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PubMed code 2573732

Compile data set for download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017536
PNG
((Flumezapine)7-Fluoro-2-methyl-10-(4-methyl-pipera...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2sc(C)cc12 |t:8|
Show InChI InChI=1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,20H,5-8H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017536
PNG
((Flumezapine)7-Fluoro-2-methyl-10-(4-methyl-pipera...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2sc(C)cc12 |t:8|
Show InChI InChI=1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,20H,5-8H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017646
PNG
(7-Chloro-2-cyclopentyl-10-(4-methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2nn(cc12)C1CCCC1 |t:8|
Show InChI InChI=1S/C20H25ClN6/c1-25-8-10-26(11-9-25)20-16-13-27(15-4-2-3-5-15)24-19(16)22-17-7-6-14(21)12-18(17)23-20/h6-7,12-13,15H,2-5,8-11H2,1H3,(H,22,24)
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n/an/a 140n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017634
PNG
(7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-propyl-2,4...)
Show SMILES CCCn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:16|
Show InChI InChI=1S/C18H23FN6/c1-3-6-25-12-14-17(22-25)20-15-5-4-13(19)11-16(15)21-18(14)24-9-7-23(2)8-10-24/h4-5,11-12H,3,6-10H2,1-2H3,(H,20,22)
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n/an/a 180n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydrase

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/a 250n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017615
PNG
(7-Chloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCn1cc2c(Nc3ccc(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:15|
Show InChI InChI=1S/C17H21ClN6/c1-3-24-11-13-16(21-24)19-14-5-4-12(18)10-15(14)20-17(13)23-8-6-22(2)7-9-23/h4-5,10-11H,3,6-9H2,1-2H3,(H,19,21)
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n/an/a 340n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017631
PNG
(2-Benzyl-7-fluoro-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(Cc3ccccc3)cc12 |t:8|
Show InChI InChI=1S/C22H23FN6/c1-27-9-11-28(12-10-27)22-18-15-29(14-16-5-3-2-4-6-16)26-21(18)24-19-8-7-17(23)13-20(19)25-22/h2-8,13,15H,9-12,14H2,1H3,(H,24,26)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017628
PNG
(7-Bromo-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Br)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19BrN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 680n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017630
PNG
(7-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 680n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017626
PNG
(7-Fluoro-2-hexyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCCCCCn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:19|
Show InChI InChI=1S/C21H29FN6/c1-3-4-5-6-9-28-15-17-20(25-28)23-18-8-7-16(22)14-19(18)24-21(17)27-12-10-26(2)11-13-27/h7-8,14-15H,3-6,9-13H2,1-2H3,(H,23,25)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017617
PNG
(6,7-Difluoro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)c(F)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H18F2N6/c1-22-3-5-24(6-4-22)16-10-9-23(2)21-15(10)19-13-7-11(17)12(18)8-14(13)20-16/h7-9H,3-6H2,1-2H3,(H,19,21)
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n/an/a 760n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017644
PNG
(8-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2c(Cl)cccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-6-8-23(9-7-21)16-11-10-22(2)20-15(11)18-13-5-3-4-12(17)14(13)19-16/h3-5,10H,6-9H2,1-2H3,(H,18,20)
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n/an/a 860n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017633
PNG
(10-(4-Cyclopropylmethyl-piperazin-1-yl)-7-fluoro-2...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(CC3CC3)CC2)n1 |c:14|
Show InChI InChI=1S/C19H23FN6/c1-24-12-15-18(23-24)21-16-5-4-14(20)10-17(16)22-19(15)26-8-6-25(7-9-26)11-13-2-3-13/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H,21,23)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017615
PNG
(7-Chloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCn1cc2c(Nc3ccc(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:15|
Show InChI InChI=1S/C17H21ClN6/c1-3-24-11-13-16(21-24)19-14-5-4-12(18)10-15(14)20-17(13)23-8-6-22(2)7-9-23/h4-5,10-11H,3,6-9H2,1-2H3,(H,19,21)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017645
PNG
(6,7-Dichloro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)c(Cl)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H18Cl2N6/c1-22-3-5-24(6-4-22)16-10-9-23(2)21-15(10)19-13-7-11(17)12(18)8-14(13)20-16/h7-9H,3-6H2,1-2H3,(H,19,21)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017625
PNG
(CHEMBL262164 | [2-Methyl-10-(4-methyl-piperazin-1-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(ccc2Nc2nn(C)cc12)C(=O)c1ccccc1 |t:8|
Show InChI InChI=1S/C23H24N6O/c1-27-10-12-29(13-11-27)23-18-15-28(2)26-22(18)24-19-9-8-17(14-20(19)25-23)21(30)16-6-4-3-5-7-16/h3-9,14-15H,10-13H2,1-2H3,(H,24,26)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017653
PNG
(7-Iodo-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4-d...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(I)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19IN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017624
PNG
(7-Fluoro-2-methyl-10-(4-methyl-4-oxy-piperazin-1-y...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CC[N+](C)([O-])CC2)n1 |c:14|
Show InChI InChI=1S/C16H19FN6O/c1-21-10-12-15(20-21)18-13-4-3-11(17)9-14(13)19-16(12)22-5-7-23(2,24)8-6-22/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017622
PNG
(6,7-Dichloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-...)
Show SMILES CCn1cc2c(Nc3cc(Cl)c(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:16|
Show InChI InChI=1S/C17H20Cl2N6/c1-3-25-10-11-16(22-25)20-14-8-12(18)13(19)9-15(14)21-17(11)24-6-4-23(2)5-7-24/h8-10H,3-7H2,1-2H3,(H,20,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017635
PNG
(7-Fluoro-2-isopropyl-10-(4-methyl-piperazin-1-yl)-...)
Show SMILES CC(C)n1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:16|
Show InChI InChI=1S/C18H23FN6/c1-12(2)25-11-14-17(22-25)20-15-5-4-13(19)10-16(15)21-18(14)24-8-6-23(3)7-9-24/h4-5,10-12H,6-9H2,1-3H3,(H,20,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017613
PNG
(2-Methyl-10-(4-methyl-piperazin-1-yl)-7-trifluorom...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(ccc2Nc2nn(C)cc12)C(F)(F)F |t:8|
Show InChI InChI=1S/C17H19F3N6/c1-24-5-7-26(8-6-24)16-12-10-25(2)23-15(12)21-13-4-3-11(17(18,19)20)9-14(13)22-16/h3-4,9-10H,5-8H2,1-2H3,(H,21,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017627
PNG
(7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-p...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)c(c12)-c1ccccc1 |t:8|
Show InChI InChI=1S/C22H23FN6/c1-27-10-12-29(13-11-27)22-19-20(15-6-4-3-5-7-15)28(2)26-21(19)24-17-9-8-16(23)14-18(17)25-22/h3-9,14H,10-13H2,1-2H3,(H,24,26)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017638
PNG
(7-Chloro-2-decyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCCCCCCCCCn1cc2c(Nc3ccc(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:23|
Show InChI InChI=1S/C25H37ClN6/c1-3-4-5-6-7-8-9-10-13-32-19-21-24(29-32)27-22-12-11-20(26)18-23(22)28-25(21)31-16-14-30(2)15-17-31/h11-12,18-19H,3-10,13-17H2,1-2H3,(H,27,29)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017641
PNG
(6-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(F)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19FN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-14-9-11(17)3-4-13(14)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017636
PNG
(7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19FN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017650
PNG
(7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-phenyl-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(cc12)-c1ccccc1 |t:8|
Show InChI InChI=1S/C21H21FN6/c1-26-9-11-27(12-10-26)21-17-14-28(16-5-3-2-4-6-16)25-20(17)23-18-8-7-15(22)13-19(18)24-21/h2-8,13-14H,9-12H2,1H3,(H,23,25)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017651
PNG
(10-(4-Benzyl-piperazin-1-yl)-7-fluoro-2-methyl-2,4...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(Cc3ccccc3)CC2)n1 |c:14|
Show InChI InChI=1S/C22H23FN6/c1-27-15-18-21(26-27)24-19-8-7-17(23)13-20(19)25-22(18)29-11-9-28(10-12-29)14-16-5-3-2-4-6-16/h2-8,13,15H,9-12,14H2,1H3,(H,24,26)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017619
PNG
(7-Fluoro-1,2-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)c(C)c12 |t:8|
Show InChI InChI=1S/C17H21FN6/c1-11-15-16(21-23(11)3)19-13-5-4-12(18)10-14(13)20-17(15)24-8-6-22(2)7-9-24/h4-5,10H,6-9H2,1-3H3,(H,19,21)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017637
PNG
(7-Chloro-2-isobutyl-10-(4-methyl-piperazin-1-yl)-2...)
Show SMILES CC(C)Cn1cc2c(Nc3ccc(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:17|
Show InChI InChI=1S/C19H25ClN6/c1-13(2)11-26-12-15-18(23-26)21-16-5-4-14(20)10-17(16)22-19(15)25-8-6-24(3)7-9-25/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,21,23)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017648
PNG
(2-Ethyl-7-fluoro-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:15|
Show InChI InChI=1S/C17H21FN6/c1-3-24-11-13-16(21-24)19-14-5-4-12(18)10-15(14)20-17(13)23-8-6-22(2)7-9-23/h4-5,10-11H,3,6-9H2,1-2H3,(H,19,21)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017622
PNG
(6,7-Dichloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-...)
Show SMILES CCn1cc2c(Nc3cc(Cl)c(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:16|
Show InChI InChI=1S/C17H20Cl2N6/c1-3-25-10-11-16(22-25)20-14-8-12(18)13(19)9-15(14)21-17(11)24-6-4-23(2)5-7-24/h8-10H,3-7H2,1-2H3,(H,20,22)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017647
PNG
(5-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cccc(Cl)c2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-6-8-23(9-7-21)16-11-10-22(2)20-15(11)19-14-12(17)4-3-5-13(14)18-16/h3-5,10H,6-9H2,1-2H3,(H,19,20)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017623
PNG
(2-[4-(7-Fluoro-2-methyl-2,4-dihydro-2,3,4,9-tetraa...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(CCO)CC2)n1 |c:14|
Show InChI InChI=1S/C17H21FN6O/c1-22-11-13-16(21-22)19-14-3-2-12(18)10-15(14)20-17(13)24-6-4-23(5-7-24)8-9-25/h2-3,10-11,25H,4-9H2,1H3,(H,19,21)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017640
PNG
(7-Fluoro-2-methyl-10-piperazin-1-yl-2,4-dihydro-2,...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCNCC2)n1 |c:14|
Show InChI InChI=1S/C15H17FN6/c1-21-9-11-14(20-21)18-12-3-2-10(16)8-13(12)19-15(11)22-6-4-17-5-7-22/h2-3,8-9,17H,4-7H2,1H3,(H,18,20)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017643
PNG
(2,6-Dimethyl-10-(4-methyl-piperazin-1-yl)-2,4-dihy...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(C)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C17H22N6/c1-12-4-5-14-15(10-12)18-16-13(11-22(3)20-16)17(19-14)23-8-6-21(2)7-9-23/h4-5,10-11H,6-9H2,1-3H3,(H,18,20)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017620
PNG
(CHEMBL86342 | N'-(7-Fluoro-2-methyl-2,4-dihydro-2,...)
Show SMILES CN(C)CCNC1=Nc2cc(F)ccc2Nc2nn(C)cc12 |t:6|
Show InChI InChI=1S/C15H19FN6/c1-21(2)7-6-17-14-11-9-22(3)20-15(11)18-12-5-4-10(16)8-13(12)19-14/h4-5,8-9H,6-7H2,1-3H3,(H,17,19)(H,18,20)
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n/an/a 6.10E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017618
PNG
(2-Methyl-10-(4-methyl-piperazin-1-yl)-2,4-dihydro-...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H20N6/c1-20-7-9-22(10-8-20)16-12-11-21(2)19-15(12)17-13-5-3-4-6-14(13)18-16/h3-6,11H,7-10H2,1-2H3,(H,17,19)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017635
PNG
(7-Fluoro-2-isopropyl-10-(4-methyl-piperazin-1-yl)-...)
Show SMILES CC(C)n1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:16|
Show InChI InChI=1S/C18H23FN6/c1-12(2)25-11-14-17(22-25)20-15-5-4-13(19)10-16(15)21-18(14)24-8-6-23(3)7-9-24/h4-5,10-12H,6-9H2,1-3H3,(H,20,22)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017630
PNG
(7-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017613
PNG
(2-Methyl-10-(4-methyl-piperazin-1-yl)-7-trifluorom...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(ccc2Nc2nn(C)cc12)C(F)(F)F |t:8|
Show InChI InChI=1S/C17H19F3N6/c1-24-5-7-26(8-6-24)16-12-10-25(2)23-15(12)21-13-4-3-11(17(18,19)20)9-14(13)22-16/h3-4,9-10H,5-8H2,1-2H3,(H,21,23)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017645
PNG
(6,7-Dichloro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)c(Cl)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H18Cl2N6/c1-22-3-5-24(6-4-22)16-10-9-23(2)21-15(10)19-13-7-11(17)12(18)8-14(13)20-16/h7-9H,3-6H2,1-2H3,(H,19,21)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017621
PNG
(7-Fluoro-1,3-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2c(C)nn(C)c12 |t:8|
Show InChI InChI=1S/C17H21FN6/c1-11-15-16(23(3)21-11)17(24-8-6-22(2)7-9-24)20-14-10-12(18)4-5-13(14)19-15/h4-5,10,19H,6-9H2,1-3H3
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017652
PNG
(7-Methanesulfonyl-2-methyl-10-(4-methyl-piperazin-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(ccc2Nc2nn(C)cc12)S(C)(=O)=O |t:8|
Show InChI InChI=1S/C17H22N6O2S/c1-21-6-8-23(9-7-21)17-13-11-22(2)20-16(13)18-14-5-4-12(26(3,24)25)10-15(14)19-17/h4-5,10-11H,6-9H2,1-3H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017625
PNG
(CHEMBL262164 | [2-Methyl-10-(4-methyl-piperazin-1-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(ccc2Nc2nn(C)cc12)C(=O)c1ccccc1 |t:8|
Show InChI InChI=1S/C23H24N6O/c1-27-10-12-29(13-11-27)23-18-15-28(2)26-22(18)24-19-9-8-17(14-20(19)25-23)21(30)16-6-4-3-5-7-16/h3-9,14-15H,10-13H2,1-2H3,(H,24,26)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017620
PNG
(CHEMBL86342 | N'-(7-Fluoro-2-methyl-2,4-dihydro-2,...)
Show SMILES CN(C)CCNC1=Nc2cc(F)ccc2Nc2nn(C)cc12 |t:6|
Show InChI InChI=1S/C15H19FN6/c1-21(2)7-6-17-14-11-9-22(3)20-15(11)18-12-5-4-10(16)8-13(12)19-14/h4-5,8-9H,6-7H2,1-3H3,(H,17,19)(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017628
PNG
(7-Bromo-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Br)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19BrN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017639
PNG
(7-Fluoro-2-methyl-10-piperidin-1-yl-2,4-dihydro-2,...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCCCC2)n1 |c:14|
Show InChI InChI=1S/C16H18FN5/c1-21-10-12-15(20-21)18-13-6-5-11(17)9-14(13)19-16(12)22-7-3-2-4-8-22/h5-6,9-10H,2-4,7-8H2,1H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017638
PNG
(7-Chloro-2-decyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCCCCCCCCCn1cc2c(Nc3ccc(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:23|
Show InChI InChI=1S/C25H37ClN6/c1-3-4-5-6-7-8-9-10-13-32-19-21-24(29-32)27-22-12-11-20(26)18-23(22)28-25(21)31-16-14-30(2)15-17-31/h11-12,18-19H,3-10,13-17H2,1-2H3,(H,27,29)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017646
PNG
(7-Chloro-2-cyclopentyl-10-(4-methyl-piperazin-1-yl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2nn(cc12)C1CCCC1 |t:8|
Show InChI InChI=1S/C20H25ClN6/c1-25-8-10-26(11-9-25)20-16-13-27(15-4-2-3-5-15)24-19(16)22-17-7-6-14(21)12-18(17)23-20/h6-7,12-13,15H,2-5,8-11H2,1H3,(H,22,24)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017632
PNG
(4-(7-Fluoro-2-methyl-2,4-dihydro-2,3,4,9-tetraaza-...)
Show SMILES CCOC(=O)N1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)cc12 |t:12|
Show InChI InChI=1S/C18H21FN6O2/c1-3-27-18(26)25-8-6-24(7-9-25)17-13-11-23(2)22-16(13)20-14-5-4-12(19)10-15(14)21-17/h4-5,10-11H,3,6-9H2,1-2H3,(H,20,22)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017633
PNG
(10-(4-Cyclopropylmethyl-piperazin-1-yl)-7-fluoro-2...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(CC3CC3)CC2)n1 |c:14|
Show InChI InChI=1S/C19H23FN6/c1-24-12-15-18(23-24)21-16-5-4-14(20)10-17(16)22-19(15)26-8-6-25(7-9-26)11-13-2-3-13/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H,21,23)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase II

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017624
PNG
(7-Fluoro-2-methyl-10-(4-methyl-4-oxy-piperazin-1-y...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CC[N+](C)([O-])CC2)n1 |c:14|
Show InChI InChI=1S/C16H19FN6O/c1-21-10-12-15(20-21)18-13-4-3-11(17)9-14(13)19-16(12)22-5-7-23(2,24)8-6-22/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017639
PNG
(7-Fluoro-2-methyl-10-piperidin-1-yl-2,4-dihydro-2,...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCCCC2)n1 |c:14|
Show InChI InChI=1S/C16H18FN5/c1-21-10-12-15(20-21)18-13-6-5-11(17)9-14(13)19-16(12)22-7-3-2-4-8-22/h5-6,9-10H,2-4,7-8H2,1H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017650
PNG
(7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-phenyl-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(cc12)-c1ccccc1 |t:8|
Show InChI InChI=1S/C21H21FN6/c1-26-9-11-27(12-10-26)21-17-14-28(16-5-3-2-4-6-16)25-20(17)23-18-8-7-15(22)13-19(18)24-21/h2-8,13-14H,9-12H2,1H3,(H,23,25)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017614
PNG
(7-Chloro-2-methyl-2,4-dihydro-2,3,4,9-tetraaza-ben...)
Show SMILES Cn1cc2c(Nc3ccc(Cl)cc3N=C2N)n1 |c:14|
Show InChI InChI=1S/C11H10ClN5/c1-17-5-7-10(13)14-9-4-6(12)2-3-8(9)15-11(7)16-17/h2-5H,1H3,(H2,13,14)(H,15,16)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017649
PNG
(7-Fluoro-2,3-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2c(C)n(C)nc12 |t:8|
Show InChI InChI=1S/C17H21FN6/c1-11-15-16(21-23(11)3)17(24-8-6-22(2)7-9-24)20-14-10-12(18)4-5-13(14)19-15/h4-5,10,19H,6-9H2,1-3H3
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017640
PNG
(7-Fluoro-2-methyl-10-piperazin-1-yl-2,4-dihydro-2,...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCNCC2)n1 |c:14|
Show InChI InChI=1S/C15H17FN6/c1-21-9-11-14(20-21)18-12-3-2-10(16)8-13(12)19-15(11)22-6-4-17-5-7-22/h2-3,8-9,17H,4-7H2,1H3,(H,18,20)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017637
PNG
(7-Chloro-2-isobutyl-10-(4-methyl-piperazin-1-yl)-2...)
Show SMILES CC(C)Cn1cc2c(Nc3ccc(Cl)cc3N=C2N2CCN(C)CC2)n1 |c:17|
Show InChI InChI=1S/C19H25ClN6/c1-13(2)11-26-12-15-18(23-26)21-16-5-4-14(20)10-17(16)22-19(15)25-8-6-24(3)7-9-25/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,21,23)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017629
PNG
(6-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-14-9-11(17)3-4-13(14)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017648
PNG
(2-Ethyl-7-fluoro-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:15|
Show InChI InChI=1S/C17H21FN6/c1-3-24-11-13-16(21-24)19-14-5-4-12(18)10-15(14)20-17(13)23-8-6-22(2)7-9-23/h4-5,10-11H,3,6-9H2,1-2H3,(H,19,21)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017634
PNG
(7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-propyl-2,4...)
Show SMILES CCCn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:16|
Show InChI InChI=1S/C18H23FN6/c1-3-6-25-12-14-17(22-25)20-15-5-4-13(19)11-16(15)21-18(14)24-9-7-23(2)8-10-24/h4-5,11-12H,3,6-10H2,1-2H3,(H,20,22)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017626
PNG
(7-Fluoro-2-hexyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Show SMILES CCCCCCn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(C)CC2)n1 |c:19|
Show InChI InChI=1S/C21H29FN6/c1-3-4-5-6-9-28-15-17-20(25-28)23-18-8-7-16(22)14-19(18)24-21(17)27-12-10-26(2)11-13-27/h7-8,14-15H,3-6,9-13H2,1-2H3,(H,23,25)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017617
PNG
(6,7-Difluoro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)c(F)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H18F2N6/c1-22-3-5-24(6-4-22)16-10-9-23(2)21-15(10)19-13-7-11(17)12(18)8-14(13)20-16/h7-9H,3-6H2,1-2H3,(H,19,21)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017618
PNG
(2-Methyl-10-(4-methyl-piperazin-1-yl)-2,4-dihydro-...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H20N6/c1-20-7-9-22(10-8-20)16-12-11-21(2)19-15(12)17-13-5-3-4-6-14(13)18-16/h3-6,11H,7-10H2,1-2H3,(H,17,19)
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n/an/a 3.80E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017641
PNG
(6-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(F)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19FN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-14-9-11(17)3-4-13(14)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 4.30E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017619
PNG
(7-Fluoro-1,2-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)c(C)c12 |t:8|
Show InChI InChI=1S/C17H21FN6/c1-11-15-16(21-23(11)3)19-13-5-4-12(18)10-14(13)20-17(15)24-8-6-22(2)7-9-24/h4-5,10H,6-9H2,1-3H3,(H,19,21)
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n/an/a 9.70E+4n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatum

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017647
PNG
(5-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cccc(Cl)c2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-6-8-23(9-7-21)16-11-10-22(2)20-15(11)19-14-12(17)4-3-5-13(14)18-16/h3-5,10H,6-9H2,1-2H3,(H,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017616
PNG
(7-Fluoro-2-methyl-10-morpholin-4-yl-2,4-dihydro-2,...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCOCC2)n1 |c:14|
Show InChI InChI=1S/C15H16FN5O/c1-20-9-11-14(19-20)17-12-3-2-10(16)8-13(12)18-15(11)21-4-6-22-7-5-21/h2-3,8-9H,4-7H2,1H3,(H,17,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017621
PNG
(7-Fluoro-1,3-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2c(C)nn(C)c12 |t:8|
Show InChI InChI=1S/C17H21FN6/c1-11-15-16(23(3)21-11)17(24-8-6-22(2)7-9-24)20-14-10-12(18)4-5-13(14)19-15/h4-5,10,19H,6-9H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017643
PNG
(2,6-Dimethyl-10-(4-methyl-piperazin-1-yl)-2,4-dihy...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(C)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C17H22N6/c1-12-4-5-14-15(10-12)18-16-13(11-22(3)20-16)17(19-14)23-8-6-21(2)7-9-23/h4-5,10-11H,6-9H2,1-3H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017614
PNG
(7-Chloro-2-methyl-2,4-dihydro-2,3,4,9-tetraaza-ben...)
Show SMILES Cn1cc2c(Nc3ccc(Cl)cc3N=C2N)n1 |c:14|
Show InChI InChI=1S/C11H10ClN5/c1-17-5-7-10(13)14-9-4-6(12)2-3-8(9)15-11(7)16-17/h2-5H,1H3,(H2,13,14)(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydrase

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017629
PNG
(6-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2ccc(Cl)cc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-14-9-11(17)3-4-13(14)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017631
PNG
(2-Benzyl-7-fluoro-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(Cc3ccccc3)cc12 |t:8|
Show InChI InChI=1S/C22H23FN6/c1-27-9-11-28(12-10-27)22-18-15-29(14-16-5-3-2-4-6-16)26-21(18)24-19-8-7-17(23)13-20(19)25-22/h2-8,13,15H,9-12,14H2,1H3,(H,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017627
PNG
(7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-p...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)c(c12)-c1ccccc1 |t:8|
Show InChI InChI=1S/C22H23FN6/c1-27-10-12-29(13-11-27)22-19-20(15-6-4-3-5-7-15)28(2)26-21(19)24-17-9-8-16(23)14-18(17)25-22/h3-9,14H,10-13H2,1-2H3,(H,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017651
PNG
(10-(4-Benzyl-piperazin-1-yl)-7-fluoro-2-methyl-2,4...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(Cc3ccccc3)CC2)n1 |c:14|
Show InChI InChI=1S/C22H23FN6/c1-27-15-18-21(26-27)24-19-8-7-17(23)13-20(19)25-22(18)29-11-9-28(10-12-29)14-16-5-3-2-4-6-16/h2-8,13,15H,9-12,14H2,1H3,(H,24,26)
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Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydrase

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017632
PNG
(4-(7-Fluoro-2-methyl-2,4-dihydro-2,3,4,9-tetraaza-...)
Show SMILES CCOC(=O)N1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)cc12 |t:12|
Show InChI InChI=1S/C18H21FN6O2/c1-3-27-18(26)25-8-6-24(7-9-25)17-13-11-23(2)22-16(13)20-14-5-4-12(19)10-15(14)21-17/h4-5,10-11H,3,6-9H2,1-2H3,(H,20,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017644
PNG
(8-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2c(Cl)cccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19ClN6/c1-21-6-8-23(9-7-21)16-11-10-22(2)20-15(11)18-13-5-3-4-12(17)14(13)19-16/h3-5,10H,6-9H2,1-2H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017616
PNG
(7-Fluoro-2-methyl-10-morpholin-4-yl-2,4-dihydro-2,...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCOCC2)n1 |c:14|
Show InChI InChI=1S/C15H16FN5O/c1-20-9-11-14(19-20)17-12-3-2-10(16)8-13(12)18-15(11)21-4-6-22-7-5-21/h2-3,8-9H,4-7H2,1H3,(H,17,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017642
PNG
(3-Methyl-10-(4-methyl-piperazin-1-yl)-3,4-dihydro-...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2c1cnn2C |t:8|
Show InChI InChI=1S/C16H20N6/c1-20-7-9-22(10-8-20)16-12-11-17-21(2)15(12)18-13-5-3-4-6-14(13)19-16/h3-6,11,18H,7-10H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017652
PNG
(7-Methanesulfonyl-2-methyl-10-(4-methyl-piperazin-...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(ccc2Nc2nn(C)cc12)S(C)(=O)=O |t:8|
Show InChI InChI=1S/C17H22N6O2S/c1-21-6-8-23(9-7-21)17-13-11-22(2)20-16(13)18-14-5-4-12(26(3,24)25)10-15(14)19-17/h4-5,10-11H,6-9H2,1-3H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017623
PNG
(2-[4-(7-Fluoro-2-methyl-2,4-dihydro-2,3,4,9-tetraa...)
Show SMILES Cn1cc2c(Nc3ccc(F)cc3N=C2N2CCN(CCO)CC2)n1 |c:14|
Show InChI InChI=1S/C17H21FN6O/c1-22-11-13-16(21-22)19-14-3-2-12(18)10-15(14)20-17(13)24-6-4-23(5-7-24)8-9-25/h2-3,10-11,25H,4-9H2,1H3,(H,19,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5


(RAT)		BDBM50017636
PNG
(7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2nn(C)cc12 |t:8|
Show InChI InChI=1S/C16H19FN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
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n/an/a 1.50E+5n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat brain.

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017642
PNG
(3-Methyl-10-(4-methyl-piperazin-1-yl)-3,4-dihydro-...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2c1cnn2C |t:8|
Show InChI InChI=1S/C16H20N6/c1-20-7-9-22(10-8-20)16-12-11-17-21(2)15(12)18-13-5-3-4-6-14(13)19-16/h3-6,11,18H,7-10H2,1-2H3
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n/an/a 1.50E+6n/an/an/an/an/an/a



Lilly Research Centre Limited

Curated by ChEMBL


Assay Description
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brain

J Med Chem 32: 2573-82 (1989)


BindingDB Entry DOI: 10.7270/Q22F7P2J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%