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PubMed code 28692292

Compile data set for download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238882
PNG
(CHEMBL4094600)
Show SMILES C[C@@H](c1ccccc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H19N5/c1-15-12-19(10-11-24-15)18-8-9-21-20(13-18)23-22(14-25-21)26-27-28(23)16(2)17-6-4-3-5-7-17/h3-14,16H,1-2H3/t16-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238893
PNG
(CHEMBL4096379)
Show SMILES Cc1cc(ccn1)-c1ccc2ncc3nnn(Cc4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C22H16FN5/c1-14-10-17(8-9-24-14)16-4-7-20-19(11-16)22-21(12-25-20)26-27-28(22)13-15-2-5-18(23)6-3-15/h2-12H,13H2,1H3
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK4


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK4 expressed in baculovirus infected Sf21 cells

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50026622
PNG
(CHEMBL408982)
Show SMILES CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
Show InChI InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238868
PNG
(CHEMBL4072795)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2OCOc2c1 |r|
Show InChI InChI=1S/C24H17FN4O2/c1-14(15-2-6-18(25)7-3-15)29-24-19-10-16(4-8-20(19)26-12-21(24)27-28-29)17-5-9-22-23(11-17)31-13-30-22/h2-12,14H,13H2,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238881
PNG
(CHEMBL4067143)
Show SMILES C[C@H](c1ccccc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H19N5/c1-15-12-19(10-11-24-15)18-8-9-21-20(13-18)23-22(14-25-21)26-27-28(23)16(2)17-6-4-3-5-7-17/h3-14,16H,1-2H3/t16-/m1/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238884
PNG
(CHEMBL4060440)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H18FN5/c1-14-11-18(9-10-25-14)17-5-8-21-20(12-17)23-22(13-26-21)27-28-29(23)15(2)16-3-6-19(24)7-4-16/h3-13,15H,1-2H3/t15-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238887
PNG
(CHEMBL4093503)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2occc2c1 |r|
Show InChI InChI=1S/C25H17FN4O/c1-15(16-2-6-20(26)7-3-16)30-25-21-13-18(4-8-22(21)27-14-23(25)28-29-30)17-5-9-24-19(12-17)10-11-31-24/h2-15H,1H3/t15-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK2 (144 to 498 residues) expressed in insect cells using S6 kinase/Rsk2 substrate peptide 2 in presence of [gamma-3...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238892
PNG
(CHEMBL4104765)
Show SMILES C[C@H](c1ccc(C)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C24H21N5/c1-15-4-6-18(7-5-15)17(3)29-24-21-13-19(20-10-11-25-16(2)12-20)8-9-22(21)26-14-23(24)27-28-29/h4-14,17H,1-3H3/t17-/m1/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperone

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238883
PNG
(CHEMBL4088668)
Show SMILES C[C@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H18FN5/c1-14-11-18(9-10-25-14)17-5-8-21-20(12-17)23-22(13-26-21)27-28-29(23)15(2)16-3-6-19(24)7-4-16/h3-13,15H,1-2H3/t15-/m1/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238885
PNG
(CHEMBL4069124)
Show SMILES CC(C)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1
Show InChI InChI=1S/C18H17N5/c1-11(2)23-18-15-9-13(14-6-7-19-12(3)8-14)4-5-16(15)20-10-17(18)21-22-23/h4-11H,1-3H3
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238886
PNG
(CHEMBL4104122)
Show SMILES CCn1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1
Show InChI InChI=1S/C17H15N5/c1-3-22-17-14-9-12(13-6-7-18-11(2)8-13)4-5-15(14)19-10-16(17)20-21-22/h4-10H,3H2,1-2H3
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50026622
PNG
(CHEMBL408982)
Show SMILES CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
Show InChI InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238893
PNG
(CHEMBL4096379)
Show SMILES Cc1cc(ccn1)-c1ccc2ncc3nnn(Cc4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C22H16FN5/c1-14-10-17(8-9-24-14)16-4-7-20-19(11-16)22-21(12-25-20)26-27-28(22)13-15-2-5-18(23)6-3-15/h2-12H,13H2,1H3
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238866
PNG
(CHEMBL4079878)
Show SMILES Cc1cc(ccn1)-c1ccc2ncc3nnn(C)c3c2c1
Show InChI InChI=1S/C16H13N5/c1-10-7-12(5-6-17-10)11-3-4-14-13(8-11)16-15(9-18-14)19-20-21(16)2/h3-9H,1-2H3
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238892
PNG
(CHEMBL4104765)
Show SMILES C[C@H](c1ccc(C)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C24H21N5/c1-15-4-6-18(7-5-15)17(3)29-24-21-13-19(20-10-11-25-16(2)12-20)8-9-22(21)26-14-23(24)27-28-29/h4-14,17H,1-3H3/t17-/m1/s1
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n/an/a 141n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238879
PNG
(CHEMBL4064426)
Show SMILES C[C@@H](c1ccc(Cl)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H18ClN5/c1-14-11-18(9-10-25-14)17-5-8-21-20(12-17)23-22(13-26-21)27-28-29(23)15(2)16-3-6-19(24)7-4-16/h3-13,15H,1-2H3/t15-/m0/s1
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n/an/a 155n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238880
PNG
(CHEMBL4086890)
Show SMILES C[C@@H](c1ccc(C)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C24H21N5/c1-15-4-6-18(7-5-15)17(3)29-24-21-13-19(20-10-11-25-16(2)12-20)8-9-22(21)26-14-23(24)27-28-29/h4-14,17H,1-3H3/t17-/m0/s1
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n/an/a 173n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238882
PNG
(CHEMBL4094600)
Show SMILES C[C@@H](c1ccccc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H19N5/c1-15-12-19(10-11-24-15)18-8-9-21-20(13-18)23-22(14-25-21)26-27-28(23)16(2)17-6-4-3-5-7-17/h3-14,16H,1-2H3/t16-/m0/s1
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n/an/a 177n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238874
PNG
(CHEMBL4100703)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(cc1)C(N)=O |r|
Show InChI InChI=1S/C24H18FN5O/c1-14(15-6-9-19(25)10-7-15)30-23-20-12-18(16-2-4-17(5-3-16)24(26)31)8-11-21(20)27-13-22(23)28-29-30/h2-14H,1H3,(H2,26,31)/t14-/m0/s1
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n/an/a 186n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238876
PNG
(CHEMBL4081470)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccncc1 |r|
Show InChI InChI=1S/C22H16FN5/c1-14(15-2-5-18(23)6-3-15)28-22-19-12-17(16-8-10-24-11-9-16)4-7-20(19)25-13-21(22)26-27-28/h2-14H,1H3/t14-/m0/s1
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n/an/a 189n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238883
PNG
(CHEMBL4088668)
Show SMILES C[C@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H18FN5/c1-14-11-18(9-10-25-14)17-5-8-21-20(12-17)23-22(13-26-21)27-28-29(23)15(2)16-3-6-19(24)7-4-16/h3-13,15H,1-2H3/t15-/m1/s1
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n/an/a 194n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238881
PNG
(CHEMBL4067143)
Show SMILES C[C@H](c1ccccc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H19N5/c1-15-12-19(10-11-24-15)18-8-9-21-20(13-18)23-22(14-25-21)26-27-28(23)16(2)17-6-4-3-5-7-17/h3-14,16H,1-2H3/t16-/m1/s1
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n/an/a 245n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238868
PNG
(CHEMBL4072795)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2OCOc2c1 |r|
Show InChI InChI=1S/C24H17FN4O2/c1-14(15-2-6-18(25)7-3-15)29-24-19-10-16(4-8-20(19)26-12-21(24)27-28-29)17-5-9-22-23(11-17)31-13-30-22/h2-12,14H,13H2,1H3/t14-/m0/s1
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n/an/a 257n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238888
PNG
(CHEMBL4063617)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C21H17FN6/c1-13(14-3-6-17(22)7-4-14)28-21-18-9-15(16-10-24-27(2)12-16)5-8-19(18)23-11-20(21)25-26-28/h3-13H,1-2H3/t13-/m0/s1
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n/an/a 280n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238886
PNG
(CHEMBL4104122)
Show SMILES CCn1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1
Show InChI InChI=1S/C17H15N5/c1-3-22-17-14-9-12(13-6-7-18-11(2)8-13)4-5-15(14)19-10-16(17)20-21-22/h4-10H,3H2,1-2H3
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n/an/a 283n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238885
PNG
(CHEMBL4069124)
Show SMILES CC(C)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1
Show InChI InChI=1S/C18H17N5/c1-11(2)23-18-15-9-13(14-6-7-19-12(3)8-14)4-5-16(15)20-10-17(18)21-22-23/h4-11H,1-3H3
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n/an/a 404n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238866
PNG
(CHEMBL4079878)
Show SMILES Cc1cc(ccn1)-c1ccc2ncc3nnn(C)c3c2c1
Show InChI InChI=1S/C16H13N5/c1-10-7-12(5-6-17-10)11-3-4-14-13(8-11)16-15(9-18-14)19-20-21(16)2/h3-9H,1-2H3
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n/an/a 420n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238890
PNG
(CHEMBL4092984)
Show SMILES COc1cc(ccn1)-c1ccc2ncc3nnn([C@@H](C)c4ccc(F)cc4)c3c2c1 |r|
Show InChI InChI=1S/C23H18FN5O/c1-14(15-3-6-18(24)7-4-15)29-23-19-11-16(17-9-10-25-22(12-17)30-2)5-8-20(19)26-13-21(23)27-28-29/h3-14H,1-2H3/t14-/m0/s1
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n/an/a 430n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238875
PNG
(CHEMBL4072220)
Show SMILES COc1ccc(cc1)-c1ccc2ncc3nnn([C@@H](C)c4ccc(F)cc4)c3c2c1 |r|
Show InChI InChI=1S/C24H19FN4O/c1-15(16-3-8-19(25)9-4-16)29-24-21-13-18(17-5-10-20(30-2)11-6-17)7-12-22(21)26-14-23(24)27-28-29/h3-15H,1-2H3/t15-/m0/s1
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n/an/a 439n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238889
PNG
(CHEMBL4082710)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)N1CCOCC1 |r|
Show InChI InChI=1S/C21H20FN5O/c1-14(15-2-4-16(22)5-3-15)27-21-18-12-17(26-8-10-28-11-9-26)6-7-19(18)23-13-20(21)24-25-27/h2-7,12-14H,8-11H2,1H3/t14-/m0/s1
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n/an/a 529n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a 690n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of human DYRK1B

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238870
PNG
(CHEMBL4104093)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(s1)C(C)=O |r|
Show InChI InChI=1S/C23H17FN4OS/c1-13(15-3-6-17(24)7-4-15)28-23-18-11-16(22-10-9-21(30-22)14(2)29)5-8-19(18)25-12-20(23)26-27-28/h3-13H,1-2H3/t13-/m0/s1
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n/an/a 993n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238876
PNG
(CHEMBL4081470)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccncc1 |r|
Show InChI InChI=1S/C22H16FN5/c1-14(15-2-5-18(23)6-3-15)28-22-19-12-17(16-8-10-24-11-9-16)4-7-20(19)25-13-21(22)26-27-28/h2-14H,1H3/t14-/m0/s1
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n/an/a 1.14E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238884
PNG
(CHEMBL4060440)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H18FN5/c1-14-11-18(9-10-25-14)17-5-8-21-20(12-17)23-22(13-26-21)27-28-29(23)15(2)16-3-6-19(24)7-4-16/h3-13,15H,1-2H3/t15-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238887
PNG
(CHEMBL4093503)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2occc2c1 |r|
Show InChI InChI=1S/C25H17FN4O/c1-15(16-2-6-20(26)7-3-16)30-25-21-13-18(4-8-22(21)27-14-23(25)28-29-30)17-5-9-24-19(12-17)10-11-31-24/h2-15H,1H3/t15-/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238880
PNG
(CHEMBL4086890)
Show SMILES C[C@@H](c1ccc(C)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C24H21N5/c1-15-4-6-18(7-5-15)17(3)29-24-21-13-19(20-10-11-25-16(2)12-20)8-9-22(21)26-14-23(24)27-28-29/h4-14,17H,1-3H3/t17-/m0/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a 1.43E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CDK9 expressed in fall armyworm sf21 cells using PDKtide as substrate in presence of [gamma-32]-ATP

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a 1.59E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GSK3beta expressed in fall armyworm sf21 cells using Phospho-glycogen synthase peptide-2 as substrate in presence of ...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238879
PNG
(CHEMBL4064426)
Show SMILES C[C@@H](c1ccc(Cl)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H18ClN5/c1-14-11-18(9-10-25-14)17-5-8-21-20(12-17)23-22(13-26-21)27-28-29(23)15(2)16-3-6-19(24)7-4-16/h3-13,15H,1-2H3/t15-/m0/s1
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n/an/a 1.76E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238890
PNG
(CHEMBL4092984)
Show SMILES COc1cc(ccn1)-c1ccc2ncc3nnn([C@@H](C)c4ccc(F)cc4)c3c2c1 |r|
Show InChI InChI=1S/C23H18FN5O/c1-14(15-3-6-18(24)7-4-15)29-23-19-11-16(17-9-10-25-22(12-17)30-2)5-8-20(19)26-13-21(23)27-28-29/h3-14H,1-2H3/t14-/m0/s1
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n/an/a 2.87E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238888
PNG
(CHEMBL4063617)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C21H17FN6/c1-13(14-3-6-17(22)7-4-14)28-21-18-9-15(16-10-24-27(2)12-16)5-8-19(18)23-11-20(21)25-26-28/h3-13H,1-2H3/t13-/m0/s1
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n/an/a 3.36E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238889
PNG
(CHEMBL4082710)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)N1CCOCC1 |r|
Show InChI InChI=1S/C21H20FN5O/c1-14(15-2-4-16(22)5-3-15)27-21-18-12-17(26-8-10-28-11-9-26)6-7-19(18)23-13-20(21)24-25-27/h2-7,12-14H,8-11H2,1H3/t14-/m0/s1
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n/an/a 3.36E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238878
PNG
(CHEMBL4078073)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccccc1 |r|
Show InChI InChI=1S/C23H17FN4/c1-15(16-7-10-19(24)11-8-16)28-23-20-13-18(17-5-3-2-4-6-17)9-12-21(20)25-14-22(23)26-27-28/h2-15H,1H3/t15-/m0/s1
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n/an/a 4.99E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK3


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a 5.59E+3n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGAND

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238875
PNG
(CHEMBL4072220)
Show SMILES COc1ccc(cc1)-c1ccc2ncc3nnn([C@@H](C)c4ccc(F)cc4)c3c2c1 |r|
Show InChI InChI=1S/C24H19FN4O/c1-15(16-3-8-19(25)9-4-16)29-24-21-13-18(17-5-10-20(30-2)11-6-17)7-12-22(21)26-14-23(24)27-28-29/h3-15H,1-2H3/t15-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of human EGFR

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of human ULK1

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238872
PNG
(CHEMBL4101671)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C24H16FN5/c1-15(17-6-9-20(25)10-7-17)30-24-21-12-19(18-4-2-16(13-26)3-5-18)8-11-22(21)27-14-23(24)28-29-30/h2-12,14-15H,1H3/t15-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Opioid receptor affinity against the Opioid receptor delta 1 by using the curve-fitting program LIGAND

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238877
PNG
(CHEMBL4059498)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(nc1)N1CCN(C)CC1 |r|
Show InChI InChI=1S/C27H26FN7/c1-18(19-3-7-22(28)8-4-19)35-27-23-15-20(5-9-24(23)29-17-25(27)31-32-35)21-6-10-26(30-16-21)34-13-11-33(2)12-14-34/h3-10,15-18H,11-14H2,1-2H3/t18-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 3


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of human DYRK3

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238891
PNG
(CHEMBL4102344)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(Br)cc3c12 |r|
Show InChI InChI=1S/C17H12BrFN4/c1-10(11-2-5-13(19)6-3-11)23-17-14-8-12(18)4-7-15(14)20-9-16(17)21-22-23/h2-10H,1H3/t10-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238872
PNG
(CHEMBL4101671)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C24H16FN5/c1-15(17-6-9-20(25)10-7-17)30-24-21-12-19(18-4-2-16(13-26)3-5-18)8-11-22(21)27-14-23(24)28-29-30/h2-12,14-15H,1H3/t15-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of human DYRK2

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238891
PNG
(CHEMBL4102344)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(Br)cc3c12 |r|
Show InChI InChI=1S/C17H12BrFN4/c1-10(11-2-5-13(19)6-3-11)23-17-14-8-12(18)4-7-15(14)20-9-16(17)21-22-23/h2-10H,1H3/t10-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238871
PNG
(CHEMBL4085242)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1cccnc1 |r|
Show InChI InChI=1S/C22H16FN5/c1-14(15-4-7-18(23)8-5-15)28-22-19-11-16(17-3-2-10-24-12-17)6-9-20(19)25-13-21(22)26-27-28/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238873
PNG
(CHEMBL4074986)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(F)c(C)c1 |r|
Show InChI InChI=1S/C24H18F2N4/c1-14-11-17(5-9-21(14)26)18-6-10-22-20(12-18)24-23(13-27-22)28-29-30(24)15(2)16-3-7-19(25)8-4-16/h3-13,15H,1-2H3/t15-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238878
PNG
(CHEMBL4078073)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccccc1 |r|
Show InChI InChI=1S/C23H17FN4/c1-15(16-7-10-19(24)11-8-16)28-23-20-13-18(17-5-3-2-4-6-17)9-12-21(20)25-14-22(23)26-27-28/h2-15H,1H3/t15-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MAPK1 expressed in Escherichia coli using MBP as substrate in presence of [gamma-32]-ATP

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238873
PNG
(CHEMBL4074986)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(F)c(C)c1 |r|
Show InChI InChI=1S/C24H18F2N4/c1-14-11-17(5-9-21(14)26)18-6-10-22-20(12-18)24-23(13-27-22)28-29-30(24)15(2)16-3-7-19(25)8-4-16/h3-13,15H,1-2H3/t15-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238877
PNG
(CHEMBL4059498)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(nc1)N1CCN(C)CC1 |r|
Show InChI InChI=1S/C27H26FN7/c1-18(19-3-7-22(28)8-4-19)35-27-23-15-20(5-9-24(23)29-17-25(27)31-32-35)21-6-10-26(30-16-21)34-13-11-33(2)12-14-34/h3-10,15-18H,11-14H2,1-2H3/t18-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CDK6 expressed in fall armyworm sf21 cells using Histone H1 as substrate in presence of [gamma-32]-ATP

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238869
PNG
(CHEMBL4086182)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1c(C)noc1C |r|
Show InChI InChI=1S/C22H18FN5O/c1-12-21(14(3)29-26-12)16-6-9-19-18(10-16)22-20(11-24-19)25-27-28(22)13(2)15-4-7-17(23)8-5-15/h4-11,13H,1-3H3/t13-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238870
PNG
(CHEMBL4104093)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(s1)C(C)=O |r|
Show InChI InChI=1S/C23H17FN4OS/c1-13(15-3-6-17(24)7-4-15)28-23-18-11-16(22-10-9-21(30-22)14(2)29)5-8-19(18)25-12-20(23)26-27-28/h3-13H,1-2H3/t13-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human AbL expressed in insect cells using Poly(Glu:Tyr) as substrate in presence of [gamma-32]-ATP

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR4 expressed in fall armyworm sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma-32]-ATP

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238871
PNG
(CHEMBL4085242)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1cccnc1 |r|
Show InChI InChI=1S/C22H16FN5/c1-14(15-4-7-18(23)8-5-15)28-22-19-11-16(17-3-2-10-24-12-17)6-9-20(19)25-13-21(22)26-27-28/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(Homo sapiens (Human))		BDBM50238874
PNG
(CHEMBL4100703)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc(cc1)C(N)=O |r|
Show InChI InChI=1S/C24H18FN5O/c1-14(15-6-9-19(25)10-7-15)30-23-20-12-18(16-2-4-17(5-3-16)24(26)31)8-11-21(20)27-13-22(23)28-29-30/h2-14H,1H3,(H2,26,31)/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DYRK1A expressed in insect cells using RRRFRPASPLRGPPK peptide as substrate after 40 mins in presence of [gamma-33P]-...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Show InChI InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human JAK2 expressed in insect cells using Poly(Glu:Tyr) as substrate in presence of [gamma-32]-ATP

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1


(Homo sapiens (Human))		BDBM50238869
PNG
(CHEMBL4086182)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1c(C)noc1C |r|
Show InChI InChI=1S/C22H18FN5O/c1-12-21(14(3)29-26-12)16-6-9-19-18(10-16)22-20(11-24-19)25-27-28(22)13(2)15-4-7-17(23)8-5-15/h4-11,13H,1-3H3/t13-/m0/s1
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Sichuan University and Collaborative Innovation Center for Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...

J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
BindingDB Entry DOI: 10.7270/Q2ZW1P55
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%