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PubMed code 23177783

Compile data set for download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50161646
PNG
((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Show SMILES C[C@H]1CNCCc2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
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PubMed
 1.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50161646
PNG
((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Show SMILES C[C@H]1CNCCc2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
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 1.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
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 3.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
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 4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
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 4.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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 12n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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 12n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
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 13n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428529
PNG
(CHEMBL2337500)
Show SMILES Clc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-5-6-3-14-4-8(6)15-11(16)9(5)10(7)13/h1-2,6,8,14H,3-4H2,(H,15,16)/t6-,8+/m1/s1
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 13n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428542
PNG
(CHEMBL2337102)
Show SMILES COc1ccc(-c2cc3[C@@H]4CNCC[C@@H]4N4CCCc(c2)c34)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C22H23F3N2O/c1-28-15-4-5-16(19(11-15)22(23,24)25)14-9-13-3-2-8-27-20-6-7-26-12-18(20)17(10-14)21(13)27/h4-5,9-11,18,20,26H,2-3,6-8,12H2,1H3/t18-,20-/m0/s1
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 14n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428543
PNG
(CHEMBL2337103)
Show SMILES C1C[C@H]2[C@@H](CN1)c1cccc3SCCCN2c13 |r|
Show InChI InChI=1S/C14H18N2S/c1-3-10-11-9-15-6-5-12(11)16-7-2-8-17-13(4-1)14(10)16/h1,3-4,11-12,15H,2,5-9H2/t11-,12-/m0/s1
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 15n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
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 23n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428539
PNG
(CHEMBL2337492)
Show SMILES CN1[C@H]2CNC[C@@H]2c2cccc(c2C1=O)C(F)(F)F |r|
Show InChI InChI=1S/C13H13F3N2O/c1-18-10-6-17-5-8(10)7-3-2-4-9(13(14,15)16)11(7)12(18)19/h2-4,8,10,17H,5-6H2,1H3/t8-,10+/m1/s1
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 24n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428527
PNG
(CHEMBL2337106)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3NC(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C14H15F3N2O/c1-2-7-3-8-9-5-18-6-11(9)19-13(20)12(8)10(4-7)14(15,16)17/h3-4,9,11,18H,2,5-6H2,1H3,(H,19,20)/t9-,11+/m1/s1
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 34n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428531
PNG
(CHEMBL2337493)
Show SMILES Clc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C11H11ClN2O/c12-8-3-1-2-6-7-4-13-5-9(7)14-11(15)10(6)8/h1-3,7,9,13H,4-5H2,(H,14,15)/t7-,9+/m1/s1
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 40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428537
PNG
(CHEMBL2337497)
Show SMILES CCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-8-9-5-15-6-11(9)16-13(17)12(8)10(14)4-7/h3-4,9,11,15H,2,5-6H2,1H3,(H,16,17)/t9-,11+/m1/s1
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 44n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428525
PNG
(CHEMBL2337504)
Show SMILES CCc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H18N2O/c1-3-9-4-8(2)13-10(5-9)11-6-15-7-12(11)16-14(13)17/h4-5,11-12,15H,3,6-7H2,1-2H3,(H,16,17)/t11-,12+/m1/s1
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 46n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428539
PNG
(CHEMBL2337492)
Show SMILES CN1[C@H]2CNC[C@@H]2c2cccc(c2C1=O)C(F)(F)F |r|
Show InChI InChI=1S/C13H13F3N2O/c1-18-10-6-17-5-8(10)7-3-2-4-9(13(14,15)16)11(7)12(18)19/h2-4,8,10,17H,5-6H2,1H3/t8-,10+/m1/s1
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 46n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428529
PNG
(CHEMBL2337500)
Show SMILES Clc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-5-6-3-14-4-8(6)15-11(16)9(5)10(7)13/h1-2,6,8,14H,3-4H2,(H,15,16)/t6-,8+/m1/s1
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 48n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428540
PNG
(CHEMBL2337499)
Show SMILES CCc1ccc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c12 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-4-9(14)12-11(7)8-5-15-6-10(8)16-13(12)17/h3-4,8,10,15H,2,5-6H2,1H3,(H,16,17)/t8-,10-/m0/s1
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 55n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
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 56n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428529
PNG
(CHEMBL2337500)
Show SMILES Clc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-5-6-3-14-4-8(6)15-11(16)9(5)10(7)13/h1-2,6,8,14H,3-4H2,(H,15,16)/t6-,8+/m1/s1
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 72n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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 73n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428531
PNG
(CHEMBL2337493)
Show SMILES Clc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C11H11ClN2O/c12-8-3-1-2-6-7-4-13-5-9(7)14-11(15)10(6)8/h1-3,7,9,13H,4-5H2,(H,14,15)/t7-,9+/m1/s1
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 73n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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 73n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428540
PNG
(CHEMBL2337499)
Show SMILES CCc1ccc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c12 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-4-9(14)12-11(7)8-5-15-6-10(8)16-13(12)17/h3-4,8,10,15H,2,5-6H2,1H3,(H,16,17)/t8-,10-/m0/s1
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 79n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428539
PNG
(CHEMBL2337492)
Show SMILES CN1[C@H]2CNC[C@@H]2c2cccc(c2C1=O)C(F)(F)F |r|
Show InChI InChI=1S/C13H13F3N2O/c1-18-10-6-17-5-8(10)7-3-2-4-9(13(14,15)16)11(7)12(18)19/h2-4,8,10,17H,5-6H2,1H3/t8-,10+/m1/s1
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 79n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428532
PNG
(CHEMBL2337105)
Show SMILES CC(C)c1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C15H20N2O/c1-8(2)10-4-9(3)14-11(5-10)12-6-16-7-13(12)17-15(14)18/h4-5,8,12-13,16H,6-7H2,1-3H3,(H,17,18)/t12-,13+/m1/s1
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 83n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428524
PNG
(CHEMBL2337503)
Show SMILES Cc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H16N2O/c1-7-3-8(2)12-9(4-7)10-5-14-6-11(10)15-13(12)16/h3-4,10-11,14H,5-6H2,1-2H3,(H,15,16)/t10-,11+/m1/s1
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 86n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428526
PNG
(CHEMBL2337104)
Show SMILES Cc1cc(cc2[C@H]3CNC[C@@H]3NC(=O)c12)C1CC1 |r|
Show InChI InChI=1S/C15H18N2O/c1-8-4-10(9-2-3-9)5-11-12-6-16-7-13(12)17-15(18)14(8)11/h4-5,9,12-13,16H,2-3,6-7H2,1H3,(H,17,18)/t12-,13+/m1/s1
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 87n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428527
PNG
(CHEMBL2337106)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3NC(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C14H15F3N2O/c1-2-7-3-8-9-5-18-6-11(9)19-13(20)12(8)10(4-7)14(15,16)17/h3-4,9,11,18H,2,5-6H2,1H3,(H,19,20)/t9-,11+/m1/s1
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 87n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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 91n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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 91n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428528
PNG
(CHEMBL2337488)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3N(C)C(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N2O/c1-3-8-4-9-10-6-19-7-12(10)20(2)14(21)13(9)11(5-8)15(16,17)18/h4-5,10,12,19H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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 140n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428528
PNG
(CHEMBL2337488)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3N(C)C(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N2O/c1-3-8-4-9-10-6-19-7-12(10)20(2)14(21)13(9)11(5-8)15(16,17)18/h4-5,10,12,19H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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 151n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428527
PNG
(CHEMBL2337106)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3NC(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C14H15F3N2O/c1-2-7-3-8-9-5-18-6-11(9)19-13(20)12(8)10(4-7)14(15,16)17/h3-4,9,11,18H,2,5-6H2,1H3,(H,19,20)/t9-,11+/m1/s1
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 157n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428543
PNG
(CHEMBL2337103)
Show SMILES C1C[C@H]2[C@@H](CN1)c1cccc3SCCCN2c13 |r|
Show InChI InChI=1S/C14H18N2S/c1-3-10-11-9-15-6-5-12(11)16-7-2-8-17-13(4-1)14(10)16/h1,3-4,11-12,15H,2,5-9H2/t11-,12-/m0/s1
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 162n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428526
PNG
(CHEMBL2337104)
Show SMILES Cc1cc(cc2[C@H]3CNC[C@@H]3NC(=O)c12)C1CC1 |r|
Show InChI InChI=1S/C15H18N2O/c1-8-4-10(9-2-3-9)5-11-12-6-16-7-13(12)17-15(18)14(8)11/h4-5,9,12-13,16H,2-3,6-7H2,1H3,(H,17,18)/t12-,13+/m1/s1
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 177n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428525
PNG
(CHEMBL2337504)
Show SMILES CCc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H18N2O/c1-3-9-4-8(2)13-10(5-9)11-6-15-7-12(11)16-14(13)17/h4-5,11-12,15H,3,6-7H2,1-2H3,(H,16,17)/t11-,12+/m1/s1
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 188n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428524
PNG
(CHEMBL2337503)
Show SMILES Cc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H16N2O/c1-7-3-8(2)12-9(4-7)10-5-14-6-11(10)15-13(12)16/h3-4,10-11,14H,5-6H2,1-2H3,(H,15,16)/t10-,11+/m1/s1
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 191n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428523
PNG
(CHEMBL2337489)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9-/m0/s1
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 192n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428544
PNG
(CHEMBL2337496)
Show SMILES Cc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-7-8-4-14-5-10(8)15-12(16)11(7)9(13)3-6/h2-3,8,10,14H,4-5H2,1H3,(H,15,16)/t8-,10+/m1/s1
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 217n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428544
PNG
(CHEMBL2337496)
Show SMILES Cc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-7-8-4-14-5-10(8)15-12(16)11(7)9(13)3-6/h2-3,8,10,14H,4-5H2,1H3,(H,15,16)/t8-,10+/m1/s1
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 253n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428531
PNG
(CHEMBL2337493)
Show SMILES Clc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C11H11ClN2O/c12-8-3-1-2-6-7-4-13-5-9(7)14-11(15)10(6)8/h1-3,7,9,13H,4-5H2,(H,14,15)/t7-,9+/m1/s1
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 258n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428528
PNG
(CHEMBL2337488)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3N(C)C(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N2O/c1-3-8-4-9-10-6-19-7-12(10)20(2)14(21)13(9)11(5-8)15(16,17)18/h4-5,10,12,19H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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 328n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428540
PNG
(CHEMBL2337499)
Show SMILES CCc1ccc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c12 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-4-9(14)12-11(7)8-5-15-6-10(8)16-13(12)17/h3-4,8,10,15H,2,5-6H2,1H3,(H,16,17)/t8-,10-/m0/s1
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 359n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428533
PNG
(CHEMBL2337502)
Show SMILES CCc1cc(Cl)c2C(=O)N(C)[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-3-8-4-9-10-6-16-7-12(10)17(2)14(18)13(9)11(15)5-8/h4-5,10,12,16H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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 393n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428544
PNG
(CHEMBL2337496)
Show SMILES Cc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-7-8-4-14-5-10(8)15-12(16)11(7)9(13)3-6/h2-3,8,10,14H,4-5H2,1H3,(H,15,16)/t8-,10+/m1/s1
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 478n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428532
PNG
(CHEMBL2337105)
Show SMILES CC(C)c1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C15H20N2O/c1-8(2)10-4-9(3)14-11(5-10)12-6-16-7-13(12)17-15(14)18/h4-5,8,12-13,16H,6-7H2,1-3H3,(H,17,18)/t12-,13+/m1/s1
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 535n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428524
PNG
(CHEMBL2337503)
Show SMILES Cc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H16N2O/c1-7-3-8(2)12-9(4-7)10-5-14-6-11(10)15-13(12)16/h3-4,10-11,14H,5-6H2,1-2H3,(H,15,16)/t10-,11+/m1/s1
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 540n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428534
PNG
(CHEMBL2337498)
Show SMILES CCCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-2-3-8-4-9-10-6-16-7-12(10)17-14(18)13(9)11(15)5-8/h4-5,10,12,16H,2-3,6-7H2,1H3,(H,17,18)/t10-,12+/m1/s1
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 556n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428525
PNG
(CHEMBL2337504)
Show SMILES CCc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H18N2O/c1-3-9-4-8(2)13-10(5-9)11-6-15-7-12(11)16-14(13)17/h4-5,11-12,15H,3,6-7H2,1-2H3,(H,16,17)/t11-,12+/m1/s1
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 703n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428534
PNG
(CHEMBL2337498)
Show SMILES CCCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-2-3-8-4-9-10-6-16-7-12(10)17-14(18)13(9)11(15)5-8/h4-5,10,12,16H,2-3,6-7H2,1H3,(H,17,18)/t10-,12+/m1/s1
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 776n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428537
PNG
(CHEMBL2337497)
Show SMILES CCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-8-9-5-15-6-11(9)16-13(17)12(8)10(14)4-7/h3-4,9,11,15H,2,5-6H2,1H3,(H,16,17)/t9-,11+/m1/s1
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 905n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428536
PNG
(CHEMBL2337491)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m0/s1
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 1.05E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428535
PNG
(CHEMBL2337495)
Show SMILES O=C1N[C@H]2CNC[C@@H]2c2ccccc12 |r|
Show InChI InChI=1S/C11H12N2O/c14-11-8-4-2-1-3-7(8)9-5-12-6-10(9)13-11/h1-4,9-10,12H,5-6H2,(H,13,14)/t9-,10+/m1/s1
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 1.06E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2C receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428542
PNG
(CHEMBL2337102)
Show SMILES COc1ccc(-c2cc3[C@@H]4CNCC[C@@H]4N4CCCc(c2)c34)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C22H23F3N2O/c1-28-15-4-5-16(19(11-15)22(23,24)25)14-9-13-3-2-8-27-20-6-7-26-12-18(20)17(10-14)21(13)27/h4-5,9-11,18,20,26H,2-3,6-8,12H2,1H3/t18-,20-/m0/s1
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 1.28E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428537
PNG
(CHEMBL2337497)
Show SMILES CCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-8-9-5-15-6-11(9)16-13(17)12(8)10(14)4-7/h3-4,9,11,15H,2,5-6H2,1H3,(H,16,17)/t9-,11+/m1/s1
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 1.49E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428533
PNG
(CHEMBL2337502)
Show SMILES CCc1cc(Cl)c2C(=O)N(C)[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-3-8-4-9-10-6-16-7-12(10)17(2)14(18)13(9)11(15)5-8/h4-5,10,12,16H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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 1.72E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428536
PNG
(CHEMBL2337491)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m0/s1
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 1.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428523
PNG
(CHEMBL2337489)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9-/m0/s1
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 1.88E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428523
PNG
(CHEMBL2337489)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9-/m0/s1
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 2.37E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428526
PNG
(CHEMBL2337104)
Show SMILES Cc1cc(cc2[C@H]3CNC[C@@H]3NC(=O)c12)C1CC1 |r|
Show InChI InChI=1S/C15H18N2O/c1-8-4-10(9-2-3-9)5-11-12-6-16-7-13(12)17-15(18)14(8)11/h4-5,9,12-13,16H,2-3,6-7H2,1H3,(H,17,18)/t12-,13+/m1/s1
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 3.18E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428532
PNG
(CHEMBL2337105)
Show SMILES CC(C)c1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C15H20N2O/c1-8(2)10-4-9(3)14-11(5-10)12-6-16-7-13(12)17-15(14)18/h4-5,8,12-13,16H,6-7H2,1-3H3,(H,17,18)/t12-,13+/m1/s1
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 3.33E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428534
PNG
(CHEMBL2337498)
Show SMILES CCCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-2-3-8-4-9-10-6-16-7-12(10)17-14(18)13(9)11(15)5-8/h4-5,10,12,16H,2-3,6-7H2,1H3,(H,17,18)/t10-,12+/m1/s1
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 4.44E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428535
PNG
(CHEMBL2337495)
Show SMILES O=C1N[C@H]2CNC[C@@H]2c2ccccc12 |r|
Show InChI InChI=1S/C11H12N2O/c14-11-8-4-2-1-3-7(8)9-5-12-6-10(9)13-11/h1-4,9-10,12H,5-6H2,(H,13,14)/t9-,10+/m1/s1
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 5.81E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428536
PNG
(CHEMBL2337491)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m0/s1
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 6.24E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428533
PNG
(CHEMBL2337502)
Show SMILES CCc1cc(Cl)c2C(=O)N(C)[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-3-8-4-9-10-6-16-7-12(10)17(2)14(18)13(9)11(15)5-8/h4-5,10,12,16H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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 6.53E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428535
PNG
(CHEMBL2337495)
Show SMILES O=C1N[C@H]2CNC[C@@H]2c2ccccc12 |r|
Show InChI InChI=1S/C11H12N2O/c14-11-8-4-2-1-3-7(8)9-5-12-6-10(9)13-11/h1-4,9-10,12H,5-6H2,(H,13,14)/t9-,10+/m1/s1
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 7.96E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]DOI from human recombinant 5-HT2A receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428527
PNG
(CHEMBL2337106)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3NC(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C14H15F3N2O/c1-2-7-3-8-9-5-18-6-11(9)19-13(20)12(8)10(4-7)14(15,16)17/h3-4,9,11,18H,2,5-6H2,1H3,(H,19,20)/t9-,11+/m1/s1
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n/an/an/an/a 101n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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n/an/an/an/a 63n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428537
PNG
(CHEMBL2337497)
Show SMILES CCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-8-9-5-15-6-11(9)16-13(17)12(8)10(14)4-7/h3-4,9,11,15H,2,5-6H2,1H3,(H,16,17)/t9-,11+/m1/s1
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n/an/an/an/a 26n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
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n/an/an/an/a 21n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50161646
PNG
((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Show SMILES C[C@H]1CNCCc2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428525
PNG
(CHEMBL2337504)
Show SMILES CCc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H18N2O/c1-3-9-4-8(2)13-10(5-9)11-6-15-7-12(11)16-14(13)17/h4-5,11-12,15H,3,6-7H2,1-2H3,(H,16,17)/t11-,12+/m1/s1
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n/an/an/an/a 856n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428528
PNG
(CHEMBL2337488)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3N(C)C(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N2O/c1-3-8-4-9-10-6-19-7-12(10)20(2)14(21)13(9)11(5-8)15(16,17)18/h4-5,10,12,19H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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n/an/an/an/a 268n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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n/an/an/an/a 9.90n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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n/an/an/an/a 2n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428526
PNG
(CHEMBL2337104)
Show SMILES Cc1cc(cc2[C@H]3CNC[C@@H]3NC(=O)c12)C1CC1 |r|
Show InChI InChI=1S/C15H18N2O/c1-8-4-10(9-2-3-9)5-11-12-6-16-7-13(12)17-15(18)14(8)11/h4-5,9,12-13,16H,2-3,6-7H2,1H3,(H,17,18)/t12-,13+/m1/s1
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n/an/an/an/a>3.00E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428535
PNG
(CHEMBL2337495)
Show SMILES O=C1N[C@H]2CNC[C@@H]2c2ccccc12 |r|
Show InChI InChI=1S/C11H12N2O/c14-11-8-4-2-1-3-7(8)9-5-12-6-10(9)13-11/h1-4,9-10,12H,5-6H2,(H,13,14)/t9-,10+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428533
PNG
(CHEMBL2337502)
Show SMILES CCc1cc(Cl)c2C(=O)N(C)[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-3-8-4-9-10-6-16-7-12(10)17(2)14(18)13(9)11(15)5-8/h4-5,10,12,16H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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n/an/an/an/a 82n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428528
PNG
(CHEMBL2337488)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3N(C)C(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N2O/c1-3-8-4-9-10-6-19-7-12(10)20(2)14(21)13(9)11(5-8)15(16,17)18/h4-5,10,12,19H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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n/an/an/an/a 2.09E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428527
PNG
(CHEMBL2337106)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3NC(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C14H15F3N2O/c1-2-7-3-8-9-5-18-6-11(9)19-13(20)12(8)10(4-7)14(15,16)17/h3-4,9,11,18H,2,5-6H2,1H3,(H,19,20)/t9-,11+/m1/s1
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n/an/an/an/a 605n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428525
PNG
(CHEMBL2337504)
Show SMILES CCc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H18N2O/c1-3-9-4-8(2)13-10(5-9)11-6-15-7-12(11)16-14(13)17/h4-5,11-12,15H,3,6-7H2,1-2H3,(H,16,17)/t11-,12+/m1/s1
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n/an/an/an/a 12n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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n/an/an/an/a 63n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428539
PNG
(CHEMBL2337492)
Show SMILES CN1[C@H]2CNC[C@@H]2c2cccc(c2C1=O)C(F)(F)F |r|
Show InChI InChI=1S/C13H13F3N2O/c1-18-10-6-17-5-8(10)7-3-2-4-9(13(14,15)16)11(7)12(18)19/h2-4,8,10,17H,5-6H2,1H3/t8-,10+/m1/s1
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n/an/an/an/a 3.30n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428537
PNG
(CHEMBL2337497)
Show SMILES CCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-8-9-5-15-6-11(9)16-13(17)12(8)10(14)4-7/h3-4,9,11,15H,2,5-6H2,1H3,(H,16,17)/t9-,11+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
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n/an/an/an/a 94n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428528
PNG
(CHEMBL2337488)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3N(C)C(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C15H17F3N2O/c1-3-8-4-9-10-6-19-7-12(10)20(2)14(21)13(9)11(5-8)15(16,17)18/h4-5,10,12,19H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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n/an/an/an/a 41n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428523
PNG
(CHEMBL2337489)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9-/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428526
PNG
(CHEMBL2337104)
Show SMILES Cc1cc(cc2[C@H]3CNC[C@@H]3NC(=O)c12)C1CC1 |r|
Show InChI InChI=1S/C15H18N2O/c1-8-4-10(9-2-3-9)5-11-12-6-16-7-13(12)17-15(18)14(8)11/h4-5,9,12-13,16H,2-3,6-7H2,1H3,(H,17,18)/t12-,13+/m1/s1
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n/an/an/an/a 27n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
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n/an/an/an/a 1.10n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428529
PNG
(CHEMBL2337500)
Show SMILES Clc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-5-6-3-14-4-8(6)15-11(16)9(5)10(7)13/h1-2,6,8,14H,3-4H2,(H,15,16)/t6-,8+/m1/s1
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n/an/an/an/a 128n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428531
PNG
(CHEMBL2337493)
Show SMILES Clc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C11H11ClN2O/c12-8-3-1-2-6-7-4-13-5-9(7)14-11(15)10(6)8/h1-3,7,9,13H,4-5H2,(H,14,15)/t7-,9+/m1/s1
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n/an/an/an/a 124n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428532
PNG
(CHEMBL2337105)
Show SMILES CC(C)c1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C15H20N2O/c1-8(2)10-4-9(3)14-11(5-10)12-6-16-7-13(12)17-15(14)18/h4-5,8,12-13,16H,6-7H2,1-3H3,(H,17,18)/t12-,13+/m1/s1
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n/an/an/an/a>3.00E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428536
PNG
(CHEMBL2337491)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m0/s1
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n/an/an/an/a 62n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428532
PNG
(CHEMBL2337105)
Show SMILES CC(C)c1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C15H20N2O/c1-8(2)10-4-9(3)14-11(5-10)12-6-16-7-13(12)17-15(14)18/h4-5,8,12-13,16H,6-7H2,1-3H3,(H,17,18)/t12-,13+/m1/s1
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n/an/an/an/a 706n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428544
PNG
(CHEMBL2337496)
Show SMILES Cc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-7-8-4-14-5-10(8)15-12(16)11(7)9(13)3-6/h2-3,8,10,14H,4-5H2,1H3,(H,15,16)/t8-,10+/m1/s1
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n/an/an/an/a 605n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428529
PNG
(CHEMBL2337500)
Show SMILES Clc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-5-6-3-14-4-8(6)15-11(16)9(5)10(7)13/h1-2,6,8,14H,3-4H2,(H,15,16)/t6-,8+/m1/s1
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n/an/an/an/a 414n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428524
PNG
(CHEMBL2337503)
Show SMILES Cc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H16N2O/c1-7-3-8(2)12-9(4-7)10-5-14-6-11(10)15-13(12)16/h3-4,10-11,14H,5-6H2,1-2H3,(H,15,16)/t10-,11+/m1/s1
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n/an/an/an/a 303n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428527
PNG
(CHEMBL2337106)
Show SMILES CCc1cc2[C@H]3CNC[C@@H]3NC(=O)c2c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C14H15F3N2O/c1-2-7-3-8-9-5-18-6-11(9)19-13(20)12(8)10(4-7)14(15,16)17/h3-4,9,11,18H,2,5-6H2,1H3,(H,19,20)/t9-,11+/m1/s1
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n/an/an/an/a 4.30n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428538
PNG
(CHEMBL2337490)
Show SMILES FC(F)(F)c1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m1/s1
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n/an/an/an/a 2n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428534
PNG
(CHEMBL2337498)
Show SMILES CCCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-2-3-8-4-9-10-6-16-7-12(10)17-14(18)13(9)11(15)5-8/h4-5,10,12,16H,2-3,6-7H2,1H3,(H,17,18)/t10-,12+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428531
PNG
(CHEMBL2337493)
Show SMILES Clc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C11H11ClN2O/c12-8-3-1-2-6-7-4-13-5-9(7)14-11(15)10(6)8/h1-3,7,9,13H,4-5H2,(H,14,15)/t7-,9+/m1/s1
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n/an/an/an/a 31n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428542
PNG
(CHEMBL2337102)
Show SMILES COc1ccc(-c2cc3[C@@H]4CNCC[C@@H]4N4CCCc(c2)c34)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C22H23F3N2O/c1-28-15-4-5-16(19(11-15)22(23,24)25)14-9-13-3-2-8-27-20-6-7-26-12-18(20)17(10-14)21(13)27/h4-5,9-11,18,20,26H,2-3,6-8,12H2,1H3/t18-,20-/m0/s1
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n/an/an/an/a 168n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428544
PNG
(CHEMBL2337496)
Show SMILES Cc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-7-8-4-14-5-10(8)15-12(16)11(7)9(13)3-6/h2-3,8,10,14H,4-5H2,1H3,(H,15,16)/t8-,10+/m1/s1
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n/an/an/an/a 523n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428534
PNG
(CHEMBL2337498)
Show SMILES CCCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-2-3-8-4-9-10-6-16-7-12(10)17-14(18)13(9)11(15)5-8/h4-5,10,12,16H,2-3,6-7H2,1H3,(H,17,18)/t10-,12+/m1/s1
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n/an/an/an/a 218n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428531
PNG
(CHEMBL2337493)
Show SMILES Clc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C11H11ClN2O/c12-8-3-1-2-6-7-4-13-5-9(7)14-11(15)10(6)8/h1-3,7,9,13H,4-5H2,(H,14,15)/t7-,9+/m1/s1
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n/an/an/an/a 2.60n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428541
PNG
(CHEMBL2337501)
Show SMILES Cc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-3-7-8-4-14-5-9(8)15-12(16)10(7)11(6)13/h2-3,8-9,14H,4-5H2,1H3,(H,15,16)/t8-,9+/m1/s1
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n/an/an/an/a 2.20n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428534
PNG
(CHEMBL2337498)
Show SMILES CCCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-2-3-8-4-9-10-6-16-7-12(10)17-14(18)13(9)11(15)5-8/h4-5,10,12,16H,2-3,6-7H2,1H3,(H,17,18)/t10-,12+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428526
PNG
(CHEMBL2337104)
Show SMILES Cc1cc(cc2[C@H]3CNC[C@@H]3NC(=O)c12)C1CC1 |r|
Show InChI InChI=1S/C15H18N2O/c1-8-4-10(9-2-3-9)5-11-12-6-16-7-13(12)17-15(18)14(8)11/h4-5,9,12-13,16H,2-3,6-7H2,1H3,(H,17,18)/t12-,13+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428535
PNG
(CHEMBL2337495)
Show SMILES O=C1N[C@H]2CNC[C@@H]2c2ccccc12 |r|
Show InChI InChI=1S/C11H12N2O/c14-11-8-4-2-1-3-7(8)9-5-12-6-10(9)13-11/h1-4,9-10,12H,5-6H2,(H,13,14)/t9-,10+/m1/s1
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n/an/an/an/a 43n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428543
PNG
(CHEMBL2337103)
Show SMILES C1C[C@H]2[C@@H](CN1)c1cccc3SCCCN2c13 |r|
Show InChI InChI=1S/C14H18N2S/c1-3-10-11-9-15-6-5-12(11)16-7-2-8-17-13(4-1)14(10)16/h1,3-4,11-12,15H,2,5-9H2/t11-,12-/m0/s1
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n/an/an/an/a 943n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor (unknown origin)

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428540
PNG
(CHEMBL2337499)
Show SMILES CCc1ccc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c12 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-4-9(14)12-11(7)8-5-15-6-10(8)16-13(12)17/h3-4,8,10,15H,2,5-6H2,1H3,(H,16,17)/t8-,10-/m0/s1
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n/an/an/an/a 2.33E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428530
PNG
(CHEMBL2337494)
Show SMILES Cc1cccc2[C@H]3CNC[C@@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H14N2O/c1-7-3-2-4-8-9-5-13-6-10(9)14-12(15)11(7)8/h2-4,9-10,13H,5-6H2,1H3,(H,14,15)/t9-,10+/m1/s1
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n/an/an/an/a 127n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428536
PNG
(CHEMBL2337491)
Show SMILES FC(F)(F)c1cccc2[C@@H]3CNC[C@H]3NC(=O)c12 |r|
Show InChI InChI=1S/C12H11F3N2O/c13-12(14,15)8-3-1-2-6-7-4-16-5-9(7)17-11(18)10(6)8/h1-3,7,9,16H,4-5H2,(H,17,18)/t7-,9+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428525
PNG
(CHEMBL2337504)
Show SMILES CCc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H18N2O/c1-3-9-4-8(2)13-10(5-9)11-6-15-7-12(11)16-14(13)17/h4-5,11-12,15H,3,6-7H2,1-2H3,(H,16,17)/t11-,12+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428532
PNG
(CHEMBL2337105)
Show SMILES CC(C)c1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C15H20N2O/c1-8(2)10-4-9(3)14-11(5-10)12-6-16-7-13(12)17-15(14)18/h4-5,8,12-13,16H,6-7H2,1-3H3,(H,17,18)/t12-,13+/m1/s1
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n/an/an/an/a 59n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428539
PNG
(CHEMBL2337492)
Show SMILES CN1[C@H]2CNC[C@@H]2c2cccc(c2C1=O)C(F)(F)F |r|
Show InChI InChI=1S/C13H13F3N2O/c1-18-10-6-17-5-8(10)7-3-2-4-9(13(14,15)16)11(7)12(18)19/h2-4,8,10,17H,5-6H2,1H3/t8-,10+/m1/s1
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n/an/an/an/a 32n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428540
PNG
(CHEMBL2337499)
Show SMILES CCc1ccc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c12 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-4-9(14)12-11(7)8-5-15-6-10(8)16-13(12)17/h3-4,8,10,15H,2,5-6H2,1H3,(H,16,17)/t8-,10-/m0/s1
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n/an/an/an/a 1.67E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428524
PNG
(CHEMBL2337503)
Show SMILES Cc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H16N2O/c1-7-3-8(2)12-9(4-7)10-5-14-6-11(10)15-13(12)16/h3-4,10-11,14H,5-6H2,1-2H3,(H,15,16)/t10-,11+/m1/s1
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n/an/an/an/a 207n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428540
PNG
(CHEMBL2337499)
Show SMILES CCc1ccc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c12 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-4-9(14)12-11(7)8-5-15-6-10(8)16-13(12)17/h3-4,8,10,15H,2,5-6H2,1H3,(H,16,17)/t8-,10-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428529
PNG
(CHEMBL2337500)
Show SMILES Clc1ccc2[C@H]3CNC[C@@H]3NC(=O)c2c1Cl |r|
Show InChI InChI=1S/C11H10Cl2N2O/c12-7-2-1-5-6-3-14-4-8(6)15-11(16)9(5)10(7)13/h1-2,6,8,14H,3-4H2,(H,15,16)/t6-,8+/m1/s1
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n/an/an/an/a 3.30n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428533
PNG
(CHEMBL2337502)
Show SMILES CCc1cc(Cl)c2C(=O)N(C)[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-3-8-4-9-10-6-16-7-12(10)17(2)14(18)13(9)11(15)5-8/h4-5,10,12,16H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428535
PNG
(CHEMBL2337495)
Show SMILES O=C1N[C@H]2CNC[C@@H]2c2ccccc12 |r|
Show InChI InChI=1S/C11H12N2O/c14-11-8-4-2-1-3-7(8)9-5-12-6-10(9)13-11/h1-4,9-10,12H,5-6H2,(H,13,14)/t9-,10+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))		BDBM50428533
PNG
(CHEMBL2337502)
Show SMILES CCc1cc(Cl)c2C(=O)N(C)[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C14H17ClN2O/c1-3-8-4-9-10-6-16-7-12(10)17(2)14(18)13(9)11(15)5-8/h4-5,10,12,16H,3,6-7H2,1-2H3/t10-,12+/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428539
PNG
(CHEMBL2337492)
Show SMILES CN1[C@H]2CNC[C@@H]2c2cccc(c2C1=O)C(F)(F)F |r|
Show InChI InChI=1S/C13H13F3N2O/c1-18-10-6-17-5-8(10)7-3-2-4-9(13(14,15)16)11(7)12(18)19/h2-4,8,10,17H,5-6H2,1H3/t8-,10+/m1/s1
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n/an/an/an/a 89n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428524
PNG
(CHEMBL2337503)
Show SMILES Cc1cc(C)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H16N2O/c1-7-3-8(2)12-9(4-7)10-5-14-6-11(10)15-13(12)16/h3-4,10-11,14H,5-6H2,1-2H3,(H,15,16)/t10-,11+/m1/s1
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50428537
PNG
(CHEMBL2337497)
Show SMILES CCc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C13H15ClN2O/c1-2-7-3-8-9-5-15-6-11(9)16-13(17)12(8)10(14)4-7/h3-4,9,11,15H,2,5-6H2,1H3,(H,16,17)/t9-,11+/m1/s1
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n/an/an/an/a 1.87E+3n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2A receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50428544
PNG
(CHEMBL2337496)
Show SMILES Cc1cc(Cl)c2C(=O)N[C@H]3CNC[C@@H]3c2c1 |r|
Show InChI InChI=1S/C12H13ClN2O/c1-6-2-7-8-4-14-5-10(8)15-12(16)11(7)9(13)3-6/h2-3,8,10,14H,4-5H2,1H3,(H,15,16)/t8-,10+/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay

Bioorg Med Chem Lett 23: 330-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.091
BindingDB Entry DOI: 10.7270/Q2V12656
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%