Found 44 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193846
(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES CCOC(=O)C1CCCN(C1)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C28H27Cl2N5O4/c1-2-39-28(38)19-4-3-13-35(16-19)25(31)17-5-7-18(8-6-17)26(36)33-23-11-9-20(29)14-22(23)27(37)34-24-12-10-21(30)15-32-24/h5-12,14-15,19,31H,2-4,13,16H2,1H3,(H,33,36)(H,32,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193867
(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES CCOC(=O)C1CCN(CC1)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C28H27Cl2N5O4/c1-2-39-28(38)19-11-13-35(14-12-19)25(31)17-3-5-18(6-4-17)26(36)33-23-9-7-20(29)15-22(23)27(37)34-24-10-8-21(30)16-32-24/h3-10,15-16,19,31H,2,11-14H2,1H3,(H,33,36)(H,32,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193871
(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES CCOC(=O)C1CCN(CC1)C(=N)c1ccc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(F)c1 Show InChI InChI=1S/C29H28Cl2FN5O5/c1-3-42-29(40)16-8-10-37(11-9-16)26(33)17-4-6-20(22(32)12-17)27(38)36-25-21(13-19(31)14-23(25)41-2)28(39)35-24-7-5-18(30)15-34-24/h4-7,12-16,33H,3,8-11H2,1-2H3,(H,36,38)(H,34,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193868
(4-{3-(5-chloro-pyridin-2-ylcarbamoyl)-4-[4-(N,N-di...)Show SMILES COC(=O)c1ccc(Sc2ccc(NC(=O)c3ccc(cc3)C(=N)N(C)C)c(c2)C(=O)Nc2ccc(Cl)cn2)cc1 Show InChI InChI=1S/C30H26ClN5O4S/c1-36(2)27(32)18-4-6-19(7-5-18)28(37)34-25-14-13-23(41-22-11-8-20(9-12-22)30(39)40-3)16-24(25)29(38)35-26-15-10-21(31)17-33-26/h4-17,32H,1-3H3,(H,34,37)(H,33,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193837
((R)-4-(5-chloro-1H-indole-2-sulfonyl)-1-[4-(N,N-di...)Show SMILES CCOC(=O)[C@H]1CN(CC(=O)N1Cc1ccc(cc1)C(=N)N(C)C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C25H28ClN5O5S/c1-4-36-25(33)21-14-30(37(34,35)22-12-18-11-19(26)9-10-20(18)28-22)15-23(32)31(21)13-16-5-7-17(8-6-16)24(27)29(2)3/h5-12,21,27-28H,4,13-15H2,1-3H3/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193870
(CHEMBL221703 | N-(5-chloro-pyridin-2-yl)-2-[4-(N,N...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Sc2ccccc2)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C28H24ClN5O2S/c1-34(2)26(30)18-8-10-19(11-9-18)27(35)32-24-14-13-22(37-21-6-4-3-5-7-21)16-23(24)28(36)33-25-15-12-20(29)17-31-25/h3-17,30H,1-2H3,(H,32,35)(H,31,33,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193861
(5-chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimet...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H19Cl2N5O2/c1-29(2)20(25)13-3-5-14(6-4-13)21(30)27-18-9-7-15(23)11-17(18)22(31)28-19-10-8-16(24)12-26-19/h3-12,25H,1-2H3,(H,27,30)(H,26,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193858
(CHEMBL218609 | N-(4-chloro-2-(5-chloropyridin-2-yl...)Show SMILES CN(C)C(=N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(c1)N1CCCCC1 Show InChI InChI=1S/C27H28Cl2N6O2/c1-34(2)25(30)17-6-9-20(23(14-17)35-12-4-3-5-13-35)26(36)32-22-10-7-18(28)15-21(22)27(37)33-24-11-8-19(29)16-31-24/h6-11,14-16,30H,3-5,12-13H2,1-2H3,(H,32,36)(H,31,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193849
(CHEMBL219106 | N-(2-(5-chloropyridin-2-ylcarbamoyl...)Show SMILES COc1ccc(NC(=O)c2ccc(cc2N2CCCCC2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C28H31ClN6O3/c1-34(2)26(30)18-7-10-21(24(15-18)35-13-5-4-6-14-35)27(36)32-23-11-9-20(38-3)16-22(23)28(37)33-25-12-8-19(29)17-31-25/h7-12,15-17,30H,4-6,13-14H2,1-3H3,(H,32,36)(H,31,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193852
(CHEMBL221756 | N-(5-Chloro-pyridin-2-yl)-2-[4-(N,N...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Sc2ccc(cc2)C(=O)N(C)C)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C31H29ClN6O3S/c1-37(2)28(33)19-5-7-20(8-6-19)29(39)35-26-15-14-24(42-23-12-9-21(10-13-23)31(41)38(3)4)17-25(26)30(40)36-27-16-11-22(32)18-34-27/h5-18,33H,1-4H3,(H,35,39)(H,34,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50113584
((E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoi...)Show SMILES C\C(=C(/F)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N Show InChI InChI=1S/C23H21FN4O3S/c1-14(16-5-4-6-17(13-16)22(25)26)21(24)23(29)28-18-11-9-15(10-12-18)19-7-2-3-8-20(19)32(27,30)31/h2-13H,1H3,(H3,25,26)(H,28,29)(H2,27,30,31)/b21-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193838
(4-{3-(5-chloro-pyridin-2-ylcarbamoyl)-4-[4-(N,N-di...)Show SMILES COC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(cc3)C(=N)N(C)C)c(c2)C(=O)Nc2ccc(Cl)cn2)cc1 Show InChI InChI=1S/C30H26ClN5O5/c1-36(2)27(32)18-4-6-19(7-5-18)28(37)34-25-14-13-23(41-22-11-8-20(9-12-22)30(39)40-3)16-24(25)29(38)35-26-15-10-21(31)17-33-26/h4-17,32H,1-3H3,(H,34,37)(H,33,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50144143
(2-{4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-[4-...)Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCOCC1)S(=O)(=O)c1cc2ccc(Cl)cc2s1 |c:4| Show InChI InChI=1S/C29H32ClN5O5S2/c1-32-9-8-31-28(32)20-2-4-21(5-3-20)29(37)35-11-10-34(19-24(35)18-26(36)33-12-14-40-15-13-33)42(38,39)27-16-22-6-7-23(30)17-25(22)41-27/h2-7,16-17,24H,8-15,18-19H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193859
(1-[2-[2-(5-chloro-pyridin-2-ylcarbamoyl)-4-methoxy...)Show SMILES CCOC(=O)C1CCN(CC1)c1cc(ccc1C(=O)Nc1ccc(OC)cc1C(=O)Nc1ccc(Cl)cn1)C(=N)N(C)C Show InChI InChI=1S/C31H35ClN6O5/c1-5-43-31(41)19-12-14-38(15-13-19)26-16-20(28(33)37(2)3)6-9-23(26)29(39)35-25-10-8-22(42-4)17-24(25)30(40)36-27-11-7-21(32)18-34-27/h6-11,16-19,33H,5,12-15H2,1-4H3,(H,35,39)(H,34,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193862
(3-{3-(5-chloro-pyridin-2-ylcarbamoyl)-4-[4-(N,N-di...)Show SMILES COC(=O)CCc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C26H26ClN5O4/c1-32(2)24(28)17-6-8-18(9-7-17)25(34)30-21-11-4-16(5-13-23(33)36-3)14-20(21)26(35)31-22-12-10-19(27)15-29-22/h4,6-12,14-15,28H,5,13H2,1-3H3,(H,30,34)(H,29,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193865
(2-(3-cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)C(=N)N2CCCC2)n(n1)-c1cc2ccccc2cc1C#N Show InChI InChI=1S/C27H24N6O/c1-18-14-25(33(31-18)24-16-21-7-3-2-6-20(21)15-22(24)17-28)27(34)30-23-10-8-19(9-11-23)26(29)32-12-4-5-13-32/h2-3,6-11,14-16,29H,4-5,12-13H2,1H3,(H,30,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193854
(CHEMBL221178 | {3-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES CCOC(=O)COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C26H26ClN5O5/c1-4-36-23(33)15-37-19-10-11-21(20(13-19)26(35)31-22-12-9-18(27)14-29-22)30-25(34)17-7-5-16(6-8-17)24(28)32(2)3/h5-14,28H,4,15H2,1-3H3,(H,30,34)(H,29,31,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193839
(2-(3-fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2CN2CCCCC2)n(n1)-c1cc2ccccc2cc1F Show InChI InChI=1S/C33H30F2N4O/c1-22-17-32(39(37-22)31-20-24-10-4-3-9-23(24)18-29(31)35)33(40)36-30-14-13-25(19-28(30)34)27-12-6-5-11-26(27)21-38-15-7-2-8-16-38/h3-6,9-14,17-20H,2,7-8,15-16,21H2,1H3,(H,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193869
(({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-p...)Show SMILES CN(CC(O)=O)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C23H19Cl2N5O4/c1-30(12-20(31)32)21(26)13-2-4-14(5-3-13)22(33)28-18-8-6-15(24)10-17(18)23(34)29-19-9-7-16(25)11-27-19/h2-11,26H,12H2,1H3,(H,28,33)(H,31,32)(H,27,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193855
(4-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES CN(CCCC(O)=O)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C25H23Cl2N5O4/c1-32(12-2-3-22(33)34)23(28)15-4-6-16(7-5-15)24(35)30-20-10-8-17(26)13-19(20)25(36)31-21-11-9-18(27)14-29-21/h4-11,13-14,28H,2-3,12H2,1H3,(H,30,35)(H,33,34)(H,29,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193845
(1-[2-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-...)Show SMILES CN(C)C(=N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(c1)N1CCCC(C1)C(O)=O Show InChI InChI=1S/C28H28Cl2N6O4/c1-35(2)25(31)16-5-8-20(23(12-16)36-11-3-4-17(15-36)28(39)40)26(37)33-22-9-6-18(29)13-21(22)27(38)34-24-10-7-19(30)14-32-24/h5-10,12-14,17,31H,3-4,11,15H2,1-2H3,(H,33,37)(H,39,40)(H,32,34,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193843
(1-[2-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-...)Show SMILES CN(C)C(=N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(c1)N1CCCCC1C(O)=O Show InChI InChI=1S/C28H28Cl2N6O4/c1-35(2)25(31)16-6-9-19(23(13-16)36-12-4-3-5-22(36)28(39)40)26(37)33-21-10-7-17(29)14-20(21)27(38)34-24-11-8-18(30)15-32-24/h6-11,13-15,22,31H,3-5,12H2,1-2H3,(H,33,37)(H,39,40)(H,32,34,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50123420
(7-[({4-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-pheny...)Show SMILES CC(=N)N1CCC(CC1)Oc1ccc(cc1)N(Cc1ccc2ccc(cc2c1)C(N)=N)S(C)(=O)=O Show InChI InChI=1S/C26H31N5O3S/c1-18(27)30-13-11-25(12-14-30)34-24-9-7-23(8-10-24)31(35(2,32)33)17-19-3-4-20-5-6-21(26(28)29)16-22(20)15-19/h3-10,15-16,25,27H,11-14,17H2,1-2H3,(H3,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193860
(4-{3-(5-chloro-pyridin-2-ylcarbamoyl)-4-[4-(N,N-di...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Sc2ccc(cc2)C(O)=O)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C29H24ClN5O4S/c1-35(2)26(31)17-3-5-18(6-4-17)27(36)33-24-13-12-22(40-21-10-7-19(8-11-21)29(38)39)15-23(24)28(37)34-25-14-9-20(30)16-32-25/h3-16,31H,1-2H3,(H,33,36)(H,38,39)(H,32,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193856
(4-{[2-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES CN(C)C(=N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(c1)N(C)CCCC(O)=O Show InChI InChI=1S/C27H28Cl2N6O4/c1-34(2)25(30)16-6-9-19(22(13-16)35(3)12-4-5-24(36)37)26(38)32-21-10-7-17(28)14-20(21)27(39)33-23-11-8-18(29)15-31-23/h6-11,13-15,30H,4-5,12H2,1-3H3,(H,32,38)(H,36,37)(H,31,33,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193853
((R)-4-(5-chloro-1H-indole-2-sulfonyl)-1-[4-(N,N-di...)Show SMILES CN(C)C(=N)c1ccc(CN2[C@H](CN(CC2=O)S(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)C(O)=O)cc1 Show InChI InChI=1S/C23H24ClN5O5S/c1-27(2)22(25)15-5-3-14(4-6-15)11-29-19(23(31)32)12-28(13-21(29)30)35(33,34)20-10-16-9-17(24)7-8-18(16)26-20/h3-10,19,25-26H,11-13H2,1-2H3,(H,31,32)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193841
(1-(2-{4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-1-...)Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCCC(C1)C(O)=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 |c:4| Show InChI InChI=1S/C31H34ClN5O6S2/c1-34-12-10-33-29(34)20-4-6-21(7-5-20)30(39)37-14-13-36(45(42,43)28-15-22-8-9-24(32)16-26(22)44-28)19-25(37)17-27(38)35-11-2-3-23(18-35)31(40)41/h4-9,15-16,23,25H,2-3,10-14,17-19H2,1H3,(H,40,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50144135
(1-(2-{4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-1-...)Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCC(CC1)C(O)=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 |c:4| Show InChI InChI=1S/C31H34ClN5O6S2/c1-34-13-10-33-29(34)20-2-4-21(5-3-20)30(39)37-15-14-36(45(42,43)28-16-23-6-7-24(32)17-26(23)44-28)19-25(37)18-27(38)35-11-8-22(9-12-35)31(40)41/h2-7,16-17,22,25H,8-15,18-19H2,1H3,(H,40,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193866
(1-(3'-fluoro-4'-{[2-(3-fluoro-naphthalen-2-yl)-5-m...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2CN2CCC(CC2)C(O)=O)n(n1)-c1cc2ccccc2cc1F Show InChI InChI=1S/C34H30F2N4O3/c1-21-16-32(40(38-21)31-19-24-7-3-2-6-23(24)17-29(31)36)33(41)37-30-11-10-25(18-28(30)35)27-9-5-4-8-26(27)20-39-14-12-22(13-15-39)34(42)43/h2-11,16-19,22H,12-15,20H2,1H3,(H,37,41)(H,42,43) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193863
(CHEMBL221979 | [[-3-(3-arbamimidoyl-phenyl)-2-fluo...)Show SMILES C\C(=C(/F)C(=O)N(CC(O)=O)c1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N Show InChI InChI=1S/C25H23FN4O5S/c1-15(17-5-4-6-18(13-17)24(27)28)23(26)25(33)30(14-22(31)32)19-11-9-16(10-12-19)20-7-2-3-8-21(20)36(29,34)35/h2-13H,14H2,1H3,(H3,27,28)(H,31,32)(H2,29,34,35)/b23-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50084617
(((7-carbamimidoyl-naphthalen-2-ylmethyl)-{4-[1-(1-...)Show SMILES CC(=N)N1CCC(CC1)Oc1ccc(cc1)N(Cc1ccc2ccc(cc2c1)C(N)=N)S(=O)(=O)CC(O)=O Show InChI InChI=1S/C27H31N5O5S/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193850
(2-(3-(5-chloropyridin-2-ylcarbamoyl)-4-(4-(N,N-dim...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(OCC(O)=O)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H22ClN5O5/c1-30(2)22(26)14-3-5-15(6-4-14)23(33)28-19-9-8-17(35-13-21(31)32)11-18(19)24(34)29-20-10-7-16(25)12-27-20/h3-12,26H,13H2,1-2H3,(H,28,33)(H,31,32)(H,27,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193844
(3-{3-(5-chloro-pyridin-2-ylcarbamoyl)-4-[4-(N,N-di...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(CCC(O)=O)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C25H24ClN5O4/c1-31(2)23(27)16-5-7-17(8-6-16)24(34)29-20-10-3-15(4-12-22(32)33)13-19(20)25(35)30-21-11-9-18(26)14-28-21/h3,5-11,13-14,27H,4,12H2,1-2H3,(H,29,34)(H,32,33)(H,28,30,35) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193864
(3-{5-[4-(imino-pyrrolidin-1-yl-methyl)-phenylcarba...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2)C(=N)N2CCCC2)n(n1)-c1cc2ccccc2cc1C(O)=O Show InChI InChI=1S/C27H25N5O3/c1-17-14-24(26(33)29-21-10-8-18(9-11-21)25(28)31-12-4-5-13-31)32(30-17)23-16-20-7-3-2-6-19(20)15-22(23)27(34)35/h2-3,6-11,14-16,28H,4-5,12-13H2,1H3,(H,29,33)(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193851
(4-{3-(5-chloro-pyridin-2-ylcarbamoyl)-4-[4-(N,N-di...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Oc2ccc(cc2)C(O)=O)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C29H24ClN5O5/c1-35(2)26(31)17-3-5-18(6-4-17)27(36)33-24-13-12-22(40-21-10-7-19(8-11-21)29(38)39)15-23(24)28(37)34-25-14-9-20(30)16-32-25/h3-16,31H,1-2H3,(H,33,36)(H,38,39)(H,32,34,37) | PDB
MMDB
Reactome pathway
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193840
(1-(2-(4-chloro-2-(5-chloropyridin-2-ylcarbamoyl)ph...)Show SMILES CN(C)C(=N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(c1)N1CCC(CC1)C(O)=O Show InChI InChI=1S/C28H28Cl2N6O4/c1-35(2)25(31)17-3-6-20(23(13-17)36-11-9-16(10-12-36)28(39)40)26(37)33-22-7-4-18(29)14-21(22)27(38)34-24-8-5-19(30)15-32-24/h3-8,13-16,31H,9-12H2,1-2H3,(H,33,37)(H,39,40)(H,32,34,38) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193857
(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES OC(=O)C1CCCN(C1)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C26H23Cl2N5O4/c27-18-7-9-21(20(12-18)25(35)32-22-10-8-19(28)13-30-22)31-24(34)16-5-3-15(4-6-16)23(29)33-11-1-2-17(14-33)26(36)37/h3-10,12-13,17,29H,1-2,11,14H2,(H,31,34)(H,36,37)(H,30,32,35) | PDB
MMDB
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KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193848
(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)Show SMILES COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1ccc(cc1F)C(=N)N1CCC(CC1)C(O)=O Show InChI InChI=1S/C27H24Cl2FN5O5/c1-40-21-12-17(29)11-19(26(37)33-22-5-3-16(28)13-32-22)23(21)34-25(36)18-4-2-15(10-20(18)30)24(31)35-8-6-14(7-9-35)27(38)39/h2-5,10-14,31H,6-9H2,1H3,(H,34,36)(H,38,39)(H,32,33,37) | PDB
MMDB
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KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193842
(1-(2-(2-(5-chloropyridin-2-ylcarbamoyl)-4-methoxyp...)Show SMILES COc1ccc(NC(=O)c2ccc(cc2N2CCC(CC2)C(O)=O)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C29H31ClN6O5/c1-35(2)26(31)18-4-7-21(24(14-18)36-12-10-17(11-13-36)29(39)40)27(37)33-23-8-6-20(41-3)15-22(23)28(38)34-25-9-5-19(30)16-32-25/h4-9,14-17,31H,10-13H2,1-3H3,(H,33,37)(H,39,40)(H,32,34,38) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50193872
(1-((4-(4-chloro-2-(5-chloropyridin-2-ylcarbamoyl)p...)Show SMILES OC(=O)C1CCN(CC1)C(=N)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C26H23Cl2N5O4/c27-18-5-7-21(20(13-18)25(35)32-22-8-6-19(28)14-30-22)31-24(34)16-3-1-15(2-4-16)23(29)33-11-9-17(10-12-33)26(36)37/h1-8,13-14,17,29H,9-12H2,(H,31,34)(H,36,37)(H,30,32,35) | PDB
MMDB
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KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM22874
(2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperi...)Show SMILES CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36) | PDB
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| Article
PubMed
| n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM22890
(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-...)Show SMILES OC(=O)COCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26) | PDB
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PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50117924
(1-Cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-pipera...)Show SMILES CC1CN(CCN1)c1cc2n(cc(C(O)=O)c(=O)c2c(C)c1F)C1CC1 Show InChI InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26) | PDB
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PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50017376
((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)Show SMILES CC(C)(C)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3 | PDB
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UniChem
Patents
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| Article
PubMed
| n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Portola Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay |
Bioorg Med Chem Lett 16: 5507-12 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05 |
More data for this
Ligand-Target Pair | |
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