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PubMed code 26299826

Compile data set for download or QSAR
Found 112 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119462
PNG
(CHEMBL3613880)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N7/c24-21-5-3-6-22(23(21)25)30-14-12-29(13-15-30)10-2-1-4-18-17-32(28-27-18)20-8-11-31-19(16-20)7-9-26-31/h3,5-9,11,16-17H,1-2,4,10,12-15H2
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 0.310n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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 0.480n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119508
PNG
(CHEMBL217981)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1
Show InChI InChI=1S/C27H35BrN6O2/c1-21-26(30-31-34(21)20-22-10-4-5-11-23(22)28)27(35)29-14-8-3-9-15-32-16-18-33(19-17-32)24-12-6-7-13-25(24)36-2/h4-7,10-13H,3,8-9,14-20H2,1-2H3,(H,29,35)
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 0.580n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119462
PNG
(CHEMBL3613880)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N7/c24-21-5-3-6-22(23(21)25)30-14-12-29(13-15-30)10-2-1-4-18-17-32(28-27-18)20-8-11-31-19(16-20)7-9-26-31/h3,5-9,11,16-17H,1-2,4,10,12-15H2
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 0.640n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119510
PNG
(CHEMBL221129)
Show SMILES CCCc1c(nnn1Cc1ccccc1Br)C(=O)NCCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C29H39BrN6O2/c1-3-11-26-28(32-33-36(26)22-23-12-5-6-13-24(23)30)29(37)31-16-9-4-10-17-34-18-20-35(21-19-34)25-14-7-8-15-27(25)38-2/h5-8,12-15H,3-4,9-11,16-22H2,1-2H3,(H,31,37)
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 0.910n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119515
PNG
(CHEMBL221866)
Show SMILES COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(CC3)c3cccc(Cl)c3Cl)c2C)cc1
Show InChI InChI=1S/C27H34Cl2N6O2/c1-20-26(31-32-35(20)19-21-9-11-22(37-2)12-10-21)27(36)30-13-4-3-5-14-33-15-17-34(18-16-33)24-8-6-7-23(28)25(24)29/h6-12H,3-5,13-19H2,1-2H3,(H,30,36)
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 1.5n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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 2.20n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119500
PNG
(CHEMBL221587)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1
Show InChI InChI=1S/C27H36N6O2/c1-22-26(29-30-33(22)21-23-11-5-3-6-12-23)27(34)28-15-9-4-10-16-31-17-19-32(20-18-31)24-13-7-8-14-25(24)35-2/h3,5-8,11-14H,4,9-10,15-21H2,1-2H3,(H,28,34)
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 2.5n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119513
PNG
(CHEMBL425285)
Show SMILES CCCc1c(nnn1Cc1ccccc1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C27H34Cl2N6O/c1-2-9-24-26(31-32-35(24)20-21-10-4-3-5-11-21)27(36)30-14-6-7-15-33-16-18-34(19-17-33)23-13-8-12-22(28)25(23)29/h3-5,8,10-13H,2,6-7,9,14-20H2,1H3,(H,30,36)
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 2.5n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119503
PNG
(CHEMBL220754)
Show SMILES COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(CC3)c3ccccc3OC)c2C)cc1
Show InChI InChI=1S/C28H38N6O3/c1-22-27(30-31-34(22)21-23-11-13-24(36-2)14-12-23)28(35)29-15-7-4-8-16-32-17-19-33(20-18-32)25-9-5-6-10-26(25)37-3/h5-6,9-14H,4,7-8,15-21H2,1-3H3,(H,29,35)
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 2.70n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119509
PNG
(CHEMBL386986)
Show SMILES CCCc1c(nnn1Cc1ccccc1Br)C(=O)NCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C28H37BrN6O2/c1-3-10-25-27(31-32-35(25)21-22-11-4-5-12-23(22)29)28(36)30-15-8-9-16-33-17-19-34(20-18-33)24-13-6-7-14-26(24)37-2/h4-7,11-14H,3,8-10,15-21H2,1-2H3,(H,30,36)
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 3n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119515
PNG
(CHEMBL221866)
Show SMILES COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(CC3)c3cccc(Cl)c3Cl)c2C)cc1
Show InChI InChI=1S/C27H34Cl2N6O2/c1-20-26(31-32-35(20)19-21-9-11-22(37-2)12-10-21)27(36)30-13-4-3-5-14-33-15-17-34(18-16-33)24-8-6-7-23(28)25(24)29/h6-12H,3-5,13-19H2,1-2H3,(H,30,36)
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 3.20n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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 3.80n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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 4n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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 4.40n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119460
PNG
(CHEMBL3613879)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N7/c23-20-4-1-5-21(22(20)24)29-13-11-28(12-14-29)9-2-3-17-16-31(27-26-17)19-7-10-30-18(15-19)6-8-25-30/h1,4-8,10,15-16H,2-3,9,11-14H2
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 5.30n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119501
PNG
(CHEMBL218607)
Show SMILES CCCc1c(nnn1Cc1ccccc1)C(=O)NCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C28H38N6O2/c1-3-11-25-27(30-31-34(25)22-23-12-5-4-6-13-23)28(35)29-16-9-10-17-32-18-20-33(21-19-32)24-14-7-8-15-26(24)36-2/h4-8,12-15H,3,9-11,16-22H2,1-2H3,(H,29,35)
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 6.40n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119513
PNG
(CHEMBL425285)
Show SMILES CCCc1c(nnn1Cc1ccccc1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C27H34Cl2N6O/c1-2-9-24-26(31-32-35(24)20-21-10-4-3-5-11-21)27(36)30-14-6-7-15-33-16-18-34(19-17-33)23-13-8-12-22(28)25(23)29/h3-5,8,10-13H,2,6-7,9,14-20H2,1H3,(H,30,36)
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 6.40n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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 6.70n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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 6.90n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119381
PNG
(CHEMBL139600 | N-(5-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1
Show InChI InChI=1S/C24H31N5O2/c1-31-23-11-4-3-10-22(23)28-17-15-27(16-18-28)13-7-2-6-12-25-24(30)20-19-26-29-14-8-5-9-21(20)29/h3-5,8-11,14,19H,2,6-7,12-13,15-18H2,1H3,(H,25,30)
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 7.10n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119504
PNG
(CHEMBL218351)
Show SMILES CCCc1c(nnn1Cc1ccc(OC)cc1)C(=O)NCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C29H40N6O3/c1-4-9-26-28(31-32-35(26)22-23-12-14-24(37-2)15-13-23)29(36)30-16-7-8-17-33-18-20-34(21-19-33)25-10-5-6-11-27(25)38-3/h5-6,10-15H,4,7-9,16-22H2,1-3H3,(H,30,36)
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 7.10n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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 7.10n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119384
PNG
(Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-p...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N3O2/c24-18-7-5-8-19(22(18)25)28-14-12-27(13-15-28)11-4-3-10-26-23(29)21-16-17-6-1-2-9-20(17)30-21/h1-2,5-9,16H,3-4,10-15H2,(H,26,29)
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 7.20n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119462
PNG
(CHEMBL3613880)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N7/c24-21-5-3-6-22(23(21)25)30-14-12-29(13-15-30)10-2-1-4-18-17-32(28-27-18)20-8-11-31-19(16-20)7-9-26-31/h3,5-9,11,16-17H,1-2,4,10,12-15H2
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 7.30n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119498
PNG
(CHEMBL373873)
Show SMILES Cc1c(nnn1Cc1ccccc1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C25H30Cl2N6O/c1-19-24(29-30-33(19)18-20-8-3-2-4-9-20)25(34)28-12-5-6-13-31-14-16-32(17-15-31)22-11-7-10-21(26)23(22)27/h2-4,7-11H,5-6,12-18H2,1H3,(H,28,34)
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 7.40n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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 8n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119460
PNG
(CHEMBL3613879)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N7/c23-20-4-1-5-21(22(20)24)29-13-11-28(12-14-29)9-2-3-17-16-31(27-26-17)19-7-10-30-18(15-19)6-8-25-30/h1,4-8,10,15-16H,2-3,9,11-14H2
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 8.5n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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 8.5n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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 9.40n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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 10n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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 11n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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 12n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119502
PNG
(CHEMBL437525)
Show SMILES COc1ccc(Cn2nnc(C(=O)NCCCCN3CCN(CC3)c3ccccc3OC)c2C)cc1
Show InChI InChI=1S/C27H36N6O3/c1-21-26(29-30-33(21)20-22-10-12-23(35-2)13-11-22)27(34)28-14-6-7-15-31-16-18-32(19-17-31)24-8-4-5-9-25(24)36-3/h4-5,8-13H,6-7,14-20H2,1-3H3,(H,28,34)
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 13n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119498
PNG
(CHEMBL373873)
Show SMILES Cc1c(nnn1Cc1ccccc1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C25H30Cl2N6O/c1-19-24(29-30-33(19)18-20-8-3-2-4-9-20)25(34)28-12-5-6-13-31-14-16-32(17-15-31)22-11-7-10-21(26)23(22)27/h2-4,7-11H,5-6,12-18H2,1H3,(H,28,34)
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 14n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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 15n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119390
PNG
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N3OS/c24-18-7-5-8-19(22(18)25)28-14-12-27(13-15-28)11-4-3-10-26-23(29)21-16-17-6-1-2-9-20(17)30-21/h1-2,5-9,16H,3-4,10-15H2,(H,26,29)
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 17n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119506
PNG
(CHEMBL385289)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1
Show InChI InChI=1S/C26H33BrN6O2/c1-20-25(29-30-33(20)19-21-9-3-4-10-22(21)27)26(34)28-13-7-8-14-31-15-17-32(18-16-31)23-11-5-6-12-24(23)35-2/h3-6,9-12H,7-8,13-19H2,1-2H3,(H,28,34)
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 17n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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 18n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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 22n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119462
PNG
(CHEMBL3613880)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N7/c24-21-5-3-6-22(23(21)25)30-14-12-29(13-15-30)10-2-1-4-18-17-32(28-27-18)20-8-11-31-19(16-20)7-9-26-31/h3,5-9,11,16-17H,1-2,4,10,12-15H2
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 23n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119386
PNG
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1
Show InChI InChI=1S/C24H29N3O2S/c1-29-21-10-4-3-9-20(21)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-5-11-22(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28)
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 25n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119504
PNG
(CHEMBL218351)
Show SMILES CCCc1c(nnn1Cc1ccc(OC)cc1)C(=O)NCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C29H40N6O3/c1-4-9-26-28(31-32-35(26)22-23-12-14-24(37-2)15-13-23)29(36)30-16-7-8-17-33-18-20-34(21-19-33)25-10-5-6-11-27(25)38-3/h5-6,10-15H,4,7-9,16-22H2,1-3H3,(H,30,36)
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 29n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50122048
PNG
(1H-Indole-2-carboxylic acid {4-[4-(2,3-dichloro-ph...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl
Show InChI InChI=1S/C23H26Cl2N4O/c24-18-7-5-9-21(22(18)25)29-14-12-28(13-15-29)11-4-3-10-26-23(30)20-16-17-6-1-2-8-19(17)27-20/h1-2,5-9,16,27H,3-4,10-15H2,(H,26,30)
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 31n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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 32n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119382
PNG
(CHEMBL344677 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-10-3-2-8-20(22)27-17-15-26(16-18-27)14-5-4-12-24-23(29)21-9-6-7-19-11-13-25-28(19)21/h2-3,6-11,13H,4-5,12,14-18H2,1H3,(H,24,29)
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 34n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119387
PNG
(CHEMBL140968 | N-(5-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-31-23-11-4-3-10-22(23)28-17-15-27(16-18-28)13-7-2-6-12-25-24(30)21-19-20-9-5-8-14-29(20)26-21/h3-5,8-11,14,19H,2,6-7,12-13,15-18H2,1H3,(H,25,30)
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 35n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119497
PNG
(CHEMBL221843)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1
Show InChI InChI=1S/C26H34N6O2/c1-21-25(28-29-32(21)20-22-10-4-3-5-11-22)26(33)27-14-8-9-15-30-16-18-31(19-17-30)23-12-6-7-13-24(23)34-2/h3-7,10-13H,8-9,14-20H2,1-2H3,(H,27,33)
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 35n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119508
PNG
(CHEMBL217981)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1
Show InChI InChI=1S/C27H35BrN6O2/c1-21-26(30-31-34(21)20-22-10-4-5-11-23(22)28)27(35)29-14-8-3-9-15-32-16-18-33(19-17-32)24-12-6-7-13-25(24)36-2/h4-7,10-13H,3,8-9,14-20H2,1-2H3,(H,29,35)
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 41n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119509
PNG
(CHEMBL386986)
Show SMILES CCCc1c(nnn1Cc1ccccc1Br)C(=O)NCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C28H37BrN6O2/c1-3-10-25-27(31-32-35(25)21-22-11-4-5-12-23(22)29)28(36)30-15-8-9-16-33-17-19-34(20-18-33)24-13-6-7-14-26(24)37-2/h4-7,11-14H,3,8-10,15-21H2,1-2H3,(H,30,36)
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 44n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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 50n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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 51n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119460
PNG
(CHEMBL3613879)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N7/c23-20-4-1-5-21(22(20)24)29-13-11-28(12-14-29)9-2-3-17-16-31(27-26-17)19-7-10-30-18(15-19)6-8-25-30/h1,4-8,10,15-16H,2-3,9,11-14H2
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 54n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119385
PNG
(CHEMBL342060 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-7-3-2-6-21(22)27-16-14-26(15-17-27)12-5-4-10-24-23(29)19-9-13-28-20(18-19)8-11-25-28/h2-3,6-9,11,13,18H,4-5,10,12,14-17H2,1H3,(H,24,29)
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 58n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119510
PNG
(CHEMBL221129)
Show SMILES CCCc1c(nnn1Cc1ccccc1Br)C(=O)NCCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C29H39BrN6O2/c1-3-11-26-28(32-33-36(26)22-23-12-5-6-13-24(23)30)29(37)31-16-9-4-10-17-34-18-20-35(21-19-34)25-14-7-8-15-27(25)38-2/h5-8,12-15H,3-4,9-11,16-22H2,1-2H3,(H,31,37)
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 62n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50119499
PNG
(CHEMBL3613873)
Show SMILES COc1ccccc1N1CCN(CCCc2cn(nn2)-c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-31-23-7-3-2-6-22(23)28-15-13-27(14-16-28)11-4-5-19-18-30(26-25-19)21-9-12-29-20(17-21)8-10-24-29/h2-3,6-10,12,17-18H,4-5,11,13-16H2,1H3
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 77n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119499
PNG
(CHEMBL3613873)
Show SMILES COc1ccccc1N1CCN(CCCc2cn(nn2)-c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-31-23-7-3-2-6-22(23)28-15-13-27(14-16-28)11-4-5-19-18-30(26-25-19)21-9-12-29-20(17-21)8-10-24-29/h2-3,6-10,12,17-18H,4-5,11,13-16H2,1H3
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 81n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119384
PNG
(Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-p...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N3O2/c24-18-7-5-8-19(22(18)25)28-14-12-27(13-15-28)11-4-3-10-26-23(29)21-16-17-6-1-2-9-20(17)30-21/h1-2,5-9,16H,3-4,10-15H2,(H,26,29)
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 82n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119499
PNG
(CHEMBL3613873)
Show SMILES COc1ccccc1N1CCN(CCCc2cn(nn2)-c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-31-23-7-3-2-6-22(23)28-15-13-27(14-16-28)11-4-5-19-18-30(26-25-19)21-9-12-29-20(17-21)8-10-24-29/h2-3,6-10,12,17-18H,4-5,11,13-16H2,1H3
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 84n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119392
PNG
(CHEMBL141845 | N-(2-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1
Show InChI InChI=1S/C21H25N5O2/c1-28-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-9-22-21(27)17-16-23-26-10-5-4-6-18(17)26/h2-8,10,16H,9,11-15H2,1H3,(H,22,27)
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 85n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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 89n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119503
PNG
(CHEMBL220754)
Show SMILES COc1ccc(Cn2nnc(C(=O)NCCCCCN3CCN(CC3)c3ccccc3OC)c2C)cc1
Show InChI InChI=1S/C28H38N6O3/c1-22-27(30-31-34(22)21-23-11-13-24(36-2)14-12-23)28(35)29-15-7-4-8-16-32-17-19-33(20-18-32)25-9-5-6-10-26(25)37-3/h5-6,9-14H,4,7-8,15-21H2,1-3H3,(H,29,35)
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 93n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119391
PNG
(CHEMBL142020 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-10-3-2-9-21(22)27-16-14-26(15-17-27)12-7-5-11-24-23(29)20-18-19-8-4-6-13-28(19)25-20/h2-4,6,8-10,13,18H,5,7,11-12,14-17H2,1H3,(H,24,29)
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 99n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119378
PNG
(CHEMBL143352 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-9-3-2-8-21(22)27-17-15-26(16-18-27)13-5-4-11-24-23(29)19-7-6-14-28-20(19)10-12-25-28/h2-3,6-10,12,14H,4-5,11,13,15-18H2,1H3,(H,24,29)
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 100n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119462
PNG
(CHEMBL3613880)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N7/c24-21-5-3-6-22(23(21)25)30-14-12-29(13-15-30)10-2-1-4-18-17-32(28-27-18)20-8-11-31-19(16-20)7-9-26-31/h3,5-9,11,16-17H,1-2,4,10,12-15H2
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 110n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119501
PNG
(CHEMBL218607)
Show SMILES CCCc1c(nnn1Cc1ccccc1)C(=O)NCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C28H38N6O2/c1-3-11-25-27(30-31-34(25)22-23-12-5-4-6-13-23)28(35)29-16-9-10-17-32-18-20-33(21-19-32)24-14-7-8-15-26(24)36-2/h4-8,12-15H,3,9-11,16-22H2,1-2H3,(H,29,35)
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 110n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119460
PNG
(CHEMBL3613879)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N7/c23-20-4-1-5-21(22(20)24)29-13-11-28(12-14-29)9-2-3-17-16-31(27-26-17)19-7-10-30-18(15-19)6-8-25-30/h1,4-8,10,15-16H,2-3,9,11-14H2
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 110n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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 110n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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 120n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119386
PNG
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1
Show InChI InChI=1S/C24H29N3O2S/c1-29-21-10-4-3-9-20(21)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-5-11-22(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28)
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 120n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119381
PNG
(CHEMBL139600 | N-(5-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1
Show InChI InChI=1S/C24H31N5O2/c1-31-23-11-4-3-10-22(23)28-17-15-27(16-18-28)13-7-2-6-12-25-24(30)20-19-26-29-14-8-5-9-21(20)29/h3-5,8-11,14,19H,2,6-7,12-13,15-18H2,1H3,(H,25,30)
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 130n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119460
PNG
(CHEMBL3613879)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N7/c23-20-4-1-5-21(22(20)24)29-13-11-28(12-14-29)9-2-3-17-16-31(27-26-17)19-7-10-30-18(15-19)6-8-25-30/h1,4-8,10,15-16H,2-3,9,11-14H2
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 130n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119500
PNG
(CHEMBL221587)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1
Show InChI InChI=1S/C27H36N6O2/c1-22-26(29-30-33(22)21-23-11-5-3-6-12-23)27(34)28-15-9-4-10-16-31-17-19-32(20-18-31)24-13-7-8-14-25(24)35-2/h3,5-8,11-14H,4,9-10,15-21H2,1-2H3,(H,28,34)
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 140n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119502
PNG
(CHEMBL437525)
Show SMILES COc1ccc(Cn2nnc(C(=O)NCCCCN3CCN(CC3)c3ccccc3OC)c2C)cc1
Show InChI InChI=1S/C27H36N6O3/c1-21-26(29-30-33(21)20-22-10-12-23(35-2)13-11-22)27(34)28-14-6-7-15-31-16-18-32(19-17-31)24-8-4-5-9-25(24)36-3/h4-5,8-13H,6-7,14-20H2,1-3H3,(H,28,34)
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 140n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119499
PNG
(CHEMBL3613873)
Show SMILES COc1ccccc1N1CCN(CCCc2cn(nn2)-c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-31-23-7-3-2-6-22(23)28-15-13-27(14-16-28)11-4-5-19-18-30(26-25-19)21-9-12-29-20(17-21)8-10-24-29/h2-3,6-10,12,17-18H,4-5,11,13-16H2,1H3
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 140n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119506
PNG
(CHEMBL385289)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3Br)c2C)CC1
Show InChI InChI=1S/C26H33BrN6O2/c1-20-25(29-30-33(20)19-21-9-3-4-10-22(21)27)26(34)28-13-7-8-14-31-15-17-32(18-16-31)23-11-5-6-12-24(23)35-2/h3-6,9-12H,7-8,13-19H2,1-2H3,(H,28,34)
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 150n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119374
PNG
(CHEMBL357684 | N-(3-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1
Show InChI InChI=1S/C22H27N5O2/c1-29-21-9-3-2-8-20(21)26-15-13-25(14-16-26)11-6-10-23-22(28)19-17-18-7-4-5-12-27(18)24-19/h2-5,7-9,12,17H,6,10-11,13-16H2,1H3,(H,23,28)
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 150n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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 160n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119377
PNG
(Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phen...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1
Show InChI InChI=1S/C24H29N3O3/c1-29-22-11-5-3-9-20(22)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-4-10-21(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28)
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 170n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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 210n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119387
PNG
(CHEMBL140968 | N-(5-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-31-23-11-4-3-10-22(23)28-17-15-27(16-18-28)13-7-2-6-12-25-24(30)21-19-20-9-5-8-14-29(20)26-21/h3-5,8-11,14,19H,2,6-7,12-13,15-18H2,1H3,(H,25,30)
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 220n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119378
PNG
(CHEMBL143352 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-9-3-2-8-21(22)27-17-15-26(16-18-27)13-5-4-11-24-23(29)19-7-6-14-28-20(19)10-12-25-28/h2-3,6-10,12,14H,4-5,11,13,15-18H2,1H3,(H,24,29)
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 290n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119385
PNG
(CHEMBL342060 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-7-3-2-6-21(22)27-16-14-26(15-17-27)12-5-4-10-24-23(29)19-9-13-28-20(18-19)8-11-25-28/h2-3,6-9,11,13,18H,4-5,10,12,14-17H2,1H3,(H,24,29)
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 310n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119391
PNG
(CHEMBL142020 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-10-3-2-9-21(22)27-16-14-26(15-17-27)12-7-5-11-24-23(29)20-18-19-8-4-6-13-28(19)25-20/h2-4,6,8-10,13,18H,5,7,11-12,14-17H2,1H3,(H,24,29)
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 330n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119374
PNG
(CHEMBL357684 | N-(3-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1
Show InChI InChI=1S/C22H27N5O2/c1-29-21-9-3-2-8-20(21)26-15-13-25(14-16-26)11-6-10-23-22(28)19-17-18-7-4-5-12-27(18)24-19/h2-5,7-9,12,17H,6,10-11,13-16H2,1H3,(H,23,28)
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 560n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119392
PNG
(CHEMBL141845 | N-(2-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1
Show InChI InChI=1S/C21H25N5O2/c1-28-20-8-3-2-7-19(20)25-14-12-24(13-15-25)11-9-22-21(27)17-16-23-26-10-5-4-6-18(17)26/h2-8,10,16H,9,11-15H2,1H3,(H,22,27)
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 580n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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 620n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119497
PNG
(CHEMBL221843)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2nnn(Cc3ccccc3)c2C)CC1
Show InChI InChI=1S/C26H34N6O2/c1-21-25(28-29-32(21)20-22-10-4-3-5-11-22)26(33)27-14-8-9-15-30-16-18-31(19-17-30)23-12-6-7-13-24(23)34-2/h3-7,10-13H,8-9,14-20H2,1-2H3,(H,27,33)
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 620n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50122048
PNG
(1H-Indole-2-carboxylic acid {4-[4-(2,3-dichloro-ph...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl
Show InChI InChI=1S/C23H26Cl2N4O/c24-18-7-5-9-21(22(18)25)29-14-12-28(13-15-29)11-4-3-10-26-23(30)20-16-17-6-1-2-8-19(17)27-20/h1-2,5-9,16,27H,3-4,10-15H2,(H,26,30)
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 760n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119382
PNG
(CHEMBL344677 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1
Show InChI InChI=1S/C23H29N5O2/c1-30-22-10-3-2-8-20(22)27-17-15-26(16-18-27)14-5-4-12-24-23(29)21-9-6-7-19-11-13-25-28(19)21/h2-3,6-11,13H,4-5,12,14-18H2,1H3,(H,24,29)
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 780n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119390
PNG
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dic...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N3OS/c24-18-7-5-8-19(22(18)25)28-14-12-27(13-15-28)11-4-3-10-26-23(29)21-16-17-6-1-2-9-20(17)30-21/h1-2,5-9,16H,3-4,10-15H2,(H,26,29)
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 1.00E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50119377
PNG
(Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phen...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1
Show InChI InChI=1S/C24H29N3O3/c1-29-22-11-5-3-9-20(22)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-4-10-21(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28)
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 1.10E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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 1.50E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50119499
PNG
(CHEMBL3613873)
Show SMILES COc1ccccc1N1CCN(CCCc2cn(nn2)-c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-31-23-7-3-2-6-22(23)28-15-13-27(14-16-28)11-4-5-19-18-30(26-25-19)21-9-12-29-20(17-21)8-10-24-29/h2-3,6-10,12,17-18H,4-5,11,13-16H2,1H3
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 1.70E+3n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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n/an/an/an/a 550n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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n/an/an/an/a 955n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50018958
PNG
(CHEBI:75401 | QUINPIROLE)
Show SMILES [H][C@]12CCCN(CCC)[C@]1([H])Cc1c[nH]nc1C2
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 51n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at pro-link-tagged D2S-ARMS2PK2 (unknown origin) expressed in HEK293 cells by beta-arrestin-2 recruitment assay

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119499
PNG
(CHEMBL3613873)
Show SMILES COc1ccccc1N1CCN(CCCc2cn(nn2)-c2ccn3nccc3c2)CC1
Show InChI InChI=1S/C23H27N7O/c1-31-23-7-3-2-6-22(23)28-15-13-27(14-16-28)11-4-5-19-18-30(26-25-19)21-9-12-29-20(17-21)8-10-24-29/h2-3,6-10,12,17-18H,4-5,11,13-16H2,1H3
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n/an/an/an/a 977n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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n/an/an/an/a 692n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50018958
PNG
(CHEBI:75401 | QUINPIROLE)
Show SMILES [H][C@]12CCCN(CCC)[C@]1([H])Cc1c[nH]nc1C2
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 617n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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n/an/an/an/a 1.10E+3n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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n/an/an/an/a 200n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119494
PNG
(CHEMBL3613875)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N7O/c25-21-5-3-6-22(24(21)26)31-12-10-30(11-13-31)8-2-1-4-19-16-33(29-28-19)20-7-9-32-23(14-20)18(17-34)15-27-32/h3,5-7,9,14-17H,1-2,4,8,10-13H2
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n/an/an/an/a 1.86E+3n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119495
PNG
(CHEMBL3613876)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C22H21Cl2N7O/c23-19-2-1-3-20(22(19)24)29-10-8-28(9-11-29)6-4-17-14-31(27-26-17)18-5-7-30-21(12-18)16(15-32)13-25-30/h1-3,5,7,12-15H,4,6,8-11H2
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n/an/an/an/a 3.55E+3n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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n/an/an/an/a 39n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119493
PNG
(CHEMBL3613874)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4ncc(C=O)c4c3)CC2)c1Cl
Show InChI InChI=1S/C23H23Cl2N7O/c24-20-4-1-5-21(23(20)25)30-11-9-29(10-12-30)7-2-3-18-15-32(28-27-18)19-6-8-31-22(13-19)17(16-33)14-26-31/h1,4-6,8,13-16H,2-3,7,9-12H2
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n/an/an/an/a 191n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119496
PNG
(CHEMBL3613877)
Show SMILES COc1ccccc1N1CCN(CCc2cn(nn2)-c2ccn3ncc(C=O)c3c2)CC1
Show InChI InChI=1S/C23H25N7O2/c1-32-23-5-3-2-4-21(23)28-12-10-27(11-13-28)8-6-19-16-30(26-25-19)20-7-9-29-22(14-20)18(17-31)15-24-29/h2-5,7,9,14-17H,6,8,10-13H2,1H3
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n/an/an/an/a 4.37E+3n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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n/an/an/an/a 158n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119462
PNG
(CHEMBL3613880)
Show SMILES Clc1cccc(N2CCN(CCCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H25Cl2N7/c24-21-5-3-6-22(23(21)25)30-14-12-29(13-15-30)10-2-1-4-18-17-32(28-27-18)20-8-11-31-19(16-20)7-9-26-31/h3,5-9,11,16-17H,1-2,4,10,12-15H2
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n/an/an/an/a 741n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50018958
PNG
(CHEBI:75401 | QUINPIROLE)
Show SMILES [H][C@]12CCCN(CCC)[C@]1([H])Cc1c[nH]nc1C2
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 1.62E+3n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119457
PNG
(CHEMBL3613878)
Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2
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n/an/an/an/a 479n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50119460
PNG
(CHEMBL3613879)
Show SMILES Clc1cccc(N2CCN(CCCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl
Show InChI InChI=1S/C22H23Cl2N7/c23-20-4-1-5-21(22(20)24)29-13-11-28(12-14-29)9-2-3-17-16-31(27-26-17)19-7-10-30-18(15-19)6-8-25-30/h1,4-8,10,15-16H,2-3,9,11-14H2
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n/an/an/an/a 1.12E+3n/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...

Bioorg Med Chem 23: 6195-209 (2015)


Article DOI: 10.1016/j.bmc.2015.07.050
BindingDB Entry DOI: 10.7270/Q2WW7KGM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%