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PubMed code 22229669

Compile data set for download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380448
PNG
(CHEMBL2018886)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C28H24N4O4/c1-17-12-21(36-27-22-14-25(34-2)26(35-3)15-24(22)29-16-30-27)10-11-23(17)32-28(33)31-20-9-8-18-6-4-5-7-19(18)13-20/h4-16H,1-3H3,(H2,31,32,33)
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n/an/a 2n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380487
PNG
(CHEMBL2018884)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H21BrN4O4/c1-14-9-17(7-8-19(14)29-24(30)28-16-6-4-5-15(25)10-16)33-23-18-11-21(31-2)22(32-3)12-20(18)26-13-27-23/h4-13H,1-3H3,(H2,28,29,30)
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n/an/a 4n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a 6n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380488
PNG
(CHEMBL2018885)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H20ClFN4O4/c1-13-8-15(5-7-19(13)30-24(31)29-14-4-6-18(26)17(25)9-14)34-23-16-10-21(32-2)22(33-3)11-20(16)27-12-28-23/h4-12H,1-3H3,(H2,29,30,31)
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n/an/a 6n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340942
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(n...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)cc3)c2cc1OC
Show InChI InChI=1S/C27H22N4O4/c1-33-24-14-22-23(15-25(24)34-2)28-16-29-26(22)35-21-11-9-19(10-12-21)30-27(32)31-20-8-7-17-5-3-4-6-18(17)13-20/h3-16H,1-2H3,(H2,30,31,32)
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n/an/a 30n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380486
PNG
(CHEMBL2018883)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(Br)cc4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H21BrN4O4/c1-14-10-17(8-9-19(14)29-24(30)28-16-6-4-15(25)5-7-16)33-23-18-11-21(31-2)22(32-3)12-20(18)26-13-27-23/h4-13H,1-3H3,(H2,28,29,30)
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n/an/a 40n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380484
PNG
(CHEMBL2018881)
Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1
Show InChI InChI=1S/C24H22N4O5/c1-30-18-6-4-5-16(11-18)28-24(29)27-15-7-9-17(10-8-15)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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n/an/a 40n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340939
PNG
(CHEMBL1761939 | N-(3-chloro-4-fluorophenyl)-N'-{4-...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H18ClFN4O4/c1-31-20-10-16-19(11-21(20)32-2)26-12-27-22(16)33-15-6-3-13(4-7-15)28-23(30)29-14-5-8-18(25)17(24)9-14/h3-12H,1-2H3,(H2,28,29,30)
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n/an/a 40n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340937
PNG
(1-(4-bromophenyl)-3-(4-(6,7-dimethoxyquinazolin-4-...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(Br)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-9-7-16(8-10-17)28-23(29)27-15-5-3-14(24)4-6-15/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a 50n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340929
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H20N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-8-16(9-11-17)27-23(28)26-15-6-4-3-5-7-15/h3-14H,1-2H3,(H2,26,27,28)
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n/an/a 60n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50162157
PNG
(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C24H22N4O5/c1-30-17-8-4-15(5-9-17)27-24(29)28-16-6-10-18(11-7-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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n/an/a 70n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340938
PNG
(1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinazol...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C23H18F2N4O4/c1-31-20-10-16-19(11-21(20)32-2)26-12-27-22(16)33-15-6-4-14(5-7-15)28-23(30)29-18-8-3-13(24)9-17(18)25/h3-12H,1-2H3,(H2,28,29,30)
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n/an/a 90n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 380n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340936
PNG
(1-butyl-3-(4-(6,7-dimethoxyquinazolin-4-yloxy)phen...)
Show SMILES CCCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H24N4O4/c1-4-5-10-22-21(26)25-14-6-8-15(9-7-14)29-20-16-11-18(27-2)19(28-3)12-17(16)23-13-24-20/h6-9,11-13H,4-5,10H2,1-3H3,(H2,22,25,26)
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n/an/a 400n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380458
PNG
(CHEMBL2018752)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C19H19ClN4O4/c1-4-28-19(25)24-14-6-5-11(7-13(14)20)23-18-12-8-16(26-2)17(27-3)9-15(12)21-10-22-18/h5-10H,4H2,1-3H3,(H,24,25)(H,21,22,23)
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n/an/a 500n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340926
PNG
(CHEMBL1761932 | ethyl 4-(6,7-dimethoxyquinazolin-4...)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H19N3O5/c1-4-26-19(23)22-12-5-7-13(8-6-12)27-18-14-9-16(24-2)17(25-3)10-15(14)20-11-21-18/h5-11H,4H2,1-3H3,(H,22,23)
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n/an/a 600n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340935
PNG
(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(4...)
Show SMILES COc1ccc(NC(=O)Nc2cccc(Oc3ncnc4cc(OC)c(OC)cc34)c2)cc1
Show InChI InChI=1S/C24H22N4O5/c1-30-17-9-7-15(8-10-17)27-24(29)28-16-5-4-6-18(11-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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n/an/a 600n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340920
PNG
(4-(4-bromo-2-fluorophenoxy)-6,7-dimethoxyquinazoli...)
Show SMILES COc1cc2ncnc(Oc3ccc(Br)c(F)c3)c2cc1OC
Show InChI InChI=1S/C16H12BrFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-11(17)12(18)5-9/h3-8H,1-2H3
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340933
PNG
(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4ccccc4)c3)c2cc1OC
Show InChI InChI=1S/C23H20N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-6-9-16(11-17)27-23(28)26-15-7-4-3-5-8-15/h3-14H,1-2H3,(H2,26,27,28)
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n/an/a 600n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380446
PNG
(CHEMBL2018756)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C20H22N4O4/c1-5-28-20(25)24-15-7-6-13(8-12(15)2)23-19-14-9-17(26-3)18(27-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 650n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340924
PNG
(CHEMBL1761930 | methyl 4-(6,7-dimethoxyquinazolin-...)
Show SMILES COC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H17N3O5/c1-23-15-8-13-14(9-16(15)24-2)19-10-20-17(13)26-12-6-4-11(5-7-12)21-18(22)25-3/h4-10H,1-3H3,(H,21,22)
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n/an/a 700n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380455
PNG
(CHEMBL2018749)
Show SMILES CCCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H24N4O4/c1-4-5-10-29-21(26)25-15-8-6-14(7-9-15)24-20-16-11-18(27-2)19(28-3)12-17(16)22-13-23-20/h6-9,11-13H,4-5,10H2,1-3H3,(H,25,26)(H,22,23,24)
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n/an/a 800n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM3567
PNG
(CHEMBL328106 | N-(4-bromophenyl)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncnc(Nc3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-10(17)4-6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 800n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380449
PNG
(CHEMBL2018757)
Show SMILES CCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C21H24N4O4/c1-5-8-29-21(26)25-16-7-6-14(9-13(16)2)24-20-15-10-18(27-3)19(28-4)11-17(15)22-12-23-20/h6-7,9-12H,5,8H2,1-4H3,(H,25,26)(H,22,23,24)
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n/an/a 850n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380461
PNG
(CHEMBL2018755)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C19H20N4O4/c1-11-7-12(5-6-14(11)23-19(24)27-4)22-18-13-8-16(25-2)17(26-3)9-15(13)20-10-21-18/h5-10H,1-4H3,(H,23,24)(H,20,21,22)
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n/an/a 850n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380449
PNG
(CHEMBL2018757)
Show SMILES CCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C21H24N4O4/c1-5-8-29-21(26)25-16-7-6-14(9-13(16)2)24-20-15-10-18(27-3)19(28-4)11-17(15)22-12-23-20/h6-7,9-12H,5,8H2,1-4H3,(H,25,26)(H,22,23,24)
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n/an/a 900n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380464
PNG
(CHEMBL2018760)
Show SMILES CCOC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1Cl
Show InChI InChI=1S/C19H19ClN4O4/c1-4-28-19(25)24-15-7-11(5-6-13(15)20)23-18-12-8-16(26-2)17(27-3)9-14(12)21-10-22-18/h5-10H,4H2,1-3H3,(H,24,25)(H,21,22,23)
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n/an/a 900n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380446
PNG
(CHEMBL2018756)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C20H22N4O4/c1-5-28-20(25)24-15-7-6-13(8-12(15)2)23-19-14-9-17(26-3)18(27-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 900n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380471
PNG
(CHEMBL2018766)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C21H24BrFN4O2/c1-4-27(5-2)8-9-29-20-12-18-15(11-19(20)28-3)21(25-13-24-18)26-17-7-6-14(22)10-16(17)23/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380458
PNG
(CHEMBL2018752)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C19H19ClN4O4/c1-4-28-19(25)24-14-6-5-11(7-13(14)20)23-18-12-8-16(26-2)17(27-3)9-15(12)21-10-22-18/h5-10H,4H2,1-3H3,(H,24,25)(H,21,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380459
PNG
(CHEMBL2018753)
Show SMILES CCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C20H21ClN4O4/c1-4-7-29-20(26)25-15-6-5-12(8-14(15)21)24-19-13-9-17(27-2)18(28-3)10-16(13)22-11-23-19/h5-6,8-11H,4,7H2,1-3H3,(H,25,26)(H,22,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50184861
PNG
(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC
Show InChI InChI=1S/C23H26N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-8-16(9-11-17)27-23(28)26-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H2,26,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340918
PNG
(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Show SMILES COc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C16H13BrFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380459
PNG
(CHEMBL2018753)
Show SMILES CCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C20H21ClN4O4/c1-4-7-29-20(26)25-15-6-5-12(8-14(15)21)24-19-13-9-17(27-2)18(28-3)10-16(13)22-11-23-19/h5-6,8-11H,4,7H2,1-3H3,(H,25,26)(H,22,23,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380474
PNG
(CHEMBL2018769)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C24H30ClN5O4/c1-5-30(6-2)10-11-34-22-14-20-17(13-21(22)32-4)23(27-15-26-20)28-16-8-9-19(18(25)12-16)29-24(31)33-7-3/h8-9,12-15H,5-7,10-11H2,1-4H3,(H,29,31)(H,26,27,28)
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n/an/a 3.35E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3567
PNG
(CHEMBL328106 | N-(4-bromophenyl)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncnc(Nc3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-10(17)4-6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380476
PNG
(CHEMBL2018771)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1C
Show InChI InChI=1S/C25H33N5O4/c1-6-30(7-2)11-12-34-23-15-21-19(14-22(23)32-5)24(27-16-26-21)28-18-9-10-20(17(4)13-18)29-25(31)33-8-3/h9-10,13-16H,6-8,11-12H2,1-5H3,(H,29,31)(H,26,27,28)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380461
PNG
(CHEMBL2018755)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C19H20N4O4/c1-11-7-12(5-6-14(11)23-19(24)27-4)22-18-13-8-16(25-2)17(26-3)9-15(13)20-10-21-18/h5-10H,1-4H3,(H,23,24)(H,20,21,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380452
PNG
(CHEMBL2018746)
Show SMILES CCCC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C21H24N4O3/c1-5-6-20(26)25-16-8-7-14(9-13(16)2)24-21-15-10-18(27-3)19(28-4)11-17(15)22-12-23-21/h7-12H,5-6H2,1-4H3,(H,25,26)(H,22,23,24)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3530
PNG
(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Show SMILES COc1cc2ncnc(Nc3ccccc3)c2cc1OC
Show InChI InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340944
PNG
(1-(3-chloro-4-fluorophenyl)-3-(4-(6,7-dimethoxyqui...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19ClFN5O3/c1-32-20-10-16-19(11-21(20)33-2)26-12-27-22(16)28-13-3-5-14(6-4-13)29-23(31)30-15-7-8-18(25)17(24)9-15/h3-12H,1-2H3,(H,26,27,28)(H2,29,30,31)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380467
PNG
(CHEMBL2016600 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H21N5O3/c1-4-20-19(25)24-13-7-5-12(6-8-13)23-18-14-9-16(26-2)17(27-3)10-15(14)21-11-22-18/h5-11H,4H2,1-3H3,(H2,20,24,25)(H,21,22,23)
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n/an/a 4.65E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380456
PNG
(CHEMBL2018750)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)OC(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C20H22N4O4/c1-12(2)28-20(25)24-14-7-5-13(6-8-14)23-19-15-9-17(26-3)18(27-4)10-16(15)21-11-22-19/h5-12H,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380480
PNG
(CHEMBL2018777)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OCC)c(Cl)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C27H36ClN5O4/c1-5-9-13-36-24-16-20-23(17-25(24)37-14-12-33(6-2)7-3)29-18-30-26(20)31-19-10-11-22(21(28)15-19)32-27(34)35-8-4/h10-11,15-18H,5-9,12-14H2,1-4H3,(H,32,34)(H,29,30,31)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380460
PNG
(CHEMBL2018754)
Show SMILES CCCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C21H23ClN4O4/c1-4-5-8-30-21(27)26-16-7-6-13(9-15(16)22)25-20-14-10-18(28-2)19(29-3)11-17(14)23-12-24-20/h6-7,9-12H,4-5,8H2,1-3H3,(H,26,27)(H,23,24,25)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380466
PNG
(CHEMBL2018762)
Show SMILES CCOC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1C
Show InChI InChI=1S/C20H22N4O4/c1-5-28-20(25)24-15-8-13(7-6-12(15)2)23-19-14-9-17(26-3)18(27-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380454
PNG
(CHEMBL2018748)
Show SMILES CCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C20H22N4O4/c1-4-9-28-20(25)24-14-7-5-13(6-8-14)23-19-15-10-17(26-2)18(27-3)11-16(15)21-12-22-19/h5-8,10-12H,4,9H2,1-3H3,(H,24,25)(H,21,22,23)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380456
PNG
(CHEMBL2018750)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)OC(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C20H22N4O4/c1-12(2)28-20(25)24-14-7-5-13(6-8-14)23-19-15-9-17(26-3)18(27-4)10-16(15)21-11-22-19/h5-12H,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 5.05E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380457
PNG
(CHEMBL2018751)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C18H17ClN4O4/c1-25-15-7-11-14(8-16(15)26-2)20-9-21-17(11)22-10-4-5-13(12(19)6-10)23-18(24)27-3/h4-9H,1-3H3,(H,23,24)(H,20,21,22)
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n/an/a 5.05E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340927
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)-3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H21N5O3/c1-30-20-12-18-19(13-21(20)31-2)24-14-25-22(18)26-16-8-10-17(11-9-16)28-23(29)27-15-6-4-3-5-7-15/h3-14H,1-2H3,(H,24,25,26)(H2,27,28,29)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380462
PNG
(CHEMBL2018758)
Show SMILES CCCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C22H26N4O4/c1-5-6-9-30-22(27)26-17-8-7-15(10-14(17)2)25-21-16-11-19(28-3)20(29-4)12-18(16)23-13-24-21/h7-8,10-13H,5-6,9H2,1-4H3,(H,26,27)(H,23,24,25)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380473
PNG
(CHEMBL2018768)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)OC)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C23H28ClN5O4/c1-5-29(6-2)9-10-33-21-13-19-16(12-20(21)31-3)22(26-14-25-19)27-15-7-8-18(17(24)11-15)28-23(30)32-4/h7-8,11-14H,5-6,9-10H2,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380463
PNG
(CHEMBL2018759)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)OC(C)C)c(C)c3)c2cc1OC
Show InChI InChI=1S/C21H24N4O4/c1-12(2)29-21(26)25-16-7-6-14(8-13(16)3)24-20-15-9-18(27-4)19(28-5)10-17(15)22-11-23-20/h6-12H,1-5H3,(H,25,26)(H,22,23,24)
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n/an/a 5.25E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380478
PNG
(CHEMBL2018775)
Show SMILES CCCCOc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C24H30BrFN4O2/c1-4-7-11-31-22-14-18-21(15-23(22)32-12-10-30(5-2)6-3)27-16-28-24(18)29-20-9-8-17(25)13-19(20)26/h8-9,13-16H,4-7,10-12H2,1-3H3,(H,27,28,29)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380464
PNG
(CHEMBL2018760)
Show SMILES CCOC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1Cl
Show InChI InChI=1S/C19H19ClN4O4/c1-4-28-19(25)24-15-7-11(5-6-13(15)20)23-18-12-8-16(26-2)17(27-3)9-14(12)21-10-22-18/h5-10H,4H2,1-3H3,(H,24,25)(H,21,22,23)
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n/an/a 5.55E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340925
PNG
(CHEMBL1761931 | Ethyl {4-[6,7-dimethoxy-quinazolin...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H20N4O4/c1-4-27-19(24)23-13-7-5-12(6-8-13)22-18-14-9-16(25-2)17(26-3)10-15(14)20-11-21-18/h5-11H,4H2,1-3H3,(H,23,24)(H,20,21,22)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340918
PNG
(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Show SMILES COc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C16H13BrFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380482
PNG
(CHEMBL2018879)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OCC)c(C)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C28H39N5O4/c1-6-10-14-36-25-17-22-24(18-26(25)37-15-13-33(7-2)8-3)29-19-30-27(22)31-21-11-12-23(20(5)16-21)32-28(34)35-9-4/h11-12,16-19H,6-10,13-15H2,1-5H3,(H,32,34)(H,29,30,31)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340923
PNG
(CHEMBL1761929 | Methyl {4-[6,7-dimethoxy-quinazoli...)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H18N4O4/c1-24-15-8-13-14(9-16(15)25-2)19-10-20-17(13)21-11-4-6-12(7-5-11)22-18(23)26-3/h4-10H,1-3H3,(H,22,23)(H,19,20,21)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380468
PNG
(CHEMBL2018763 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H25N5O3/c1-4-5-10-22-21(27)26-15-8-6-14(7-9-15)25-20-16-11-18(28-2)19(29-3)12-17(16)23-13-24-20/h6-9,11-13H,4-5,10H2,1-3H3,(H2,22,26,27)(H,23,24,25)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380463
PNG
(CHEMBL2018759)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)OC(C)C)c(C)c3)c2cc1OC
Show InChI InChI=1S/C21H24N4O4/c1-12(2)29-21(26)25-16-7-6-14(8-13(16)3)24-20-15-9-18(27-4)19(28-5)10-17(15)22-11-23-20/h6-12H,1-5H3,(H,25,26)(H,22,23,24)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340920
PNG
(4-(4-bromo-2-fluorophenoxy)-6,7-dimethoxyquinazoli...)
Show SMILES COc1cc2ncnc(Oc3ccc(Br)c(F)c3)c2cc1OC
Show InChI InChI=1S/C16H12BrFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-11(17)12(18)5-9/h3-8H,1-2H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380457
PNG
(CHEMBL2018751)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C18H17ClN4O4/c1-25-15-7-11-14(8-16(15)26-2)20-9-21-17(11)22-10-4-5-13(12(19)6-10)23-18(24)27-3/h4-9H,1-3H3,(H,23,24)(H,20,21,22)
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n/an/a 6.15E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380469
PNG
(CHEMBL2018764)
Show SMILES COc1cccc(NC(=O)Nc2ccc(Nc3ncnc4cc(OC)c(OC)cc34)cc2)c1
Show InChI InChI=1S/C24H23N5O4/c1-31-18-6-4-5-17(11-18)29-24(30)28-16-9-7-15(8-10-16)27-23-19-12-21(32-2)22(33-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H,25,26,27)(H2,28,29,30)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380460
PNG
(CHEMBL2018754)
Show SMILES CCCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C21H23ClN4O4/c1-4-5-8-30-21(27)26-16-7-6-13(9-15(16)22)25-20-14-10-18(28-2)19(29-3)11-17(14)23-12-24-20/h6-7,9-12H,4-5,8H2,1-3H3,(H,26,27)(H,23,24,25)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380472
PNG
(CHEMBL2018767)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(C)c(Br)c3)c2cc1OC
Show InChI InChI=1S/C22H27BrN4O2/c1-5-27(6-2)9-10-29-21-13-19-17(12-20(21)28-4)22(25-14-24-19)26-16-8-7-15(3)18(23)11-16/h7-8,11-14H,5-6,9-10H2,1-4H3,(H,24,25,26)
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n/an/a 6.45E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380466
PNG
(CHEMBL2018762)
Show SMILES CCOC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1C
Show InChI InChI=1S/C20H22N4O4/c1-5-28-20(25)24-15-8-13(7-6-12(15)2)23-19-14-9-17(26-3)18(27-4)10-16(14)21-11-22-19/h6-11H,5H2,1-4H3,(H,24,25)(H,21,22,23)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380447
PNG
(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H32N6O3/c1-5-25-24(31)29-18-10-8-17(9-11-18)28-23-19-14-21(32-4)22(15-20(19)26-16-27-23)33-13-12-30(6-2)7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H2,25,29,31)(H,26,27,28)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380455
PNG
(CHEMBL2018749)
Show SMILES CCCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H24N4O4/c1-4-5-10-29-21(26)25-15-8-6-14(7-9-15)24-20-16-11-18(27-2)19(28-3)12-17(16)22-13-23-20/h6-9,11-13H,4-5,10H2,1-3H3,(H,25,26)(H,22,23,24)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380453
PNG
(CHEMBL2018747)
Show SMILES CCCCC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C22H26N4O3/c1-5-6-7-21(27)26-17-9-8-15(10-14(17)2)25-22-16-11-19(28-3)20(29-4)12-18(16)23-13-24-22/h8-13H,5-7H2,1-4H3,(H,26,27)(H,23,24,25)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340923
PNG
(CHEMBL1761929 | Methyl {4-[6,7-dimethoxy-quinazoli...)
Show SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H18N4O4/c1-24-15-8-13-14(9-16(15)25-2)19-10-20-17(13)21-11-4-6-12(7-5-11)22-18(23)26-3/h4-10H,1-3H3,(H,22,23)(H,19,20,21)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380470
PNG
(CHEMBL2018765)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C21H24ClFN4O2/c1-4-27(5-2)8-9-29-20-12-18-15(11-19(20)28-3)21(25-13-24-18)26-14-6-7-17(23)16(22)10-14/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380475
PNG
(CHEMBL2018770)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)OC)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H31N5O4/c1-6-29(7-2)10-11-33-22-14-20-18(13-21(22)31-4)23(26-15-25-20)27-17-8-9-19(16(3)12-17)28-24(30)32-5/h8-9,12-15H,6-7,10-11H2,1-5H3,(H,28,30)(H,25,26,27)
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n/an/a 6.95E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM3530
PNG
(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Show SMILES COc1cc2ncnc(Nc3ccccc3)c2cc1OC
Show InChI InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380454
PNG
(CHEMBL2018748)
Show SMILES CCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C20H22N4O4/c1-4-9-28-20(25)24-14-7-5-13(6-8-14)23-19-15-10-17(26-2)18(27-3)11-16(15)21-12-22-19/h5-8,10-12H,4,9H2,1-3H3,(H,24,25)(H,21,22,23)
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n/an/a 7.05E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380465
PNG
(CHEMBL2018761)
Show SMILES COC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1C
Show InChI InChI=1S/C19H20N4O4/c1-11-5-6-12(7-14(11)23-19(24)27-4)22-18-13-8-16(25-2)17(26-3)9-15(13)20-10-21-18/h5-10H,1-4H3,(H,23,24)(H,20,21,22)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380477
PNG
(CHEMBL2018774)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1C
Show InChI InChI=1S/C25H33N5O4/c1-6-30(7-2)11-12-34-23-14-19-21(15-22(23)32-5)26-16-27-24(19)28-18-9-10-20(17(4)13-18)29-25(31)33-8-3/h9-10,13-16H,6-8,11-12H2,1-5H3,(H,29,31)(H,26,27,28)
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n/an/a 7.25E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380451
PNG
(CHEMBL2018745)
Show SMILES CCC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H20N4O3/c1-4-18(24)22-12-5-7-13(8-6-12)23-19-14-9-16(25-2)17(26-3)10-15(14)20-11-21-19/h5-11H,4H2,1-3H3,(H,22,24)(H,20,21,23)
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n/an/a 7.30E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380479
PNG
(CHEMBL2018776)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OC)c(Cl)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C26H34ClN5O4/c1-5-8-12-35-23-15-19-22(16-24(23)36-13-11-32(6-2)7-3)28-17-29-25(19)30-18-9-10-21(20(27)14-18)31-26(33)34-4/h9-10,14-17H,5-8,11-13H2,1-4H3,(H,31,33)(H,28,29,30)
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n/an/a 7.40E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380450
PNG
(CHEMBL2018773)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC
Show InChI InChI=1S/C21H24BrFN4O2/c1-4-27(5-2)8-9-29-20-11-15-18(12-19(20)28-3)24-13-25-21(15)26-17-7-6-14(22)10-16(17)23/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 7.45E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380462
PNG
(CHEMBL2018758)
Show SMILES CCCCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C22H26N4O4/c1-5-6-9-30-22(27)26-17-8-7-15(10-14(17)2)25-21-16-11-19(28-3)20(29-4)12-18(16)23-13-24-21/h7-8,10-13H,5-6,9H2,1-4H3,(H,26,27)(H,23,24,25)
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n/an/a 7.60E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380465
PNG
(CHEMBL2018761)
Show SMILES COC(=O)Nc1cc(Nc2ncnc3cc(OC)c(OC)cc23)ccc1C
Show InChI InChI=1S/C19H20N4O4/c1-11-5-6-12(7-14(11)23-19(24)27-4)22-18-13-8-16(25-2)17(26-3)9-15(13)20-10-21-18/h5-10H,1-4H3,(H,23,24)(H,20,21,22)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380483
PNG
(CHEMBL2018880)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(C)=O)c3)c2cc1OC
Show InChI InChI=1S/C18H17N3O4/c1-11(22)21-12-5-4-6-13(7-12)25-18-14-8-16(23-2)17(24-3)9-15(14)19-10-20-18/h4-10H,1-3H3,(H,21,22)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380450
PNG
(CHEMBL2018773)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC
Show InChI InChI=1S/C21H24BrFN4O2/c1-4-27(5-2)8-9-29-20-11-15-18(12-19(20)28-3)24-13-25-21(15)26-17-7-6-14(22)10-16(17)23/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380480
PNG
(CHEMBL2018777)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OCC)c(Cl)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C27H36ClN5O4/c1-5-9-13-36-24-16-20-23(17-25(24)37-14-12-33(6-2)7-3)29-18-30-26(20)31-19-10-11-22(21(28)15-19)32-27(34)35-8-4/h10-11,15-18H,5-9,12-14H2,1-4H3,(H,32,34)(H,29,30,31)
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n/an/a 9.15E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50380481
PNG
(CHEMBL2018878)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OC)c(C)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C27H37N5O4/c1-6-9-13-35-24-16-21-23(17-25(24)36-14-12-32(7-2)8-3)28-18-29-26(21)30-20-10-11-22(19(4)15-20)31-27(33)34-5/h10-11,15-18H,6-9,12-14H2,1-5H3,(H,31,33)(H,28,29,30)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380472
PNG
(CHEMBL2018767)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(C)c(Br)c3)c2cc1OC
Show InChI InChI=1S/C22H27BrN4O2/c1-5-27(6-2)9-10-29-21-13-19-17(12-20(21)28-4)22(25-14-24-19)26-16-8-7-15(3)18(23)11-16/h7-8,11-14H,5-6,9-10H2,1-4H3,(H,24,25,26)
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n/an/a 9.45E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50340917
PNG
(4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...)
Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3
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n/an/a 9.80E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380470
PNG
(CHEMBL2018765)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C21H24ClFN4O2/c1-4-27(5-2)8-9-29-20-12-18-15(11-19(20)28-3)21(25-13-24-18)26-14-6-7-17(23)16(22)10-14/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 9.90E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380483
PNG
(CHEMBL2018880)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(C)=O)c3)c2cc1OC
Show InChI InChI=1S/C18H17N3O4/c1-11(22)21-12-5-4-6-13(7-12)25-18-14-8-16(23-2)17(24-3)9-15(14)19-10-20-18/h4-10H,1-3H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380485
PNG
(CHEMBL2018882)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-8-6-15(7-9-17)27-23(29)28-16-5-3-4-14(24)10-16/h3-13H,1-2H3,(H2,27,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380451
PNG
(CHEMBL2018745)
Show SMILES CCC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H20N4O3/c1-4-18(24)22-12-5-7-13(8-6-12)23-19-14-9-16(25-2)17(26-3)10-15(14)20-11-21-19/h5-11H,4H2,1-3H3,(H,22,24)(H,20,21,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340927
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl)-3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H21N5O3/c1-30-20-12-18-19(13-21(20)31-2)24-14-25-22(18)26-16-8-10-17(11-9-16)28-23(29)27-15-6-4-3-5-7-15/h3-14H,1-2H3,(H,24,25,26)(H2,27,28,29)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380469
PNG
(CHEMBL2018764)
Show SMILES COc1cccc(NC(=O)Nc2ccc(Nc3ncnc4cc(OC)c(OC)cc34)cc2)c1
Show InChI InChI=1S/C24H23N5O4/c1-31-18-6-4-5-17(11-18)29-24(30)28-16-9-7-15(8-10-16)27-23-19-12-21(32-2)22(33-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H,25,26,27)(H2,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380471
PNG
(CHEMBL2018766)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C21H24BrFN4O2/c1-4-27(5-2)8-9-29-20-12-18-15(11-19(20)28-3)21(25-13-24-18)26-17-7-6-14(22)10-16(17)23/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380479
PNG
(CHEMBL2018776)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OC)c(Cl)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C26H34ClN5O4/c1-5-8-12-35-23-15-19-22(16-24(23)36-13-11-32(6-2)7-3)28-17-29-25(19)30-18-9-10-21(20(27)14-18)31-26(33)34-4/h9-10,14-17H,5-8,11-13H2,1-4H3,(H,31,33)(H,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50162157
PNG
(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1
Show InChI InChI=1S/C24H22N4O5/c1-30-17-8-4-15(5-9-17)27-24(29)28-16-6-10-18(11-7-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380473
PNG
(CHEMBL2018768)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)OC)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C23H28ClN5O4/c1-5-29(6-2)9-10-33-21-13-19-16(12-20(21)31-3)22(26-14-25-19)27-15-7-8-18(17(24)11-15)28-23(30)32-4/h7-8,11-14H,5-6,9-10H2,1-4H3,(H,28,30)(H,25,26,27)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50184861
PNG
(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC
Show InChI InChI=1S/C23H26N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-8-16(9-11-17)27-23(28)26-15-6-4-3-5-7-15/h8-15H,3-7H2,1-2H3,(H2,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340939
PNG
(CHEMBL1761939 | N-(3-chloro-4-fluorophenyl)-N'-{4-...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H18ClFN4O4/c1-31-20-10-16-19(11-21(20)32-2)26-12-27-22(16)33-15-6-3-13(4-7-15)28-23(30)29-14-5-8-18(25)17(24)9-14/h3-12H,1-2H3,(H2,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340925
PNG
(CHEMBL1761931 | Ethyl {4-[6,7-dimethoxy-quinazolin...)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H20N4O4/c1-4-27-19(24)23-13-7-5-12(6-8-13)22-18-14-9-16(25-2)17(26-3)10-15(14)20-11-21-18/h5-11H,4H2,1-3H3,(H,23,24)(H,20,21,22)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380468
PNG
(CHEMBL2018763 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCCCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H25N5O3/c1-4-5-10-22-21(27)26-15-8-6-14(7-9-15)25-20-16-11-18(28-2)19(29-3)12-17(16)23-13-24-20/h6-9,11-13H,4-5,10H2,1-3H3,(H2,22,26,27)(H,23,24,25)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380482
PNG
(CHEMBL2018879)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OCC)c(C)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C28H39N5O4/c1-6-10-14-36-25-17-22-24(18-26(25)37-15-13-33(7-2)8-3)29-19-30-27(22)31-21-11-12-23(20(5)16-21)32-28(34)35-9-4/h11-12,16-19H,6-10,13-15H2,1-5H3,(H,32,34)(H,29,30,31)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340926
PNG
(CHEMBL1761932 | ethyl 4-(6,7-dimethoxyquinazolin-4...)
Show SMILES CCOC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H19N3O5/c1-4-26-19(23)22-12-5-7-13(8-6-12)27-18-14-9-16(24-2)17(25-3)10-15(14)20-11-21-18/h5-11H,4H2,1-3H3,(H,22,23)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340929
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H20N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-8-16(9-11-17)27-23(28)26-15-6-4-3-5-7-15/h3-14H,1-2H3,(H2,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340935
PNG
(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(4...)
Show SMILES COc1ccc(NC(=O)Nc2cccc(Oc3ncnc4cc(OC)c(OC)cc34)c2)cc1
Show InChI InChI=1S/C24H22N4O5/c1-30-17-9-7-15(8-10-17)27-24(29)28-16-5-4-6-18(11-16)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380488
PNG
(CHEMBL2018885)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H20ClFN4O4/c1-13-8-15(5-7-19(13)30-24(31)29-14-4-6-18(26)17(25)9-14)34-23-16-10-21(32-2)22(33-3)11-20(16)27-12-28-23/h4-12H,1-3H3,(H2,29,30,31)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380452
PNG
(CHEMBL2018746)
Show SMILES CCCC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C21H24N4O3/c1-5-6-20(26)25-16-8-7-14(9-13(16)2)24-21-15-10-18(27-3)19(28-4)11-17(15)22-12-23-21/h7-12H,5-6H2,1-4H3,(H,25,26)(H,22,23,24)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380481
PNG
(CHEMBL2018878)
Show SMILES CCCCOc1cc2c(Nc3ccc(NC(=O)OC)c(C)c3)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C27H37N5O4/c1-6-9-13-35-24-16-21-23(17-25(24)36-14-12-32(7-2)8-3)28-18-29-26(21)30-20-10-11-22(19(4)15-20)31-27(33)34-5/h10-11,15-18H,6-9,12-14H2,1-5H3,(H,31,33)(H,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340924
PNG
(CHEMBL1761930 | methyl 4-(6,7-dimethoxyquinazolin-...)
Show SMILES COC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H17N3O5/c1-23-15-8-13-14(9-16(15)24-2)19-10-20-17(13)26-12-6-4-11(5-7-12)21-18(22)25-3/h4-10H,1-3H3,(H,21,22)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380453
PNG
(CHEMBL2018747)
Show SMILES CCCCC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1C
Show InChI InChI=1S/C22H26N4O3/c1-5-6-7-21(27)26-17-9-8-15(10-14(17)2)25-22-16-11-19(28-3)20(29-4)12-18(16)23-13-24-22/h8-13H,5-7H2,1-4H3,(H,26,27)(H,23,24,25)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380474
PNG
(CHEMBL2018769)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1Cl
Show InChI InChI=1S/C24H30ClN5O4/c1-5-30(6-2)10-11-34-22-14-20-17(13-21(22)32-4)23(27-15-26-20)28-16-8-9-19(18(25)12-16)29-24(31)33-7-3/h8-9,12-15H,5-7,10-11H2,1-4H3,(H,29,31)(H,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340938
PNG
(1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinazol...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C23H18F2N4O4/c1-31-20-10-16-19(11-21(20)32-2)26-12-27-22(16)33-15-6-4-14(5-7-15)28-23(30)29-18-8-3-13(24)9-17(18)25/h3-12H,1-2H3,(H2,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340942
PNG
(1-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(n...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)cc3)c2cc1OC
Show InChI InChI=1S/C27H22N4O4/c1-33-24-14-22-23(15-25(24)34-2)28-16-29-26(22)35-21-11-9-19(10-12-21)30-27(32)31-20-8-7-17-5-3-4-6-18(17)13-20/h3-16H,1-2H3,(H2,30,31,32)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380484
PNG
(CHEMBL2018881)
Show SMILES COc1cccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1
Show InChI InChI=1S/C24H22N4O5/c1-30-18-6-4-5-16(11-18)28-24(29)27-15-7-9-17(10-8-15)33-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H2,27,28,29)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380487
PNG
(CHEMBL2018884)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H21BrN4O4/c1-14-9-17(7-8-19(14)29-24(30)28-16-6-4-5-15(25)10-16)33-23-18-11-21(31-2)22(32-3)12-20(18)26-13-27-23/h4-13H,1-3H3,(H2,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380447
PNG
(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1
Show InChI InChI=1S/C24H32N6O3/c1-5-25-24(31)29-18-10-8-17(9-11-18)28-23-19-14-21(32-4)22(15-20(19)26-16-27-23)33-13-12-30(6-2)7-3/h8-11,14-16H,5-7,12-13H2,1-4H3,(H2,25,29,31)(H,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340944
PNG
(1-(3-chloro-4-fluorophenyl)-3-(4-(6,7-dimethoxyqui...)
Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19ClFN5O3/c1-32-20-10-16-19(11-21(20)33-2)26-12-27-22(16)28-13-3-5-14(6-4-13)29-23(31)30-15-7-8-18(25)17(24)9-15/h3-12H,1-2H3,(H,26,27,28)(H2,29,30,31)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380475
PNG
(CHEMBL2018770)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(NC(=O)OC)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H31N5O4/c1-6-29(7-2)10-11-33-22-14-20-18(13-21(22)31-4)23(26-15-25-20)27-17-8-9-19(16(3)12-17)28-24(30)32-5/h8-9,12-15H,6-7,10-11H2,1-5H3,(H,28,30)(H,25,26,27)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380477
PNG
(CHEMBL2018774)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OCCN(CC)CC)cc23)cc1C
Show InChI InChI=1S/C25H33N5O4/c1-6-30(7-2)11-12-34-23-14-19-21(15-22(23)32-5)26-16-27-24(19)28-18-9-10-20(17(4)13-18)29-25(31)33-8-3/h9-10,13-16H,6-8,11-12H2,1-5H3,(H,29,31)(H,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340937
PNG
(1-(4-bromophenyl)-3-(4-(6,7-dimethoxyquinazolin-4-...)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(Br)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C23H19BrN4O4/c1-30-20-11-18-19(12-21(20)31-2)25-13-26-22(18)32-17-9-7-16(8-10-17)28-23(29)27-15-5-3-14(24)4-6-15/h3-13H,1-2H3,(H2,27,28,29)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380486
PNG
(CHEMBL2018883)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(Br)cc4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C24H21BrN4O4/c1-14-10-17(8-9-19(14)29-24(30)28-16-6-4-15(25)5-7-16)33-23-18-11-21(31-2)22(32-3)12-20(18)26-13-27-23/h4-13H,1-3H3,(H2,28,29,30)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340917
PNG
(4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...)
Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380467
PNG
(CHEMBL2016600 | N-{4-[6,7-Dimethoxy-quinazolin-4-y...)
Show SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H21N5O3/c1-4-20-19(25)24-13-7-5-12(6-8-13)23-18-14-9-16(26-2)17(27-3)10-15(14)21-11-22-18/h5-11H,4H2,1-3H3,(H2,20,24,25)(H,21,22,23)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380476
PNG
(CHEMBL2018771)
Show SMILES CCOC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1C
Show InChI InChI=1S/C25H33N5O4/c1-6-30(7-2)11-12-34-23-15-21-19(14-22(23)32-5)24(27-16-26-21)28-18-9-10-20(17(4)13-18)29-25(31)33-8-3/h9-10,13-16H,6-8,11-12H2,1-5H3,(H,29,31)(H,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380478
PNG
(CHEMBL2018775)
Show SMILES CCCCOc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCN(CC)CC
Show InChI InChI=1S/C24H30BrFN4O2/c1-4-7-11-31-22-14-18-21(15-23(22)32-12-10-30(5-2)6-3)27-16-28-24(18)29-20-9-8-17(25)13-19(20)26/h8-9,13-16H,4-7,10-12H2,1-3H3,(H,27,28,29)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340936
PNG
(1-butyl-3-(4-(6,7-dimethoxyquinazolin-4-yloxy)phen...)
Show SMILES CCCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C21H24N4O4/c1-4-5-10-22-21(26)25-14-6-8-15(9-7-14)29-20-16-11-18(27-2)19(28-3)12-17(16)23-13-24-20/h6-9,11-13H,4-5,10H2,1-3H3,(H2,22,25,26)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50340933
PNG
(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4ccccc4)c3)c2cc1OC
Show InChI InChI=1S/C23H20N4O4/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)31-17-10-6-9-16(11-17)27-23(28)26-15-7-4-3-5-8-15/h3-14H,1-2H3,(H2,26,27,28)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50380448
PNG
(CHEMBL2018886)
Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)c(C)c3)c2cc1OC
Show InChI InChI=1S/C28H24N4O4/c1-17-12-21(36-27-22-14-25(34-2)26(35-3)15-24(22)29-16-30-27)10-11-23(17)32-28(33)31-20-9-8-18-6-4-5-7-19(18)13-20/h4-16H,1-3H3,(H2,31,32,33)
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Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting

J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%