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PubMed code 7658435

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3297
PNG
(4-Anilinoquinazoline deriv. 48 | 4-N-(3-bromopheny...)
Show SMILES Nc1ccc2c(Nc3cccc(Br)c3)ncnc2c1
Show InChI InChI=1S/C14H11BrN4/c15-9-2-1-3-11(6-9)19-14-12-5-4-10(16)7-13(12)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 0.100n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3303
PNG
(4-Anilinoquinazoline deriv. 54 | 4-N-(3-bromopheny...)
Show SMILES Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N
Show InChI InChI=1S/C14H12BrN5/c15-8-2-1-3-9(4-8)20-14-10-5-11(16)12(17)6-13(10)18-7-19-14/h1-7H,16-17H2,(H,18,19,20)
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n/an/a 0.120n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3302
PNG
(4-Anilinoquinazoline deriv. 53 | 4-[(3-bromophenyl...)
Show SMILES Oc1cc2ncnc(Nc3cccc(Br)c3)c2cc1O
Show InChI InChI=1S/C14H10BrN3O2/c15-8-2-1-3-9(4-8)18-14-10-5-12(19)13(20)6-11(10)16-7-17-14/h1-7,19-20H,(H,16,17,18)
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n/an/a 0.170n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3294
PNG
(4-Anilinoquinazoline deriv. 45 | 4-N-(3-bromopheny...)
Show SMILES Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C14H11BrN4/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 0.790n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3289
PNG
(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Show SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C17H17N3O2/c1-21-15-8-13-14(9-16(15)22-2)19-11-20-17(13)18-10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3298
PNG
(4-Anilinoquinazoline deriv. 49 | CHEMBL93181 | N-(...)
Show SMILES COc1ccc2c(Nc3cccc(Br)c3)ncnc2c1
Show InChI InChI=1S/C15H12BrN3O/c1-20-12-5-6-13-14(8-12)17-9-18-15(13)19-11-4-2-3-10(16)7-11/h2-9H,1H3,(H,17,18,19)
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n/an/a 10n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3263
PNG
(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Show SMILES Clc1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H10ClN3/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H,(H,16,17,18)
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n/an/a 23n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3264
PNG
(4-Anilino quinazoline deriv. 15 | CHEMBL290096 | N...)
Show SMILES Brc1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H10BrN3/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H,(H,16,17,18)
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n/an/a 27n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3288
PNG
(4-(Benzylamino)quinazoline deriv. 39 | 4-(benzylam...)
Show SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1O
Show InChI InChI=1S/C16H15N3O2/c1-21-15-8-13-12(7-14(15)20)16(19-10-18-13)17-9-11-5-3-2-4-6-11/h2-8,10,20H,9H2,1H3,(H,17,18,19)
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n/an/a 56n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3283
PNG
(4-(Benzylamino)quinazoline deriv. 34 | N-benzyl-7-...)
Show SMILES COc1ccc2c(NCc3ccccc3)ncnc2c1
Show InChI InChI=1S/C16H15N3O/c1-20-13-7-8-14-15(9-13)18-11-19-16(14)17-10-12-5-3-2-4-6-12/h2-9,11H,10H2,1H3,(H,17,18,19)
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n/an/a 58n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3265
PNG
(4-Anilino quinazoline deriv. 16 | CHEMBL92825 | N-...)
Show SMILES Ic1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H10IN3/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H,(H,16,17,18)
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n/an/a 80n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3300
PNG
(4-Anilinoquinazoline deriv. 51 | 4-N-(3-bromopheny...)
Show SMILES Nc1cccc2c(Nc3cccc(Br)c3)ncnc12
Show InChI InChI=1S/C14H11BrN4/c15-9-3-1-4-10(7-9)19-14-11-5-2-6-12(16)13(11)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 105n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3292
PNG
(4-Anilinoquinazoline deriv. 43 | N-(3-bromophenyl)...)
Show SMILES COc1cccc2ncnc(Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C15H12BrN3O/c1-20-13-7-3-6-12-14(13)15(18-9-17-12)19-11-5-2-4-10(16)8-11/h2-9H,1H3,(H,17,18,19)
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n/an/a 139n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3280
PNG
(4-(Benzylamino)quinazoline deriv. 31 | N-benzyl-6-...)
Show SMILES COc1ccc2ncnc(NCc3ccccc3)c2c1
Show InChI InChI=1S/C16H15N3O/c1-20-13-7-8-15-14(9-13)16(19-11-18-15)17-10-12-5-3-2-4-6-12/h2-9,11H,10H2,1H3,(H,17,18,19)
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n/an/a 200n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3256
PNG
(4-(Benzylamino)quinazoline deriv. 7 | N-benzylquin...)
Show SMILES C(Nc1ncnc2ccccc12)c1ccccc1
Show InChI InChI=1S/C15H13N3/c1-2-6-12(7-3-1)10-16-15-13-8-4-5-9-14(13)17-11-18-15/h1-9,11H,10H2,(H,16,17,18)
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n/an/a 320n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3259
PNG
(4-Anilino quinazoline deriv. 10 | CHEMBL289959 | N...)
Show SMILES N(c1ccccc1)c1ncnc2ccccc12
Show InChI InChI=1S/C14H11N3/c1-2-6-11(7-3-1)17-14-12-8-4-5-9-13(12)15-10-16-14/h1-10H,(H,15,16,17)
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n/an/a 344n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3295
PNG
(4-Anilinoquinazoline deriv. 46 | CHEMBL52197 | N-(...)
Show SMILES COc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C15H12BrN3O/c1-20-12-5-6-14-13(8-12)15(18-9-17-14)19-11-4-2-3-10(16)7-11/h2-9H,1H3,(H,17,18,19)
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n/an/a 348n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3290
PNG
(4-Anilinoquinazoline deriv. 41 | N-(3-bromophenyl)...)
Show SMILES [O-][N+](=O)c1cccc2ncnc(Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C14H9BrN4O2/c15-9-3-1-4-10(7-9)18-14-13-11(16-8-17-14)5-2-6-12(13)19(20)21/h1-8H,(H,16,17,18)
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n/an/a 355n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3291
PNG
(4-Anilinoquinazoline deriv. 42 | 4-N-(3-bromopheny...)
Show SMILES Nc1cccc2ncnc(Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C14H11BrN4/c15-9-3-1-4-10(7-9)19-14-13-11(16)5-2-6-12(13)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 439n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3266
PNG
(4-Anilino quinazoline deriv. 17 | CHEMBL92824 | N-...)
Show SMILES FC(F)(F)c1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C15H10F3N3/c16-15(17,18)10-4-3-5-11(8-10)21-14-12-6-1-2-7-13(12)19-9-20-14/h1-9H,(H,19,20,21)
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n/an/a 577n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3287
PNG
(4-(Benzylamino)quinazoline deriv. 38 | 4-(benzylam...)
Show SMILES COc1cc2c(NCc3ccccc3)ncnc2cc1O
Show InChI InChI=1S/C16H15N3O2/c1-21-15-7-12-13(8-14(15)20)18-10-19-16(12)17-9-11-5-3-2-4-6-11/h2-8,10,20H,9H2,1H3,(H,17,18,19)
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n/an/a 588n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3268
PNG
(4-(3-bromophenoxy)quinazoline | 4-Anilino quinazol...)
Show SMILES Brc1cccc(Oc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H9BrN2O/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H
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n/an/a 756n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3261
PNG
(4-Anilino quinazoline deriv. 12 | N-(3-methoxyphen...)
Show SMILES COc1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C15H13N3O/c1-19-12-6-4-5-11(9-12)18-15-13-7-2-3-8-14(13)16-10-17-15/h2-10H,1H3,(H,16,17,18)
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n/an/a 842n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3293
PNG
(4-Anilinoquinazoline deriv. 44 | CHEMBL329161 | N-...)
Show SMILES [O-][N+](=O)c1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C14H9BrN4O2/c15-9-2-1-3-10(6-9)18-14-12-7-11(19(20)21)4-5-13(12)16-8-17-14/h1-8H,(H,16,17,18)
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n/an/a 897n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3262
PNG
(4-Anilino quinazoline deriv. 13 | N-(3-methylpheny...)
Show SMILES Cc1cccc(Nc2ncnc3ccccc23)c1
Show InChI InChI=1S/C15H13N3/c1-11-5-4-6-12(9-11)18-15-13-7-2-3-8-14(13)16-10-17-15/h2-10H,1H3,(H,16,17,18)
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n/an/a 910n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3301
PNG
(4-Anilinoquinazoline deriv. 52 | N-(3-bromophenyl)...)
Show SMILES COc1cccc2c(Nc3cccc(Br)c3)ncnc12
Show InChI InChI=1S/C15H12BrN3O/c1-20-13-7-3-6-12-14(13)17-9-18-15(12)19-11-5-2-4-10(16)8-11/h2-9H,1H3,(H,17,18,19)
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n/an/a 974n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3274
PNG
(4-[(3-Bromophenyl)amino]-1,2,3-benzotriazine | Ben...)
Show SMILES Brc1cccc(Nc2nnnc3ccccc23)c1
Show InChI InChI=1S/C13H9BrN4/c14-9-4-3-5-10(8-9)15-13-11-6-1-2-7-12(11)16-18-17-13/h1-8H,(H,15,16,17)
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3282
PNG
(4-(Benzylamino)quinazoline deriv. 33 | 4-N-benzylq...)
Show SMILES Nc1ccc2c(NCc3ccccc3)ncnc2c1
Show InChI InChI=1S/C15H14N4/c16-12-6-7-13-14(8-12)18-10-19-15(13)17-9-11-4-2-1-3-5-11/h1-8,10H,9,16H2,(H,17,18,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3296
PNG
(4-Anilinoquinazoline deriv. 47 | 4-[(3-Bromophenyl...)
Show SMILES [O-][N+](=O)c1ccc2c(Nc3cccc(Br)c3)ncnc2c1
Show InChI InChI=1S/C14H9BrN4O2/c15-9-2-1-3-10(6-9)18-14-12-5-4-11(19(20)21)7-13(12)16-8-17-14/h1-8H,(H,16,17,18)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3267
PNG
(4-Anilino quinazoline deriv. 18 | N-(pyridin-3-yl)...)
Show SMILES N(c1cccnc1)c1ncnc2ccccc12
Show InChI InChI=1S/C13H10N4/c1-2-6-12-11(5-1)13(16-9-15-12)17-10-4-3-7-14-8-10/h1-9H,(H,15,16,17)
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n/an/a>1.00E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3279
PNG
(4-(Benzylamino)quinazoline deriv. 30 | 4-N-benzylq...)
Show SMILES Nc1ccc2ncnc(NCc3ccccc3)c2c1
Show InChI InChI=1S/C15H14N4/c16-12-6-7-14-13(8-12)15(19-10-18-14)17-9-11-4-2-1-3-5-11/h1-8,10H,9,16H2,(H,17,18,19)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3255
PNG
(4-Anilino quinazoline deriv. 6 | N-(2-phenylethyl)...)
Show SMILES C(Cc1ccccc1)Nc1ncnc2ccccc12
Show InChI InChI=1S/C16H15N3/c1-2-6-13(7-3-1)10-11-17-16-14-8-4-5-9-15(14)18-12-19-16/h1-9,12H,10-11H2,(H,17,18,19)
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n/an/a 4.10E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3277
PNG
(4-(Benzylamino)quinazoline deriv. 28 | N-benzyl-5-...)
Show SMILES COc1cccc2ncnc(NCc3ccccc3)c12
Show InChI InChI=1S/C16H15N3O/c1-20-14-9-5-8-13-15(14)16(19-11-18-13)17-10-12-6-3-2-4-7-12/h2-9,11H,10H2,1H3,(H,17,18,19)
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n/an/a 4.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3269
PNG
(N-(3-bromophenyl)quinolin-4-amine | quinoline deri...)
Show SMILES Brc1cccc(Nc2ccnc3ccccc23)c1
Show InChI InChI=1S/C15H11BrN2/c16-11-4-3-5-12(10-11)18-15-8-9-17-14-7-2-1-6-13(14)15/h1-10H,(H,17,18)
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n/an/a 5.50E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3281
PNG
(4-(Benzylamino)quinazoline deriv. 32 | N-benzyl-7-...)
Show SMILES [O-][N+](=O)c1ccc2c(NCc3ccccc3)ncnc2c1
Show InChI InChI=1S/C15H12N4O2/c20-19(21)12-6-7-13-14(8-12)17-10-18-15(13)16-9-11-4-2-1-3-5-11/h1-8,10H,9H2,(H,16,17,18)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3257
PNG
(4-(Benzylamino)quinazoline deriv. 8 | N-[(4-chloro...)
Show SMILES Clc1ccc(CNc2ncnc3ccccc23)cc1
Show InChI InChI=1S/C15H12ClN3/c16-12-7-5-11(6-8-12)9-17-15-13-3-1-2-4-14(13)18-10-19-15/h1-8,10H,9H2,(H,17,18,19)
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n/an/a 7.00E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3275
PNG
(4-(Benzylamino)quinazoline deriv. 26 | N-benzyl-5-...)
Show SMILES [O-][N+](=O)c1cccc2ncnc(NCc3ccccc3)c12
Show InChI InChI=1S/C15H12N4O2/c20-19(21)13-8-4-7-12-14(13)15(18-10-17-12)16-9-11-5-2-1-3-6-11/h1-8,10H,9H2,(H,16,17,18)
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3271
PNG
(N-(3-bromophenyl)cinnolin-4-amine | cinnoline deri...)
Show SMILES Brc1cccc(Nc2cnnc3ccccc23)c1
Show InChI InChI=1S/C14H10BrN3/c15-10-4-3-5-11(8-10)17-14-9-16-18-13-7-2-1-6-12(13)14/h1-9H,(H,17,18)
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n/an/a>1.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3278
PNG
(4-(Benzylamino)quinazoline deriv. 29 | N-benzyl-6-...)
Show SMILES [O-][N+](=O)c1ccc2ncnc(NCc3ccccc3)c2c1
Show InChI InChI=1S/C15H12N4O2/c20-19(21)12-6-7-14-13(8-12)15(18-10-17-14)16-9-11-4-2-1-3-5-11/h1-8,10H,9H2,(H,16,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3286
PNG
(4-(Benzylamino)quinazoline deriv. 37 | N-benzyl-8-...)
Show SMILES COc1cccc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C16H15N3O/c1-20-14-9-5-8-13-15(14)18-11-19-16(13)17-10-12-6-3-2-4-7-12/h2-9,11H,10H2,1H3,(H,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3284
PNG
(4-(Benzylamino)quinazoline deriv. 35 | N-benzyl-8-...)
Show SMILES [O-][N+](=O)c1cccc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C15H12N4O2/c20-19(21)13-8-4-7-12-14(13)17-10-18-15(12)16-9-11-5-2-1-3-6-11/h1-8,10H,9H2,(H,16,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3276
PNG
(4-(Benzylamino)quinazoline deriv. 27 | 4-N-benzylq...)
Show SMILES Nc1cccc2ncnc(NCc3ccccc3)c12
Show InChI InChI=1S/C15H14N4/c16-12-7-4-8-13-14(12)15(19-10-18-13)17-9-11-5-2-1-3-6-11/h1-8,10H,9,16H2,(H,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3285
PNG
(4-(Benzylamino)quinazoline deriv. 36 | 4-N-benzylq...)
Show SMILES Nc1cccc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C15H14N4/c16-13-8-4-7-12-14(13)18-10-19-15(12)17-9-11-5-2-1-3-6-11/h1-8,10H,9,16H2,(H,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3258
PNG
(4-(Benzylamino)quinazoline deriv. 9 | N-[(4-methox...)
Show SMILES COc1ccc(CNc2ncnc3ccccc23)cc1
Show InChI InChI=1S/C16H15N3O/c1-20-13-8-6-12(7-9-13)10-17-16-14-4-2-3-5-15(14)18-11-19-16/h2-9,11H,10H2,1H3,(H,17,18,19)
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n/an/a 1.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3299
PNG
(4-Anilinoquinazoline deriv. 50 | N-(3-bromophenyl)...)
Show SMILES [O-][N+](=O)c1cccc2c(Nc3cccc(Br)c3)ncnc12
Show InChI InChI=1S/C14H9BrN4O2/c15-9-3-1-4-10(7-9)18-14-11-5-2-6-12(19(20)21)13(11)16-8-17-14/h1-8H,(H,16,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3270
PNG
(N-(3-bromophenyl)isoquinolin-1-amine | isoquinolin...)
Show SMILES Brc1cccc(Nc2nccc3ccccc23)c1
Show InChI InChI=1S/C15H11BrN2/c16-12-5-3-6-13(10-12)18-15-14-7-2-1-4-11(14)8-9-17-15/h1-10H,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3272
PNG
(N-(3-bromophenyl)phthalazin-1-amine | phthalazine ...)
Show SMILES Brc1cccc(Nc2nncc3ccccc23)c1
Show InChI InChI=1S/C14H10BrN3/c15-11-5-3-6-12(8-11)17-14-13-7-2-1-4-10(13)9-16-18-14/h1-9H,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3260
PNG
(4-Anilino quinazoline deriv. 11 | N-methyl-N-pheny...)
Show SMILES CN(c1ccccc1)c1ncnc2ccccc12
Show InChI InChI=1S/C15H13N3/c1-18(12-7-3-2-4-8-12)15-13-9-5-6-10-14(13)16-11-17-15/h2-11H,1H3
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n/an/a 1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM3273
PNG
(N-(3-bromophenyl)quinoxalin-2-amine | quinoxaline ...)
Show SMILES Brc1cccc(Nc2cnc3ccccc3n2)c1
Show InChI InChI=1S/C14H10BrN3/c15-10-4-3-5-11(8-10)17-14-9-16-12-6-1-2-7-13(12)18-14/h1-9H,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%