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PubMed code 22796349

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))		BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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 0.5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397952
PNG
(CHEMBL2179979)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](Sc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H17NOS/c18-15-11-10-12-6-4-5-9-14(12)17(16(15)19)20-13-7-2-1-3-8-13/h1-9,15,17H,10-11,18H2/t15-,17+/m0/s1
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 60n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397953
PNG
(CHEMBL2179978)
Show SMILES N[C@H]1CCc2ccccc2[C@H](Sc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H17NOS/c18-15-11-10-12-6-4-5-9-14(12)17(16(15)19)20-13-7-2-1-3-8-13/h1-9,15,17H,10-11,18H2/t15-,17-/m0/s1
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 60n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397954
PNG
(CHEMBL2179977)
Show SMILES N[C@H]1CCc2ccccc2[C@H](SCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C18H19NOS/c19-16-11-10-14-8-4-5-9-15(14)18(17(16)20)21-12-13-6-2-1-3-7-13/h1-9,16,18H,10-12,19H2/t16-,18-/m0/s1
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 83n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397955
PNG
(CHEMBL2179976)
Show SMILES N[C@H]1CCc2ccccc2[C@H](F)C1=O |r|
Show InChI InChI=1S/C11H12FNO/c12-10-8-4-2-1-3-7(8)5-6-9(13)11(10)14/h1-4,9-10H,5-6,13H2/t9-,10-/m0/s1
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 300n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM23973
PNG
(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Show SMILES NC1Cc2ccccc2CC1=O
Show InChI InChI=1S/C10H11NO/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,9H,5-6,11H2
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 500n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of APN

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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 500n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM50397948
PNG
(CHEMBL2179975)
Show SMILES N[C@H]1CCc2ccccc2CC1=O |r|
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2/t10-/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of APN

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397948
PNG
(CHEMBL2179975)
Show SMILES N[C@H]1CCc2ccccc2CC1=O |r|
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2/t10-/m0/s1
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 1.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397949
PNG
(CHEMBL2179973)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C20H23NO/c21-19-14-13-16-10-4-5-11-17(16)18(20(19)22)12-6-9-15-7-2-1-3-8-15/h1-5,7-8,10-11,18-19H,6,9,12-14,21H2/t18-,19+/m1/s1
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 1.20E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397950
PNG
(CHEMBL2179972)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](Cc2ccccc2)C1=O |r|
Show InChI InChI=1S/C18H19NO/c19-17-11-10-14-8-4-5-9-15(14)16(18(17)20)12-13-6-2-1-3-7-13/h1-9,16-17H,10-12,19H2/t16-,17+/m1/s1
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 1.30E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397951
PNG
(CHEMBL2179981)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C19H21NO/c20-18-13-11-15-8-4-5-9-16(15)17(19(18)21)12-10-14-6-2-1-3-7-14/h1-9,17-18H,10-13,20H2/t17-,18+/m1/s1
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 2.20E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397954
PNG
(CHEMBL2179977)
Show SMILES N[C@H]1CCc2ccccc2[C@H](SCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C18H19NOS/c19-16-11-10-14-8-4-5-9-15(14)18(17(16)20)21-12-13-6-2-1-3-7-13/h1-9,16,18H,10-12,19H2/t16-,18-/m0/s1
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 4.00E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397956
PNG
(CHEMBL2179974)
Show SMILES N=C1CCc2ccccc2C(Cc2ccccc2)C1=O
Show InChI InChI=1S/C18H17NO/c19-17-11-10-14-8-4-5-9-15(14)16(18(17)20)12-13-6-2-1-3-7-13/h1-9,16,19H,10-12H2
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 8.00E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50397957
PNG
(CHEMBL2179980)
Show SMILES N[C@H]1CCc2ccccc2[C@H](CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C19H21NO/c20-18-13-11-15-8-4-5-9-16(15)17(19(18)21)12-10-14-6-2-1-3-7-14/h1-9,17-18H,10-13,20H2/t17-,18-/m0/s1
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 8.80E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397954
PNG
(CHEMBL2179977)
Show SMILES N[C@H]1CCc2ccccc2[C@H](SCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C18H19NOS/c19-16-11-10-14-8-4-5-9-15(14)18(17(16)20)21-12-13-6-2-1-3-7-13/h1-9,16,18H,10-12,19H2/t16-,18-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397952
PNG
(CHEMBL2179979)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](Sc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H17NOS/c18-15-11-10-12-6-4-5-9-14(12)17(16(15)19)20-13-7-2-1-3-8-13/h1-9,15,17H,10-11,18H2/t15-,17+/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397953
PNG
(CHEMBL2179978)
Show SMILES N[C@H]1CCc2ccccc2[C@H](Sc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H17NOS/c18-15-11-10-12-6-4-5-9-14(12)17(16(15)19)20-13-7-2-1-3-8-13/h1-9,15,17H,10-11,18H2/t15-,17-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397949
PNG
(CHEMBL2179973)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C20H23NO/c21-19-14-13-16-10-4-5-11-17(16)18(20(19)22)12-6-9-15-7-2-1-3-8-15/h1-5,7-8,10-11,18-19H,6,9,12-14,21H2/t18-,19+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397951
PNG
(CHEMBL2179981)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C19H21NO/c20-18-13-11-15-8-4-5-9-16(15)17(19(18)21)12-10-14-6-2-1-3-7-14/h1-9,17-18H,10-13,20H2/t17-,18+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397953
PNG
(CHEMBL2179978)
Show SMILES N[C@H]1CCc2ccccc2[C@H](Sc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H17NOS/c18-15-11-10-12-6-4-5-9-14(12)17(16(15)19)20-13-7-2-1-3-8-13/h1-9,15,17H,10-11,18H2/t15-,17-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397950
PNG
(CHEMBL2179972)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](Cc2ccccc2)C1=O |r|
Show InChI InChI=1S/C18H19NO/c19-17-11-10-14-8-4-5-9-15(14)16(18(17)20)12-13-6-2-1-3-7-13/h1-9,16-17H,10-12,19H2/t16-,17+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397949
PNG
(CHEMBL2179973)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C20H23NO/c21-19-14-13-16-10-4-5-11-17(16)18(20(19)22)12-6-9-15-7-2-1-3-8-15/h1-5,7-8,10-11,18-19H,6,9,12-14,21H2/t18-,19+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397951
PNG
(CHEMBL2179981)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C19H21NO/c20-18-13-11-15-8-4-5-9-16(15)17(19(18)21)12-10-14-6-2-1-3-7-14/h1-9,17-18H,10-13,20H2/t17-,18+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397950
PNG
(CHEMBL2179972)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](Cc2ccccc2)C1=O |r|
Show InChI InChI=1S/C18H19NO/c19-17-11-10-14-8-4-5-9-15(14)16(18(17)20)12-13-6-2-1-3-7-13/h1-9,16-17H,10-12,19H2/t16-,17+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397952
PNG
(CHEMBL2179979)
Show SMILES N[C@H]1CCc2ccccc2[C@@H](Sc2ccccc2)C1=O |r|
Show InChI InChI=1S/C17H17NOS/c18-15-11-10-12-6-4-5-9-14(12)17(16(15)19)20-13-7-2-1-3-8-13/h1-9,15,17H,10-11,18H2/t15-,17+/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM23973
PNG
(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Show SMILES NC1Cc2ccccc2CC1=O
Show InChI InChI=1S/C10H11NO/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,9H,5-6,11H2
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 1.20E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397956
PNG
(CHEMBL2179974)
Show SMILES N=C1CCc2ccccc2C(Cc2ccccc2)C1=O
Show InChI InChI=1S/C18H17NO/c19-17-11-10-14-8-4-5-9-15(14)16(18(17)20)12-13-6-2-1-3-7-13/h1-9,16,19H,10-12H2
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 3.80E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397957
PNG
(CHEMBL2179980)
Show SMILES N[C@H]1CCc2ccccc2[C@H](CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C19H21NO/c20-18-13-11-15-8-4-5-9-16(15)17(19(18)21)12-10-14-6-2-1-3-7-14/h1-9,17-18H,10-13,20H2/t17-,18-/m0/s1
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 4.70E+5n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by Dixon-plot analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397955
PNG
(CHEMBL2179976)
Show SMILES N[C@H]1CCc2ccccc2[C@H](F)C1=O |r|
Show InChI InChI=1S/C11H12FNO/c12-10-8-4-2-1-3-7(8)5-6-9(13)11(10)14/h1-4,9-10H,5-6,13H2/t9-,10-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM50397948
PNG
(CHEMBL2179975)
Show SMILES N[C@H]1CCc2ccccc2CC1=O |r|
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2/t10-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397948
PNG
(CHEMBL2179975)
Show SMILES N[C@H]1CCc2ccccc2CC1=O |r|
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2/t10-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM50397955
PNG
(CHEMBL2179976)
Show SMILES N[C@H]1CCc2ccccc2[C@H](F)C1=O |r|
Show InChI InChI=1S/C11H12FNO/c12-10-8-4-2-1-3-7(8)5-6-9(13)11(10)14/h1-4,9-10H,5-6,13H2/t9-,10-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophootmetric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))		BDBM23973
PNG
(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Show SMILES NC1Cc2ccccc2CC1=O
Show InChI InChI=1S/C10H11NO/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,9H,5-6,11H2
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>1.00E+6n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis

Bioorg Med Chem 20: 4942-53 (2012)


Article DOI: 10.1016/j.bmc.2012.06.041
BindingDB Entry DOI: 10.7270/Q2RB75Q1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%