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PubMed code 23770449

Compile data set for download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10|
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 2n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10|
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437558
PNG
(CHEMBL598022)
Show SMILES CCCCCCCCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C30H46N4O2/c1-4-5-6-7-8-9-10-11-12-13-22-34-29(35)25-16-14-15-24-27(18-17-26(28(24)25)30(34)36)32-20-19-31-21-23-33(2)3/h14-18,31-32H,4-13,19-23H2,1-3H3
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n/an/a 2.62E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437557
PNG
(CHEMBL2407635)
Show SMILES CCCCCCCCCCCCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C34H54N4O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26-38-33(39)29-20-18-19-28-31(22-21-30(32(28)29)34(38)40)36-24-23-35-25-27-37(2)3/h18-22,35-36H,4-17,23-27H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437558
PNG
(CHEMBL598022)
Show SMILES CCCCCCCCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C30H46N4O2/c1-4-5-6-7-8-9-10-11-12-13-22-34-29(35)25-16-14-15-24-27(18-17-26(28(24)25)30(34)36)32-20-19-31-21-23-33(2)3/h14-18,31-32H,4-13,19-23H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437559
PNG
(CHEMBL598852)
Show SMILES CCCCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C26H38N4O2/c1-4-5-6-7-8-9-18-30-25(31)21-12-10-11-20-23(14-13-22(24(20)21)26(30)32)28-16-15-27-17-19-29(2)3/h10-14,27-28H,4-9,15-19H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437557
PNG
(CHEMBL2407635)
Show SMILES CCCCCCCCCCCCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C34H54N4O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26-38-33(39)29-20-18-19-28-31(22-21-30(32(28)29)34(38)40)36-24-23-35-25-27-37(2)3/h18-22,35-36H,4-17,23-27H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437561
PNG
(CHEMBL2407518)
Show SMILES CCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C22H30N4O2/c1-4-5-14-26-21(27)17-8-6-7-16-19(10-9-18(20(16)17)22(26)28)24-12-11-23-13-15-25(2)3/h6-10,23-24H,4-5,11-15H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437560
PNG
(CHEMBL2407519)
Show SMILES CCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C24H34N4O2/c1-4-5-6-7-16-28-23(29)19-10-8-9-18-21(12-11-20(22(18)19)24(28)30)26-14-13-25-15-17-27(2)3/h8-12,25-26H,4-7,13-17H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437559
PNG
(CHEMBL598852)
Show SMILES CCCCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C26H38N4O2/c1-4-5-6-7-8-9-18-30-25(31)21-12-10-11-20-23(14-13-22(24(20)21)26(30)32)28-16-15-27-17-19-29(2)3/h10-14,27-28H,4-9,15-19H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437562
PNG
(CHEMBL2407517)
Show SMILES CCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C20H26N4O2/c1-4-24-19(25)15-7-5-6-14-17(9-8-16(18(14)15)20(24)26)22-11-10-21-12-13-23(2)3/h5-9,21-22H,4,10-13H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437561
PNG
(CHEMBL2407518)
Show SMILES CCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C22H30N4O2/c1-4-5-14-26-21(27)17-8-6-7-16-19(10-9-18(20(16)17)22(26)28)24-12-11-23-13-15-25(2)3/h6-10,23-24H,4-5,11-15H2,1-3H3
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East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437560
PNG
(CHEMBL2407519)
Show SMILES CCCCCCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C24H34N4O2/c1-4-5-6-7-16-28-23(29)19-10-8-9-18-21(12-11-20(22(18)19)24(28)30)26-14-13-25-15-17-27(2)3/h8-12,25-26H,4-7,13-17H2,1-3H3
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East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437563
PNG
(CHEMBL2407516)
Show SMILES CN(C)CCNCCNc1ccc2C(=O)N(C)C(=O)c3cccc1c23
Show InChI InChI=1S/C19H24N4O2/c1-22(2)12-11-20-9-10-21-16-8-7-15-17-13(16)5-4-6-14(17)18(24)23(3)19(15)25/h4-8,20-21H,9-12H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437562
PNG
(CHEMBL2407517)
Show SMILES CCN1C(=O)c2cccc3c(NCCNCCN(C)C)ccc(C1=O)c23
Show InChI InChI=1S/C20H26N4O2/c1-4-24-19(25)15-7-5-6-14-17(9-8-16(18(14)15)20(24)26)22-11-10-21-12-13-23(2)3/h5-9,21-22H,4,10-13H2,1-3H3
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East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437563
PNG
(CHEMBL2407516)
Show SMILES CN(C)CCNCCNc1ccc2C(=O)N(C)C(=O)c3cccc1c23
Show InChI InChI=1S/C19H24N4O2/c1-22(2)12-11-20-9-10-21-16-8-7-15-17-13(16)5-4-6-14(17)18(24)23(3)19(15)25/h4-8,20-21H,9-12H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA


Eur J Med Chem 65: 477-86 (2013)


Article DOI: 10.1016/j.ejmech.2013.05.002
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%