Found 18 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50018997
(CHEMBL3287467)Show SMILES Oc1ccc2C[C@@]34CN(CC5CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O/c30-22-8-7-20-13-26-14-21-11-19-3-1-2-4-24(19)28-25(21)15-27(26,23(20)12-22)9-10-29(17-26)16-18-5-6-18/h1-4,7-8,11-12,18,30H,5-6,9-10,13-17H2/t26-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.941 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPDPE from delta-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50018998
(CHEMBL3287468)Show SMILES Oc1ccc2C[C@@]34CN(CC5(O)CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O2/c30-21-6-5-19-13-25-14-20-11-18-3-1-2-4-23(18)28-24(20)15-27(25,22(19)12-21)9-10-29(16-25)17-26(31)7-8-26/h1-6,11-12,30-31H,7-10,13-17H2/t25-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPDPE from delta-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50019000
(CHEMBL3287470)Show SMILES CN1CC[C@]23Cc4nc5ccccc5cc4C[C@]2(Cc2ccc(O)cc32)C1 |r| Show InChI InChI=1S/C24H24N2O/c1-26-9-8-24-14-22-18(10-16-4-2-3-5-21(16)25-22)13-23(24,15-26)12-17-6-7-19(27)11-20(17)24/h2-7,10-11,27H,8-9,12-15H2,1H3/t23-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPDPE from delta-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50019000
(CHEMBL3287470)Show SMILES CN1CC[C@]23Cc4nc5ccccc5cc4C[C@]2(Cc2ccc(O)cc32)C1 |r| Show InChI InChI=1S/C24H24N2O/c1-26-9-8-24-14-22-18(10-16-4-2-3-5-21(16)25-22)13-23(24,15-26)12-17-6-7-19(27)11-20(17)24/h2-7,10-11,27H,8-9,12-15H2,1H3/t23-,24-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from mu-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50018996
(CHEMBL3287466)Show SMILES Oc1ccc2C[C@]34CCC(=O)C[C@]3(CCN(CC3CC3)C4)c2c1 |r| Show InChI InChI=1S/C20H25NO2/c22-16-4-3-15-10-19-6-5-17(23)11-20(19,18(15)9-16)7-8-21(13-19)12-14-1-2-14/h3-4,9,14,22H,1-2,5-8,10-13H2/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]U-69593 from kappa-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50018999
(CHEMBL3287469)Show SMILES Oc1ccc2C[C@@]34CN(Cc5ccccc5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C30H28N2O/c33-25-11-10-23-16-29-17-24-14-22-8-4-5-9-27(22)31-28(24)18-30(29,26(23)15-25)12-13-32(20-29)19-21-6-2-1-3-7-21/h1-11,14-15,33H,12-13,16-20H2/t29-,30-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPDPE from delta-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50018996
(CHEMBL3287466)Show SMILES Oc1ccc2C[C@]34CCC(=O)C[C@]3(CCN(CC3CC3)C4)c2c1 |r| Show InChI InChI=1S/C20H25NO2/c22-16-4-3-15-10-19-6-5-17(23)11-20(19,18(15)9-16)7-8-21(13-19)12-14-1-2-14/h3-4,9,14,22H,1-2,5-8,10-13H2/t19-,20+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from mu-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50018999
(CHEMBL3287469)Show SMILES Oc1ccc2C[C@@]34CN(Cc5ccccc5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C30H28N2O/c33-25-11-10-23-16-29-17-24-14-22-8-4-5-9-27(22)31-28(24)18-30(29,26(23)15-25)12-13-32(20-29)19-21-6-2-1-3-7-21/h1-11,14-15,33H,12-13,16-20H2/t29-,30-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from mu-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50018997
(CHEMBL3287467)Show SMILES Oc1ccc2C[C@@]34CN(CC5CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O/c30-22-8-7-20-13-26-14-21-11-19-3-1-2-4-24(19)28-25(21)15-27(26,23(20)12-22)9-10-29(17-26)16-18-5-6-18/h1-4,7-8,11-12,18,30H,5-6,9-10,13-17H2/t26-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]U-69593 from kappa-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50018997
(CHEMBL3287467)Show SMILES Oc1ccc2C[C@@]34CN(CC5CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O/c30-22-8-7-20-13-26-14-21-11-19-3-1-2-4-24(19)28-25(21)15-27(26,23(20)12-22)9-10-29(17-26)16-18-5-6-18/h1-4,7-8,11-12,18,30H,5-6,9-10,13-17H2/t26-,27-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from mu-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50019000
(CHEMBL3287470)Show SMILES CN1CC[C@]23Cc4nc5ccccc5cc4C[C@]2(Cc2ccc(O)cc32)C1 |r| Show InChI InChI=1S/C24H24N2O/c1-26-9-8-24-14-22-18(10-16-4-2-3-5-21(16)25-22)13-23(24,15-26)12-17-6-7-19(27)11-20(17)24/h2-7,10-11,27H,8-9,12-15H2,1H3/t23-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]U-69593 from kappa-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50018998
(CHEMBL3287468)Show SMILES Oc1ccc2C[C@@]34CN(CC5(O)CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O2/c30-21-6-5-19-13-25-14-20-11-18-3-1-2-4-23(18)28-24(20)15-27(25,22(19)12-21)9-10-29(16-25)17-26(31)7-8-26/h1-6,11-12,30-31H,7-10,13-17H2/t25-,27-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 415 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DAMGO from mu-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50018996
(CHEMBL3287466)Show SMILES Oc1ccc2C[C@]34CCC(=O)C[C@]3(CCN(CC3CC3)C4)c2c1 |r| Show InChI InChI=1S/C20H25NO2/c22-16-4-3-15-10-19-6-5-17(23)11-20(19,18(15)9-16)7-8-21(13-19)12-14-1-2-14/h3-4,9,14,22H,1-2,5-8,10-13H2/t19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 448 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPDPE from delta-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50018999
(CHEMBL3287469)Show SMILES Oc1ccc2C[C@@]34CN(Cc5ccccc5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C30H28N2O/c33-25-11-10-23-16-29-17-24-14-22-8-4-5-9-27(22)31-28(24)18-30(29,26(23)15-25)12-13-32(20-29)19-21-6-2-1-3-7-21/h1-11,14-15,33H,12-13,16-20H2/t29-,30-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 594 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]U-69593 from kappa-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50018998
(CHEMBL3287468)Show SMILES Oc1ccc2C[C@@]34CN(CC5(O)CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O2/c30-21-6-5-19-13-25-14-20-11-18-3-1-2-4-23(18)28-24(20)15-27(25,22(19)12-21)9-10-29(16-25)17-26(31)7-8-26/h1-6,11-12,30-31H,7-10,13-17H2/t25-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 879 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Displacement of [3H]U-69593 from kappa-opioid receptor (unknown origin) |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50018997
(CHEMBL3287467)Show SMILES Oc1ccc2C[C@@]34CN(CC5CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O/c30-22-8-7-20-13-26-14-21-11-19-3-1-2-4-24(19)28-25(21)15-27(26,23(20)12-22)9-10-29(17-26)16-18-5-6-18/h1-4,7-8,11-12,18,30H,5-6,9-10,13-17H2/t26-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Agonist activity at delta-opioid receptor (unknown origin) by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50018997
(CHEMBL3287467)Show SMILES Oc1ccc2C[C@@]34CN(CC5CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O/c30-22-8-7-20-13-26-14-21-11-19-3-1-2-4-24(19)28-25(21)15-27(26,23(20)12-22)9-10-29(17-26)16-18-5-6-18/h1-4,7-8,11-12,18,30H,5-6,9-10,13-17H2/t26-,27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 836 | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Agonist activity at kappa-opioid receptor (unknown origin) by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50018997
(CHEMBL3287467)Show SMILES Oc1ccc2C[C@@]34CN(CC5CC5)CC[C@@]3(Cc3nc5ccccc5cc3C4)c2c1 |r| Show InChI InChI=1S/C27H28N2O/c30-22-8-7-20-13-26-14-21-11-19-3-1-2-4-24(19)28-25(21)15-27(26,23(20)12-22)9-10-29(17-26)16-18-5-6-18/h1-4,7-8,11-12,18,30H,5-6,9-10,13-17H2/t26-,27-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 197 | n/a | n/a | n/a | n/a |
University of Tsukuba
Curated by ChEMBL
| Assay Description
Agonist activity at mu-opioid receptor (unknown origin) by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 24: 2851-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.098
BindingDB Entry DOI: 10.7270/Q2DB83FW |
More data for this
Ligand-Target Pair | |
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