Found 51 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390149
(CHEMBL2069680)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C22H26BrN3O5/c1-28-18-12-15(13-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-4-6-17(7-5-16)26-8-10-31-11-9-26/h4-7,12-14,21H,8-11H2,1-3H3,(H,25,27)/b24-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390149
(CHEMBL2069680)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C22H26BrN3O5/c1-28-18-12-15(13-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-4-6-17(7-5-16)26-8-10-31-11-9-26/h4-7,12-14,21H,8-11H2,1-3H3,(H,25,27)/b24-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390148
(CHEMBL2069681)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCCS1(=O)=O Show InChI InChI=1S/C21H24BrN3O6S/c1-29-17-11-14(12-18(30-2)19(17)22)13-23-24-21(26)20(31-3)15-5-7-16(8-6-15)25-9-4-10-32(25,27)28/h5-8,11-13,20H,4,9-10H2,1-3H3,(H,24,26)/b23-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390137
(CHEMBL2069694)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cccn1 Show InChI InChI=1S/C21H21BrN4O4/c1-28-17-11-14(12-18(29-2)19(17)22)13-23-25-21(27)20(30-3)15-5-7-16(8-6-15)26-10-4-9-24-26/h4-13,20H,1-3H3,(H,25,27)/b23-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390137
(CHEMBL2069694)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cccn1 Show InChI InChI=1S/C21H21BrN4O4/c1-28-17-11-14(12-18(29-2)19(17)22)13-23-25-21(27)20(30-3)15-5-7-16(8-6-15)26-10-4-9-24-26/h4-13,20H,1-3H3,(H,25,27)/b23-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390138
(CHEMBL2069693)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1ccnn1 Show InChI InChI=1S/C20H20BrN5O4/c1-28-16-10-13(11-17(29-2)18(16)21)12-23-24-20(27)19(30-3)14-4-6-15(7-5-14)26-9-8-22-25-26/h4-12,19H,1-3H3,(H,24,27)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390159
(CHEMBL2069696)Show SMILES COc1cc(\C=N\NC(=O)C(OC(C)C)c2ccc(cc2)N2CCOCC2)cc(OC)c1Br Show InChI InChI=1S/C24H30BrN3O5/c1-16(2)33-23(18-5-7-19(8-6-18)28-9-11-32-12-10-28)24(29)27-26-15-17-13-20(30-3)22(25)21(14-17)31-4/h5-8,13-16,23H,9-12H2,1-4H3,(H,27,29)/b26-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390136
(CHEMBL2069695)Show SMILES CCOC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C23H28BrN3O5/c1-4-32-22(17-5-7-18(8-6-17)27-9-11-31-12-10-27)23(28)26-25-15-16-13-19(29-2)21(24)20(14-16)30-3/h5-8,13-15,22H,4,9-12H2,1-3H3,(H,26,28)/b25-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390162
(CHEMBL2069687)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccc2ncccc12 Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-10-13(11-18(28-2)19(17)22)12-24-25-21(26)20(29-3)15-6-4-8-16-14(15)7-5-9-23-16/h4-12,20H,1-3H3,(H,25,26)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390143
(CHEMBL2069686)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cnc2ccccc2c1 Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-8-13(9-18(28-2)19(17)22)11-24-25-21(26)20(29-3)15-10-14-6-4-5-7-16(14)23-12-15/h4-12,20H,1-3H3,(H,25,26)/b24-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390158
(CHEMBL2069697)Show SMILES CCOC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cccn1 Show InChI InChI=1S/C22H23BrN4O4/c1-4-31-21(16-6-8-17(9-7-16)27-11-5-10-25-27)22(28)26-24-14-15-12-18(29-2)20(23)19(13-15)30-3/h5-14,21H,4H2,1-3H3,(H,26,28)/b24-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390145
(CHEMBL2069684)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(nc1)N1CCOCC1 Show InChI InChI=1S/C21H25BrN4O5/c1-28-16-10-14(11-17(29-2)19(16)22)12-24-25-21(27)20(30-3)15-4-5-18(23-13-15)26-6-8-31-9-7-26/h4-5,10-13,20H,6-9H2,1-3H3,(H,25,27)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390144
(CHEMBL2069685)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(nc1)N1CCCCC1 Show InChI InChI=1S/C22H27BrN4O4/c1-29-17-11-15(12-18(30-2)20(17)23)13-25-26-22(28)21(31-3)16-7-8-19(24-14-16)27-9-5-4-6-10-27/h7-8,11-14,21H,4-6,9-10H2,1-3H3,(H,26,28)/b25-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390160
(CHEMBL2069692)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cnnn1 Show InChI InChI=1S/C19H19BrN6O4/c1-28-15-8-12(9-16(29-2)17(15)20)10-21-23-19(27)18(30-3)13-4-6-14(7-5-13)26-11-22-24-25-26/h4-11,18H,1-3H3,(H,23,27)/b21-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390142
(CHEMBL2069688)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccnc2ccccc12 Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-10-13(11-18(28-2)19(17)22)12-24-25-21(26)20(29-3)15-8-9-23-16-7-5-4-6-14(15)16/h4-12,20H,1-3H3,(H,25,26)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390139
(CHEMBL2069691)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1cncn1 Show InChI InChI=1S/C20H20BrN5O4/c1-28-16-8-13(9-17(29-2)18(16)21)10-23-25-20(27)19(30-3)14-4-6-15(7-5-14)26-12-22-11-24-26/h4-12,19H,1-3H3,(H,25,27)/b23-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390156
(CHEMBL2069673)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21BrN2O6/c1-25-16-8-12(9-17(26-2)18(16)21)11-22-23-20(24)19(27-3)13-4-5-14-15(10-13)29-7-6-28-14/h4-5,8-11,19H,6-7H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390154
(CHEMBL2069675)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccc(c1)N(C)C Show InChI InChI=1S/C20H24BrN3O4/c1-24(2)15-8-6-7-14(11-15)19(28-5)20(25)23-22-12-13-9-16(26-3)18(21)17(10-13)27-4/h6-12,19H,1-5H3,(H,23,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390153
(CHEMBL2069676)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N(C)C Show InChI InChI=1S/C20H24BrN3O4/c1-24(2)15-8-6-14(7-9-15)19(28-5)20(25)23-22-12-13-10-16(26-3)18(21)17(11-13)27-4/h6-12,19H,1-5H3,(H,23,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390150
(CHEMBL2069679)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCCC1 Show InChI InChI=1S/C22H26BrN3O4/c1-28-18-12-15(13-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-6-8-17(9-7-16)26-10-4-5-11-26/h6-9,12-14,21H,4-5,10-11H2,1-3H3,(H,25,27)/b24-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390157
(CHEMBL2069698)Show SMILES COc1cc(\C=N\NC(=O)C(OC(C)C)c2ccc(cc2)-n2cccn2)cc(OC)c1Br Show InChI InChI=1S/C23H25BrN4O4/c1-15(2)32-22(17-6-8-18(9-7-17)28-11-5-10-26-28)23(29)27-25-14-16-12-19(30-3)21(24)20(13-16)31-4/h5-15,22H,1-4H3,(H,27,29)/b25-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390122
(CHEMBL2069663)Show SMILES CCOc1cc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)cc(Cl)c1OC Show InChI InChI=1S/C21H23ClN2O6/c1-4-28-18-10-13(9-15(22)20(18)27-3)12-23-24-21(25)19(26-2)14-5-6-16-17(11-14)30-8-7-29-16/h5-6,9-12,19H,4,7-8H2,1-3H3,(H,24,25)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390121
(CHEMBL2069664)Show SMILES CCOc1cc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)cc(Br)c1OC Show InChI InChI=1S/C21H23BrN2O6/c1-4-28-18-10-13(9-15(22)20(18)27-3)12-23-24-21(25)19(26-2)14-5-6-16-17(11-14)30-8-7-29-16/h5-6,9-12,19H,4,7-8H2,1-3H3,(H,24,25)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390151
(CHEMBL2069678)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccc(c1)N1CCCC1 Show InChI InChI=1S/C22H26BrN3O4/c1-28-18-11-15(12-19(29-2)20(18)23)14-24-25-22(27)21(30-3)16-7-6-8-17(13-16)26-9-4-5-10-26/h6-8,11-14,21H,4-5,9-10H2,1-3H3,(H,25,27)/b24-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390155
(CHEMBL2069674)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc2OCOc2c1 Show InChI InChI=1S/C19H19BrN2O6/c1-24-15-6-11(7-16(25-2)17(15)20)9-21-22-19(23)18(26-3)12-4-5-13-14(8-12)28-10-27-13/h4-9,18H,10H2,1-3H3,(H,22,23)/b21-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390147
(CHEMBL2069682)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCS(=O)(=O)CC1 Show InChI InChI=1S/C22H26BrN3O6S/c1-30-18-12-15(13-19(31-2)20(18)23)14-24-25-22(27)21(32-3)16-4-6-17(7-5-16)26-8-10-33(28,29)11-9-26/h4-7,12-14,21H,8-11H2,1-3H3,(H,25,27)/b24-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390140
(CHEMBL2069690)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)-n1ccnc1 Show InChI InChI=1S/C21H21BrN4O4/c1-28-17-10-14(11-18(29-2)19(17)22)12-24-25-21(27)20(30-3)15-4-6-16(7-5-15)26-9-8-23-13-26/h4-13,20H,1-3H3,(H,25,27)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390152
(CHEMBL2069677)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCN(C)CC1 Show InChI InChI=1S/C23H29BrN4O4/c1-27-9-11-28(12-10-27)18-7-5-17(6-8-18)22(32-4)23(29)26-25-15-16-13-19(30-2)21(24)20(14-16)31-3/h5-8,13-15,22H,9-12H2,1-4H3,(H,26,29)/b25-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390114
(CHEMBL2069672)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(C)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C21H24N2O6/c1-13-17(25-2)9-14(10-18(13)26-3)12-22-23-21(24)20(27-4)15-5-6-16-19(11-15)29-8-7-28-16/h5-6,9-12,20H,7-8H2,1-4H3,(H,23,24)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390146
(CHEMBL2069683)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1cccnc1 Show InChI InChI=1S/C17H18BrN3O4/c1-23-13-7-11(8-14(24-2)15(13)18)9-20-21-17(22)16(25-3)12-5-4-6-19-10-12/h4-10,16H,1-3H3,(H,21,22)/b20-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390123
(CHEMBL2069662)Show SMILES COC(C(=O)N\N=C\c1cc(Br)c(OC)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21BrN2O6/c1-25-17-9-12(8-14(21)19(17)27-3)11-22-23-20(24)18(26-2)13-4-5-15-16(10-13)29-7-6-28-15/h4-5,8-11,18H,6-7H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390132
(CHEMBL2069654)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(OC)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C21H24N2O7/c1-25-17-9-13(10-18(26-2)20(17)28-4)12-22-23-21(24)19(27-3)14-5-6-15-16(11-14)30-8-7-29-15/h5-6,9-12,19H,7-8H2,1-4H3,(H,23,24)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390124
(CHEMBL2069661)Show SMILES COC(C(=O)N\N=C\c1cc(Cl)c(OC)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21ClN2O6/c1-25-17-9-12(8-14(21)19(17)27-3)11-22-23-20(24)18(26-2)13-4-5-15-16(10-13)29-7-6-28-15/h4-5,8-11,18H,6-7H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390130
(CHEMBL2069656)Show SMILES CCOc1cc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)ccc1OC Show InChI InChI=1S/C21H24N2O6/c1-4-27-18-11-14(5-7-16(18)25-2)13-22-23-21(24)20(26-3)15-6-8-17-19(12-15)29-10-9-28-17/h5-8,11-13,20H,4,9-10H2,1-3H3,(H,23,24)/b22-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390118
(CHEMBL2069668)Show SMILES COC(C(=O)N\N=C\c1ccc(Cl)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H19ClN2O5/c1-24-16-9-12(3-5-14(16)20)11-21-22-19(23)18(25-2)13-4-6-15-17(10-13)27-8-7-26-15/h3-6,9-11,18H,7-8H2,1-2H3,(H,22,23)/b21-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390125
(CHEMBL2069660)Show SMILES COC(C(=O)N\N=C\c1cc(F)c(OC)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21FN2O6/c1-25-17-9-12(8-14(21)19(17)27-3)11-22-23-20(24)18(26-2)13-4-5-15-16(10-13)29-7-6-28-15/h4-5,8-11,18H,6-7H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390117
(CHEMBL2069669)Show SMILES COC(C(=O)N\N=C\c1ccc(Br)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H19BrN2O5/c1-24-16-9-12(3-5-14(16)20)11-21-22-19(23)18(25-2)13-4-6-15-17(10-13)27-8-7-26-15/h3-6,9-11,18H,7-8H2,1-2H3,(H,22,23)/b21-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390134
(CHEMBL2069652)Show SMILES COC(C(=O)N\N=C\c1ccc(OC)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H22N2O6/c1-24-15-6-4-13(10-17(15)25-2)12-21-22-20(23)19(26-3)14-5-7-16-18(11-14)28-9-8-27-16/h4-7,10-12,19H,8-9H2,1-3H3,(H,22,23)/b21-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390161
(CHEMBL2069665)Show SMILES COC(C(=O)N\N=C\c1ccc(C)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H22N2O5/c1-13-4-5-14(10-17(13)24-2)12-21-22-20(23)19(25-3)15-6-7-16-18(11-15)27-9-8-26-16/h4-7,10-12,19H,8-9H2,1-3H3,(H,22,23)/b21-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390120
(CHEMBL2069666)Show SMILES COC(C(=O)N\N=C\c1ccc(c(OC)c1)C(F)(F)F)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H19F3N2O5/c1-27-16-9-12(3-5-14(16)20(21,22)23)11-24-25-19(26)18(28-2)13-4-6-15-17(10-13)30-8-7-29-15/h3-6,9-11,18H,7-8H2,1-2H3,(H,25,26)/b24-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390126
(CHEMBL2069659)Show SMILES COC(C(=O)N\N=C\c1ccc(OC)c(OC)c1Br)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21BrN2O6/c1-25-15-7-5-13(17(21)19(15)27-3)11-22-23-20(24)18(26-2)12-4-6-14-16(10-12)29-9-8-28-14/h4-7,10-11,18H,8-9H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390131
(CHEMBL2069655)Show SMILES CCOc1ccc(\C=N\NC(=O)C(OC)c2ccc3OCCOc3c2)cc1OCC Show InChI InChI=1S/C22H26N2O6/c1-4-27-17-8-6-15(12-19(17)28-5-2)14-23-24-22(25)21(26-3)16-7-9-18-20(13-16)30-11-10-29-18/h6-9,12-14,21H,4-5,10-11H2,1-3H3,(H,24,25)/b23-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 223 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390133
(CHEMBL2069653)Show SMILES COC(C(=O)N\N=C\c1cc(OC)cc(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H22N2O6/c1-24-15-8-13(9-16(11-15)25-2)12-21-22-20(23)19(26-3)14-4-5-17-18(10-14)28-7-6-27-17/h4-5,8-12,19H,6-7H2,1-3H3,(H,22,23)/b21-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 275 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390141
(CHEMBL2069689)Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H21BrN4O4/c1-25-14-8-6-5-7-13(14)23-19(25)18(29-4)20(26)24-22-11-12-9-15(27-2)17(21)16(10-12)28-3/h5-11,18H,1-4H3,(H,24,26)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 279 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390135
(CHEMBL2069651)Show InChI InChI=1S/C18H20N2O4/c1-22-15-10-9-13(11-16(15)23-2)12-19-20-18(21)17(24-3)14-7-5-4-6-8-14/h4-12,17H,1-3H3,(H,20,21)/b19-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 359 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390128
(CHEMBL2069658)Show SMILES COC(C(=O)N\N=C\c1ccc(OC)c(OC)c1F)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21FN2O6/c1-25-15-7-5-13(17(21)19(15)27-3)11-22-23-20(24)18(26-2)12-4-6-14-16(10-12)29-9-8-28-14/h4-7,10-11,18H,8-9H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 382 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390119
(CHEMBL2069667)Show SMILES COC(C(=O)N\N=C\c1ccc(F)c(OC)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H19FN2O5/c1-24-16-9-12(3-5-14(16)20)11-21-22-19(23)18(25-2)13-4-6-15-17(10-13)27-8-7-26-15/h3-6,9-11,18H,7-8H2,1-2H3,(H,22,23)/b21-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 507 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390116
(CHEMBL2069670)Show SMILES COC(C(=O)N\N=C\c1ccc(F)c(Br)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C18H16BrFN2O4/c1-24-17(12-3-5-15-16(9-12)26-7-6-25-15)18(23)22-21-10-11-2-4-14(20)13(19)8-11/h2-5,8-10,17H,6-7H2,1H3,(H,22,23)/b21-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390127
(CHEMBL2069312)Show SMILES COC(C(=O)N\N=C\c1ccc(OC)c(OC)c1Cl)c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H21ClN2O6/c1-25-15-7-5-13(17(21)19(15)27-3)11-22-23-20(24)18(26-2)12-4-6-14-16(10-12)29-9-8-28-14/h4-7,10-11,18H,8-9H2,1-3H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390115
(CHEMBL2069671)Show SMILES COC(C(=O)N\N=C\c1ccc(C#N)c(F)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H16FN3O4/c1-25-18(13-4-5-16-17(9-13)27-7-6-26-16)19(24)23-22-11-12-2-3-14(10-21)15(20)8-12/h2-5,8-9,11,18H,6-7H2,1H3,(H,23,24)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50390129
(CHEMBL2069657)Show SMILES COC(C(=O)N\N=C\c1ccc(OC)c(O)c1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H20N2O6/c1-24-15-5-3-12(9-14(15)22)11-20-21-19(23)18(25-2)13-4-6-16-17(10-13)27-8-7-26-16/h3-6,9-11,18,22H,7-8H2,1-2H3,(H,21,23)/b20-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 22: 5595-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65 |
More data for this
Ligand-Target Pair | |
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