Affinity Data by PubMed id=21332213

PubMed code 21332213

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50339607 (1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50066974 (7-Benzyl-2,3-dihydroxy-6-methyl-4-propyl-naphthale...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50339607 (1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50339605 (1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid \| C...) Show SMILES OC(=O)c1cc2cc(ccc2n1O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50339605 (1-Hydroxy-5-phenyl-1H-indole-2-carboxylic Acid \| C...) Show SMILES OC(=O)c1cc2cc(ccc2n1O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.57E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50339606 (1-Hydroxy-6-phenyl-1H-indole-2-carboxylic Acid \| C...) Show SMILES OC(=O)c1cc2ccc(cc2n1O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.98E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM50339606 (1-Hydroxy-6-phenyl-1H-indole-2-carboxylic Acid \| C...) Show SMILES OC(=O)c1cc2ccc(cc2n1O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.54E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM23251 (1,2,5-Thiadiazole, TDA1 \| 4-hydroxy-1,2,5-thiadiaz...) Show SMILES OC(=O)c1ns[nH]c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
L-lactate dehydrogenase A chain (Homo sapiens (Human))	BDBM23242 (1,2(1,5)-Isoxazole, IOA1 \| 3-hydroxy-1,2-oxazole-4...) Show SMILES OC(=O)c1co[nH]c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%