-4-18)28(2,26)27/h3-8,11-12,15,17,24H,9-10,13-14H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168186
PNG
(4-[5-(1-Methyl-piperidin-4-yl)-2-(4-trifluorometho...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(OC(F)(F)F)cc1)-c1ccncc1
Show InChI InChI=1S/C22H22F3N3O/c1-28-12-8-16(9-13-28)20-14-19(15-6-10-26-11-7-15)21(27-20)17-2-4-18(5-3-17)29-22(23,24)25/h2-7,10-11,14,16,27H,8-9,12-13H2,1H3
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n/an/a 46n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168191
PNG
(4-[5-(1-Methyl-piperidin-4-yl)-3-pyridin-4-yl-1H-p...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(O)cc1)-c1ccncc1
Show InChI InChI=1S/C21H23N3O/c1-24-12-8-16(9-13-24)20-14-19(15-6-10-22-11-7-15)21(23-20)17-2-4-18(25)5-3-17/h2-7,10-11,14,16,23,25H,8-9,12-13H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168182
PNG
(4-[5-(1-Methyl-piperidin-4-yl)-2-(4-trifluoromethy...)
Show SMILES CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(cc1)C(F)(F)F)-c1ccncc1
Show InChI InChI=1S/C22H22F3N3/c1-28-12-8-16(9-13-28)20-14-19(15-6-10-26-11-7-15)21(27-20)17-2-4-18(5-3-17)22(23,24)25/h2-7,10-11,14,16,27H,8-9,12-13H2,1H3
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Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168173
PNG
(4-[5-(4-Fluoro-phenyl)-4-(3-methyl-isoxazol-5-yl)-...)
Show SMILES CN1CCC(CC1)c1cc(-c2cc(C)no2)c([nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O/c1-13-11-19(25-23-13)17-12-18(14-7-9-24(2)10-8-14)22-20(17)15-3-5-16(21)6-4-15/h3-6,11-12,14,22H,7-10H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)		BDBM50168188
PNG
(3-(4-Fluoro-phenyl)-6-(1-methyl-piperidin-4-yl)-4-...)
Show SMILES CN1CCC(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN4/c1-26-12-8-16(9-13-26)20-14-19(15-6-10-23-11-7-15)21(25-24-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16H,8-9,12-13H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase

Bioorg Med Chem Lett 15: 3296-301 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.060
BindingDB Entry DOI: 10.7270/Q24M9421
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%