Affinity Data by PubMed id=18983141

PubMed code 18983141

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50216551 (3-pentyl-1H-pyrazole-5-carboxylic acid \| 5-butylpy...) Show SMILES CCCCCc1cc(n[nH]1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity at GPR109a				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50132140 (1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic...) Show SMILES OC(=O)c1n[nH]c2CCCc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	156	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity at GPR109a				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50132142 (4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid \|...) Show SMILES OC(=O)c1n[nH]c2CCCCc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity at GPR109a				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50208138 ((+)-acifran \| (-)-acifran \| 5-Methyl-4-oxo-5-pheny...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1 \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50208138 ((+)-acifran \| (-)-acifran \| 5-Methyl-4-oxo-5-pheny...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1 \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hydroxycarboxylic acid receptor 3 (Homo sapiens (Human))	BDBM50208138 ((+)-acifran \| (-)-acifran \| 5-Methyl-4-oxo-5-pheny...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1 \|c:3\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50241028 (1-Isopropyl-1H-benzotriazole-5-carboxylic acid \| 1...) Show SMILES CC(C)n1nnc2cc(ccc12)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50208122 ((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Cl)c1 \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 3 (Homo sapiens (Human))	BDBM50208122 ((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Cl)c1 \|c:3\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 3 (Homo sapiens (Human))	BDBM50208137 ((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Br)c1 \|c:3\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50208137 ((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...) Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Br)c1 \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP production				J Med Chem 51: 7653-62 (2008) Article DOI: 10.1021/jm800896z BindingDB Entry DOI: 10.7270/Q27D2TZ5
Arena Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%