Found 27 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387018
(CHEMBL2046534)Show SMILES CCN(CC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C24H30N2O4/c1-7-26(8-2)20-11-9-10-19-18(20)12-16(3)24(25-19)30-23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387020
(CHEMBL2049194)Show SMILES Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)CC4CC4)c3cc2C)c(C)c1 Show InChI InChI=1S/C27H33N3/c1-17-12-18(2)26(19(3)13-17)29-27-20(4)14-23-24(28-27)6-5-7-25(23)30(15-21-8-9-21)16-22-10-11-22/h5-7,12-14,21-22H,8-11,15-16H2,1-4H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387025
(CHEMBL2046525)Show SMILES CCCN(CCC)c1cccc2nc(Oc3c(C)cc(C)cc3C)c(C)cc12 Show InChI InChI=1S/C25H32N2O/c1-7-12-27(13-8-2)23-11-9-10-22-21(23)16-20(6)25(26-22)28-24-18(4)14-17(3)15-19(24)5/h9-11,14-16H,7-8,12-13H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387017
(CHEMBL2049193)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)cc12 Show InChI InChI=1S/C25H33N3/c1-7-12-28(13-8-2)23-11-9-10-22-21(23)16-20(6)25(26-22)27-24-18(4)14-17(3)15-19(24)5/h9-11,14-16H,7-8,12-13H2,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387022
(CHEMBL2049196)Show SMILES Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(C)c1 Show InChI InChI=1S/C28H35N3O/c1-18-14-19(2)27(20(3)15-18)30-28-21(4)16-24-25(29-28)6-5-7-26(24)31(17-22-8-9-22)23-10-12-32-13-11-23/h5-7,14-16,22-23H,8-13,17H2,1-4H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387015
(CHEMBL2049190)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 Show InChI InChI=1S/C23H30N4O/c1-6-11-27(12-7-2)19-10-8-9-18-21(19)26-23(28)22(24-18)25-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387026
(CHEMBL2046526)Show SMILES CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C26H34N2O4/c1-7-12-28(13-8-2)22-11-9-10-21-20(22)14-18(3)26(27-21)32-25-23(30-5)15-19(17-29-4)16-24(25)31-6/h9-11,14-16H,7-8,12-13,17H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387013
(CHEMBL2049188)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 Show InChI InChI=1S/C24H32N4/c1-7-12-28(13-8-2)21-11-9-10-20-23(21)25-19(6)24(26-20)27-22-17(4)14-16(3)15-18(22)5/h9-11,14-15H,7-8,12-13H2,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387029
(CHEMBL2046529)Show SMILES COCc1cc(OC)c(Oc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(OC)c1 Show InChI InChI=1S/C29H36N2O5/c1-19-14-23-24(6-5-7-25(23)31(17-20-8-9-20)22-10-12-35-13-11-22)30-29(19)36-28-26(33-3)15-21(18-32-2)16-27(28)34-4/h5-7,14-16,20,22H,8-13,17-18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387026
(CHEMBL2046526)Show SMILES CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C26H34N2O4/c1-7-12-28(13-8-2)22-11-9-10-21-20(22)14-18(3)26(27-21)32-25-23(30-5)15-19(17-29-4)16-24(25)31-6/h9-11,14-16H,7-8,12-13,17H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 163 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387018
(CHEMBL2046534)Show SMILES CCN(CC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C24H30N2O4/c1-7-26(8-2)20-11-9-10-19-18(20)12-16(3)24(25-19)30-23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387014
(CHEMBL2049189)Show SMILES CCCC(CCC)Nc1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 Show InChI InChI=1S/C25H34N4/c1-7-10-20(11-8-2)27-21-12-9-13-22-24(21)26-19(6)25(28-22)29-23-17(4)14-16(3)15-18(23)5/h9,12-15,20,27H,7-8,10-11H2,1-6H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 197 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387022
(CHEMBL2049196)Show SMILES Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(C)c1 Show InChI InChI=1S/C28H35N3O/c1-18-14-19(2)27(20(3)15-18)30-28-21(4)16-24-25(29-28)6-5-7-26(24)31(17-22-8-9-22)23-10-12-32-13-11-23/h5-7,14-16,22-23H,8-13,17H2,1-4H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 255 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387030
(CHEMBL2046530)Show SMILES CCN(C1CCOCC1)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C27H34N2O5/c1-6-29(20-10-12-33-13-11-20)23-9-7-8-22-21(23)14-18(2)27(28-22)34-26-24(31-4)15-19(17-30-3)16-25(26)32-5/h7-9,14-16,20H,6,10-13,17H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 323 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387017
(CHEMBL2049193)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)cc12 Show InChI InChI=1S/C25H33N3/c1-7-12-28(13-8-2)23-11-9-10-22-21(23)16-20(6)25(26-22)27-24-18(4)14-17(3)15-19(24)5/h9-11,14-16H,7-8,12-13H2,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 372 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387015
(CHEMBL2049190)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 Show InChI InChI=1S/C23H30N4O/c1-6-11-27(12-7-2)19-10-8-9-18-21(19)26-23(28)22(24-18)25-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 469 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387023
(CHEMBL2049197)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C26H35N3O3/c1-7-12-29(13-8-2)22-11-9-10-21-20(22)14-18(3)26(27-21)28-25-23(31-5)15-19(17-30-4)16-24(25)32-6/h9-11,14-16H,7-8,12-13,17H2,1-6H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 472 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387013
(CHEMBL2049188)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 Show InChI InChI=1S/C24H32N4/c1-7-12-28(13-8-2)21-11-9-10-20-23(21)25-19(6)24(26-20)27-22-17(4)14-16(3)15-18(22)5/h9-11,14-15H,7-8,12-13H2,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 563 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387028
(CHEMBL2046528)Show SMILES CCN(CC1CCOCC1)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C28H36N2O5/c1-6-30(17-20-10-12-34-13-11-20)24-9-7-8-23-22(24)14-19(2)28(29-23)35-27-25(32-4)15-21(18-31-3)16-26(27)33-5/h7-9,14-16,20H,6,10-13,17-18H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 646 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387016
(CHEMBL2049191)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)n(C)c12 Show InChI InChI=1S/C24H32N4O/c1-7-12-28(13-8-2)20-11-9-10-19-22(20)27(6)24(29)23(25-19)26-21-17(4)14-16(3)15-18(21)5/h9-11,14-15H,7-8,12-13H2,1-6H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 672 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387021
(CHEMBL2049195)Show SMILES Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)CC4CCOCC4)c3cc2C)c(C)c1 Show InChI InChI=1S/C29H37N3O/c1-19-14-20(2)28(21(3)15-19)31-29-22(4)16-25-26(30-29)6-5-7-27(25)32(17-23-8-9-23)18-24-10-12-33-13-11-24/h5-7,14-16,23-24H,8-13,17-18H2,1-4H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 742 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387027
(CHEMBL2046527)Show SMILES COCc1cc(OC)c(Oc2nc3cccc(N(CC4CC4)CC4CCOCC4)c3cc2C)c(OC)c1 Show InChI InChI=1S/C30H38N2O5/c1-20-14-24-25(31-30(20)37-29-27(34-3)15-23(19-33-2)16-28(29)35-4)6-5-7-26(24)32(17-21-8-9-21)18-22-10-12-36-13-11-22/h5-7,14-16,21-22H,8-13,17-19H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 762 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387032
(CHEMBL2046532)Show SMILES COCc1cc(OC)c(Oc2nc3cccc(NC4CCCCC4)c3cc2C)c(OC)c1 Show InChI InChI=1S/C26H32N2O4/c1-17-13-20-21(27-19-9-6-5-7-10-19)11-8-12-22(20)28-26(17)32-25-23(30-3)14-18(16-29-2)15-24(25)31-4/h8,11-15,19,27H,5-7,9-10,16H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387019
(CHEMBL2049192)Show SMILES CCCN(CCC)c1cccc2nc(N(C)c3c(C)cc(C)cc3C)c(=O)n(C)c12 Show InChI InChI=1S/C25H34N4O/c1-8-13-29(14-9-2)21-12-10-11-20-23(21)28(7)25(30)24(26-20)27(6)22-18(4)15-17(3)16-19(22)5/h10-12,15-16H,8-9,13-14H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387033
(CHEMBL2046533)Show SMILES CCN(Cc1ccncc1)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C28H31N3O4/c1-6-31(17-20-10-12-29-13-11-20)24-9-7-8-23-22(24)14-19(2)28(30-23)35-27-25(33-4)15-21(18-32-3)16-26(27)34-5/h7-16H,6,17-18H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387031
(CHEMBL2046531)Show SMILES CCC(CC)Nc1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 Show InChI InChI=1S/C25H32N2O4/c1-7-18(8-2)26-20-10-9-11-21-19(20)12-16(3)25(27-21)31-24-22(29-5)13-17(15-28-4)14-23(24)30-6/h9-14,18,26H,7-8,15H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387024
(CHEMBL2049198)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(OC)cc(OC)cc3OC)c(C)cc12 Show InChI InChI=1S/C25H33N3O3/c1-7-12-28(13-8-2)21-11-9-10-20-19(21)14-17(3)25(26-20)27-24-22(30-5)15-18(29-4)16-23(24)31-6/h9-11,14-16H,7-8,12-13H2,1-6H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
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