Found 7 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50005215
(CHEMBL3109274)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc(cc(c2)-c2ccccn2)-c2ccccn2)c1 Show InChI InChI=1S/C28H24N4O4S/c1-3-37(33,34)22-10-11-26(35-2)25(17-22)32-28-31-18-27(36-28)21-15-19(23-8-4-6-12-29-23)14-20(16-21)24-9-5-7-13-30-24/h4-18H,3H2,1-2H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM5875
(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccn2)c1 Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)18-10-11-21(29-2)20(14-18)26-23-25-15-22(30-23)17-8-6-7-16(13-17)19-9-4-5-12-24-19/h4-15H,3H2,1-2H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4814
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50005212
(CHEMBL3109275)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc(cc(c2)-c2ccccn2)-c2cccnc2)c1 Show InChI InChI=1S/C28H24N4O4S/c1-3-37(33,34)23-9-10-26(35-2)25(16-23)32-28-31-18-27(36-28)22-14-20(19-7-6-11-29-17-19)13-21(15-22)24-8-4-5-12-30-24/h4-18H,3H2,1-2H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50005213
(CHEMBL3109276)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc(cc(c2)-c2cccnc2)-c2cccnc2)c1 Show InChI InChI=1S/C28H24N4O4S/c1-3-37(33,34)24-8-9-26(35-2)25(15-24)32-28-31-18-27(36-28)23-13-21(19-6-4-10-29-16-19)12-22(14-23)20-7-5-11-30-17-20/h4-18H,3H2,1-2H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50005214
(CHEMBL3109277)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc(Br)cc(c2)-c2ccccn2)c1 Show InChI InChI=1S/C23H20BrN3O4S/c1-3-32(28,29)18-7-8-21(30-2)20(13-18)27-23-26-14-22(31-23)16-10-15(11-17(24)12-16)19-6-4-5-9-25-19/h4-14H,3H2,1-2H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 202 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay |
Eur J Med Chem 72: 146-59 (2014)
Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919 |
More data for this Ligand-Target Pair | |