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PubMed code 22489952

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Translocator protein


(Rattus norvegicus (rat))		BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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 0.5n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388407
PNG
(CHEMBL2058825)
Show SMILES CCCCCCN(CCCCCC)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C27H35N3O/c1-3-5-7-14-20-30(21-15-8-6-4-2)27(31)26-28-24-19-13-12-18-23(24)25(29-26)22-16-10-9-11-17-22/h9-13,16-19H,3-8,14-15,20-21H2,1-2H3
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 0.690n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388424
PNG
(CHEMBL2059062)
Show SMILES CC[C@@H](C)N(C)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1 |r|
Show InChI InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-12-8-6-10-15(17)18(23-19)14-9-5-7-11-16(14)21/h5-13H,4H2,1-3H3/t13-/m1/s1
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 1.55n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388426
PNG
(CHEMBL2059064)
Show SMILES CC[C@@H](C)N(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2ccccc2n1 |r|
Show InChI InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-8-6-5-7-16(17)18(23-19)14-9-11-15(21)12-10-14/h5-13H,4H2,1-3H3/t13-/m1/s1
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 1.57n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388423
PNG
(CHEMBL2059061)
Show SMILES CC[C@H](C)N(C)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1 |r|
Show InChI InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-12-8-6-10-15(17)18(23-19)14-9-5-7-11-16(14)21/h5-13H,4H2,1-3H3/t13-/m0/s1
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 2.20n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388406
PNG
(CHEMBL2058824)
Show SMILES CCCCCN(CCCCC)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C25H31N3O/c1-3-5-12-18-28(19-13-6-4-2)25(29)24-26-22-17-11-10-16-21(22)23(27-24)20-14-8-7-9-15-20/h7-11,14-17H,3-6,12-13,18-19H2,1-2H3
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 2.48n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388425
PNG
(CHEMBL2059063)
Show SMILES CC[C@H](C)N(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2ccccc2n1 |r|
Show InChI InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-8-6-5-7-16(17)18(23-19)14-9-11-15(21)12-10-14/h5-13H,4H2,1-3H3/t13-/m0/s1
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 2.51n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388413
PNG
(CHEMBL2059048)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2ccccc2n1
Show InChI InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-8-6-5-7-16(17)18(23-19)14-9-11-15(21)12-10-14/h5-13H,4H2,1-3H3
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 2.67n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388401
PNG
(CHEMBL2058819)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C20H21N3O/c1-4-14(2)23(3)20(24)19-21-17-13-9-8-12-16(17)18(22-19)15-10-6-5-7-11-15/h5-14H,4H2,1-3H3
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 3n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388408
PNG
(CHEMBL2059040)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1
Show InChI InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-12-8-6-10-15(17)18(23-19)14-9-5-7-11-16(14)21/h5-13H,4H2,1-3H3
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 3.06n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388405
PNG
(CHEMBL2058823)
Show SMILES CCCCN(CCCC)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C23H27N3O/c1-3-5-16-26(17-6-4-2)23(27)22-24-20-15-11-10-14-19(20)21(25-22)18-12-8-7-9-13-18/h7-15H,3-6,16-17H2,1-2H3
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 3.30n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388417
PNG
(CHEMBL2059051)
Show SMILES CCCCCCN(CCCCCC)C(=O)c1nc(-c2ccc(Cl)cc2)c2ccccc2n1
Show InChI InChI=1S/C27H34ClN3O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)26-29-24-14-10-9-13-23(24)25(30-26)21-15-17-22(28)18-16-21/h9-10,13-18H,3-8,11-12,19-20H2,1-2H3
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 3.42n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388420
PNG
(CHEMBL2059055)
Show SMILES CCCCCCN(CCCCCC)C(=O)c1nc(-c2ccc(Cl)cc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C27H33Cl2N3O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)26-30-24-16-15-22(29)19-23(24)25(31-26)20-11-13-21(28)14-12-20/h11-16,19H,3-10,17-18H2,1-2H3
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 4.31n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388421
PNG
(CHEMBL2059059)
Show SMILES CC[C@H](C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2n1 |r|
Show InChI InChI=1S/C20H21N3O/c1-4-14(2)23(3)20(24)19-21-17-13-9-8-12-16(17)18(22-19)15-10-6-5-7-11-15/h5-14H,4H2,1-3H3/t14-/m0/s1
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 6.09n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388422
PNG
(CHEMBL2059060)
Show SMILES CC[C@@H](C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2n1 |r|
Show InChI InChI=1S/C20H21N3O/c1-4-14(2)23(3)20(24)19-21-17-13-9-8-12-16(17)18(22-19)15-10-6-5-7-11-15/h5-14H,4H2,1-3H3/t14-/m1/s1
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 6.41n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388409
PNG
(CHEMBL2059041)
Show SMILES CC(C)CN(C)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1
Show InChI InChI=1S/C20H20ClN3O/c1-13(2)12-24(3)20(25)19-22-17-11-7-5-9-15(17)18(23-19)14-8-4-6-10-16(14)21/h4-11,13H,12H2,1-3H3
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 6.98n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388399
PNG
(CHEMBL2059046)
Show SMILES Clc1ccccc1-c1nc(nc2ccccc12)C(=O)N1CCCCCC1
Show InChI InChI=1S/C21H20ClN3O/c22-17-11-5-3-9-15(17)19-16-10-4-6-12-18(16)23-20(24-19)21(26)25-13-7-1-2-8-14-25/h3-6,9-12H,1-2,7-8,13-14H2
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 8.77n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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 9.30n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Translocator protein


(Rattus norvegicus (rat))		BDBM50388410
PNG
(CHEMBL2059042)
Show SMILES CC(C)N(C)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1
Show InChI InChI=1S/C19H18ClN3O/c1-12(2)23(3)19(24)18-21-16-11-7-5-9-14(16)17(22-18)13-8-4-6-10-15(13)20/h4-12H,1-3H3
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 12.5n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388414
PNG
(CHEMBL2059049)
Show SMILES CC(C)CN(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2ccccc2n1
Show InChI InChI=1S/C20H20ClN3O/c1-13(2)12-24(3)20(25)19-22-17-7-5-4-6-16(17)18(23-19)14-8-10-15(21)11-9-14/h4-11,13H,12H2,1-3H3
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 20.7n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM22040
PNG
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10|
Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
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 23n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388429
PNG
(CHEMBL2059259)
Show SMILES CCCCCCN(CCCCCC)C(=O)c1nc(-c2ccccc2Cl)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C27H33Cl2N3O/c1-3-5-7-11-17-32(18-12-8-6-4-2)27(33)26-30-24-16-15-20(28)19-22(24)25(31-26)21-13-9-10-14-23(21)29/h9-10,13-16,19H,3-8,11-12,17-18H2,1-2H3
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 30.4n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388404
PNG
(CHEMBL2058822)
Show SMILES CCCN(CCC)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C21H23N3O/c1-3-14-24(15-4-2)21(25)20-22-18-13-9-8-12-17(18)19(23-20)16-10-6-5-7-11-16/h5-13H,3-4,14-15H2,1-2H3
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 36.8n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388428
PNG
(CHEMBL2059251)
Show SMILES CCCCCCN(CCCCCC)C(=O)c1nc(-c2ccccc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C27H34ClN3O/c1-3-5-7-12-18-31(19-13-8-6-4-2)27(32)26-29-24-17-16-22(28)20-23(24)25(30-26)21-14-10-9-11-15-21/h9-11,14-17,20H,3-8,12-13,18-19H2,1-2H3
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 38.5n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388400
PNG
(CHEMBL2058818)
Show SMILES CCCCN(C)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C20H21N3O/c1-3-4-14-23(2)20(24)19-21-17-13-9-8-12-16(17)18(22-19)15-10-6-5-7-11-15/h5-13H,3-4,14H2,1-2H3
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 46n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388412
PNG
(CHEMBL2059045)
Show SMILES Clc1ccccc1-c1nc(nc2ccccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H18ClN3O/c21-16-10-4-2-8-14(16)18-15-9-3-5-11-17(15)22-19(23-18)20(25)24-12-6-1-7-13-24/h2-5,8-11H,1,6-7,12-13H2
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 46n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388415
PNG
(CHEMBL2059050)
Show SMILES CC(C)N(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2ccccc2n1
Show InChI InChI=1S/C19H18ClN3O/c1-12(2)23(3)19(24)18-21-16-7-5-4-6-15(16)17(22-18)13-8-10-14(20)11-9-13/h4-12H,1-3H3
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 50.4n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388433
PNG
(CHEMBL2059265)
Show SMILES CC(C)CN(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C20H19Cl2N3O/c1-12(2)11-25(3)20(26)19-23-17-9-8-15(22)10-16(17)18(24-19)13-4-6-14(21)7-5-13/h4-10,12H,11H2,1-3H3
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 60.7n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388411
PNG
(CHEMBL2059043)
Show SMILES CCCCCCN(CCCCCC)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1
Show InChI InChI=1S/C27H34ClN3O/c1-3-5-7-13-19-31(20-14-8-6-4-2)27(32)26-29-24-18-12-10-16-22(24)25(30-26)21-15-9-11-17-23(21)28/h9-12,15-18H,3-8,13-14,19-20H2,1-2H3
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 65.1n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388402
PNG
(CHEMBL2058820)
Show SMILES CC(C)CN(C)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C20H21N3O/c1-14(2)13-23(3)20(24)19-21-17-12-8-7-11-16(17)18(22-19)15-9-5-4-6-10-15/h4-12,14H,13H2,1-3H3
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 66.5n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388403
PNG
(CHEMBL2058821)
Show SMILES CC(C)N(C)C(=O)c1nc(-c2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C19H19N3O/c1-13(2)22(3)19(23)18-20-16-12-8-7-11-15(16)17(21-18)14-9-5-4-6-10-14/h4-13H,1-3H3
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 70.3n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388416
PNG
(CHEMBL2059054)
Show SMILES Clc1ccc(cc1)-c1nc(nc2ccccc12)C(=O)N1CCCCCC1
Show InChI InChI=1S/C21H20ClN3O/c22-16-11-9-15(10-12-16)19-17-7-3-4-8-18(17)23-20(24-19)21(26)25-13-5-1-2-6-14-25/h3-4,7-12H,1-2,5-6,13-14H2
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 84.3n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388432
PNG
(CHEMBL2059264)
Show SMILES CCC(C)N(C)C(=O)c1nc(-c2ccc(Cl)cc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C20H19Cl2N3O/c1-4-12(2)25(3)20(26)19-23-17-10-9-15(22)11-16(17)18(24-19)13-5-7-14(21)8-6-13/h5-12H,4H2,1-3H3
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 179n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388430
PNG
(CHEMBL2059261)
Show SMILES Clc1ccc2nc(nc(-c3ccccc3Cl)c2c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H17Cl2N3O/c21-13-8-9-17-15(12-13)18(14-6-2-3-7-16(14)22)24-19(23-17)20(26)25-10-4-1-5-11-25/h2-3,6-9,12H,1,4-5,10-11H2
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 273n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388431
PNG
(CHEMBL2059262)
Show SMILES Clc1ccc2nc(nc(-c3ccccc3Cl)c2c1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C21H19Cl2N3O/c22-14-9-10-18-16(13-14)19(15-7-3-4-8-17(15)23)25-20(24-18)21(27)26-11-5-1-2-6-12-26/h3-4,7-10,13H,1-2,5-6,11-12H2
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 415n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388419
PNG
(CHEMBL2059053)
Show SMILES Clc1ccc(cc1)-c1nc(nc2ccccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H18ClN3O/c21-15-10-8-14(9-11-15)18-16-6-2-3-7-17(16)22-19(23-18)20(25)24-12-4-1-5-13-24/h2-3,6-11H,1,4-5,12-13H2
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 493n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388418
PNG
(CHEMBL2059052)
Show SMILES Clc1ccc(cc1)-c1nc(nc2ccccc12)C(=O)N1CCCC1
Show InChI InChI=1S/C19H16ClN3O/c20-14-9-7-13(8-10-14)17-15-5-1-2-6-16(15)21-18(22-17)19(24)23-11-3-4-12-23/h1-2,5-10H,3-4,11-12H2
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 644n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))		BDBM50388427
PNG
(CHEMBL2059249)
Show SMILES CC(C)CN(C)C(=O)c1nc(-c2ccccc2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C20H20ClN3O/c1-13(2)12-24(3)20(25)19-22-17-10-9-15(21)11-16(17)18(23-19)14-7-5-4-6-8-14/h4-11,13H,12H2,1-3H3
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 842n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay

J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%