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PubMed code 17251021

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/a 50n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26674
PNG
(6-(2-hydroxy-5-methylphenyl)-2-oxo-4-phenyl-1,2-di...)
Show SMILES Cc1ccc(O)c(c1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)17-10-14(13-5-3-2-4-6-13)16(11-20)19(23)21-17/h2-10,22H,1H3,(H,21,23)
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n/an/a 340n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26675
PNG
(4-(2-hydroxy-5-methylphenyl)-2-oxo-6-phenyl-1,2-di...)
Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)14-10-17(13-5-3-2-4-6-13)21-19(23)16(14)11-20/h2-10,22H,1H3,(H,21,23)
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n/an/a 370n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26676
PNG
(6-(2-hydroxyphenyl)-4-(4-hydroxyphenyl)-2-oxo-1,2-...)
Show SMILES Oc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1O
Show InChI InChI=1S/C18H12N2O3/c19-10-15-14(11-5-7-12(21)8-6-11)9-16(20-18(15)23)13-3-1-2-4-17(13)22/h1-9,21-22H,(H,20,23)
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n/an/a 430n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26684
PNG
(4-oxo-6-(thiophen-2-yl)-9-oxa-3-azatricyclo[8.4.0....)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2cccs2)c1C#N
Show InChI InChI=1S/C17H10N2O2S/c18-8-11-15(14-6-3-7-22-14)12-9-21-13-5-2-1-4-10(13)16(12)19-17(11)20/h1-7H,9H2,(H,19,20)
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n/an/a 460n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26685
PNG
(6-(furan-2-yl)-4-oxo-9-oxa-3-azatricyclo[8.4.0.0^{...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccco2)c1C#N
Show InChI InChI=1S/C17H10N2O3/c18-8-11-15(14-6-3-7-21-14)12-9-22-13-5-2-1-4-10(13)16(12)19-17(11)20/h1-7H,9H2,(H,19,20)
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n/an/a 870n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26686
PNG
(6-(4-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccc(cc1)-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-12-7-5-11(6-8-12)17-14(9-21)19(23)22-18-13-3-1-2-4-16(13)24-10-15(17)18/h1-8H,10H2,(H,22,23)
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n/an/a 920n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26679
PNG
(2-oxo-4,6-bis(thiophen-2-yl)-1,2-dihydropyridine-3...)
Show SMILES O=c1[nH]c(cc(-c2cccs2)c1C#N)-c1cccs1
Show InChI InChI=1S/C14H8N2OS2/c15-8-10-9(12-3-1-5-18-12)7-11(16-14(10)17)13-4-2-6-19-13/h1-7H,(H,16,17)
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n/an/a 990n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26677
PNG
(4-(3-chlorophenyl)-6-(5-ethyl-2-hydroxyphenyl)-2-o...)
Show SMILES CCc1ccc(O)c(c1)-c1cc(-c2cccc(Cl)c2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H15ClN2O2/c1-2-12-6-7-19(24)16(8-12)18-10-15(17(11-22)20(25)23-18)13-4-3-5-14(21)9-13/h3-10,24H,2H2,1H3,(H,23,25)
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n/an/a 1.03E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26678
PNG
(6-(3-bromo-4-methoxyphenyl)-2-oxo-4-(trifluorometh...)
Show SMILES COc1ccc(cc1Br)-c1cc(c(C#N)c(=O)[nH]1)C(F)(F)F
Show InChI InChI=1S/C14H8BrF3N2O2/c1-22-12-3-2-7(4-10(12)15)11-5-9(14(16,17)18)8(6-19)13(21)20-11/h2-5H,1H3,(H,20,21)
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n/an/a 1.14E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26687
PNG
(6-(2-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccccc1-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N |(1.13,.04,;2.47,.81,;3.8,.03,;5.14,.81,;5.14,2.35,;3.8,3.12,;2.47,2.35,;1.13,3.12,;-.2,2.35,;-.2,.8,;-1.53,.03,;-2.87,.8,;-4.2,.03,;-5.53,.8,;-5.53,2.35,;-4.2,3.12,;-2.87,2.35,;-1.53,3.12,;-1.53,4.66,;-.2,5.43,;-.2,6.97,;1.13,4.66,;2.47,5.43,;3.8,6.2,)|
Show InChI InChI=1S/C19H11ClN2O2/c20-15-7-3-1-5-11(15)17-13(9-21)19(23)22-18-12-6-2-4-8-16(12)24-10-14(17)18/h1-8H,10H2,(H,22,23)
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n/an/a 1.23E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26691
PNG
(4-oxo-6-(thiophen-2-yl)-9-thia-3-azatricyclo[8.4.0...)
Show SMILES O=c1[nH]c-2c(CSc3ccccc-23)c(-c2cccs2)c1C#N
Show InChI InChI=1S/C17H10N2OS2/c18-8-11-15(14-6-3-7-21-14)12-9-22-13-5-2-1-4-10(13)16(12)19-17(11)20/h1-7H,9H2,(H,19,20)
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n/an/a 1.49E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26683
PNG
(2-{3-amino-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl...)
Show SMILES Nc1n[nH]c2nc(cc(-c3ccccc3)c12)-c1cc(Br)ccc1O
Show InChI InChI=1S/C18H13BrN4O/c19-11-6-7-15(24)13(8-11)14-9-12(10-4-2-1-3-5-10)16-17(20)22-23-18(16)21-14/h1-9,24H,(H3,20,21,22,23)
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n/an/a 1.77E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26680
PNG
(2-oxo-4-(thiophen-2-yl)-6-(trifluoromethyl)-1,2-di...)
Show SMILES FC(F)(F)c1cc(-c2cccs2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C11H5F3N2OS/c12-11(13,14)9-4-6(8-2-1-3-18-8)7(5-15)10(17)16-9/h1-4H,(H,16,17)
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n/an/a 3.54E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26682
PNG
(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Show SMILES Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N3O/c19-11-16-15(12-4-2-1-3-5-12)10-17(21-18(16)20)13-6-8-14(22)9-7-13/h1-10,22H,(H2,20,21)
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n/an/a 4.41E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26692
PNG
(4-oxo-6-(pyridin-3-yl)-9-thia-3-azatricyclo[8.4.0....)
Show SMILES O=c1[nH]c-2c(CSc3ccccc-23)c(-c2cccnc2)c1C#N
Show InChI InChI=1S/C18H11N3OS/c19-8-13-16(11-4-3-7-20-9-11)14-10-23-15-6-2-1-5-12(15)17(14)21-18(13)22/h1-7,9H,10H2,(H,21,22)
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n/an/a 4.79E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26681
PNG
(6-(furan-2-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihyd...)
Show SMILES FC(F)(F)c1cc([nH]c(=O)c1C#N)-c1ccco1
Show InChI InChI=1S/C11H5F3N2O2/c12-11(13,14)7-4-8(9-2-1-3-18-9)16-10(17)6(7)5-15/h1-4H,(H,16,17)
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n/an/a 1.60E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26696
PNG
(ethyl 3-methyl-4,8-dioxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES CCOC(=O)C1=C2C(N(C)C(=O)C1)c1ccccc1OC2=O |t:5|
Show InChI InChI=1S/C16H15NO5/c1-3-21-15(19)10-8-12(18)17(2)14-9-6-4-5-7-11(9)22-16(20)13(10)14/h4-7,14H,3,8H2,1-2H3
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n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26688
PNG
(6-(4-methoxyphenyl)-4-oxo-9-oxa-3-azatricyclo[8.4....)
Show SMILES COc1ccc(cc1)-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C20H14N2O3/c1-24-13-8-6-12(7-9-13)18-15(10-21)20(23)22-19-14-4-2-3-5-17(14)25-11-16(18)19/h2-9H,11H2,1H3,(H,22,23)
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n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26693
PNG
(6-(2-chlorophenyl)-4-oxo-9-thia-3-azatricyclo[8.4....)
Show SMILES Clc1ccccc1-c1c2CSc3ccccc3-c2[nH]c(=O)c1C#N |(3.8,4.66,;3.8,3.12,;5.14,2.35,;5.14,.81,;3.8,.03,;2.47,.81,;2.47,2.35,;1.13,3.12,;-.2,2.35,;-.2,.8,;-1.53,.03,;-2.87,.8,;-4.2,.03,;-5.53,.8,;-5.53,2.35,;-4.2,3.12,;-2.87,2.35,;-1.53,3.12,;-1.53,4.66,;-.2,5.43,;-.2,6.97,;1.13,4.66,;2.47,5.43,;3.8,6.2,)|
Show InChI InChI=1S/C19H11ClN2OS/c20-15-7-3-1-5-11(15)17-13(9-21)19(23)22-18-12-6-2-4-8-16(12)24-10-14(17)18/h1-8H,10H2,(H,22,23)
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n/an/a 2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26690
PNG
(4-oxo-6-(pyridin-2-yl)-9-oxa-3-azatricyclo[8.4.0.0...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccccn2)c1C#N
Show InChI InChI=1S/C18H11N3O2/c19-9-12-16(14-6-3-4-8-20-14)13-10-23-15-7-2-1-5-11(15)17(13)21-18(12)22/h1-8H,10H2,(H,21,22)
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n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26694
PNG
(6-(4-fluorophenyl)-4-oxo-9-thia-3-azatricyclo[8.4....)
Show SMILES Fc1ccc(cc1)-c1c2CSc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11FN2OS/c20-12-7-5-11(6-8-12)17-14(9-21)19(23)22-18-13-3-1-2-4-16(13)24-10-15(17)18/h1-8H,10H2,(H,22,23)
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n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26689
PNG
(2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N
Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)
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n/an/a 2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26695
PNG
(4-oxo-6-(pyridin-4-yl)-3-azatricyclo[8.4.0.0^{2,7}...)
Show SMILES O=c1[nH]c-2c(CCc3ccccc-23)c(-c2ccncc2)c1C#N
Show InChI InChI=1S/C19H13N3O/c20-11-16-17(13-7-9-21-10-8-13)15-6-5-12-3-1-2-4-14(12)18(15)22-19(16)23/h1-4,7-10H,5-6H2,(H,22,23)
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PubMed
n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%