Found 82 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50366567
(ATOMOXETINE)Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
DrugBank
MCE
PC cid
PC sid
UniChem
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243211
((2S,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM22417
(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)Show InChI InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM30130
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243154
(CHEMBL487690 | cis-3-(4-chlorophenoxy)-N,N-dimethy...)Show SMILES CN(C)[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| Show InChI InChI=1S/C17H18ClNO/c1-19(2)16-11-17(15-6-4-3-5-14(15)16)20-13-9-7-12(18)8-10-13/h3-10,16-17H,11H2,1-2H3/t16-,17+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243209
(CHEMBL486044 | trans-N-methyl-3-(o-tolyloxy)-2,3-d...)Show InChI InChI=1S/C17H19NO/c1-12-7-3-6-10-16(12)19-17-11-15(18-2)13-8-4-5-9-14(13)17/h3-10,15,17-18H,11H2,1-2H3/t15-,17-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243155
(CHEMBL487691 | cis-3-(4-methoxyphenoxy)-N,N-dimeth...)Show SMILES COc1ccc(O[C@H]2C[C@@H](N(C)C)c3ccccc23)cc1 |r| Show InChI InChI=1S/C18H21NO2/c1-19(2)17-12-18(16-7-5-4-6-15(16)17)21-14-10-8-13(20-3)9-11-14/h4-11,17-18H,12H2,1-3H3/t17-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243210
(CHEMBL520201 | trans-N,N-dimethyl-3-(o-tolyloxy)-2...)Show InChI InChI=1S/C18H21NO/c1-13-8-4-7-11-17(13)20-18-12-16(19(2)3)14-9-5-6-10-15(14)18/h4-11,16,18H,12H2,1-3H3/t16-,18-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243157
(CHEMBL521392 | cis-N,N-dimethyl-3-(o-tolyloxy)-2,3...)Show SMILES CN(C)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C18H21NO/c1-13-8-4-7-11-17(13)20-18-12-16(19(2)3)14-9-5-6-10-15(14)18/h4-11,16,18H,12H2,1-3H3/t16-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243210
(CHEMBL520201 | trans-N,N-dimethyl-3-(o-tolyloxy)-2...)Show InChI InChI=1S/C18H21NO/c1-13-8-4-7-11-17(13)20-18-12-16(19(2)3)14-9-5-6-10-15(14)18/h4-11,16,18H,12H2,1-3H3/t16-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243268
((2S,4S)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50366567
(ATOMOXETINE)Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
DrugBank
MCE
PC cid
PC sid
UniChem
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243209
(CHEMBL486044 | trans-N-methyl-3-(o-tolyloxy)-2,3-d...)Show InChI InChI=1S/C17H19NO/c1-12-7-3-6-10-16(12)19-17-11-15(18-2)13-8-4-5-9-14(13)17/h3-10,15,17-18H,11H2,1-2H3/t15-,17-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243267
((2R,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243266
((2R,4S)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50243211
((2S,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243157
(CHEMBL521392 | cis-N,N-dimethyl-3-(o-tolyloxy)-2,3...)Show SMILES CN(C)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C18H21NO/c1-13-8-4-7-11-17(13)20-18-12-16(19(2)3)14-9-5-6-10-15(14)18/h4-11,16,18H,12H2,1-3H3/t16-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243103
(CHEMBL488222 | cis-3-(4-chlorophenoxy)-N-methyl-2,...)Show SMILES CN[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| Show InChI InChI=1S/C16H16ClNO/c1-18-15-10-16(14-5-3-2-4-13(14)15)19-12-8-6-11(17)7-9-12/h2-9,15-16,18H,10H2,1H3/t15-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243209
(CHEMBL486044 | trans-N-methyl-3-(o-tolyloxy)-2,3-d...)Show InChI InChI=1S/C17H19NO/c1-12-7-3-6-10-16(12)19-17-11-15(18-2)13-8-4-5-9-14(13)17/h3-10,15,17-18H,11H2,1-2H3/t15-,17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243265
((2S,4R)-N,N-dimethyl-4-(o-tolyloxy)-1,2,3,4-tetrah...)Show SMILES CN(C)[C@@H]1C[C@@H](Oc2ccccc2C)c2ccccc2C1 |r| Show InChI InChI=1S/C19H23NO/c1-14-8-4-7-11-18(14)21-19-13-16(20(2)3)12-15-9-5-6-10-17(15)19/h4-11,16,19H,12-13H2,1-3H3/t16-,19+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243270
(CHEMBL447598 | cis-N-methyl-4-(o-tolyloxy)-1,2,3,4...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-11-16(19-2)14-8-4-5-9-15(14)18/h3-10,16,18-19H,11-12H2,1-2H3/t16-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243211
((2S,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243208
(CHEMBL486043 | trans-3-(o-tolyloxy)-2,3-dihydro-1H...)Show InChI InChI=1S/C16H17NO/c1-11-6-2-5-9-15(11)18-16-10-14(17)12-7-3-4-8-13(12)16/h2-9,14,16H,10,17H2,1H3/t14-,16-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243269
(CHEMBL453061 | cis-4-(o-tolyloxy)-1,2,3,4-tetrahyd...)Show InChI InChI=1S/C17H19NO/c1-12-6-2-5-9-16(12)19-17-11-10-15(18)13-7-3-4-8-14(13)17/h2-9,15,17H,10-11,18H2,1H3/t15-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243156
(CHEMBL446570 | cis-N-methyl-3-(o-tolyloxy)-2,3-dih...)Show InChI InChI=1S/C17H19NO/c1-12-7-3-6-10-16(12)19-17-11-15(18-2)13-8-4-5-9-14(13)17/h3-10,15,17-18H,11H2,1-2H3/t15-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243265
((2S,4R)-N,N-dimethyl-4-(o-tolyloxy)-1,2,3,4-tetrah...)Show SMILES CN(C)[C@@H]1C[C@@H](Oc2ccccc2C)c2ccccc2C1 |r| Show InChI InChI=1S/C19H23NO/c1-14-8-4-7-11-18(14)21-19-13-16(20(2)3)12-15-9-5-6-10-17(15)19/h4-11,16,19H,12-13H2,1-3H3/t16-,19+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243152
(CHEMBL520735 | cis-N,N-dimethyl-3-phenoxy-2,3-dihy...)Show InChI InChI=1S/C17H19NO/c1-18(2)16-12-17(15-11-7-6-10-14(15)16)19-13-8-4-3-5-9-13/h3-11,16-17H,12H2,1-2H3/t16-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243208
(CHEMBL486043 | trans-3-(o-tolyloxy)-2,3-dihydro-1H...)Show InChI InChI=1S/C16H17NO/c1-11-6-2-5-9-15(11)18-16-10-14(17)12-7-3-4-8-13(12)16/h2-9,14,16H,10,17H2,1H3/t14-,16-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243271
(CHEMBL453321 | trans-4-(o-tolyloxy)-1,2,3,4-tetrah...)Show InChI InChI=1S/C17H19NO/c1-12-6-2-5-9-16(12)19-17-11-10-15(18)13-7-3-4-8-14(13)17/h2-9,15,17H,10-11,18H2,1H3/t15-,17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243270
(CHEMBL447598 | cis-N-methyl-4-(o-tolyloxy)-1,2,3,4...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-11-16(19-2)14-8-4-5-9-15(14)18/h3-10,16,18-19H,11-12H2,1-2H3/t16-,18+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243271
(CHEMBL453321 | trans-4-(o-tolyloxy)-1,2,3,4-tetrah...)Show InChI InChI=1S/C17H19NO/c1-12-6-2-5-9-16(12)19-17-11-10-15(18)13-7-3-4-8-14(13)17/h2-9,15,17H,10-11,18H2,1H3/t15-,17-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243269
(CHEMBL453061 | cis-4-(o-tolyloxy)-1,2,3,4-tetrahyd...)Show InChI InChI=1S/C17H19NO/c1-12-6-2-5-9-16(12)19-17-11-10-15(18)13-7-3-4-8-14(13)17/h2-9,15,17H,10-11,18H2,1H3/t15-,17+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243268
((2S,4S)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243207
(CHEMBL486237 | cis-N-isopropyl-N-methyl-3-(o-tolyl...)Show SMILES CC(C)N(C)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C20H25NO/c1-14(2)21(4)18-13-20(17-11-7-6-10-16(17)18)22-19-12-8-5-9-15(19)3/h5-12,14,18,20H,13H2,1-4H3/t18-,20+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM22417
(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)Show InChI InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3 | PDB
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MCE
PC cid
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| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243156
(CHEMBL446570 | cis-N-methyl-3-(o-tolyloxy)-2,3-dih...)Show InChI InChI=1S/C17H19NO/c1-12-7-3-6-10-16(12)19-17-11-15(18-2)13-8-4-5-9-14(13)17/h3-10,15,17-18H,11H2,1-2H3/t15-,17+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243154
(CHEMBL487690 | cis-3-(4-chlorophenoxy)-N,N-dimethy...)Show SMILES CN(C)[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| Show InChI InChI=1S/C17H18ClNO/c1-19(2)16-11-17(15-6-4-3-5-14(15)16)20-13-9-7-12(18)8-10-13/h3-10,16-17H,11H2,1-2H3/t16-,17+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243152
(CHEMBL520735 | cis-N,N-dimethyl-3-phenoxy-2,3-dihy...)Show InChI InChI=1S/C17H19NO/c1-18(2)16-12-17(15-11-7-6-10-14(15)16)19-13-8-4-3-5-9-13/h3-11,16-17H,12H2,1-2H3/t16-,17+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243105
(CHEMBL530334 | cis-3-phenoxy-2,3-dihydro-1H-inden-...)Show InChI InChI=1S/C15H15NO/c16-14-10-15(13-9-5-4-8-12(13)14)17-11-6-2-1-3-7-11/h1-9,14-15H,10,16H2/t14-,15+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243206
(CHEMBL486236 | cis-N,N-diethyl-3-(o-tolyloxy)-2,3-...)Show SMILES CCN(CC)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C20H25NO/c1-4-21(5-2)18-14-20(17-12-8-7-11-16(17)18)22-19-13-9-6-10-15(19)3/h6-13,18,20H,4-5,14H2,1-3H3/t18-,20+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243106
(CHEMBL445185 | cis-N-methyl-3-phenoxy-2,3-dihydro-...)Show InChI InChI=1S/C16H17NO/c1-17-15-11-16(14-10-6-5-9-13(14)15)18-12-7-3-2-4-8-12/h2-10,15-17H,11H2,1H3/t15-,16+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM30130
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243269
(CHEMBL453061 | cis-4-(o-tolyloxy)-1,2,3,4-tetrahyd...)Show InChI InChI=1S/C17H19NO/c1-12-6-2-5-9-16(12)19-17-11-10-15(18)13-7-3-4-8-14(13)17/h2-9,15,17H,10-11,18H2,1H3/t15-,17+/m1/s1 | PDB
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243153
(CHEMBL488424 | cis-3-(4-chlorophenoxy)-2,3-dihydro...)Show InChI InChI=1S/C15H14ClNO/c16-10-5-7-11(8-6-10)18-15-9-14(17)12-3-1-2-4-13(12)15/h1-8,14-15H,9,17H2/t14-,15+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM22417
(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)Show InChI InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243206
(CHEMBL486236 | cis-N,N-diethyl-3-(o-tolyloxy)-2,3-...)Show SMILES CCN(CC)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C20H25NO/c1-4-21(5-2)18-14-20(17-12-8-7-11-16(17)18)22-19-13-9-6-10-15(19)3/h6-13,18,20H,4-5,14H2,1-3H3/t18-,20+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243205
(CHEMBL486235 | cis-N-ethyl-3-(o-tolyloxy)-2,3-dihy...)Show InChI InChI=1S/C18H21NO/c1-3-19-16-12-18(15-10-6-5-9-14(15)16)20-17-11-7-4-8-13(17)2/h4-11,16,18-19H,3,12H2,1-2H3/t16-,18+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243205
(CHEMBL486235 | cis-N-ethyl-3-(o-tolyloxy)-2,3-dihy...)Show InChI InChI=1S/C18H21NO/c1-3-19-16-12-18(15-10-6-5-9-14(15)16)20-17-11-7-4-8-13(17)2/h4-11,16,18-19H,3,12H2,1-2H3/t16-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243206
(CHEMBL486236 | cis-N,N-diethyl-3-(o-tolyloxy)-2,3-...)Show SMILES CCN(CC)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C20H25NO/c1-4-21(5-2)18-14-20(17-12-8-7-11-16(17)18)22-19-13-9-6-10-15(19)3/h6-13,18,20H,4-5,14H2,1-3H3/t18-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50366567
(ATOMOXETINE)Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
DrugBank
MCE
PC cid
PC sid
UniChem
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243158
(CHEMBL487869 | cis-3-(2-methoxyphenoxy)-N,N-dimeth...)Show SMILES COc1ccccc1O[C@H]1C[C@@H](N(C)C)c2ccccc12 |r| Show InChI InChI=1S/C18H21NO2/c1-19(2)15-12-18(14-9-5-4-8-13(14)15)21-17-11-7-6-10-16(17)20-3/h4-11,15,18H,12H2,1-3H3/t15-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243267
((2R,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243266
((2R,4S)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243210
(CHEMBL520201 | trans-N,N-dimethyl-3-(o-tolyloxy)-2...)Show InChI InChI=1S/C18H21NO/c1-13-8-4-7-11-17(13)20-18-12-16(19(2)3)14-9-5-6-10-15(14)18/h4-11,16,18H,12H2,1-3H3/t16-,18-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243158
(CHEMBL487869 | cis-3-(2-methoxyphenoxy)-N,N-dimeth...)Show SMILES COc1ccccc1O[C@H]1C[C@@H](N(C)C)c2ccccc12 |r| Show InChI InChI=1S/C18H21NO2/c1-19(2)15-12-18(14-9-5-4-8-13(14)15)21-17-11-7-6-10-16(17)20-3/h4-11,15,18H,12H2,1-3H3/t15-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243153
(CHEMBL488424 | cis-3-(4-chlorophenoxy)-2,3-dihydro...)Show InChI InChI=1S/C15H14ClNO/c16-10-5-7-11(8-6-10)18-15-9-14(17)12-3-1-2-4-13(12)15/h1-8,14-15H,9,17H2/t14-,15+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243103
(CHEMBL488222 | cis-3-(4-chlorophenoxy)-N-methyl-2,...)Show SMILES CN[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| Show InChI InChI=1S/C16H16ClNO/c1-18-15-10-16(14-5-3-2-4-13(14)15)19-12-8-6-11(17)7-9-12/h2-9,15-16,18H,10H2,1H3/t15-,16+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243103
(CHEMBL488222 | cis-3-(4-chlorophenoxy)-N-methyl-2,...)Show SMILES CN[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| Show InChI InChI=1S/C16H16ClNO/c1-18-15-10-16(14-5-3-2-4-13(14)15)19-12-8-6-11(17)7-9-12/h2-9,15-16,18H,10H2,1H3/t15-,16+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243266
((2R,4S)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243156
(CHEMBL446570 | cis-N-methyl-3-(o-tolyloxy)-2,3-dih...)Show InChI InChI=1S/C17H19NO/c1-12-7-3-6-10-16(12)19-17-11-15(18-2)13-8-4-5-9-14(13)17/h3-10,15,17-18H,11H2,1-2H3/t15-,17+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243106
(CHEMBL445185 | cis-N-methyl-3-phenoxy-2,3-dihydro-...)Show InChI InChI=1S/C16H17NO/c1-17-15-11-16(14-10-6-5-9-13(14)15)18-12-7-3-2-4-8-12/h2-10,15-17H,11H2,1H3/t15-,16+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243105
(CHEMBL530334 | cis-3-phenoxy-2,3-dihydro-1H-inden-...)Show InChI InChI=1S/C15H15NO/c16-14-10-15(13-9-5-4-8-12(13)14)17-11-6-2-1-3-7-11/h1-9,14-15H,10,16H2/t14-,15+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243270
(CHEMBL447598 | cis-N-methyl-4-(o-tolyloxy)-1,2,3,4...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-11-16(19-2)14-8-4-5-9-15(14)18/h3-10,16,18-19H,11-12H2,1-2H3/t16-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243268
((2S,4S)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM30130
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243155
(CHEMBL487691 | cis-3-(4-methoxyphenoxy)-N,N-dimeth...)Show SMILES COc1ccc(O[C@H]2C[C@@H](N(C)C)c3ccccc23)cc1 |r| Show InChI InChI=1S/C18H21NO2/c1-19(2)17-12-18(16-7-5-4-6-15(16)17)21-14-10-8-13(20-3)9-11-14/h4-11,17-18H,12H2,1-3H3/t17-,18+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243154
(CHEMBL487690 | cis-3-(4-chlorophenoxy)-N,N-dimethy...)Show SMILES CN(C)[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| Show InChI InChI=1S/C17H18ClNO/c1-19(2)16-11-17(15-6-4-3-5-14(15)16)20-13-9-7-12(18)8-10-13/h3-10,16-17H,11H2,1-2H3/t16-,17+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243211
((2S,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18+/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243205
(CHEMBL486235 | cis-N-ethyl-3-(o-tolyloxy)-2,3-dihy...)Show InChI InChI=1S/C18H21NO/c1-3-19-16-12-18(15-10-6-5-9-14(15)16)20-17-11-7-4-8-13(17)2/h4-11,16,18-19H,3,12H2,1-2H3/t16-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243153
(CHEMBL488424 | cis-3-(4-chlorophenoxy)-2,3-dihydro...)Show InChI InChI=1S/C15H14ClNO/c16-10-5-7-11(8-6-10)18-15-9-14(17)12-3-1-2-4-13(12)15/h1-8,14-15H,9,17H2/t14-,15+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243157
(CHEMBL521392 | cis-N,N-dimethyl-3-(o-tolyloxy)-2,3...)Show SMILES CN(C)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C18H21NO/c1-13-8-4-7-11-17(13)20-18-12-16(19(2)3)14-9-5-6-10-15(14)18/h4-11,16,18H,12H2,1-3H3/t16-,18+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243158
(CHEMBL487869 | cis-3-(2-methoxyphenoxy)-N,N-dimeth...)Show SMILES COc1ccccc1O[C@H]1C[C@@H](N(C)C)c2ccccc12 |r| Show InChI InChI=1S/C18H21NO2/c1-19(2)15-12-18(14-9-5-4-8-13(14)15)21-17-11-7-6-10-16(17)20-3/h4-11,15,18H,12H2,1-3H3/t15-,18+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243155
(CHEMBL487691 | cis-3-(4-methoxyphenoxy)-N,N-dimeth...)Show SMILES COc1ccc(O[C@H]2C[C@@H](N(C)C)c3ccccc23)cc1 |r| Show InChI InChI=1S/C18H21NO2/c1-19(2)17-12-18(16-7-5-4-6-15(16)17)21-14-10-8-13(20-3)9-11-14/h4-11,17-18H,12H2,1-3H3/t17-,18+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243271
(CHEMBL453321 | trans-4-(o-tolyloxy)-1,2,3,4-tetrah...)Show InChI InChI=1S/C17H19NO/c1-12-6-2-5-9-16(12)19-17-11-10-15(18)13-7-3-4-8-14(13)17/h2-9,15,17H,10-11,18H2,1H3/t15-,17-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243265
((2S,4R)-N,N-dimethyl-4-(o-tolyloxy)-1,2,3,4-tetrah...)Show SMILES CN(C)[C@@H]1C[C@@H](Oc2ccccc2C)c2ccccc2C1 |r| Show InChI InChI=1S/C19H23NO/c1-14-8-4-7-11-18(14)21-19-13-16(20(2)3)12-15-9-5-6-10-17(15)19/h4-11,16,19H,12-13H2,1-3H3/t16-,19+/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243207
(CHEMBL486237 | cis-N-isopropyl-N-methyl-3-(o-tolyl...)Show SMILES CC(C)N(C)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C20H25NO/c1-14(2)21(4)18-13-20(17-11-7-6-10-16(17)18)22-19-12-8-5-9-15(19)3/h5-12,14,18,20H,13H2,1-4H3/t18-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243267
((2R,4R)-N-methyl-4-(o-tolyloxy)-1,2,3,4-tetrahydro...)Show InChI InChI=1S/C18H21NO/c1-13-7-3-6-10-17(13)20-18-12-15(19-2)11-14-8-4-5-9-16(14)18/h3-10,15,18-19H,11-12H2,1-2H3/t15-,18-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243208
(CHEMBL486043 | trans-3-(o-tolyloxy)-2,3-dihydro-1H...)Show InChI InChI=1S/C16H17NO/c1-11-6-2-5-9-15(11)18-16-10-14(17)12-7-3-4-8-13(12)16/h2-9,14,16H,10,17H2,1H3/t14-,16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243106
(CHEMBL445185 | cis-N-methyl-3-phenoxy-2,3-dihydro-...)Show InChI InChI=1S/C16H17NO/c1-17-15-11-16(14-10-6-5-9-13(14)15)18-12-7-3-2-4-8-12/h2-10,15-17H,11H2,1H3/t15-,16+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243152
(CHEMBL520735 | cis-N,N-dimethyl-3-phenoxy-2,3-dihy...)Show InChI InChI=1S/C17H19NO/c1-18(2)16-12-17(15-11-7-6-10-14(15)16)19-13-8-4-3-5-9-13/h3-11,16-17H,12H2,1-2H3/t16-,17+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243105
(CHEMBL530334 | cis-3-phenoxy-2,3-dihydro-1H-inden-...)Show InChI InChI=1S/C15H15NO/c16-14-10-15(13-9-5-4-8-12(13)14)17-11-6-2-1-3-7-11/h1-9,14-15H,10,16H2/t14-,15+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243207
(CHEMBL486237 | cis-N-isopropyl-N-methyl-3-(o-tolyl...)Show SMILES CC(C)N(C)[C@@H]1C[C@H](Oc2ccccc2C)c2ccccc12 |r| Show InChI InChI=1S/C20H25NO/c1-14(2)21(4)18-13-20(17-11-7-6-10-16(17)18)22-19-12-8-5-9-15(19)3/h5-12,14,18,20H,13H2,1-4H3/t18-,20+/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dopamine uptake at human DAT in human HEK293 cells |
Bioorg Med Chem Lett 18: 4224-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.057
BindingDB Entry DOI: 10.7270/Q2T154J4 |
More data for this
Ligand-Target Pair | |
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