Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50396097
(CHEMBL2170856)Show SMILES Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O Show InChI InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human U2OS cell lysate measured after 24 hrs by TRAP assay |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50396097
(CHEMBL2170856)Show SMILES Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O Show InChI InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human MDA-MB-435 cell lysate measured after 24 hrs by TRAP assay |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50157547
(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)Show InChI InChI=1S/C15H10O6/c16-9-3-1-7(5-12(9)19)13-6-11(18)8-2-4-10(17)14(20)15(8)21-13/h1-6,16-17,19-20H | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233825
(CHEMBL4081286)Show SMILES Oc1cc([123I])c(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI InChI=1S/C15H9IO6/c16-8-4-12(20)11(19)3-7(8)13-5-10(18)6-1-2-9(17)14(21)15(6)22-13/h1-5,17,19-21H | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 969 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233823
(CHEMBL4097807)Show SMILES Oc1cccc(C(=O)Nc2cc([123I])cc(NC(=O)c3cccc(O)c3O)c2)c1O Show InChI InChI=1S/C20H15IN2O6/c21-10-7-11(22-19(28)13-3-1-5-15(24)17(13)26)9-12(8-10)23-20(29)14-4-2-6-16(25)18(14)27/h1-9,24-27H,(H,22,28)(H,23,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human MDA-MB-435 cell lysate measured after 24 hrs by TRAP assay |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233823
(CHEMBL4097807)Show SMILES Oc1cccc(C(=O)Nc2cc([123I])cc(NC(=O)c3cccc(O)c3O)c2)c1O Show InChI InChI=1S/C20H15IN2O6/c21-10-7-11(22-19(28)13-3-1-5-15(24)17(13)26)9-12(8-10)23-20(29)14-4-2-6-16(25)18(14)27/h1-9,24-27H,(H,22,28)(H,23,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity in human U2OS cell lysate measured after 24 hrs by TRAP assay |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233826
(CHEMBL4090090)Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2cc([123I])c(O)c(O)c2o1 Show InChI InChI=1S/C15H9IO6/c16-8-4-7-10(18)5-12(22-15(7)14(21)13(8)20)6-1-2-9(17)11(19)3-6/h1-5,17,19-21H | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233824
(CHEMBL4070673)Show SMILES Oc1ccc2c(oc(cc2=O)-c2cc(O)c(O)c([123I])c2)c1O Show InChI InChI=1S/C15H9IO6/c16-8-3-6(4-11(19)13(8)20)12-5-10(18)7-1-2-9(17)14(21)15(7)22-12/h1-5,17,19-21H | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50126186
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase activity isolated from HEK293 cells assessed as reduction in dNTP incorporation using 5'-biotinylated AATCCGTCGAGCAGAG... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50126186
(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)Show InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233827
(CHEMBL4076246)Show SMILES C\C(=C/C(=O)Nc1cc([123I])ccc1C(O)=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C21H16INO3/c1-13(15-7-6-14-4-2-3-5-16(14)11-15)10-20(24)23-19-12-17(22)8-9-18(19)21(25)26/h2-12H,1H3,(H,23,24)(H,25,26)/b13-10+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50233828
(CHEMBL4062047)Show SMILES C\C(=C/C(=O)Nc1ccc([123I])cc1C(O)=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C21H16INO3/c1-13(15-7-6-14-4-2-3-5-16(14)11-15)10-20(24)23-19-9-8-17(22)12-18(19)21(25)26/h2-12H,1H3,(H,23,24)(H,25,26)/b13-10+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea... |
Eur J Med Chem 125: 117-129 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.028
BindingDB Entry DOI: 10.7270/Q2NS0X5V |
More data for this
Ligand-Target Pair | |
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