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PubMed code 20196613

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308556
PNG
(3-(4-(3-hydroxypropyl)piperazin-1-yl)-1-(2-propoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C25H34N6O4/c1-3-14-35-15-12-31-22-16-20(19-5-6-23(34-2)27-17-19)26-18-21(22)28-24(25(31)33)30-10-8-29(9-11-30)7-4-13-32/h5-6,16-18,32H,3-4,7-15H2,1-2H3
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n/an/a 0.180n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308563
PNG
(3-(4-(2-hydroxy-2-methylpropyl)piperazin-1-yl)-1-(...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC(C)(C)O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C26H36N6O4/c1-5-13-36-14-12-32-22-15-20(19-6-7-23(35-4)28-16-19)27-17-21(22)29-24(25(32)33)31-10-8-30(9-11-31)18-26(2,3)34/h6-7,15-17,34H,5,8-14,18H2,1-4H3
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n/an/a 0.210n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308558
PNG
(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O3/c1-4-13-33-14-12-30-21-15-19(18-6-7-22(32-3)26-16-18)25-17-20(21)27-23(24(30)31)29-10-8-28(5-2)9-11-29/h6-7,15-17H,4-5,8-14H2,1-3H3
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n/an/a 0.220n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308564
PNG
((R)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(C[C@@H](C)O)CC2)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C25H34N6O4/c1-4-12-35-13-11-31-22-14-20(19-5-6-23(34-3)27-15-19)26-16-21(22)28-24(25(31)33)30-9-7-29(8-10-30)17-18(2)32/h5-6,14-16,18,32H,4,7-13,17H2,1-3H3/t18-/m1/s1
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n/an/a 0.230n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50300957
PNG
(3-(2-aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H26N6O3/c1-3-9-29-10-8-26-17-11-15(14-4-5-18(28-2)24-12-14)23-13-16(17)25-19(20(26)27)22-7-6-21/h4-5,11-13H,3,6-10,21H2,1-2H3,(H,22,25)
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n/an/a 0.25n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308561
PNG
((+/-)-3-(4-((2R,3R)-3-hydroxybutan-2-yl)piperazin-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC2)[C@H](C)[C@@H](C)O)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C26H36N6O4/c1-5-13-36-14-12-32-23-15-21(20-6-7-24(35-4)28-16-20)27-17-22(23)29-25(26(32)34)31-10-8-30(9-11-31)18(2)19(3)33/h6-7,15-19,33H,5,8-14H2,1-4H3/t18-,19-/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308553
PNG
((S)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(C[C@H](C)O)CC2)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C25H34N6O4/c1-4-12-35-13-11-31-22-14-20(19-5-6-23(34-3)27-15-19)26-16-21(22)28-24(25(31)33)30-9-7-29(8-10-30)17-18(2)32/h5-6,14-16,18,32H,4,7-13,17H2,1-3H3/t18-/m0/s1
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n/an/a 0.310n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308562
PNG
((+/-)-3-(4-((2S,3R)-3-hydroxybutan-2-yl)piperazin-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC2)[C@@H](C)[C@@H](C)O)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C26H36N6O4/c1-5-13-36-14-12-32-23-15-21(20-6-7-24(35-4)28-16-20)27-17-22(23)29-25(26(32)34)31-10-8-30(9-11-31)18(2)19(3)33/h6-7,15-19,33H,5,8-14H2,1-4H3/t18-,19+/m0/s1
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n/an/a 0.330n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308555
PNG
(3-(4-(2-hydroxyethyl)-1,4-diazepan-1-yl)-1-(2-isop...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C25H34N6O4/c1-3-14-35-15-12-31-22-16-20(19-5-6-23(34-2)27-17-19)26-18-21(22)28-24(25(31)33)30-8-4-7-29(9-10-30)11-13-32/h5-6,16-18,32H,3-4,7-15H2,1-2H3
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n/an/a 0.720n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308554
PNG
(3-(4-(3-hydroxypropyl)-1,4-diazepan-1-yl)-1-(2-pro...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCCN(CCCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C26H36N6O4/c1-3-15-36-16-13-32-23-17-21(20-6-7-24(35-2)28-18-20)27-19-22(23)29-25(26(32)34)31-10-4-8-30(11-12-31)9-5-14-33/h6-7,17-19,33H,3-5,8-16H2,1-2H3
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50300958
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCNCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H30N6O4/c1-3-11-32-12-9-28-19-13-17(16-4-5-20(31-2)26-14-16)25-15-18(19)27-21(22(28)30)24-7-6-23-8-10-29/h4-5,13-15,23,29H,3,6-12H2,1-2H3,(H,24,27)
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308559
PNG
(3-((1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-(...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2C[C@H]3C[C@@H]2CN3)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C23H28N6O3/c1-3-7-32-8-6-28-20-10-18(15-4-5-21(31-2)26-11-15)25-13-19(20)27-22(23(28)30)29-14-16-9-17(29)12-24-16/h4-5,10-11,13,16-17,24H,3,6-9,12,14H2,1-2H3/t16-,17-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50308560
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCNCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H28N6O3/c1-3-11-31-12-10-28-19-13-17(16-4-5-20(30-2)25-14-16)24-15-18(19)26-21(22(28)29)27-8-6-23-7-9-27/h4-5,13-15,23H,3,6-12H2,1-2H3
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n/an/a 3.30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50308562
PNG
((+/-)-3-(4-((2S,3R)-3-hydroxybutan-2-yl)piperazin-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC2)[C@@H](C)[C@@H](C)O)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C26H36N6O4/c1-5-13-36-14-12-32-23-15-21(20-6-7-24(35-4)28-16-20)27-17-22(23)29-25(26(32)34)31-10-8-30(9-11-31)18(2)19(3)33/h6-7,15-19,33H,5,8-14H2,1-4H3/t18-,19+/m0/s1
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n/an/a 54n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50308564
PNG
((R)-3-(4-(2-hydroxypropyl)piperazin-1-yl)-1-(2-iso...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(C[C@@H](C)O)CC2)c1=O)-c1ccc(OC)nc1 |r|
Show InChI InChI=1S/C25H34N6O4/c1-4-12-35-13-11-31-22-14-20(19-5-6-23(34-3)27-15-19)26-16-21(22)28-24(25(31)33)30-9-7-29(8-10-30)17-18(2)32/h5-6,14-16,18,32H,4,7-13,17H2,1-3H3/t18-/m1/s1
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n/an/a 230n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50308558
PNG
(3-(4-ethylpiperazin-1-yl)-1-(2-propoxyethyl)-7-(6-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O3/c1-4-13-33-14-12-30-21-15-19(18-6-7-22(32-3)26-16-18)25-17-20(21)27-23(24(30)31)29-10-8-28(5-2)9-11-29/h6-7,15-17H,4-5,8-14H2,1-3H3
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n/an/a 320n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50308560
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-1-(2-propoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCNCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H28N6O3/c1-3-11-31-12-10-28-19-13-17(16-4-5-20(30-2)25-14-16)24-15-18(19)26-21(22(28)29)27-8-6-23-7-9-27/h4-5,13-15,23H,3,6-12H2,1-2H3
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n/an/a 670n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a 1.79E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Phosphodiesterase 1A (PDE1A)


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE1A


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE7B


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE8B


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE4A


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE4B


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE1C


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE4C


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE4D


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))
BDBM50308557
PNG
(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCN(CCO)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE1B


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50300958
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCNCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H30N6O4/c1-3-11-32-12-9-28-19-13-17(16-4-5-20(31-2)26-14-16)25-15-18(19)27-21(22(28)30)24-7-6-23-8-10-29/h4-5,13-15,23,29H,3,6-12H2,1-2H3,(H,24,27)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp method


J Med Chem 53: 2656-60 (2010)


Article DOI: 10.1021/jm901781q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%