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PubMed code 19307114

Compile data set for download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249132
PNG
((4-((1H-imidazol-2-yl)methyl)piperidin-1-yl)(4'-fl...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(Cc2ncc[nH]2)CC1
Show InChI InChI=1S/C22H22FN3O/c23-20-7-5-18(6-8-20)17-1-3-19(4-2-17)22(27)26-13-9-16(10-14-26)15-21-24-11-12-25-21/h1-8,11-12,16H,9-10,13-15H2,(H,24,25)
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n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249483
PNG
(1-(biphenyl-4-ylsulfonyl)-4-(1H-imidazol-2-yl)pipe...)
Show SMILES O=S(=O)(N1CCC(CC1)c1ncc[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O2S/c24-26(25,23-14-10-18(11-15-23)20-21-12-13-22-20)19-8-6-17(7-9-19)16-4-2-1-3-5-16/h1-9,12-13,18H,10-11,14-15H2,(H,21,22)
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n/an/a 0.300n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249464
PNG
((4-((1H-imidazol-2-yl)methyl)piperidin-1-yl)(biphe...)
Show SMILES O=C(N1CCC(Cc2ncc[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H23N3O/c26-22(20-8-6-19(7-9-20)18-4-2-1-3-5-18)25-14-10-17(11-15-25)16-21-23-12-13-24-21/h1-9,12-13,17H,10-11,14-16H2,(H,23,24)
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n/an/a 0.400n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249131
PNG
(1-(4'-fluorobiphenyl-4-ylsulfonyl)-4-(1H-imidazol-...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1ncc[nH]1
Show InChI InChI=1S/C20H20FN3O2S/c21-18-5-1-15(2-6-18)16-3-7-19(8-4-16)27(25,26)24-13-9-17(10-14-24)20-22-11-12-23-20/h1-8,11-12,17H,9-10,13-14H2,(H,22,23)
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n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249134
PNG
(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Show SMILES CC(C)c1cc(nc(N)n1)-c1ccc(F)c2ccccc12
Show InChI InChI=1S/C17H16FN3/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13/h3-10H,1-2H3,(H2,19,20,21)
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n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249486
PNG
((4-(1H-imidazol-2-yl)piperidin-1-yl)(4'-fluorobiph...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1ncc[nH]1
Show InChI InChI=1S/C21H20FN3O/c22-19-7-5-16(6-8-19)15-1-3-18(4-2-15)21(26)25-13-9-17(10-14-25)20-23-11-12-24-20/h1-8,11-12,17H,9-10,13-14H2,(H,23,24)
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n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249176
PNG
(2-(1-(biphenyl-4-ylsulfonyl)piperidin-4-yl)-1H-ben...)
Show SMILES O=S(=O)(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H23N3O2S/c28-30(29,21-12-10-19(11-13-21)18-6-2-1-3-7-18)27-16-14-20(15-17-27)24-25-22-8-4-5-9-23(22)26-24/h1-13,20H,14-17H2,(H,25,26)
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n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249482
PNG
((4-((1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-y...)
Show SMILES O=C(N1CCC(Cc2nc3ccccc3[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H25N3O/c30-26(22-12-10-21(11-13-22)20-6-2-1-3-7-20)29-16-14-19(15-17-29)18-25-27-23-8-4-5-9-24(23)28-25/h1-13,19H,14-18H2,(H,27,28)
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n/an/a 2.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249462
PNG
((4-(1H-imidazol-2-yl)piperidin-1-yl)(biphenyl-4-yl...)
Show SMILES O=C(N1CCC(CC1)c1ncc[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H21N3O/c25-21(24-14-10-18(11-15-24)20-22-12-13-23-20)19-8-6-17(7-9-19)16-4-2-1-3-5-16/h1-9,12-13,18H,10-11,14-15H2,(H,22,23)
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n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249126
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(biphe...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H23N3O/c29-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)28-16-14-20(15-17-28)24-26-22-8-4-5-9-23(22)27-24/h1-13,20H,14-17H2,(H,26,27)
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n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249128
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(2-phe...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1cnc(nc1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O/c29-23(18-14-24-21(25-15-18)16-6-2-1-3-7-16)28-12-10-17(11-13-28)22-26-19-8-4-5-9-20(19)27-22/h1-9,14-15,17H,10-13H2,(H,26,27)
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n/an/a 2.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249427
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4'-me...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H25N3O2/c1-31-22-12-10-19(11-13-22)18-6-8-21(9-7-18)26(30)29-16-14-20(15-17-29)25-27-23-4-2-3-5-24(23)28-25/h2-13,20H,14-17H2,1H3,(H,27,28)
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n/an/a 3.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249180
PNG
(5-((4-(6-chlorothieno[2,3-d]pyrimidin-4-ylamino)pi...)
Show SMILES Fc1ccc(CN2CCC(CC2)Nc2ncnc3sc(Cl)cc23)cc1C#N
Show InChI InChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)
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n/an/a 3.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249129
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(3-met...)
Show SMILES COc1cc(ccc1C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C26H25N3O2/c1-31-24-17-20(18-7-3-2-4-8-18)11-12-21(24)26(30)29-15-13-19(14-16-29)25-27-22-9-5-6-10-23(22)28-25/h2-12,17,19H,13-16H2,1H3,(H,27,28)
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n/an/a 4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249130
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-eth...)
Show SMILES CCOc1nc(ncc1C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C25H25N5O2/c1-2-32-24-19(16-26-22(29-24)17-8-4-3-5-9-17)25(31)30-14-12-18(13-15-30)23-27-20-10-6-7-11-21(20)28-23/h3-11,16,18H,2,12-15H2,1H3,(H,27,28)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249484
PNG
(4-((1H-imidazol-2-yl)methyl)-1-(biphenyl-4-ylsulfo...)
Show SMILES O=S(=O)(N1CCC(Cc2ncc[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H23N3O2S/c25-27(26,20-8-6-19(7-9-20)18-4-2-1-3-5-18)24-14-10-17(11-15-24)16-21-22-12-13-23-21/h1-9,12-13,17H,10-11,14-16H2,(H,22,23)
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n/an/a 6.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249132
PNG
((4-((1H-imidazol-2-yl)methyl)piperidin-1-yl)(4'-fl...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(Cc2ncc[nH]2)CC1
Show InChI InChI=1S/C22H22FN3O/c23-20-7-5-18(6-8-20)17-1-3-19(4-2-17)22(27)26-13-9-16(10-14-26)15-21-24-11-12-25-21/h1-8,11-12,16H,9-10,13-15H2,(H,24,25)
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n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249459
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(5-phe...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O/c29-24(22-11-10-19(16-25-22)17-6-2-1-3-7-17)28-14-12-18(13-15-28)23-26-20-8-4-5-9-21(20)27-23/h1-11,16,18H,12-15H2,(H,26,27)
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n/an/a 12n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249464
PNG
((4-((1H-imidazol-2-yl)methyl)piperidin-1-yl)(biphe...)
Show SMILES O=C(N1CCC(Cc2ncc[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H23N3O/c26-22(20-8-6-19(7-9-20)18-4-2-1-3-5-18)25-14-10-17(11-15-25)16-21-23-12-13-24-21/h1-9,12-13,17H,10-11,14-16H2,(H,23,24)
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249173
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C24H22N4O/c29-24(19-10-8-17(9-11-19)20-5-3-4-14-25-20)28-15-12-18(13-16-28)23-26-21-6-1-2-7-22(21)27-23/h1-11,14,18H,12-13,15-16H2,(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249134
PNG
(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Show SMILES CC(C)c1cc(nc(N)n1)-c1ccc(F)c2ccccc12
Show InChI InChI=1S/C17H16FN3/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13/h3-10H,1-2H3,(H2,19,20,21)
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n/an/a 19n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249175
PNG
(3-(4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carbon...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C24H22N4O2/c29-23-18(10-11-19(27-23)16-6-2-1-3-7-16)24(30)28-14-12-17(13-15-28)22-25-20-8-4-5-9-21(20)26-22/h1-11,17H,12-15H2,(H,25,26)(H,27,29)
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n/an/a 22n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249131
PNG
(1-(4'-fluorobiphenyl-4-ylsulfonyl)-4-(1H-imidazol-...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)c1ncc[nH]1
Show InChI InChI=1S/C20H20FN3O2S/c21-18-5-1-15(2-6-18)16-3-7-19(8-4-16)27(25,26)24-13-9-17(10-14-24)20-22-11-12-23-20/h1-8,11-12,17H,9-10,13-14H2,(H,22,23)
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n/an/a 30n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249424
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-cyc...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C25H29N3O/c29-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)28-16-14-20(15-17-28)24-26-22-8-4-5-9-23(22)27-24/h4-5,8-13,18,20H,1-3,6-7,14-17H2,(H,26,27)
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n/an/a 31n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249483
PNG
(1-(biphenyl-4-ylsulfonyl)-4-(1H-imidazol-2-yl)pipe...)
Show SMILES O=S(=O)(N1CCC(CC1)c1ncc[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21N3O2S/c24-26(25,23-14-10-18(11-15-23)20-21-12-13-22-20)19-8-6-17(7-9-19)16-4-2-1-3-5-16/h1-9,12-13,18H,10-11,14-15H2,(H,21,22)
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n/an/a 32n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249486
PNG
((4-(1H-imidazol-2-yl)piperidin-1-yl)(4'-fluorobiph...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1ncc[nH]1
Show InChI InChI=1S/C21H20FN3O/c22-19-7-5-16(6-8-19)15-1-3-18(4-2-15)21(26)25-13-9-17(10-14-25)20-23-11-12-24-20/h1-8,11-12,17H,9-10,13-14H2,(H,23,24)
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n/an/a 35n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249425
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(pi...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C24H28N4O/c29-24(19-8-10-20(11-9-19)27-14-4-1-5-15-27)28-16-12-18(13-17-28)23-25-21-6-2-3-7-22(21)26-23/h2-3,6-11,18H,1,4-5,12-17H2,(H,25,26)
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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249177
PNG
(2-(1-(biphenyl-4-ylmethyl)piperidin-4-yl)-1H-benzo...)
Show SMILES C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H25N3/c1-2-6-20(7-3-1)21-12-10-19(11-13-21)18-28-16-14-22(15-17-28)25-26-23-8-4-5-9-24(23)27-25/h1-13,22H,14-18H2,(H,26,27)
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n/an/a 65n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249462
PNG
((4-(1H-imidazol-2-yl)piperidin-1-yl)(biphenyl-4-yl...)
Show SMILES O=C(N1CCC(CC1)c1ncc[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H21N3O/c25-21(24-14-10-18(11-15-24)20-22-12-13-23-20)19-8-6-17(7-9-19)16-4-2-1-3-5-16/h1-9,12-13,18H,10-11,14-15H2,(H,22,23)
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n/an/a 76n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249460
PNG
(CHEMBL472416 | biphenyl-4-yl(4-(1-methyl-1H-benzo[...)
Show SMILES Cn1c(nc2ccccc12)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H25N3O/c1-28-24-10-6-5-9-23(24)27-25(28)21-15-17-29(18-16-21)26(30)22-13-11-20(12-14-22)19-7-3-2-4-8-19/h2-14,21H,15-18H2,1H3
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n/an/a 80n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249456
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4'-(t...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H22F3N3O2/c27-26(28,29)34-21-11-9-18(10-12-21)17-5-7-20(8-6-17)25(33)32-15-13-19(14-16-32)24-30-22-3-1-2-4-23(22)31-24/h1-12,19H,13-16H2,(H,30,31)
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n/an/a 95n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249174
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ncccn1
Show InChI InChI=1S/C23H21N5O/c29-23(18-8-6-16(7-9-18)21-24-12-3-13-25-21)28-14-10-17(11-15-28)22-26-19-4-1-2-5-20(19)27-22/h1-9,12-13,17H,10-11,14-15H2,(H,26,27)
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n/an/a 120n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249179
PNG
((3-(1H-benzo[d]imidazol-2-yl)azetidin-1-yl)(biphen...)
Show SMILES O=C(N1CC(C1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H19N3O/c27-23(18-12-10-17(11-13-18)16-6-2-1-3-7-16)26-14-19(15-26)22-24-20-8-4-5-9-21(20)25-22/h1-13,19H,14-15H2,(H,24,25)
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n/an/a 150n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249180
PNG
(5-((4-(6-chlorothieno[2,3-d]pyrimidin-4-ylamino)pi...)
Show SMILES Fc1ccc(CN2CCC(CC2)Nc2ncnc3sc(Cl)cc23)cc1C#N
Show InChI InChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)
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n/an/a 270n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249482
PNG
((4-((1H-benzo[d]imidazol-2-yl)methyl)piperidin-1-y...)
Show SMILES O=C(N1CCC(Cc2nc3ccccc3[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H25N3O/c30-26(22-12-10-21(11-13-22)20-6-2-1-3-7-20)29-16-14-19(15-17-29)18-25-27-23-8-4-5-9-24(23)28-25/h1-13,19H,14-18H2,(H,27,28)
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n/an/a 300n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249172
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C24H22N4O/c29-24(19-9-7-17(8-10-19)20-4-3-13-25-16-20)28-14-11-18(12-15-28)23-26-21-5-1-2-6-22(21)27-23/h1-10,13,16,18H,11-12,14-15H2,(H,26,27)
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n/an/a 340n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249458
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-phe...)
Show SMILES O=C(C1CCC(CC1)c1ccccc1)N1CCC(CC1)c1nc2ccccc2[nH]1 |(22.17,-46.12,;22.16,-44.58,;20.83,-43.81,;20.83,-42.28,;19.5,-41.51,;18.16,-42.28,;18.16,-43.82,;19.5,-44.59,;16.84,-41.51,;16.84,-39.96,;15.51,-39.19,;14.17,-39.96,;14.18,-41.51,;15.51,-42.27,;23.49,-43.8,;24.83,-44.58,;26.16,-43.81,;26.17,-42.27,;24.83,-41.5,;23.49,-42.27,;27.5,-41.51,;27.66,-39.98,;29.17,-39.66,;29.93,-38.33,;31.47,-38.33,;32.24,-39.67,;31.47,-41,;29.93,-40.99,;28.9,-42.14,)|
Show InChI InChI=1S/C25H29N3O/c29-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)28-16-14-20(15-17-28)24-26-22-8-4-5-9-23(22)27-24/h1-9,19-21H,10-17H2,(H,26,27)
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n/an/a 610n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249128
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(2-phe...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1cnc(nc1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O/c29-23(18-14-24-21(25-15-18)16-6-2-1-3-7-16)28-12-10-17(11-13-28)22-26-19-8-4-5-9-20(19)27-22/h1-9,14-15,17H,10-13H2,(H,26,27)
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n/an/a 710n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249176
PNG
(2-(1-(biphenyl-4-ylsulfonyl)piperidin-4-yl)-1H-ben...)
Show SMILES O=S(=O)(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H23N3O2S/c28-30(29,21-12-10-19(11-13-21)18-6-2-1-3-7-18)27-16-14-20(15-17-27)24-25-22-8-4-5-9-23(22)26-24/h1-13,20H,14-17H2,(H,25,26)
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n/an/a 840n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249130
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-eth...)
Show SMILES CCOc1nc(ncc1C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C25H25N5O2/c1-2-32-24-19(16-26-22(29-24)17-8-4-3-5-9-17)25(31)30-14-12-18(13-15-30)23-27-20-10-6-7-11-21(20)28-23/h3-11,16,18H,2,12-15H2,1H3,(H,27,28)
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n/an/a 910n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249484
PNG
(4-((1H-imidazol-2-yl)methyl)-1-(biphenyl-4-ylsulfo...)
Show SMILES O=S(=O)(N1CCC(Cc2ncc[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H23N3O2S/c25-27(26,20-8-6-19(7-9-20)18-4-2-1-3-5-18)24-14-10-17(11-15-24)16-21-22-12-13-23-21/h1-9,12-13,17H,10-11,14-16H2,(H,22,23)
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n/an/a 990n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249485
PNG
(2-((1-(biphenyl-4-ylsulfonyl)piperidin-4-yl)methyl...)
Show SMILES O=S(=O)(N1CCC(Cc2nc3ccccc3[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H25N3O2S/c29-31(30,22-12-10-21(11-13-22)20-6-2-1-3-7-20)28-16-14-19(15-17-28)18-25-26-23-8-4-5-9-24(23)27-25/h1-13,19H,14-18H2,(H,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249424
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-cyc...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C25H29N3O/c29-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)28-16-14-20(15-17-28)24-26-22-8-4-5-9-23(22)27-24/h4-5,8-13,18,20H,1-3,6-7,14-17H2,(H,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249126
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(biphe...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H23N3O/c29-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)28-16-14-20(15-17-28)24-26-22-8-4-5-9-23(22)27-24/h1-13,20H,14-17H2,(H,26,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249129
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(3-met...)
Show SMILES COc1cc(ccc1C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C26H25N3O2/c1-31-24-17-20(18-7-3-2-4-8-18)11-12-21(24)26(30)29-15-13-19(14-16-29)25-27-22-9-5-6-10-23(22)28-25/h2-12,17,19H,13-16H2,1H3,(H,27,28)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249171
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C24H22N4O/c29-24(20-7-5-17(6-8-20)18-9-13-25-14-10-18)28-15-11-19(12-16-28)23-26-21-3-1-2-4-22(21)27-23/h1-10,13-14,19H,11-12,15-16H2,(H,26,27)
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n/an/a>1.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249461
PNG
((4-(benzo[d]oxazol-2-yl)piperidin-1-yl)(biphenyl-4...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2o1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H22N2O2/c28-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)27-16-14-20(15-17-27)24-26-22-8-4-5-9-23(22)29-24/h1-13,20H,14-17H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249173
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C24H22N4O/c29-24(19-10-8-17(9-11-19)20-5-3-4-14-25-20)28-15-12-18(13-16-28)23-26-21-6-1-2-7-22(21)27-23/h1-11,14,18H,12-13,15-16H2,(H,26,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249426
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-mor...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C23H26N4O2/c28-23(18-5-7-19(8-6-18)26-13-15-29-16-14-26)27-11-9-17(10-12-27)22-24-20-3-1-2-4-21(20)25-22/h1-8,17H,9-16H2,(H,24,25)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249457
PNG
(4'-(4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carbo...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O2/c27-24(31)19-9-5-17(6-10-19)18-7-11-21(12-8-18)26(32)30-15-13-20(14-16-30)25-28-22-3-1-2-4-23(22)29-25/h1-12,20H,13-16H2,(H2,27,31)(H,28,29)
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n/an/a>2.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249459
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(5-phe...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O/c29-24(22-11-10-19(16-25-22)17-6-2-1-3-7-17)28-14-12-18(13-15-28)23-26-20-8-4-5-9-21(20)27-23/h1-11,16,18H,12-15H2,(H,26,27)
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n/an/a>2.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249174
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ncccn1
Show InChI InChI=1S/C23H21N5O/c29-23(18-8-6-16(7-9-18)21-24-12-3-13-25-21)28-14-10-17(11-15-28)22-26-19-4-1-2-5-20(19)27-22/h1-9,12-13,17H,10-11,14-15H2,(H,26,27)
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n/an/a>2.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249179
PNG
((3-(1H-benzo[d]imidazol-2-yl)azetidin-1-yl)(biphen...)
Show SMILES O=C(N1CC(C1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H19N3O/c27-23(18-12-10-17(11-13-18)16-6-2-1-3-7-16)26-14-19(15-26)22-24-20-8-4-5-9-21(20)25-22/h1-13,19H,14-15H2,(H,24,25)
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n/an/a>2.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249175
PNG
(3-(4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carbon...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C24H22N4O2/c29-23-18(10-11-19(27-23)16-6-2-1-3-7-16)24(30)28-14-12-17(13-15-28)22-25-20-8-4-5-9-21(20)26-22/h1-11,17H,12-15H2,(H,25,26)(H,27,29)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249427
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4'-me...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H25N3O2/c1-31-22-12-10-19(11-13-22)18-6-8-21(9-7-18)26(30)29-16-14-20(15-17-29)25-27-23-4-2-3-5-24(23)28-25/h2-13,20H,14-17H2,1H3,(H,27,28)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249463
PNG
(1-(biphenylcarbonyl)piperidine-4-carboxamide | CHE...)
Show SMILES NC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H20N2O2/c20-18(22)16-10-12-21(13-11-16)19(23)17-8-6-15(7-9-17)14-4-2-1-3-5-14/h1-9,16H,10-13H2,(H2,20,22)
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n/an/a>6.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249178
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperazin-1-yl)(biphe...)
Show SMILES O=C(N1CCN(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O/c29-23(20-12-10-19(11-13-20)18-6-2-1-3-7-18)27-14-16-28(17-15-27)24-25-21-8-4-5-9-22(21)26-24/h1-13H,14-17H2,(H,25,26)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249177
PNG
(2-(1-(biphenyl-4-ylmethyl)piperidin-4-yl)-1H-benzo...)
Show SMILES C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H25N3/c1-2-6-20(7-3-1)21-12-10-19(11-13-21)18-28-16-14-22(15-17-28)25-26-23-8-4-5-9-24(23)27-25/h1-13,22H,14-18H2,(H,26,27)
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n/an/a 7.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249460
PNG
(CHEMBL472416 | biphenyl-4-yl(4-(1-methyl-1H-benzo[...)
Show SMILES Cn1c(nc2ccccc12)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H25N3O/c1-28-24-10-6-5-9-23(24)27-25(28)21-15-17-29(18-16-21)26(30)22-13-11-20(12-14-22)19-7-3-2-4-8-19/h2-14,21H,15-18H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249127
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(pheny...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C19H19N3O/c23-19(15-6-2-1-3-7-15)22-12-10-14(11-13-22)18-20-16-8-4-5-9-17(16)21-18/h1-9,14H,10-13H2,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249127
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(pheny...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C19H19N3O/c23-19(15-6-2-1-3-7-15)22-12-10-14(11-13-22)18-20-16-8-4-5-9-17(16)21-18/h1-9,14H,10-13H2,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249425
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(pi...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C24H28N4O/c29-24(19-8-10-20(11-9-19)27-14-4-1-5-15-27)28-16-12-18(13-17-28)23-25-21-6-2-3-7-22(21)26-23/h2-3,6-11,18H,1,4-5,12-17H2,(H,25,26)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249170
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-bro...)
Show SMILES Brc1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C19H18BrN3O/c20-15-7-5-14(6-8-15)19(24)23-11-9-13(10-12-23)18-21-16-3-1-2-4-17(16)22-18/h1-8,13H,9-12H2,(H,21,22)
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n/an/a>1.30E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249171
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C24H22N4O/c29-24(20-7-5-17(6-8-20)18-9-13-25-14-10-18)28-15-11-19(12-16-28)23-26-21-3-1-2-4-22(21)27-23/h1-10,13-14,19H,11-12,15-16H2,(H,26,27)
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n/an/a>1.30E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249172
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(py...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C24H22N4O/c29-24(19-9-7-17(8-10-19)20-4-3-13-25-16-20)28-14-11-18(12-15-28)23-26-21-5-1-2-6-22(21)27-23/h1-10,13,16,18H,11-12,14-15H2,(H,26,27)
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n/an/a>1.40E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249456
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4'-(t...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H22F3N3O2/c27-26(28,29)34-21-11-9-18(10-12-21)17-5-7-20(8-6-17)25(33)32-15-13-19(14-16-32)24-30-22-3-1-2-4-23(22)31-24/h1-12,19H,13-16H2,(H,30,31)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249461
PNG
((4-(benzo[d]oxazol-2-yl)piperidin-1-yl)(biphenyl-4...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2o1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H22N2O2/c28-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)27-16-14-20(15-17-27)24-26-22-8-4-5-9-23(22)29-24/h1-13,20H,14-17H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249458
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-phe...)
Show SMILES O=C(C1CCC(CC1)c1ccccc1)N1CCC(CC1)c1nc2ccccc2[nH]1 |(22.17,-46.12,;22.16,-44.58,;20.83,-43.81,;20.83,-42.28,;19.5,-41.51,;18.16,-42.28,;18.16,-43.82,;19.5,-44.59,;16.84,-41.51,;16.84,-39.96,;15.51,-39.19,;14.17,-39.96,;14.18,-41.51,;15.51,-42.27,;23.49,-43.8,;24.83,-44.58,;26.16,-43.81,;26.17,-42.27,;24.83,-41.5,;23.49,-42.27,;27.5,-41.51,;27.66,-39.98,;29.17,-39.66,;29.93,-38.33,;31.47,-38.33,;32.24,-39.67,;31.47,-41,;29.93,-40.99,;28.9,-42.14,)|
Show InChI InChI=1S/C25H29N3O/c29-25(21-12-10-19(11-13-21)18-6-2-1-3-7-18)28-16-14-20(15-17-28)24-26-22-8-4-5-9-23(22)27-24/h1-9,19-21H,10-17H2,(H,26,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249485
PNG
(2-((1-(biphenyl-4-ylsulfonyl)piperidin-4-yl)methyl...)
Show SMILES O=S(=O)(N1CCC(Cc2nc3ccccc3[nH]2)CC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H25N3O2S/c29-31(30,22-12-10-21(11-13-22)20-6-2-1-3-7-20)28-16-14-19(15-17-28)18-25-26-23-8-4-5-9-24(23)27-25/h1-13,19H,14-18H2,(H,26,27)
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n/an/a>2.30E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249457
PNG
(4'-(4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carbo...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H24N4O2/c27-24(31)19-9-5-17(6-10-19)18-7-11-21(12-8-18)26(32)30-15-13-20(14-16-30)25-28-22-3-1-2-4-23(22)29-25/h1-12,20H,13-16H2,(H2,27,31)(H,28,29)
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n/an/a>2.40E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249178
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperazin-1-yl)(biphe...)
Show SMILES O=C(N1CCN(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O/c29-23(20-12-10-19(11-13-20)18-6-2-1-3-7-18)27-14-16-28(17-15-27)24-25-21-8-4-5-9-22(21)26-24/h1-13H,14-17H2,(H,25,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249170
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-bro...)
Show SMILES Brc1ccc(cc1)C(=O)N1CCC(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C19H18BrN3O/c20-15-7-5-14(6-8-15)19(24)23-11-9-13(10-12-23)18-21-16-3-1-2-4-17(16)22-18/h1-8,13H,9-12H2,(H,21,22)
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n/an/a>2.60E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50249426
PNG
((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-mor...)
Show SMILES O=C(N1CCC(CC1)c1nc2ccccc2[nH]1)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C23H26N4O2/c28-23(18-5-7-19(8-6-18)26-13-15-29-16-14-26)27-11-9-17(10-12-27)22-24-20-3-1-2-4-21(20)25-22/h1-8,17H,9-16H2,(H,24,25)
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n/an/a>2.60E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL


Assay Description
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux ...

Bioorg Med Chem Lett 19: 2206-10 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.126
BindingDB Entry DOI: 10.7270/Q20Z735D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%