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PubMed code 24825301

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018896
PNG
(CHEMBL3287089)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2NC(=O)Cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2N2O7S/c1-33-19-8-12(9-22(29)30)2-5-17(19)34-18-6-4-16-14(11-21(28)26-16)23(18)27-35(31,32)20-7-3-13(24)10-15(20)25/h2-8,10,27H,9,11H2,1H3,(H,26,28)(H,29,30)
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n/an/a 3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50302828
PNG
(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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n/an/a 3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018898
PNG
(CHEMBL3287082)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Show InChI InChI=1S/C26H22Cl2N2O6S/c1-35-23-10-14(11-25(31)32)2-7-21(23)36-22-8-6-19-17(13-20(29-19)15-3-4-15)26(22)30-37(33,34)24-9-5-16(27)12-18(24)28/h2,5-10,12-13,15,29-30H,3-4,11H2,1H3,(H,31,32)
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n/an/a 8n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018897
PNG
(CHEMBL3287081)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)ccc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2N2O6S/c1-28-10-9-16-18(28)5-7-20(34-19-6-3-14(12-23(29)30)11-21(19)33-2)24(16)27-35(31,32)22-8-4-15(25)13-17(22)26/h3-11,13,27H,12H2,1-2H3,(H,29,30)
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n/an/a 9n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50302828
PNG
(2-(4-(4-(butylcarbamoyl)-2-(2,4-dichlorophenylsulf...)
Show SMILES CCCCNC(=O)c1ccc(Oc2ccc(CC(O)=O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
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n/an/a 12n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018896
PNG
(CHEMBL3287089)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2NC(=O)Cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2N2O7S/c1-33-19-8-12(9-22(29)30)2-5-17(19)34-18-6-4-16-14(11-21(28)26-16)23(18)27-35(31,32)20-7-3-13(24)10-15(20)25/h2-8,10,27H,9,11H2,1H3,(H,26,28)(H,29,30)
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n/an/a 17n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018897
PNG
(CHEMBL3287081)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)ccc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2N2O6S/c1-28-10-9-16-18(28)5-7-20(34-19-6-3-14(12-23(29)30)11-21(19)33-2)24(16)27-35(31,32)22-8-4-15(25)13-17(22)26/h3-11,13,27H,12H2,1-2H3,(H,29,30)
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018894
PNG
(CHEMBL3287086)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)c(C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H22Cl2N2O6S/c1-14-10-17-19(29(14)2)6-8-21(35-20-7-4-15(12-24(30)31)11-22(20)34-3)25(17)28-36(32,33)23-9-5-16(26)13-18(23)27/h4-11,13,28H,12H2,1-3H3,(H,30,31)
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n/an/a 22n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018898
PNG
(CHEMBL3287082)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Show InChI InChI=1S/C26H22Cl2N2O6S/c1-35-23-10-14(11-25(31)32)2-7-21(23)36-22-8-6-19-17(13-20(29-19)15-3-4-15)26(22)30-37(33,34)24-9-5-16(27)12-18(24)28/h2,5-10,12-13,15,29-30H,3-4,11H2,1H3,(H,31,32)
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n/an/a 25n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018894
PNG
(CHEMBL3287086)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)c(C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H22Cl2N2O6S/c1-14-10-17-19(29(14)2)6-8-21(35-20-7-4-15(12-24(30)31)11-22(20)34-3)25(17)28-36(32,33)23-9-5-16(26)13-18(23)27/h4-11,13,28H,12H2,1-3H3,(H,30,31)
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n/an/a 27n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018895
PNG
(CHEMBL3287088)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C#N
Show InChI InChI=1S/C24H17Cl2N3O6S/c1-34-21-8-13(9-23(30)31)2-5-19(21)35-20-6-4-18-16(11-15(12-27)28-18)24(20)29-36(32,33)22-7-3-14(25)10-17(22)26/h2-8,10-11,28-29H,9H2,1H3,(H,30,31)
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n/an/a 27n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018896
PNG
(CHEMBL3287089)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2NC(=O)Cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2N2O7S/c1-33-19-8-12(9-22(29)30)2-5-17(19)34-18-6-4-16-14(11-21(28)26-16)23(18)27-35(31,32)20-7-3-13(24)10-15(20)25/h2-8,10,27H,9,11H2,1H3,(H,26,28)(H,29,30)
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n/an/a 31n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018899
PNG
(CHEMBL3287083)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(CC(C)C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C27H26Cl2N2O6S/c1-15(2)10-18-14-19-21(30-18)6-8-23(37-22-7-4-16(12-26(32)33)11-24(22)36-3)27(19)31-38(34,35)25-9-5-17(28)13-20(25)29/h4-9,11,13-15,30-31H,10,12H2,1-3H3,(H,32,33)
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n/an/a 32n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018900
PNG
(CHEMBL3287084)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C(C)(C)C
Show InChI InChI=1S/C27H26Cl2N2O6S/c1-27(2,3)24-14-17-19(30-24)7-9-21(37-20-8-5-15(12-25(32)33)11-22(20)36-4)26(17)31-38(34,35)23-10-6-16(28)13-18(23)29/h5-11,13-14,30-31H,12H2,1-4H3,(H,32,33)
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n/an/a 32n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018897
PNG
(CHEMBL3287081)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)ccc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2N2O6S/c1-28-10-9-16-18(28)5-7-20(34-19-6-3-14(12-23(29)30)11-21(19)33-2)24(16)27-35(31,32)22-8-4-15(25)13-17(22)26/h3-11,13,27H,12H2,1-2H3,(H,29,30)
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n/an/a 40n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018847
PNG
(CHEMBL3287085)
Show SMILES CCCc1cc2c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c(Oc3ccc(CC(O)=O)cc3OC)ccc2[nH]1
Show InChI InChI=1S/C26H24Cl2N2O6S/c1-3-4-17-14-18-20(29-17)7-9-22(36-21-8-5-15(12-25(31)32)11-23(21)35-2)26(18)30-37(33,34)24-10-6-16(27)13-19(24)28/h5-11,13-14,29-30H,3-4,12H2,1-2H3,(H,31,32)
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n/an/a 45n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018899
PNG
(CHEMBL3287083)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(CC(C)C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C27H26Cl2N2O6S/c1-15(2)10-18-14-19-21(30-18)6-8-23(37-22-7-4-16(12-26(32)33)11-24(22)36-3)27(19)31-38(34,35)25-9-5-17(28)13-20(25)29/h4-9,11,13-15,30-31H,10,12H2,1-3H3,(H,32,33)
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n/an/a 48n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018897
PNG
(CHEMBL3287081)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)ccc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H20Cl2N2O6S/c1-28-10-9-16-18(28)5-7-20(34-19-6-3-14(12-23(29)30)11-21(19)33-2)24(16)27-35(31,32)22-8-4-15(25)13-17(22)26/h3-11,13,27H,12H2,1-2H3,(H,29,30)
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n/an/a 56n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018894
PNG
(CHEMBL3287086)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)c(C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H22Cl2N2O6S/c1-14-10-17-19(29(14)2)6-8-21(35-20-7-4-15(12-24(30)31)11-22(20)34-3)25(17)28-36(32,33)23-9-5-16(26)13-18(23)27/h4-11,13,28H,12H2,1-3H3,(H,30,31)
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n/an/a 56n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018847
PNG
(CHEMBL3287085)
Show SMILES CCCc1cc2c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c(Oc3ccc(CC(O)=O)cc3OC)ccc2[nH]1
Show InChI InChI=1S/C26H24Cl2N2O6S/c1-3-4-17-14-18-20(29-17)7-9-22(36-21-8-5-15(12-25(31)32)11-23(21)35-2)26(18)30-37(33,34)24-10-6-16(27)13-19(24)28/h5-11,13-14,29-30H,3-4,12H2,1-2H3,(H,31,32)
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n/an/a 57n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018899
PNG
(CHEMBL3287083)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(CC(C)C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C27H26Cl2N2O6S/c1-15(2)10-18-14-19-21(30-18)6-8-23(37-22-7-4-16(12-26(32)33)11-24(22)36-3)27(19)31-38(34,35)25-9-5-17(28)13-20(25)29/h4-9,11,13-15,30-31H,10,12H2,1-3H3,(H,32,33)
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n/an/a 62n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018898
PNG
(CHEMBL3287082)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Show InChI InChI=1S/C26H22Cl2N2O6S/c1-35-23-10-14(11-25(31)32)2-7-21(23)36-22-8-6-19-17(13-20(29-19)15-3-4-15)26(22)30-37(33,34)24-9-5-16(27)12-18(24)28/h2,5-10,12-13,15,29-30H,3-4,11H2,1H3,(H,31,32)
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n/an/a 74n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018894
PNG
(CHEMBL3287086)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2n(C)c(C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H22Cl2N2O6S/c1-14-10-17-19(29(14)2)6-8-21(35-20-7-4-15(12-24(30)31)11-22(20)34-3)25(17)28-36(32,33)23-9-5-16(26)13-18(23)27/h4-11,13,28H,12H2,1-3H3,(H,30,31)
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n/an/a 76n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018895
PNG
(CHEMBL3287088)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C#N
Show InChI InChI=1S/C24H17Cl2N3O6S/c1-34-21-8-13(9-23(30)31)2-5-19(21)35-20-6-4-18-16(11-15(12-27)28-18)24(20)29-36(32,33)22-7-3-14(25)10-17(22)26/h2-8,10-11,28-29H,9H2,1H3,(H,30,31)
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n/an/a 82n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018847
PNG
(CHEMBL3287085)
Show SMILES CCCc1cc2c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c(Oc3ccc(CC(O)=O)cc3OC)ccc2[nH]1
Show InChI InChI=1S/C26H24Cl2N2O6S/c1-3-4-17-14-18-20(29-17)7-9-22(36-21-8-5-15(12-25(31)32)11-23(21)35-2)26(18)30-37(33,34)24-10-6-16(27)13-19(24)28/h5-11,13-14,29-30H,3-4,12H2,1-2H3,(H,31,32)
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n/an/a 110n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018899
PNG
(CHEMBL3287083)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(CC(C)C)cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C27H26Cl2N2O6S/c1-15(2)10-18-14-19-21(30-18)6-8-23(37-22-7-4-16(12-26(32)33)11-24(22)36-3)27(19)31-38(34,35)25-9-5-17(28)13-20(25)29/h4-9,11,13-15,30-31H,10,12H2,1-3H3,(H,32,33)
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n/an/a 110n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018895
PNG
(CHEMBL3287088)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C#N
Show InChI InChI=1S/C24H17Cl2N3O6S/c1-34-21-8-13(9-23(30)31)2-5-19(21)35-20-6-4-18-16(11-15(12-27)28-18)24(20)29-36(32,33)22-7-3-14(25)10-17(22)26/h2-8,10-11,28-29H,9H2,1H3,(H,30,31)
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n/an/a 130n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018847
PNG
(CHEMBL3287085)
Show SMILES CCCc1cc2c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c(Oc3ccc(CC(O)=O)cc3OC)ccc2[nH]1
Show InChI InChI=1S/C26H24Cl2N2O6S/c1-3-4-17-14-18-20(29-17)7-9-22(36-21-8-5-15(12-25(31)32)11-23(21)35-2)26(18)30-37(33,34)24-10-6-16(27)13-19(24)28/h5-11,13-14,29-30H,3-4,12H2,1-2H3,(H,31,32)
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n/an/a 130n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018895
PNG
(CHEMBL3287088)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C#N
Show InChI InChI=1S/C24H17Cl2N3O6S/c1-34-21-8-13(9-23(30)31)2-5-19(21)35-20-6-4-18-16(11-15(12-27)28-18)24(20)29-36(32,33)22-7-3-14(25)10-17(22)26/h2-8,10-11,28-29H,9H2,1H3,(H,30,31)
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n/an/a 130n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50018901
PNG
(CHEMBL3287087)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(C)c(Cl)c2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H19Cl3N2O6S/c1-12-23(27)22-16(28-12)5-7-18(35-17-6-3-13(10-21(30)31)9-19(17)34-2)24(22)29-36(32,33)20-8-4-14(25)11-15(20)26/h3-9,11,28-29H,10H2,1-2H3,(H,30,31)
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n/an/a 220n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human CRTH2 expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018898
PNG
(CHEMBL3287082)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Show InChI InChI=1S/C26H22Cl2N2O6S/c1-35-23-10-14(11-25(31)32)2-7-21(23)36-22-8-6-19-17(13-20(29-19)15-3-4-15)26(22)30-37(33,34)24-9-5-16(27)12-18(24)28/h2,5-10,12-13,15,29-30H,3-4,11H2,1H3,(H,31,32)
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n/an/a 350n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018901
PNG
(CHEMBL3287087)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(C)c(Cl)c2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H19Cl3N2O6S/c1-12-23(27)22-16(28-12)5-7-18(35-17-6-3-13(10-21(30)31)9-19(17)34-2)24(22)29-36(32,33)20-8-4-14(25)11-15(20)26/h3-9,11,28-29H,10H2,1-2H3,(H,30,31)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018896
PNG
(CHEMBL3287089)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2NC(=O)Cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H18Cl2N2O7S/c1-33-19-8-12(9-22(29)30)2-5-17(19)34-18-6-4-16-14(11-21(28)26-16)23(18)27-35(31,32)20-7-3-13(24)10-15(20)25/h2-8,10,27H,9,11H2,1H3,(H,26,28)(H,29,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in presence of 50% human plasma by scintillation counting

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))		BDBM50018900
PNG
(CHEMBL3287084)
Show SMILES COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C(C)(C)C
Show InChI InChI=1S/C27H26Cl2N2O6S/c1-27(2,3)24-14-17-19(30-24)7-9-21(37-20-8-5-15(12-25(32)33)11-22(20)36-4)26(17)31-38(34,35)23-10-6-16(28)13-18(23)29/h5-11,13-14,30-31H,12H2,1-4H3,(H,32,33)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-PGD2 from human DP receptor expressed in HEK293 cells in buffer solution with 0.5% bovine serum albumin by scintillation countin...

Bioorg Med Chem Lett 24: 2877-80 (2014)


Article DOI: 10.1016/j.bmcl.2014.04.092
BindingDB Entry DOI: 10.7270/Q25X2BGN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%