Affinity Data by PubMed id=16206837

PubMed code 16206837

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosinase (Homo sapiens (Human))	BDBM50218211 (1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl \| CHEMBL3...) Show SMILES Cc1ccc(CN2CCC(CC2)N2CCCCC2)cc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50198715 ((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...) Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.68E+3	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50218209 (CHEMBL250773 \| Tyrosinase Inhibitor, 3 \| naphthale...) Show SMILES O=C(N1CCC(CC1)N1CCCCC1)c1ccc2ccccc2c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.64E+3	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM85773 (Tyrosinase Inhibitor, 8) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.76E+3	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50031467 (5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE \| 5-Hyd...) Show SMILES OCc1cc(=O)c(O)co1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.67E+4	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50218210 (2,2,2-trifluoro-1-(4-(piperidin-1-yl)piperidin-1-y...) Show SMILES FC(F)(F)C(=O)N1CCC(CC1)N1CCCCC1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM85774 (Tyrosinase Inhibitor, 10) Show SMILES C(CCN1CCC(CC1)N1CCCCC1)COc1ccccc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50218205 (1-(4-(piperidin-1-yl)piperidin-1-yl)ethanone \| CHE...) Show SMILES CC(=O)N1CCC(CC1)N1CCCCC1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.99E+4	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50218206 (1,4'-bipiperidine \| 1,4'-bipiperidyl \| 4-PIPERIDIN...) Show SMILES C1CCN(CC1)C1CCNCC1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.11E+5	n/a	n/a	n/a	n/a	6.8	37
University of Karachi					Assay Description Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...				J Enzyme Inhib Med Chem 20: 401-7 (2005) Article DOI: 10.1080/14756360500179333 BindingDB Entry DOI: 10.7270/Q29G5KBN
University of Karachi					More data for this Ligand-Target Pair

* indicates data uncertainty>20%