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PubMed code 6471063

Compile data set for download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50241379
PNG
((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Show SMILES CSc1ccc(cc1)C(=O)c1[nH]c(=O)[nH]c1C
Show InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
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n/an/a 1.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a 5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50225309
PNG
(CHEBI:34988 | Sulmazole)
Show SMILES COc1cc(ccc1-c1nc2ccc[nH]c2n1)[S+](C)[O-]
Show InChI InChI=1S/C14H13N3O2S/c1-19-12-8-9(20(2)18)5-6-10(12)13-16-11-4-3-7-15-14(11)17-13/h3-8H,1-2H3,(H,15,16,17)
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n/an/a 5.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction III of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 5.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction II of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 8.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction II of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 3.40E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction I of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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PubMed
n/an/a 3.40E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of fraction I of guinea pig phosphodiesterase

J Med Chem 27: 1099-101 (1984)


BindingDB Entry DOI: 10.7270/Q26Q1W70
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%