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PubMed code 24611879

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50447275
PNG
(CHEMBL3114185)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H20F6N4O3S/c1-2-3-16-13-30(35(33,34)17-8-9-18(28)29-12-17)10-11-31(16)15-6-4-14(5-7-15)19(32,20(22,23)24)21(25,26)27/h4-9,12,16,32H,10-11,13H2,1H3,(H2,28,29)/t16-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009124
PNG
(CHEMBL3237987)
Show SMILES CC#CCC(O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-5-13-23(32,24(25,26)27)18-7-9-19(10-8-18)31-15-14-30(17-20(31)6-4-2)35(33,34)21-11-12-22(28)29-16-21/h7-12,16,20,32H,13-15,17H2,1-2H3,(H2,28,29)/t20-,23?/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009122
PNG
(CHEMBL3237986)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(CC#C)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C23H23F3N4O3S/c1-3-5-19-16-29(34(32,33)20-10-11-21(27)28-15-20)13-14-30(19)18-8-6-17(7-9-18)22(31,12-4-2)23(24,25)26/h2,6-11,15,19,31H,12-14,16H2,1H3,(H2,27,28)/t19-,22?/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009116
PNG
(CHEMBL3237981)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O4S/c1-2-3-17-13-27(33(31,32)18-8-9-19(25)26-12-18)10-11-28(17)16-6-4-15(5-7-16)20(30,14-29)21(22,23)24/h4-9,12,17,29-30H,10-11,13-14H2,1H3,(H2,25,26)/t17-,20-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50447271
PNG
(CHEMBL3114187)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O3S/c1-3-4-17-14-27(32(30,31)18-9-10-19(25)26-13-18)11-12-28(17)16-7-5-15(6-8-16)20(2,29)21(22,23)24/h5-10,13,17,29H,11-12,14H2,1-2H3,(H2,25,26)/t17-,20+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009107
PNG
(CHEMBL3238309)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H19F6N5O3S/c1-2-3-14-12-30(35(33,34)15-5-6-16(27)28-11-15)8-9-31(14)17-7-4-13(10-29-17)18(32,19(21,22)23)20(24,25)26/h4-7,10-11,14,32H,8-9,12H2,1H3,(H2,27,28)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009155
PNG
(CHEMBL3238310)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(cn1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H18F6N6O3S/c1-2-3-13-11-30(35(33,34)14-4-5-15(26)27-10-14)6-7-31(13)16-28-8-12(9-29-16)17(32,18(20,21)22)19(23,24)25/h4-5,8-10,13,32H,6-7,11H2,1H3,(H2,26,27)/t13-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009111
PNG
(CHEMBL3238308)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009110
PNG
(CHEMBL3238307)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009118
PNG
(CHEMBL3238313)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009121
PNG
(CHEMBL3237985)
Show SMILES COCC(O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H25F3N4O4S/c1-3-4-18-14-28(34(31,32)19-9-10-20(26)27-13-19)11-12-29(18)17-7-5-16(6-8-17)21(30,15-33-2)22(23,24)25/h5-10,13,18,30H,11-12,14-15H2,1-2H3,(H2,26,27)/t18-,21?/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009104
PNG
(CHEMBL3238303)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[S@](=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009109
PNG
(CHEMBL3238306)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19?/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009117
PNG
(CHEMBL3238312)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19?/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009120
PNG
(CHEMBL3237984)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(CC#N)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C22H22F3N5O3S/c1-2-3-18-15-29(34(32,33)19-8-9-20(27)28-14-19)12-13-30(18)17-6-4-16(5-7-17)21(31,10-11-26)22(23,24)25/h4-9,14,18,31H,10,12-13,15H2,1H3,(H2,27,28)/t18-,21?/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009115
PNG
(CHEMBL3237980)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O4S/c1-2-3-17-13-27(33(31,32)18-8-9-19(25)26-12-18)10-11-28(17)16-6-4-15(5-7-16)20(30,14-29)21(22,23)24/h4-9,12,17,29-30H,10-11,13-14H2,1H3,(H2,25,26)/t17-,20+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009094
PNG
(CHEMBL3237993)
Show SMILES CNS(=O)(=O)c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H23N5O4S2/c1-3-4-16-14-23(30(27,28)18-9-10-19(20)22-13-18)11-12-24(16)15-5-7-17(8-6-15)29(25,26)21-2/h5-10,13,16,21H,11-12,14H2,1-2H3,(H2,20,22)/t16-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009102
PNG
(CHEMBL3238301)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31?/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009128
PNG
(CHEMBL3237983)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](O)(CN)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H24F3N5O3S/c1-2-3-17-13-28(33(31,32)18-8-9-19(26)27-12-18)10-11-29(17)16-6-4-15(5-7-16)20(30,14-25)21(22,23)24/h4-9,12,17,30H,10-11,13-14,25H2,1H3,(H2,26,27)/t17-,20-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009147
PNG
(CHEMBL3238316)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(s1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H20F3N5O3S2/c1-3-4-12-11-25(31(28,29)13-5-6-15(22)23-9-13)7-8-26(12)16-24-10-14(30-16)17(2,27)18(19,20)21/h5-6,9-10,12,27H,7-8,11H2,1-2H3,(H2,22,23)/t12-,17?/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009114
PNG
(CHEMBL3237992)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(N)(=O)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H21N5O4S2/c1-2-3-15-13-22(29(26,27)17-8-9-18(19)21-12-17)10-11-23(15)14-4-6-16(7-5-14)28(20,24)25/h4-9,12,15H,10-11,13H2,1H3,(H2,19,21)(H2,20,24,25)/t15-/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009108
PNG
(CHEMBL3238311)
Show SMILES CNS(=O)(=O)c1ccc(nc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H22N6O4S2/c1-3-4-14-13-23(30(27,28)16-5-7-17(19)21-12-16)9-10-24(14)18-8-6-15(11-22-18)29(25,26)20-2/h5-8,11-12,14,20H,9-10,13H2,1-2H3,(H2,19,21)/t14-/m0/s1
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n/an/a 68n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009105
PNG
(CHEMBL3238305)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(nc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-8-18(24)26-12-16)9-10-28(15)14-5-7-17(25-11-14)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,26)/t15-,19?/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009119
PNG
(CHEMBL3238314)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009143
PNG
(CHEMBL3238315)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H17F6N5O3S2/c1-2-3-11-10-28(34(31,32)12-4-5-14(25)26-8-12)6-7-29(11)15-27-9-13(33-15)16(30,17(19,20)21)18(22,23)24/h4-5,8-9,11,30H,6-7,10H2,1H3,(H2,25,26)/t11-/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009095
PNG
(CHEMBL3237994)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NC1CC1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H25N5O4S2/c1-2-3-18-15-25(32(29,30)20-10-11-21(22)23-14-20)12-13-26(18)17-6-8-19(9-7-17)31(27,28)24-16-4-5-16/h6-11,14,16,18,24H,4-5,12-13,15H2,1H3,(H2,22,23)/t18-/m0/s1
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n/an/a 101n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009103
PNG
(CHEMBL3238302)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[S@@](=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31+/m0/s1
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n/an/a 182n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009100
PNG
(CHEMBL3238296)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NC(C)C)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H27N5O4S2/c1-4-5-18-15-25(32(29,30)20-10-11-21(22)23-14-20)12-13-26(18)17-6-8-19(9-7-17)31(27,28)24-16(2)3/h6-11,14,16,18,24H,12-13,15H2,1-3H3,(H2,22,23)/t18-/m0/s1
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n/an/a 235n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009112
PNG
(CHEMBL3238300)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=N)(=O)C1CC1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H25N5O3S2/c1-2-3-17-15-25(31(28,29)20-10-11-21(22)24-14-20)12-13-26(17)16-4-6-18(7-5-16)30(23,27)19-8-9-19/h4-7,10-11,14,17,19,23H,8-9,12-13,15H2,1H3,(H2,22,24)/t17-,30?/m0/s1
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n/an/a 256n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009098
PNG
(CHEMBL3238304)
Show SMILES CN=S(=O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H22F3N5O3S2/c1-3-4-16-14-27(33(30,31)18-9-10-19(24)26-13-18)11-12-28(16)15-5-7-17(8-6-15)32(29,25-2)20(21,22)23/h5-10,13,16H,11-12,14H2,1-2H3,(H2,24,26)/t16-,32?/m0/s1
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n/an/a 266n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009113
PNG
(CHEMBL3238299)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)(=N)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H23N5O3S2/c1-3-4-16-14-23(29(26,27)18-9-10-19(20)22-13-18)11-12-24(16)15-5-7-17(8-6-15)28(2,21)25/h5-10,13,16,21H,11-12,14H2,1-2H3,(H2,20,22)/t16-,28?/m0/s1
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n/an/a 310n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009096
PNG
(CHEMBL3238297)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NCC1CC1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C22H27N5O4S2/c1-2-3-19-16-26(33(30,31)21-10-11-22(23)24-15-21)12-13-27(19)18-6-8-20(9-7-18)32(28,29)25-14-17-4-5-17/h6-11,15,17,19,25H,4-5,12-14,16H2,1H3,(H2,23,24)/t19-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009125
PNG
(CHEMBL3237982)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CN)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H24F3N5O3S/c1-2-3-17-13-28(33(31,32)18-8-9-19(26)27-12-18)10-11-29(17)16-6-4-15(5-7-16)20(30,14-25)21(22,23)24/h4-9,12,17,30H,10-11,13-14,25H2,1H3,(H2,26,27)/t17-,20+/m0/s1
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n/an/a 374n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009099
PNG
(CHEMBL3237991)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)(=O)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H22N4O4S2/c1-3-4-16-14-22(29(26,27)18-9-10-19(20)21-13-18)11-12-23(16)15-5-7-17(8-6-15)28(2,24)25/h5-10,13,16H,11-12,14H2,1-2H3,(H2,20,21)/t16-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009089
PNG
(CHEMBL3237979)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(C)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O2S/c1-3-4-18-14-27(31(29,30)19-9-10-20(25)26-13-19)11-12-28(18)17-7-5-16(6-8-17)15(2)21(22,23)24/h5-10,13,15,18H,11-12,14H2,1-2H3,(H2,25,26)/t15?,18-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009088
PNG
(CHEMBL3237988)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(C)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22N4O3S/c1-3-4-18-14-23(28(26,27)19-9-10-20(21)22-13-19)11-12-24(18)17-7-5-16(6-8-17)15(2)25/h5-10,13,18H,11-12,14H2,1-2H3,(H2,21,22)/t18-/m0/s1
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n/an/a 1.09E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009097
PNG
(CHEMBL3238298)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)Nc1ccccc1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C24H25N5O4S2/c1-2-6-21-18-28(35(32,33)23-13-14-24(25)26-17-23)15-16-29(21)20-9-11-22(12-10-20)34(30,31)27-19-7-4-3-5-8-19/h3-5,7-14,17,21,27H,15-16,18H2,1H3,(H2,25,26)/t21-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009087
PNG
(CHEMBL3237989)
Show SMILES CNC(=O)c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H23N5O3S/c1-3-4-17-14-24(29(27,28)18-9-10-19(21)23-13-18)11-12-25(17)16-7-5-15(6-8-16)20(26)22-2/h5-10,13,17H,11-12,14H2,1-2H3,(H2,21,23)(H,22,26)/t17-/m0/s1
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n/an/a 3.07E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009091
PNG
(CHEMBL3237990)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H22N4O3S2/c1-3-4-16-14-22(28(25,26)18-9-10-19(20)21-13-18)11-12-23(16)15-5-7-17(8-6-15)27(2)24/h5-10,13,16H,11-12,14H2,1-2H3,(H2,20,21)/t16-,27?/m0/s1
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n/an/a 3.36E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))		BDBM50009090
PNG
(CHEMBL3237978)
Show SMILES CC#C[C@H]1CN(CCN1c1ccccc1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H20N4O2S/c1-2-6-16-14-21(11-12-22(16)15-7-4-3-5-8-15)25(23,24)17-9-10-18(19)20-13-17/h3-5,7-10,13,16H,11-12,14H2,1H3,(H2,19,20)/t16-/m0/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by A...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009105
PNG
(CHEMBL3238305)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(nc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-8-18(24)26-12-16)9-10-28(15)14-5-7-17(25-11-14)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,26)/t15-,19?/m0/s1
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n/an/an/an/a 1.45E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009113
PNG
(CHEMBL3238299)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)(=N)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H23N5O3S2/c1-3-4-16-14-23(29(26,27)18-9-10-19(20)22-13-18)11-12-24(16)15-5-7-17(8-6-15)28(2,21)25/h5-10,13,16,21H,11-12,14H2,1-2H3,(H2,20,22)/t16-,28?/m0/s1
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n/an/an/an/a 704n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009115
PNG
(CHEMBL3237980)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O4S/c1-2-3-17-13-27(33(31,32)18-8-9-19(25)26-12-18)10-11-28(17)16-6-4-15(5-7-16)20(30,14-29)21(22,23)24/h4-9,12,17,29-30H,10-11,13-14H2,1H3,(H2,25,26)/t17-,20+/m0/s1
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n/an/an/an/a 98n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009119
PNG
(CHEMBL3238314)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19-/m0/s1
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n/an/an/an/a 155n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009121
PNG
(CHEMBL3237985)
Show SMILES COCC(O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H25F3N4O4S/c1-3-4-18-14-28(34(31,32)19-9-10-20(26)27-13-19)11-12-29(18)17-7-5-16(6-8-17)21(30,15-33-2)22(23,24)25/h5-10,13,18,30H,11-12,14-15H2,1-2H3,(H2,26,27)/t18-,21?/m0/s1
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n/an/an/an/a 202n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009147
PNG
(CHEMBL3238316)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(s1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H20F3N5O3S2/c1-3-4-12-11-25(31(28,29)13-5-6-15(22)23-9-13)7-8-26(12)16-24-10-14(30-16)17(2,27)18(19,20)21/h5-6,9-10,12,27H,7-8,11H2,1-2H3,(H2,22,23)/t12-,17?/m0/s1
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n/an/an/an/a>1.25E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009088
PNG
(CHEMBL3237988)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(C)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22N4O3S/c1-3-4-18-14-23(28(26,27)19-9-10-20(21)22-13-19)11-12-24(18)17-7-5-16(6-8-17)15(2)25/h5-10,13,18H,11-12,14H2,1-2H3,(H2,21,22)/t18-/m0/s1
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n/an/an/an/a>1.25E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009091
PNG
(CHEMBL3237990)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H22N4O3S2/c1-3-4-16-14-22(28(25,26)18-9-10-19(20)21-13-18)11-12-23(16)15-5-7-17(8-6-15)27(2)24/h5-10,13,16H,11-12,14H2,1-2H3,(H2,20,21)/t16-,27?/m0/s1
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n/an/an/an/a>1.25E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009094
PNG
(CHEMBL3237993)
Show SMILES CNS(=O)(=O)c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H23N5O4S2/c1-3-4-16-14-23(30(27,28)18-9-10-19(20)22-13-18)11-12-24(16)15-5-7-17(8-6-15)29(25,26)21-2/h5-10,13,16,21H,11-12,14H2,1-2H3,(H2,20,22)/t16-/m0/s1
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n/an/an/an/a 97n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009100
PNG
(CHEMBL3238296)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NC(C)C)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H27N5O4S2/c1-4-5-18-15-25(32(29,30)20-10-11-21(22)23-14-20)12-13-26(18)17-6-8-19(9-7-17)31(27,28)24-16(2)3/h6-11,14,16,18,24H,12-13,15H2,1-3H3,(H2,22,23)/t18-/m0/s1
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n/an/an/an/a 178n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009110
PNG
(CHEMBL3238307)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19+/m0/s1
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n/an/an/an/a 160n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009099
PNG
(CHEMBL3237991)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(C)(=O)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H22N4O4S2/c1-3-4-16-14-22(29(26,27)18-9-10-19(20)21-13-18)11-12-23(16)15-5-7-17(8-6-15)28(2,24)25/h5-10,13,16H,11-12,14H2,1-2H3,(H2,20,21)/t16-/m0/s1
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n/an/an/an/a 936n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009102
PNG
(CHEMBL3238301)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31?/m0/s1
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n/an/an/an/a 567n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009107
PNG
(CHEMBL3238309)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H19F6N5O3S/c1-2-3-14-12-30(35(33,34)15-5-6-16(27)28-11-15)8-9-31(14)17-7-4-13(10-29-17)18(32,19(21,22)23)20(24,25)26/h4-7,10-11,14,32H,8-9,12H2,1H3,(H2,27,28)/t14-/m0/s1
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n/an/an/an/a 421n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009108
PNG
(CHEMBL3238311)
Show SMILES CNS(=O)(=O)c1ccc(nc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H22N6O4S2/c1-3-4-14-13-23(30(27,28)16-5-7-17(19)21-12-16)9-10-24(14)18-8-6-15(11-22-18)29(25,26)20-2/h5-8,11-12,14,20H,9-10,13H2,1-2H3,(H2,19,21)/t14-/m0/s1
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n/an/an/an/a 381n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009124
PNG
(CHEMBL3237987)
Show SMILES CC#CCC(O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-5-13-23(32,24(25,26)27)18-7-9-19(10-8-18)31-15-14-30(17-20(31)6-4-2)35(33,34)21-11-12-22(28)29-16-21/h7-12,16,20,32H,13-15,17H2,1-2H3,(H2,28,29)/t20-,23?/m0/s1
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n/an/an/an/a 137n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009128
PNG
(CHEMBL3237983)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](O)(CN)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H24F3N5O3S/c1-2-3-17-13-28(33(31,32)18-8-9-19(26)27-12-18)10-11-29(17)16-6-4-15(5-7-16)20(30,14-25)21(22,23)24/h4-9,12,17,30H,10-11,13-14,25H2,1H3,(H2,26,27)/t17-,20-/m0/s1
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n/an/an/an/a 537n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009089
PNG
(CHEMBL3237979)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(C)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O2S/c1-3-4-18-14-27(31(29,30)19-9-10-20(25)26-13-19)11-12-28(18)17-7-5-16(6-8-17)15(2)21(22,23)24/h5-10,13,15,18H,11-12,14H2,1-2H3,(H2,25,26)/t15?,18-/m0/s1
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n/an/an/an/a 1.56E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009095
PNG
(CHEMBL3237994)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NC1CC1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H25N5O4S2/c1-2-3-18-15-25(32(29,30)20-10-11-21(22)23-14-20)12-13-26(18)17-6-8-19(9-7-17)31(27,28)24-16-4-5-16/h6-11,14,16,18,24H,4-5,12-13,15H2,1H3,(H2,22,23)/t18-/m0/s1
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n/an/an/an/a 254n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009096
PNG
(CHEMBL3238297)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)NCC1CC1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C22H27N5O4S2/c1-2-3-19-16-26(33(30,31)21-10-11-22(23)24-15-21)12-13-27(19)18-6-8-20(9-7-18)32(28,29)25-14-17-4-5-17/h6-11,15,17,19,25H,4-5,12-14,16H2,1H3,(H2,23,24)/t19-/m0/s1
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n/an/an/an/a 271n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009103
PNG
(CHEMBL3238302)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[S@@](=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31+/m0/s1
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n/an/an/an/a 2.22E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009122
PNG
(CHEMBL3237986)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(CC#C)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C23H23F3N4O3S/c1-3-5-19-16-29(34(32,33)20-10-11-21(27)28-15-20)13-14-30(19)18-8-6-17(7-9-18)22(31,12-4-2)23(24,25)26/h2,6-11,15,19,31H,12-14,16H2,1H3,(H2,27,28)/t19-,22?/m0/s1
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n/an/an/an/a 130n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009125
PNG
(CHEMBL3237982)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](O)(CN)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H24F3N5O3S/c1-2-3-17-13-28(33(31,32)18-8-9-19(26)27-12-18)10-11-29(17)16-6-4-15(5-7-16)20(30,14-25)21(22,23)24/h4-9,12,17,30H,10-11,13-14,25H2,1H3,(H2,26,27)/t17-,20+/m0/s1
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n/an/an/an/a 5.67E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009155
PNG
(CHEMBL3238310)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(cn1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H18F6N6O3S/c1-2-3-13-11-30(35(33,34)14-4-5-15(26)27-10-14)6-7-31(13)16-28-8-12(9-29-16)17(32,18(20,21)22)19(23,24)25/h4-5,8-10,13,32H,6-7,11H2,1H3,(H2,26,27)/t13-/m0/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50447275
PNG
(CHEMBL3114185)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H20F6N4O3S/c1-2-3-16-13-30(35(33,34)17-8-9-18(28)29-12-17)10-11-31(16)15-6-4-14(5-7-15)19(32,20(22,23)24)21(25,26)27/h4-9,12,16,32H,10-11,13H2,1H3,(H2,28,29)/t16-/m0/s1
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n/an/an/an/a 202n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50447271
PNG
(CHEMBL3114187)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O3S/c1-3-4-17-14-27(32(30,31)18-9-10-19(25)26-13-18)11-12-28(17)16-7-5-15(6-8-16)20(2,29)21(22,23)24/h5-10,13,17,29H,11-12,14H2,1-2H3,(H2,25,26)/t17-,20+/m0/s1
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n/an/an/an/a 120n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009087
PNG
(CHEMBL3237989)
Show SMILES CNC(=O)c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H23N5O3S/c1-3-4-17-14-24(29(27,28)18-9-10-19(21)23-13-18)11-12-25(17)16-7-5-15(6-8-16)20(26)22-2/h5-10,13,17H,11-12,14H2,1-2H3,(H2,21,23)(H,22,26)/t17-/m0/s1
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n/an/an/an/a 4.05E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009112
PNG
(CHEMBL3238300)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=N)(=O)C1CC1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H25N5O3S2/c1-2-3-17-15-25(31(28,29)20-10-11-21(22)24-14-20)12-13-26(17)16-4-6-18(7-5-16)30(23,27)19-8-9-19/h4-7,10-11,14,17,19,23H,8-9,12-13,15H2,1H3,(H2,22,24)/t17-,30?/m0/s1
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n/an/an/an/a 208n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009114
PNG
(CHEMBL3237992)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(N)(=O)=O)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H21N5O4S2/c1-2-3-15-13-22(29(26,27)17-8-9-18(19)21-12-17)10-11-23(15)14-4-6-16(7-5-14)28(20,24)25/h4-9,12,15H,10-11,13H2,1H3,(H2,19,21)(H2,20,24,25)/t15-/m0/s1
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n/an/an/an/a 37n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009116
PNG
(CHEMBL3237981)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C21H23F3N4O4S/c1-2-3-17-13-27(33(31,32)18-8-9-19(25)26-12-18)10-11-28(17)16-6-4-15(5-7-16)20(30,14-29)21(22,23)24/h4-9,12,17,29-30H,10-11,13-14H2,1H3,(H2,25,26)/t17-,20-/m0/s1
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n/an/an/an/a 89n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009118
PNG
(CHEMBL3238313)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@](O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19+/m0/s1
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n/an/an/an/a 349n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009104
PNG
(CHEMBL3238303)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[S@](=N)(=O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C19H20F3N5O3S2/c1-2-3-15-13-26(32(29,30)17-8-9-18(23)25-12-17)10-11-27(15)14-4-6-16(7-5-14)31(24,28)19(20,21)22/h4-9,12,15,24H,10-11,13H2,1H3,(H2,23,25)/t15-,31-/m0/s1
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n/an/an/an/a 388n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009117
PNG
(CHEMBL3238312)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(O)(CO)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O4S/c1-2-3-15-12-27(33(31,32)16-5-6-17(24)25-11-16)8-9-28(15)18-7-4-14(10-26-18)19(30,13-29)20(21,22)23/h4-7,10-11,15,29-30H,8-9,12-13H2,1H3,(H2,24,25)/t15-,19?/m0/s1
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n/an/an/an/a 145n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009120
PNG
(CHEMBL3237984)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(CC#N)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C22H22F3N5O3S/c1-2-3-18-15-29(34(32,33)19-8-9-20(27)28-14-19)12-13-30(18)17-6-4-16(5-7-17)21(31,10-11-26)22(23,24)25/h4-9,14,18,31H,10,12-13,15H2,1H3,(H2,27,28)/t18-,21?/m0/s1
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n/an/an/an/a 219n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009143
PNG
(CHEMBL3238315)
Show SMILES CC#C[C@H]1CN(CCN1c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C18H17F6N5O3S2/c1-2-3-11-10-28(34(31,32)12-4-5-14(25)26-8-12)6-7-29(11)15-27-9-13(33-15)16(30,17(19,20)21)18(22,23)24/h4-5,8-9,11,30H,6-7,10H2,1H3,(H2,25,26)/t11-/m0/s1
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n/an/an/an/a>1.25E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009109
PNG
(CHEMBL3238306)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19?/m0/s1
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n/an/an/an/a 294n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009111
PNG
(CHEMBL3238308)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cn1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C20H22F3N5O3S/c1-3-4-15-13-27(32(30,31)16-6-7-17(24)25-12-16)9-10-28(15)18-8-5-14(11-26-18)19(2,29)20(21,22)23/h5-8,11-12,15,29H,9-10,13H2,1-2H3,(H2,24,25)/t15-,19-/m0/s1
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n/an/an/an/a 382n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009097
PNG
(CHEMBL3238298)
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)S(=O)(=O)Nc1ccccc1)S(=O)(=O)c1ccc(N)nc1 |r|
Show InChI InChI=1S/C24H25N5O4S2/c1-2-6-21-18-28(35(32,33)23-13-14-24(25)26-17-23)15-16-29(21)20-9-11-22(12-10-20)34(30,31)27-19-7-4-3-5-8-19/h3-5,7-14,17,21,27H,15-16,18H2,1H3,(H2,25,26)/t21-/m0/s1
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n/an/an/an/a>1.25E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Mus musculus)		BDBM50009098
PNG
(CHEMBL3238304)
Show SMILES CN=S(=O)(c1ccc(cc1)N1CCN(C[C@@H]1C#CC)S(=O)(=O)c1ccc(N)nc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H22F3N5O3S2/c1-3-4-16-14-27(33(30,31)18-9-10-19(24)26-13-18)11-12-28(16)15-5-7-17(8-6-15)32(29,25-2)20(21,22)23/h5-10,13,16H,11-12,14H2,1-2H3,(H2,24,26)/t16-,32?/m0/s1
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n/an/an/an/a 2.06E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GKRP-GK interaction in mouse hepatocytes assessed as induction of GK translocation from nucleus to cytoplasm incubated for 20 mins prio...

J Med Chem 57: 3094-116 (2014)


Article DOI: 10.1021/jm5000497
BindingDB Entry DOI: 10.7270/Q2V126BF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%