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PubMed code 2016728

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50006878
PNG
((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)cc2)C1=O)c1ccccc1 |c:9|
Show InChI InChI=1S/C24H22N4O2/c1-16-12-14-18(15-13-16)25-24(30)27-22-23(29)28(2)20-11-7-6-10-19(20)21(26-22)17-8-4-3-5-9-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranes

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50006878
PNG
((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)cc2)C1=O)c1ccccc1 |c:9|
Show InChI InChI=1S/C24H22N4O2/c1-16-12-14-18(15-13-16)25-24(30)27-22-23(29)28(2)20-11-7-6-10-19(20)21(26-22)17-8-4-3-5-9-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 5.30n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50006878
PNG
((R)-1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)cc2)C1=O)c1ccccc1 |c:9|
Show InChI InChI=1S/C24H22N4O2/c1-16-12-14-18(15-13-16)25-24(30)27-22-23(29)28(2)20-11-7-6-10-19(20)21(26-22)17-8-4-3-5-9-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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n/an/a 7.30n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranes

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50006842
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-isopropox...)
Show SMILES CC(C)Oc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3
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n/an/a 9.30n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011943
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-dimethyla...)
Show SMILES CN(C)c1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H23BrN4O/c1-30(2)19-6-5-7-20(15-19)31-25(29-24-9-4-3-8-21(24)26(31)32)13-10-17-16-28-23-12-11-18(27)14-22(17)23/h3-9,11-12,14-16,28H,10,13H2,1-2H3
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n/an/a 16n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50006838
PNG
(2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-isopropoxy-phenyl...)
Show SMILES CC(C)Oc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H25N3O2/c1-18(2)32-21-9-7-8-20(16-21)30-26(29-25-13-6-4-11-23(25)27(30)31)15-14-19-17-28-24-12-5-3-10-22(19)24/h3-13,16-18,28H,14-15H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011957
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-ethyl-phe...)
Show SMILES CCc1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H22BrN3O/c1-2-17-7-11-20(12-8-17)30-25(29-24-6-4-3-5-21(24)26(30)31)14-9-18-16-28-23-13-10-19(27)15-22(18)23/h3-8,10-13,15-16,28H,2,9,14H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011939
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-methoxy-p...)
Show SMILES COc1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3O2/c1-31-19-10-8-18(9-11-19)29-24(28-23-5-3-2-4-20(23)25(29)30)13-6-16-15-27-22-12-7-17(26)14-21(16)22/h2-5,7-12,14-15,27H,6,13H2,1H3
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n/an/a 31n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011953
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-dimethyla...)
Show SMILES CN(C)c1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H23BrN4O/c1-30(2)19-9-11-20(12-10-19)31-25(29-24-6-4-3-5-21(24)26(31)32)14-7-17-16-28-23-13-8-18(27)15-22(17)23/h3-6,8-13,15-16,28H,7,14H2,1-2H3
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n/an/a 33n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011954
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-methylsul...)
Show SMILES CSc1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3OS/c1-31-19-10-8-18(9-11-19)29-24(28-23-5-3-2-4-20(23)25(29)30)13-6-16-15-27-22-12-7-17(26)14-21(16)22/h2-5,7-12,14-15,27H,6,13H2,1H3
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n/an/a 37n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011965
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-isopropyl...)
Show SMILES CC(C)c1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O/c1-17(2)18-7-11-21(12-8-18)31-26(30-25-6-4-3-5-22(25)27(31)32)14-9-19-16-29-24-13-10-20(28)15-23(19)24/h3-8,10-13,15-17,29H,9,14H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011942
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-methoxy-p...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3O2/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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n/an/a 38n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011942
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-methoxy-p...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3O2/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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n/an/a 38n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011948
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-methylsul...)
Show SMILES CSc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3OS/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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n/an/a 46n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011940
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H22BrN3O/c1-2-17-6-5-7-20(14-17)30-25(29-24-9-4-3-8-21(24)26(30)31)13-10-18-16-28-23-12-11-19(27)15-22(18)23/h3-9,11-12,14-16,28H,2,10,13H2,1H3
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n/an/a 46n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011945
PNG
(2-[2-(5-Chloro-1H-indol-3-yl)-ethyl]-3-(3-methoxy-...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Cl)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20ClN3O2/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011946
PNG
(3-(3-Methoxy-phenyl)-2-[2-(5-methyl-1H-indol-3-yl)...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(C)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H23N3O2/c1-17-10-12-23-22(14-17)18(16-27-23)11-13-25-28-24-9-4-3-8-21(24)26(30)29(25)19-6-5-7-20(15-19)31-2/h3-10,12,14-16,27H,11,13H2,1-2H3
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n/an/a 55n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011950
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-propoxy-p...)
Show SMILES CCCOc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O2/c1-2-14-33-21-7-5-6-20(16-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-17-29-24-12-11-19(28)15-23(18)24/h3-9,11-12,15-17,29H,2,10,13-14H2,1H3
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n/an/a 58n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011958
PNG
(2-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-3-(3-methoxy...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(OC)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H23N3O3/c1-31-19-7-5-6-18(14-19)29-25(28-24-9-4-3-8-21(24)26(29)30)13-10-17-16-27-23-12-11-20(32-2)15-22(17)23/h3-9,11-12,14-16,27H,10,13H2,1-2H3
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n/an/a 67n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011966
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-cyclopent...)
Show SMILES Brc1ccc2[nH]cc(CCc3nc4ccccc4c(=O)n3-c3cccc(OC4CCCC4)c3)c2c1
Show InChI InChI=1S/C29H26BrN3O2/c30-20-13-14-26-25(16-20)19(18-31-26)12-15-28-32-27-11-4-3-10-24(27)29(34)33(28)21-6-5-9-23(17-21)35-22-7-1-2-8-22/h3-6,9-11,13-14,16-18,22,31H,1-2,7-8,12,15H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011962
PNG
(3-(3-Ethyl-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-...)
Show SMILES CCc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H23N3O/c1-2-18-8-7-9-20(16-18)29-25(28-24-13-6-4-11-22(24)26(29)30)15-14-19-17-27-23-12-5-3-10-21(19)23/h3-13,16-17,27H,2,14-15H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50006842
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-isopropox...)
Show SMILES CC(C)Oc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011961
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-ethoxy-ph...)
Show SMILES CCOc1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H22BrN3O2/c1-2-32-20-11-9-19(10-12-20)30-25(29-24-6-4-3-5-21(24)26(30)31)14-7-17-16-28-23-13-8-18(27)15-22(17)23/h3-6,8-13,15-16,28H,2,7,14H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011952
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-propyl]-3-(3-ethyl-ph...)
Show SMILES CCc1cccc(c1)-n1c(CC(C)c2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O/c1-3-18-7-6-8-20(14-18)31-26(30-25-10-5-4-9-21(25)27(31)32)13-17(2)23-16-29-24-12-11-19(28)15-22(23)24/h4-12,14-17,29H,3,13H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011947
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(4-isopropox...)
Show SMILES CC(C)Oc1ccc(cc1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O2/c1-17(2)33-21-11-9-20(10-12-21)31-26(30-25-6-4-3-5-22(25)27(31)32)14-7-18-16-29-24-13-8-19(28)15-23(18)24/h3-6,8-13,15-17,29H,7,14H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011941
PNG
(2-[2-(5-Fluoro-1H-indol-3-yl)-ethyl]-3-(3-methoxy-...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(F)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20FN3O2/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011964
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3,4-dimetho...)
Show SMILES COc1ccc(cc1OC)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H22BrN3O3/c1-32-23-11-9-18(14-24(23)33-2)30-25(29-22-6-4-3-5-19(22)26(30)31)12-7-16-15-28-21-10-8-17(27)13-20(16)21/h3-6,8-11,13-15,28H,7,12H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011949
PNG
(2-[2-(1H-Indol-3-yl)-ethyl]-3-m-tolyl-3H-quinazoli...)
Show SMILES Cc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H21N3O/c1-17-7-6-8-19(15-17)28-24(27-23-12-5-3-10-21(23)25(28)29)14-13-18-16-26-22-11-4-2-9-20(18)22/h2-12,15-16,26H,13-14H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011956
PNG
(2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-methoxy-phenyl)-3...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H21N3O2/c1-30-19-8-6-7-18(15-19)28-24(27-23-12-5-3-10-21(23)25(28)29)14-13-17-16-26-22-11-4-2-9-20(17)22/h2-12,15-16,26H,13-14H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50006842
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-isopropox...)
Show SMILES CC(C)Oc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3
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n/an/a 160n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011963
PNG
(3-Benzo[1,3]dioxol-5-yl-2-[2-(1H-indol-3-yl)-ethyl...)
Show SMILES O=c1n(c(CCc2c[nH]c3ccccc23)nc2ccccc12)-c1ccc2OCOc2c1
Show InChI InChI=1S/C25H19N3O3/c29-25-19-6-2-4-8-21(19)27-24(12-9-16-14-26-20-7-3-1-5-18(16)20)28(25)17-10-11-22-23(13-17)31-15-30-22/h1-8,10-11,13-14,26H,9,12,15H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011960
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-trifluoro...)
Show SMILES FC(F)(F)c1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H17BrF3N3O/c26-17-9-10-21-20(13-17)15(14-30-21)8-11-23-31-22-7-2-1-6-19(22)24(33)32(23)18-5-3-4-16(12-18)25(27,28)29/h1-7,9-10,12-14,30H,8,11H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50011940
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H22BrN3O/c1-2-17-6-5-7-20(14-17)30-25(29-24-9-4-3-8-21(24)26(30)31)13-10-18-16-28-23-12-11-19(27)15-22(18)23/h3-9,11-12,14-16,28H,2,10,13H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranes

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50011942
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-methoxy-p...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3O2/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011959
PNG
(3-(3-Bromo-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-...)
Show SMILES Brc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C24H18BrN3O/c25-17-6-5-7-18(14-17)28-23(27-22-11-4-2-9-20(22)24(28)29)13-12-16-15-26-21-10-3-1-8-19(16)21/h1-11,14-15,26H,12-13H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011955
PNG
(2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H18F3N3O/c26-25(27,28)17-6-5-7-18(14-17)31-23(30-22-11-4-2-9-20(22)24(31)32)13-12-16-15-29-21-10-3-1-8-19(16)21/h1-11,14-15,29H,12-13H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50006837
PNG
(2-[2-(1H-Indol-3-yl)-ethyl]-3-phenyl-3H-quinazolin...)
Show SMILES O=c1n(c(CCc2c[nH]c3ccccc23)nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C24H19N3O/c28-24-20-11-5-7-13-22(20)26-23(27(24)18-8-2-1-3-9-18)15-14-17-16-25-21-12-6-4-10-19(17)21/h1-13,16,25H,14-15H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011944
PNG
(3-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H...)
Show SMILES Clc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C24H18ClN3O/c25-17-6-5-7-18(14-17)28-23(27-22-11-4-2-9-20(22)24(28)29)13-12-16-15-26-21-10-3-1-8-19(16)21/h1-11,14-15,26H,12-13H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(MOUSE)		BDBM50011951
PNG
(3-(3-Fluoro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H...)
Show SMILES Fc1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C24H18FN3O/c25-17-6-5-7-18(14-17)28-23(27-22-11-4-2-9-20(22)24(28)29)13-12-16-15-26-21-10-3-1-8-19(16)21/h1-11,14-15,26H,12-13H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50011940
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C26H22BrN3O/c1-2-17-6-5-7-20(14-17)30-25(29-24-9-4-3-8-21(24)26(30)31)13-10-18-16-28-23-12-11-19(27)15-22(18)23/h3-9,11-12,14-16,28H,2,10,13H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50011942
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-ethyl]-3-(3-methoxy-p...)
Show SMILES COc1cccc(c1)-n1c(CCc2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20BrN3O2/c1-31-19-6-4-5-18(14-19)29-24(28-23-8-3-2-7-20(23)25(29)30)12-9-16-15-27-22-11-10-17(26)13-21(16)22/h2-8,10-11,13-15,27H,9,12H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50011952
PNG
(2-[2-(5-Bromo-1H-indol-3-yl)-propyl]-3-(3-ethyl-ph...)
Show SMILES CCc1cccc(c1)-n1c(CC(C)c2c[nH]c3ccc(Br)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C27H24BrN3O/c1-3-18-7-6-8-20(14-18)31-26(30-25-10-5-4-9-21(25)27(31)32)13-17(2)23-16-29-24-12-11-19(28)15-22(23)24/h4-12,14-17,29H,3,13H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
Gastrin/cholecystokinin type B receptor


(Homo sapiens (Human))		BDBM50011955
PNG
(2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-trifluoromethyl-p...)
Show SMILES FC(F)(F)c1cccc(c1)-n1c(CCc2c[nH]c3ccccc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H18F3N3O/c26-25(27,28)17-6-5-7-18(14-17)31-23(30-22-11-4-2-9-20(22)24(31)32)13-12-16-15-29-21-10-3-1-8-19(16)21/h1-11,14-15,29H,12-13H2
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n/an/a 8.20E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor

J Med Chem 34: 1505-8 (1991)


BindingDB Entry DOI: 10.7270/Q2Z60N1P
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%