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PubMed code 23600806

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490888
PNG
(CHEMBL2347725)
Show SMILES COc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCN(C)CC3)sc2c1
Show InChI InChI=1S/C22H27N5O2S/c1-26-11-13-27(14-12-26)10-9-23-21(28)25-22-24-18-8-7-16(15-20(18)30-22)17-5-3-4-6-19(17)29-2/h3-8,15H,9-14H2,1-2H3,(H2,23,24,25,28)
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n/an/a 0.0150n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490916
PNG
(CHEMBL2347722)
Show SMILES COc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1
Show InChI InChI=1S/C21H24N4O3S/c1-27-18-5-3-2-4-16(18)15-6-7-17-19(14-15)29-21(23-17)24-20(26)22-8-9-25-10-12-28-13-11-25/h2-7,14H,8-13H2,1H3,(H2,22,23,24,26)
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n/an/a 0.0210n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490895
PNG
(CHEMBL2347711)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccccc1OCC
Show InChI InChI=1S/C18H19N3O2S/c1-3-19-17(22)21-18-20-14-10-9-12(11-16(14)24-18)13-7-5-6-8-15(13)23-4-2/h5-11H,3-4H2,1-2H3,(H2,19,20,21,22)
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n/an/a 0.0640n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490889
PNG
(CHEMBL2347723)
Show SMILES COc1ccccc1-c1ccc2nc(NC(=O)NCCO)sc2c1
Show InChI InChI=1S/C17H17N3O3S/c1-23-14-5-3-2-4-12(14)11-6-7-13-15(10-11)24-17(19-13)20-16(22)18-8-9-21/h2-7,10,21H,8-9H2,1H3,(H2,18,19,20,22)
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n/an/a 0.0640n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490918
PNG
(CHEMBL2347710)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccccc1OC
Show InChI InChI=1S/C17H17N3O2S/c1-3-18-16(21)20-17-19-13-9-8-11(10-15(13)23-17)12-6-4-5-7-14(12)22-2/h4-10H,3H2,1-2H3,(H2,18,19,20,21)
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n/an/a 0.110n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490890
PNG
(CHEMBL2347719)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccc(N)cc1OC
Show InChI InChI=1S/C17H18N4O2S/c1-3-19-16(22)21-17-20-13-7-4-10(8-15(13)24-17)12-6-5-11(18)9-14(12)23-2/h4-9H,3,18H2,1-2H3,(H2,19,20,21,22)
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n/an/a 0.110n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490932
PNG
(CHEMBL2347729)
Show SMILES CCOc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCNCC3)sc2c1
Show InChI InChI=1S/C22H27N5O2S/c1-2-29-19-6-4-3-5-17(19)16-7-8-18-20(15-16)30-22(25-18)26-21(28)24-11-14-27-12-9-23-10-13-27/h3-8,15,23H,2,9-14H2,1H3,(H2,24,25,26,28)
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n/an/a 0.120n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490886
PNG
(CHEMBL2347728)
Show SMILES CCOc1ccccc1-c1ccc2nc(NC(=O)NCCCO)sc2c1
Show InChI InChI=1S/C19H21N3O3S/c1-2-25-16-7-4-3-6-14(16)13-8-9-15-17(12-13)26-19(21-15)22-18(24)20-10-5-11-23/h3-4,6-9,12,23H,2,5,10-11H2,1H3,(H2,20,21,22,24)
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n/an/a 0.130n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490908
PNG
(CHEMBL2347724)
Show SMILES COc1ccccc1-c1ccc2nc(NC(=O)NCCCO)sc2c1
Show InChI InChI=1S/C18H19N3O3S/c1-24-15-6-3-2-5-13(15)12-7-8-14-16(11-12)25-18(20-14)21-17(23)19-9-4-10-22/h2-3,5-8,11,22H,4,9-10H2,1H3,(H2,19,20,21,23)
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n/an/a 0.160n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490915
PNG
(CHEMBL2347727)
Show SMILES CCOc1ccccc1-c1ccc2nc(NC(=O)NCCO)sc2c1
Show InChI InChI=1S/C18H19N3O3S/c1-2-24-15-6-4-3-5-13(15)12-7-8-14-16(11-12)25-18(20-14)21-17(23)19-9-10-22/h3-8,11,22H,2,9-10H2,1H3,(H2,19,20,21,23)
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n/an/a 0.180n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490887
PNG
(CHEMBL2347726)
Show SMILES CCOc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1
Show InChI InChI=1S/C22H26N4O3S/c1-2-29-19-6-4-3-5-17(19)16-7-8-18-20(15-16)30-22(24-18)25-21(27)23-9-10-26-11-13-28-14-12-26/h3-8,15H,2,9-14H2,1H3,(H2,23,24,25,27)
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n/an/a 0.230n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490923
PNG
(CHEMBL2347716)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C16H15N3OS/c1-2-17-15(20)19-16-18-13-9-8-12(10-14(13)21-16)11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H2,17,18,19,20)
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n/an/a 0.310n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490929
PNG
(CHEMBL2347721)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccncc1OC
Show InChI InChI=1S/C16H16N4O2S/c1-3-18-15(21)20-16-19-12-5-4-10(8-14(12)23-16)11-6-7-17-9-13(11)22-2/h4-9H,3H2,1-2H3,(H2,18,19,20,21)
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n/an/a 0.510n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50322535
PNG
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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n/an/a 0.580n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490933
PNG
(CHEMBL2347731)
Show SMILES CCc1ccccc1-c1ccc2nc(NC(=O)NCCN(C)C)sc2c1
Show InChI InChI=1S/C20H24N4OS/c1-4-14-7-5-6-8-16(14)15-9-10-17-18(13-15)26-20(22-17)23-19(25)21-11-12-24(2)3/h5-10,13H,4,11-12H2,1-3H3,(H2,21,22,23,25)
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n/an/a 0.770n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490885
PNG
(CHEMBL2347730)
Show SMILES CCc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1
Show InChI InChI=1S/C22H26N4O2S/c1-2-16-5-3-4-6-18(16)17-7-8-19-20(15-17)29-22(24-19)25-21(27)23-9-10-26-11-13-28-14-12-26/h3-8,15H,2,9-14H2,1H3,(H2,23,24,25,27)
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n/an/a 0.890n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490912
PNG
(CHEMBL2347720)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C18H19N3O3S/c1-4-19-17(22)21-18-20-14-8-5-11(9-16(14)25-18)13-7-6-12(23-2)10-15(13)24-3/h5-10H,4H2,1-3H3,(H2,19,20,21,22)
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n/an/a 1.20n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490891
PNG
(CHEMBL2347717)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccncc1
Show InChI InChI=1S/C15H14N4OS/c1-2-17-14(20)19-15-18-12-4-3-11(9-13(12)21-15)10-5-7-16-8-6-10/h3-9H,2H2,1H3,(H2,17,18,19,20)
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n/an/a 2n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490903
PNG
(CHEMBL2347741)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1OCC
Show InChI InChI=1S/C18H20N4O2/c1-3-19-18(23)22-17-20-14-10-9-12(11-15(14)21-17)13-7-5-6-8-16(13)24-4-2/h5-11H,3-4H2,1-2H3,(H3,19,20,21,22,23)
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n/an/a 2.30n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490927
PNG
(CHEMBL2347713)
Show SMILES CCCOc1ccccc1-c1ccc2nc(NC(=O)NCC)sc2c1
Show InChI InChI=1S/C19H21N3O2S/c1-3-11-24-16-8-6-5-7-14(16)13-9-10-15-17(12-13)25-19(21-15)22-18(23)20-4-2/h5-10,12H,3-4,11H2,1-2H3,(H2,20,21,22,23)
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n/an/a 2.80n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490894
PNG
(CHEMBL2347712)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-2-21-15(24)23-16-22-12-8-7-10(9-14(12)26-16)11-5-3-4-6-13(11)25-17(18,19)20/h3-9H,2H2,1H3,(H2,21,22,23,24)
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n/an/a 3.60n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490917
PNG
(CHEMBL2347718)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2s1)-c1ccc(OC)cc1
Show InChI InChI=1S/C17H17N3O2S/c1-3-18-16(21)20-17-19-14-9-6-12(10-15(14)23-17)11-4-7-13(22-2)8-5-11/h4-10H,3H2,1-2H3,(H2,18,19,20,21)
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n/an/a 5.60n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490913
PNG
(CHEMBL2347709)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2o1)-c1ccccc1OC
Show InChI InChI=1S/C17H17N3O3/c1-3-18-16(21)20-17-19-13-9-8-11(10-15(13)23-17)12-6-4-5-7-14(12)22-2/h4-10H,3H2,1-2H3,(H2,18,19,20,21)
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n/an/a 6.10n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490904
PNG
(CHEMBL2347739)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1OC
Show InChI InChI=1S/C17H18N4O2/c1-3-18-17(22)21-16-19-13-9-8-11(10-14(13)20-16)12-6-4-5-7-15(12)23-2/h4-10H,3H2,1-2H3,(H3,18,19,20,21,22)
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n/an/a 6.20n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490920
PNG
(CHEMBL2347747)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1c(OC)cccc1OC
Show InChI InChI=1S/C18H20N4O3/c1-4-19-18(23)22-17-20-12-9-8-11(10-13(12)21-17)16-14(24-2)6-5-7-15(16)25-3/h5-10H,4H2,1-3H3,(H3,19,20,21,22,23)
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n/an/a 11n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490892
PNG
(CHEMBL2347715)
Show SMILES CCNC(=O)Nc1nc2ccc(nc2s1)-c1ccccc1OC
Show InChI InChI=1S/C16H16N4O2S/c1-3-17-15(21)20-16-19-12-9-8-11(18-14(12)23-16)10-6-4-5-7-13(10)22-2/h4-9H,3H2,1-2H3,(H2,17,19,20,21)
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n/an/a 14n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490893
PNG
(CHEMBL2347714)
Show SMILES CCNC(=O)Nc1nc2cc(OC)c(cc2s1)-c1ccccc1OC
Show InChI InChI=1S/C18H19N3O3S/c1-4-19-17(22)21-18-20-13-10-15(24-3)12(9-16(13)25-18)11-7-5-6-8-14(11)23-2/h5-10H,4H2,1-3H3,(H2,19,20,21,22)
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n/an/a 15n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490931
PNG
(CHEMBL2347736)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1C
Show InChI InChI=1S/C17H18N4O/c1-3-18-17(22)21-16-19-14-9-8-12(10-15(14)20-16)13-7-5-4-6-11(13)2/h4-10H,3H2,1-2H3,(H3,18,19,20,21,22)
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n/an/a 17n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490906
PNG
(CHEMBL2347737)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4O/c1-2-18-16(22)21-15-19-13-8-7-10(9-14(13)20-15)11-5-3-4-6-12(11)17/h3-9H,2H2,1H3,(H3,18,19,20,21,22)
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n/an/a 21n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490901
PNG
(CHEMBL2347745)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1c(C)cccc1Cl
Show InChI InChI=1S/C17H17ClN4O/c1-3-19-17(23)22-16-20-13-8-7-11(9-14(13)21-16)15-10(2)5-4-6-12(15)18/h4-9H,3H2,1-2H3,(H3,19,20,21,22,23)
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n/an/a 23n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490907
PNG
(CHEMBL2347753)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1cccs1
Show InChI InChI=1S/C15H14N4O2S/c1-2-16-15(21)19-14-17-10-6-5-9(8-11(10)18-14)13(20)12-4-3-7-22-12/h3-8H,2H2,1H3,(H3,16,17,18,19,21)
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n/an/a 23n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490899
PNG
(CHEMBL2347749)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccnc(C)c1
Show InChI InChI=1S/C16H17N5O/c1-3-17-16(22)21-15-19-13-5-4-11(9-14(13)20-15)12-6-7-18-10(2)8-12/h4-9H,3H2,1-2H3,(H3,17,19,20,21,22)
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n/an/a 39n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490900
PNG
(CHEMBL2347746)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-19-16(23)22-15-20-12-7-6-9(8-13(12)21-15)14-10(17)4-3-5-11(14)18/h3-8H,2H2,1H3,(H3,19,20,21,22,23)
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n/an/a 43n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490924
PNG
(CHEMBL472525)
Show SMILES CCNC(=O)Nc1nc2cc(ccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O/c1-2-17-16(21)20-15-18-13-9-8-12(10-14(13)19-15)11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H3,17,18,19,20,21)
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n/an/a 44n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490922
PNG
(CHEMBL2347738)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1CC
Show InChI InChI=1S/C18H20N4O/c1-3-12-7-5-6-8-14(12)13-9-10-15-16(11-13)21-17(20-15)22-18(23)19-4-2/h5-11H,3-4H2,1-2H3,(H3,19,20,21,22,23)
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n/an/a 45n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490914
PNG
(CHEMBL2347744)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1c(C)cccc1C
Show InChI InChI=1S/C18H20N4O/c1-4-19-18(23)22-17-20-14-9-8-13(10-15(14)21-17)16-11(2)6-5-7-12(16)3/h5-10H,4H2,1-3H3,(H3,19,20,21,22,23)
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n/an/a 45n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490921
PNG
(CHEMBL2347742)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1OC(C)C
Show InChI InChI=1S/C19H22N4O2/c1-4-20-19(24)23-18-21-15-10-9-13(11-16(15)22-18)14-7-5-6-8-17(14)25-12(2)3/h5-12H,4H2,1-3H3,(H3,20,21,22,23,24)
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n/an/a 47n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490926
PNG
(CHEMBL2347733)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C16H15FN4O/c1-2-18-16(22)21-15-19-13-7-6-11(9-14(13)20-15)10-4-3-5-12(17)8-10/h3-9H,2H2,1H3,(H3,18,19,20,21,22)
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n/an/a 81n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490905
PNG
(CHEMBL2347734)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1cccc(C)c1
Show InChI InChI=1S/C17H18N4O/c1-3-18-17(22)21-16-19-14-8-7-13(10-15(14)20-16)12-6-4-5-11(2)9-12/h4-10H,3H2,1-2H3,(H3,18,19,20,21,22)
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n/an/a 139n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490911
PNG
(CHEMBL2347740)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C17H15F3N4O2/c1-2-21-16(25)24-15-22-12-8-7-10(9-13(12)23-15)11-5-3-4-6-14(11)26-17(18,19)20/h3-9H,2H2,1H3,(H3,21,22,23,24,25)
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n/an/a 168n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490930
PNG
(CHEMBL2347751)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccnn1CC
Show InChI InChI=1S/C15H18N6O/c1-3-16-15(22)20-14-18-11-6-5-10(9-12(11)19-14)13-7-8-17-21(13)4-2/h5-9H,3-4H2,1-2H3,(H3,16,18,19,20,22)
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n/an/a 172n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490898
PNG
(CHEMBL2347750)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccncc1C
Show InChI InChI=1S/C16H17N5O/c1-3-18-16(22)21-15-19-13-5-4-11(8-14(13)20-15)12-6-7-17-9-10(12)2/h4-9H,3H2,1-2H3,(H3,18,19,20,21,22)
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n/an/a 177n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490925
PNG
(CHEMBL2347706)
Show SMILES CCNC(=O)Nc1nc2ccc(Oc3cccc(OC)c3)cc2[nH]1
Show InChI InChI=1S/C17H18N4O3/c1-3-18-17(22)21-16-19-14-8-7-13(10-15(14)20-16)24-12-6-4-5-11(9-12)23-2/h4-10H,3H2,1-2H3,(H3,18,19,20,21,22)
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n/an/a 183n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490910
PNG
(CHEMBL2347748)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccncc1
Show InChI InChI=1S/C15H15N5O/c1-2-17-15(21)20-14-18-12-4-3-11(9-13(12)19-14)10-5-7-16-8-6-10/h3-9H,2H2,1H3,(H3,17,18,19,20,21)
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n/an/a 200n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490897
PNG
(CHEMBL2347752)
Show SMILES CCNC(=O)Nc1nc2ccc(Oc3ccccc3Cl)cc2[nH]1
Show InChI InChI=1S/C16H15ClN4O2/c1-2-18-16(22)21-15-19-12-8-7-10(9-13(12)20-15)23-14-6-4-3-5-11(14)17/h3-9H,2H2,1H3,(H3,18,19,20,21,22)
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n/an/a 239n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM97233
PNG
(CHEMBL9514 | MLS001164242 | N-[6-(2-thenoyl)-1H-be...)
Show SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1cccs1
Show InChI InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
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Article
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n/an/a 640n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490934
PNG
(CHEMBL2347732)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccc(C)cc1
Show InChI InChI=1S/C17H18N4O/c1-3-18-17(22)21-16-19-14-9-8-13(10-15(14)20-16)12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,19,20,21,22)
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n/an/a 699n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490928
PNG
(CHEMBL2347735)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H15N5O/c1-2-19-17(23)22-16-20-14-7-6-13(9-15(14)21-16)12-5-3-4-11(8-12)10-18/h3-9H,2H2,1H3,(H3,19,20,21,22,23)
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n/an/a 953n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490919
PNG
(CHEMBL472524)
Show SMILES CCNC(=O)Nc1nc2cc(ccc2[nH]1)-c1cccnc1
Show InChI InChI=1S/C15H15N5O/c1-2-17-15(21)20-14-18-12-6-5-10(8-13(12)19-14)11-4-3-7-16-9-11/h3-9H,2H2,1H3,(H3,17,18,19,20,21)
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n/an/a 1.39E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490902
PNG
(CHEMBL2347743)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)-c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C22H20N4O2/c1-2-23-22(27)26-21-24-18-13-12-15(14-19(18)25-21)17-10-6-7-11-20(17)28-16-8-4-3-5-9-16/h3-14H,2H2,1H3,(H3,23,24,25,26,27)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490909
PNG
(CHEMBL2347708)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C16H16N6O2/c1-2-18-16(24)22-15-20-12-4-3-10(9-13(12)21-15)14(23)19-11-5-7-17-8-6-11/h3-9H,2H2,1H3,(H,17,19,23)(H3,18,20,21,22,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50490896
PNG
(CHEMBL2347707)
Show SMILES CCNC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C16H22N6O2/c1-3-17-16(24)20-15-18-12-5-4-11(10-13(12)19-15)14(23)22-8-6-21(2)7-9-22/h4-5,10H,3,6-9H2,1-2H3,(H3,17,18,19,20,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Korea Institute of Science and Technology (KAIST)

Curated by ChEMBL


Assay Description
Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase...

J Med Chem 56: 3531-45 (2013)


Article DOI: 10.1021/jm301891t
BindingDB Entry DOI: 10.7270/Q2BG2RW2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%