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PubMed code 17585749

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20531
PNG
(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H13F3N4/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H,(H,25,26,27)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20531
PNG
(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H13F3N4/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H,(H,25,26,27)
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n/an/a 0.600n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20530
PNG
(N-[6-(4-tert-butylphenyl)pyrimidin-4-yl]quinolin-7...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C23H22N4/c1-23(2,3)18-9-6-17(7-10-18)21-14-22(26-15-25-21)27-19-11-8-16-5-4-12-24-20(16)13-19/h4-15H,1-3H3,(H,25,26,27)
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n/an/a 1.90n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20530
PNG
(N-[6-(4-tert-butylphenyl)pyrimidin-4-yl]quinolin-7...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C23H22N4/c1-23(2,3)18-9-6-17(7-10-18)21-14-22(26-15-25-21)27-19-11-8-16-5-4-12-24-20(16)13-19/h4-15H,1-3H3,(H,25,26,27)
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n/an/a 2n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
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n/an/a 3.70n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
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n/an/a 4.20n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20531
PNG
(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H13F3N4/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H,(H,25,26,27)
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n/an/a 4.5n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20531
PNG
(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H13F3N4/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H,(H,25,26,27)
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n/an/a 6.60n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20530
PNG
(N-[6-(4-tert-butylphenyl)pyrimidin-4-yl]quinolin-7...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C23H22N4/c1-23(2,3)18-9-6-17(7-10-18)21-14-22(26-15-25-21)27-19-11-8-16-5-4-12-24-20(16)13-19/h4-15H,1-3H3,(H,25,26,27)
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n/an/a 6.90n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
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n/an/a 7.40n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20532
PNG
(7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Oc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C20H12F3N3O/c21-20(22,23)15-6-3-14(4-7-15)18-11-19(26-12-25-18)27-16-8-5-13-2-1-9-24-17(13)10-16/h1-12H
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n/an/a 8n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20530
PNG
(N-[6-(4-tert-butylphenyl)pyrimidin-4-yl]quinolin-7...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3cccnc3c2)ncn1
Show InChI InChI=1S/C23H22N4/c1-23(2,3)18-9-6-17(7-10-18)21-14-22(26-15-25-21)27-19-11-8-16-5-4-12-24-20(16)13-19/h4-15H,1-3H3,(H,25,26,27)
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n/an/a 22n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20518
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)25-17-8-9-19-20(12-17)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,23,24,25)
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n/an/a 51n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20510
PNG
((2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-ben...)
Show SMILES CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
Show InChI InChI=1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
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n/an/a 79n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20529
PNG
(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[4-(trifluo...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C19H14F3N3O2/c20-19(21,22)13-3-1-12(2-4-13)15-10-18(24-11-23-15)25-14-5-6-16-17(9-14)27-8-7-26-16/h1-6,9-11H,7-8H2,(H,23,24,25)
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n/an/a 120n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20518
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)25-17-8-9-19-20(12-17)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,23,24,25)
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n/an/a 120n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20514
PNG
(4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccnc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-6-4-16(5-7-18)17-10-11-24-22(14-17)25-19-8-9-20-21(15-19)27-13-12-26-20/h4-11,14-15H,12-13H2,1-3H3,(H,24,25)
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n/an/a 230n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20529
PNG
(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[4-(trifluo...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C19H14F3N3O2/c20-19(21,22)13-3-1-12(2-4-13)15-10-18(24-11-23-15)25-14-5-6-16-17(9-14)27-8-7-26-16/h1-6,9-11H,7-8H2,(H,23,24,25)
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n/an/a 250n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20518
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)25-17-8-9-19-20(12-17)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,23,24,25)
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n/an/a 270n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20526
PNG
(4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Oc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H22N2O3/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)27-17-8-9-19-20(12-17)26-11-10-25-19/h4-9,12-14H,10-11H2,1-3H3
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n/an/a 290n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20510
PNG
((2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-ben...)
Show SMILES CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
Show InChI InChI=1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
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n/an/a 350n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20529
PNG
(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[4-(trifluo...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C19H14F3N3O2/c20-19(21,22)13-3-1-12(2-4-13)15-10-18(24-11-23-15)25-14-5-6-16-17(9-14)27-8-7-26-16/h1-6,9-11H,7-8H2,(H,23,24,25)
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n/an/a 430n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20526
PNG
(4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Oc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H22N2O3/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)27-17-8-9-19-20(12-17)26-11-10-25-19/h4-9,12-14H,10-11H2,1-3H3
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n/an/a 670n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20518
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)25-17-8-9-19-20(12-17)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,23,24,25)
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n/an/a 680n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20524
PNG
(4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ncnc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C21H22N4O2/c1-21(2,3)15-6-4-14(5-7-15)19-22-13-23-20(25-19)24-16-8-9-17-18(12-16)27-11-10-26-17/h4-9,12-13H,10-11H2,1-3H3,(H,22,23,24,25)
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n/an/a 760n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20521
PNG
(5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cnnc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)17-6-4-15(5-7-17)16-12-21(25-23-14-16)24-18-8-9-19-20(13-18)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,24,25)
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n/an/a 780n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20522
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)cnn1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)19-12-18(14-23-25-19)24-17-8-9-20-21(13-17)27-11-10-26-20/h4-9,12-14H,10-11H2,1-3H3,(H,24,25)
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n/an/a 840n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20528
PNG
(4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Cc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-7-5-17(6-8-18)20-14-19(24-15-25-20)12-16-4-9-21-22(13-16)27-11-10-26-21/h4-9,13-15H,10-12H2,1-3H3
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n/an/a 914n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20529
PNG
(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[4-(trifluo...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C19H14F3N3O2/c20-19(21,22)13-3-1-12(2-4-13)15-10-18(24-11-23-15)25-14-5-6-16-17(9-14)27-8-7-26-16/h1-6,9-11H,7-8H2,(H,23,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20515
PNG
(5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cncc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-6-4-16(5-7-18)17-12-20(15-24-14-17)25-19-8-9-21-22(13-19)27-11-10-26-21/h4-9,12-15,25H,10-11H2,1-3H3
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n/an/a 1.21E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20514
PNG
(4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccnc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-6-4-16(5-7-18)17-10-11-24-22(14-17)25-19-8-9-20-21(15-19)27-13-12-26-20/h4-11,14-15H,12-13H2,1-3H3,(H,24,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20525
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CN(c1ccc2OCCOc2c1)c1cc(ncn1)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C23H25N3O2/c1-23(2,3)17-7-5-16(6-8-17)19-14-22(25-15-24-19)26(4)18-9-10-20-21(13-18)28-12-11-27-20/h5-10,13-15H,11-12H2,1-4H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20528
PNG
(4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Cc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-7-5-17(6-8-18)20-14-19(24-15-25-20)12-16-4-9-21-22(13-16)27-11-10-26-21/h4-9,13-15H,10-12H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20515
PNG
(5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cncc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)18-6-4-16(5-7-18)17-12-20(15-24-14-17)25-19-8-9-21-22(13-19)27-11-10-26-21/h4-9,12-15,25H,10-11H2,1-3H3
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Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20519
PNG
(4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccnc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-10-11-23-21(25-18)24-17-8-9-19-20(14-17)27-13-12-26-19/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20513
PNG
(N-[3-(4-tert-butylphenyl)phenyl]-2,3-dihydro-1,4-b...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C24H25NO2/c1-24(2,3)19-9-7-17(8-10-19)18-5-4-6-20(15-18)25-21-11-12-22-23(16-21)27-14-13-26-22/h4-12,15-16,25H,13-14H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20512
PNG
(3-[(4-tert-butylphenyl)methyl]-1-(2,3-dihydro-1,4-...)
Show SMILES CC(C)(C)c1ccc(Cc2cccn(-c3ccc4OCCOc4c3)c2=O)cc1
Show InChI InChI=1S/C24H25NO3/c1-24(2,3)19-8-6-17(7-9-19)15-18-5-4-12-25(23(18)26)20-10-11-21-22(16-20)28-14-13-27-21/h4-12,16H,13-15H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20523
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cncc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-13-23-14-21(25-18)24-17-8-9-19-20(12-17)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,24,25)
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20517
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)17-9-7-16(8-10-17)19-5-4-6-22(25-19)24-18-11-12-20-21(15-18)27-14-13-26-20/h4-12,15H,13-14H2,1-3H3,(H,24,25)
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Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20513
PNG
(N-[3-(4-tert-butylphenyl)phenyl]-2,3-dihydro-1,4-b...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C24H25NO2/c1-24(2,3)19-9-7-17(8-10-19)18-5-4-6-20(15-18)25-21-11-12-22-23(16-21)27-14-13-26-22/h4-12,15-16,25H,13-14H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20512
PNG
(3-[(4-tert-butylphenyl)methyl]-1-(2,3-dihydro-1,4-...)
Show SMILES CC(C)(C)c1ccc(Cc2cccn(-c3ccc4OCCOc4c3)c2=O)cc1
Show InChI InChI=1S/C24H25NO3/c1-24(2,3)19-8-6-17(7-9-19)15-18-5-4-12-25(23(18)26)20-10-11-21-22(16-20)28-14-13-27-21/h4-12,16H,13-15H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20523
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cncc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-13-23-14-21(25-18)24-17-8-9-19-20(12-17)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,24,25)
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20516
PNG
(2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ccn1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)17-6-4-16(5-7-17)20-14-19(10-11-24-20)25-18-8-9-21-22(15-18)27-13-12-26-21/h4-11,14-15H,12-13H2,1-3H3,(H,24,25)
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20520
PNG
(2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1nccc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)21-23-11-10-20(25-21)24-17-8-9-18-19(14-17)27-13-12-26-18/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20517
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)17-9-7-16(8-10-17)19-5-4-6-22(25-19)24-18-11-12-20-21(15-18)27-14-13-26-20/h4-12,15H,13-14H2,1-3H3,(H,24,25)
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20527
PNG
(4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Sc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H22N2O2S/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)27-17-8-9-19-20(12-17)26-11-10-25-19/h4-9,12-14H,10-11H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20511
PNG
((3E)-3-[(4-tert-butylphenyl)methylidene]-1-(2,3-di...)
Show SMILES CC(C)(C)c1ccc(\C=C2/CCCN(C2=O)c2ccc3OCCOc3c2)cc1
Show InChI InChI=1S/C24H27NO3/c1-24(2,3)19-8-6-17(7-9-19)15-18-5-4-12-25(23(18)26)20-10-11-21-22(16-20)28-14-13-27-21/h6-11,15-16H,4-5,12-14H2,1-3H3/b18-15+
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20511
PNG
((3E)-3-[(4-tert-butylphenyl)methylidene]-1-(2,3-di...)
Show SMILES CC(C)(C)c1ccc(\C=C2/CCCN(C2=O)c2ccc3OCCOc3c2)cc1
Show InChI InChI=1S/C24H27NO3/c1-24(2,3)19-8-6-17(7-9-19)15-18-5-4-12-25(23(18)26)20-10-11-21-22(16-20)28-14-13-27-21/h6-11,15-16H,4-5,12-14H2,1-3H3/b18-15+
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20519
PNG
(4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccnc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)18-10-11-23-21(25-18)24-17-8-9-19-20(14-17)27-13-12-26-19/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20516
PNG
(2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)ccn1
Show InChI InChI=1S/C23H24N2O2/c1-23(2,3)17-6-4-16(5-7-17)20-14-19(10-11-24-20)25-18-8-9-21-22(15-18)27-13-12-26-21/h4-11,14-15H,12-13H2,1-3H3,(H,24,25)
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Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20525
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CN(c1ccc2OCCOc2c1)c1cc(ncn1)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C23H25N3O2/c1-23(2,3)17-7-5-16(6-8-17)19-14-22(25-15-24-19)26(4)18-9-10-20-21(13-18)28-12-11-27-20/h5-10,13-15H,11-12H2,1-4H3
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20524
PNG
(4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ncnc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C21H22N4O2/c1-21(2,3)15-6-4-14(5-7-15)19-22-13-23-20(25-19)24-16-8-9-17-18(12-16)27-11-10-26-17/h4-9,12-13H,10-11H2,1-3H3,(H,22,23,24,25)
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20521
PNG
(5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cnnc(Nc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)17-6-4-15(5-7-17)16-12-21(25-23-14-16)24-18-8-9-19-20(13-18)27-11-10-26-19/h4-9,12-14H,10-11H2,1-3H3,(H,24,25)
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20527
PNG
(4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Sc2ccc3OCCOc3c2)ncn1
Show InChI InChI=1S/C22H22N2O2S/c1-22(2,3)16-6-4-15(5-7-16)18-13-21(24-14-23-18)27-17-8-9-19-20(12-17)26-11-10-25-19/h4-9,12-14H,10-11H2,1-3H3
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20522
PNG
(6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(Nc2ccc3OCCOc3c2)cnn1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)19-12-18(14-23-25-19)24-17-8-9-20-21(13-17)27-11-10-26-20/h4-9,12-14H,10-11H2,1-3H3,(H,24,25)
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Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20520
PNG
(2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodio...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1nccc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C22H23N3O2/c1-22(2,3)16-6-4-15(5-7-16)21-23-11-10-20(25-21)24-17-8-9-18-19(14-17)27-13-12-26-18/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)
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n/an/a>4.00E+3n/an/an/an/a7.422



Amgen



Assay Description
TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...

J Med Chem 50: 3497-514 (2007)


Article DOI: 10.1021/jm070189q
BindingDB Entry DOI: 10.7270/Q2W957GV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%