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PubMed code 7853341

Compile data set for download or QSAR
Found 115 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1 |(5.41,-4.43,;4.65,-5.78,;6.2,-5.78,;6.97,-7.12,;6.97,-4.45,;8.52,-4.1,;8.52,-2.56,;9.86,-1.78,;11.19,-2.56,;11.19,-4.1,;9.86,-4.88,;9.09,-3.78,;9.09,-2.9,;3.1,-5.81,;2.36,-7.19,;.82,-7.2,;.01,-5.88,;.78,-4.52,;2.32,-4.49,;4.65,-7.23,;3.39,-7.96,;3.38,-9.41,;4.64,-10.15,;5.91,-9.42,;5.91,-7.97,)|
Show InChI InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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 0.0450n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1 |(5.41,-4.43,;4.65,-5.78,;6.2,-5.78,;6.97,-7.12,;6.97,-4.45,;8.52,-4.1,;8.52,-2.56,;9.86,-1.78,;11.19,-2.56,;11.19,-4.1,;9.86,-4.88,;9.09,-3.78,;9.09,-2.9,;3.1,-5.81,;2.36,-7.19,;.82,-7.2,;.01,-5.88,;.78,-4.52,;2.32,-4.49,;4.65,-7.23,;3.39,-7.96,;3.38,-9.41,;4.64,-10.15,;5.91,-9.42,;5.91,-7.97,)|
Show InChI InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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 0.0510n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1 |(5.41,-4.43,;4.65,-5.78,;6.2,-5.78,;6.97,-7.12,;6.97,-4.45,;8.52,-4.1,;8.52,-2.56,;9.86,-1.78,;11.19,-2.56,;11.19,-4.1,;9.86,-4.88,;9.09,-3.78,;9.09,-2.9,;3.1,-5.81,;2.36,-7.19,;.82,-7.2,;.01,-5.88,;.78,-4.52,;2.32,-4.49,;4.65,-7.23,;3.39,-7.96,;3.38,-9.41,;4.64,-10.15,;5.91,-9.42,;5.91,-7.97,)|
Show InChI InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
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 0.240n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1 |c:7,(3.93,-23.86,;3.93,-25.41,;5.26,-26.18,;6.02,-24.84,;4.53,-24.44,;5.26,-23.08,;6.61,-23.86,;6.61,-25.41,;7.94,-23.09,;9.34,-23.71,;10.37,-22.57,;11.9,-22.57,;12.67,-21.25,;11.9,-19.91,;10.37,-19.91,;9.61,-21.23,;8.1,-21.55,)|
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 9.60n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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 14n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1 |c:7,(3.93,-23.86,;3.93,-25.41,;5.26,-26.18,;6.02,-24.84,;4.53,-24.44,;5.26,-23.08,;6.61,-23.86,;6.61,-25.41,;7.94,-23.09,;9.34,-23.71,;10.37,-22.57,;11.9,-22.57,;12.67,-21.25,;11.9,-19.91,;10.37,-19.91,;9.61,-21.23,;8.1,-21.55,)|
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 31n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036195
PNG
(3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1coc2ccccc12 |c:7,(22.77,-5.83,;21.83,-6.3,;22.45,-7.56,;21.13,-6.9,;21.13,-5.36,;22.45,-4.58,;23.78,-5.36,;23.78,-6.9,;25.13,-4.59,;26.35,-5.52,;27.61,-4.64,;27.17,-3.16,;27.96,-1.85,;27.21,-.5,;25.67,-.48,;24.89,-1.78,;25.63,-3.13,)|
Show InChI InChI=1S/C15H15NO/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 34n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036173
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-...)
Show SMILES C1CN2CCC1C(=C2)c1csc2ccccc12 |c:7,(9.64,-13.75,;8.71,-14.22,;9.33,-15.48,;8.01,-14.82,;8.01,-13.28,;9.33,-12.51,;10.66,-13.28,;10.66,-14.82,;12,-12.51,;13.23,-13.45,;14.49,-12.56,;14.05,-11.09,;14.84,-9.78,;14.09,-8.43,;12.55,-8.41,;11.77,-9.71,;12.51,-11.06,)|
Show InChI InChI=1S/C15H15NS/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 37n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036171
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octane | CHE...)
Show SMILES C1CN2CCC1C(C2)c1cc2ccccc2o1 |(14.72,-24.47,;13.78,-24.93,;14.4,-26.2,;13.08,-25.54,;13.08,-24,;14.4,-23.2,;15.74,-24,;15.74,-25.54,;17.23,-23.59,;17.7,-22.12,;19.25,-22.12,;20.28,-20.99,;21.77,-21.31,;22.26,-22.78,;21.21,-23.9,;19.71,-23.59,;18.47,-24.5,)|
Show InChI InChI=1S/C15H17NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9,11,13H,5-8,10H2
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 57n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2 |(11.53,-10.54,;11.06,-12,;12.31,-12.92,;13.55,-12,;15.05,-12.32,;16.1,-11.2,;15.62,-9.72,;14.12,-9.4,;13.08,-10.54,;9.56,-12.42,;9.56,-13.97,;8.22,-14.62,;7.61,-13.36,;8.54,-12.89,;8.22,-11.62,;6.9,-12.42,;6.9,-13.97,)|
Show InChI InChI=1S/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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 59n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1 |c:7,(3.93,-23.86,;3.93,-25.41,;5.26,-26.18,;6.02,-24.84,;4.53,-24.44,;5.26,-23.08,;6.61,-23.86,;6.61,-25.41,;7.94,-23.09,;9.34,-23.71,;10.37,-22.57,;11.9,-22.57,;12.67,-21.25,;11.9,-19.91,;10.37,-19.91,;9.61,-21.23,;8.1,-21.55,)|
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 59n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2 |(11.53,-10.54,;11.06,-12,;12.31,-12.92,;13.55,-12,;15.05,-12.32,;16.1,-11.2,;15.62,-9.72,;14.12,-9.4,;13.08,-10.54,;9.56,-12.42,;9.56,-13.97,;8.22,-14.62,;7.61,-13.36,;8.54,-12.89,;8.22,-11.62,;6.9,-12.42,;6.9,-13.97,)|
Show InChI InChI=1S/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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 59n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1 |c:7,(17.86,-23.53,;17.86,-25.08,;19.19,-25.85,;19.95,-24.52,;18.46,-24.12,;19.19,-22.75,;20.54,-23.53,;20.54,-25.08,;21.87,-22.76,;23.27,-23.39,;24.3,-22.24,;25.83,-22.25,;26.6,-20.92,;25.83,-19.59,;24.3,-19.59,;23.54,-20.91,;22.03,-21.23,)|
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 81n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036173
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-...)
Show SMILES C1CN2CCC1C(=C2)c1csc2ccccc12 |c:7,(9.64,-13.75,;8.71,-14.22,;9.33,-15.48,;8.01,-14.82,;8.01,-13.28,;9.33,-12.51,;10.66,-13.28,;10.66,-14.82,;12,-12.51,;13.23,-13.45,;14.49,-12.56,;14.05,-11.09,;14.84,-9.78,;14.09,-8.43,;12.55,-8.41,;11.77,-9.71,;12.51,-11.06,)|
Show InChI InChI=1S/C15H15NS/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 96n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036195
PNG
(3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1coc2ccccc12 |c:7,(22.77,-5.83,;21.83,-6.3,;22.45,-7.56,;21.13,-6.9,;21.13,-5.36,;22.45,-4.58,;23.78,-5.36,;23.78,-6.9,;25.13,-4.59,;26.35,-5.52,;27.61,-4.64,;27.17,-3.16,;27.96,-1.85,;27.21,-.5,;25.67,-.48,;24.89,-1.78,;25.63,-3.13,)|
Show InChI InChI=1S/C15H15NO/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 99n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036190
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene |...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2o1 |c:7,(-6.76,-24.05,;-7.7,-24.52,;-7.08,-25.79,;-8.4,-25.13,;-8.4,-23.58,;-7.08,-22.79,;-5.74,-23.58,;-5.74,-25.13,;-4.25,-23.17,;-3.77,-21.71,;-2.22,-21.71,;-1.19,-20.56,;.31,-20.88,;.8,-22.36,;-.25,-23.5,;-1.75,-23.17,;-3,-24.08,)|
Show InChI InChI=1S/C14H14N2O/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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 100n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036173
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-...)
Show SMILES C1CN2CCC1C(=C2)c1csc2ccccc12 |c:7,(9.64,-13.75,;8.71,-14.22,;9.33,-15.48,;8.01,-14.82,;8.01,-13.28,;9.33,-12.51,;10.66,-13.28,;10.66,-14.82,;12,-12.51,;13.23,-13.45,;14.49,-12.56,;14.05,-11.09,;14.84,-9.78,;14.09,-8.43,;12.55,-8.41,;11.77,-9.71,;12.51,-11.06,)|
Show InChI InChI=1S/C15H15NS/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 110n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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 110n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2 |(11.53,-10.54,;11.06,-12,;12.31,-12.92,;13.55,-12,;15.05,-12.32,;16.1,-11.2,;15.62,-9.72,;14.12,-9.4,;13.08,-10.54,;9.56,-12.42,;9.56,-13.97,;8.22,-14.62,;7.61,-13.36,;8.54,-12.89,;8.22,-11.62,;6.9,-12.42,;6.9,-13.97,)|
Show InChI InChI=1S/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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 160n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2 |(11.53,-10.54,;11.06,-12,;12.31,-12.92,;13.55,-12,;15.05,-12.32,;16.1,-11.2,;15.62,-9.72,;14.12,-9.4,;13.08,-10.54,;9.56,-12.42,;9.56,-13.97,;8.22,-14.62,;7.61,-13.36,;8.54,-12.89,;8.22,-11.62,;6.9,-12.42,;6.9,-13.97,)|
Show InChI InChI=1S/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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 160n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036195
PNG
(3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1coc2ccccc12 |c:7,(22.77,-5.83,;21.83,-6.3,;22.45,-7.56,;21.13,-6.9,;21.13,-5.36,;22.45,-4.58,;23.78,-5.36,;23.78,-6.9,;25.13,-4.59,;26.35,-5.52,;27.61,-4.64,;27.17,-3.16,;27.96,-1.85,;27.21,-.5,;25.67,-.48,;24.89,-1.78,;25.63,-3.13,)|
Show InChI InChI=1S/C15H15NO/c1-2-4-15-12(3-1)14(10-17-15)13-9-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 160n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036170
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene ...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2s1 |c:7,(-2.89,-19.08,;-3.82,-19.55,;-3.21,-20.81,;-4.53,-20.16,;-4.53,-18.61,;-3.21,-17.82,;-1.87,-18.61,;-1.87,-20.16,;-.38,-18.19,;.1,-16.73,;1.65,-16.73,;2.68,-15.59,;4.18,-15.91,;4.67,-17.39,;3.62,-18.52,;2.12,-18.19,;.88,-19.11,)|
Show InChI InChI=1S/C14H14N2S/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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 170n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036171
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octane | CHE...)
Show SMILES C1CN2CCC1C(C2)c1cc2ccccc2o1 |(14.72,-24.47,;13.78,-24.93,;14.4,-26.2,;13.08,-25.54,;13.08,-24,;14.4,-23.2,;15.74,-24,;15.74,-25.54,;17.23,-23.59,;17.7,-22.12,;19.25,-22.12,;20.28,-20.99,;21.77,-21.31,;22.26,-22.78,;21.21,-23.9,;19.71,-23.59,;18.47,-24.5,)|
Show InChI InChI=1S/C15H17NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9,11,13H,5-8,10H2
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 200n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036193
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]oct-2-ene...)
Show SMILES COc1ccccc1C1=CN2CCC1CC2 |t:9,(8.93,-5.49,;10.47,-5.39,;11.15,-4.01,;12.7,-3.91,;13.37,-2.54,;12.52,-1.25,;10.99,-1.34,;10.31,-2.72,;8.83,-3.12,;8.83,-4.67,;7.49,-5.32,;6.87,-4.06,;7.8,-3.59,;7.5,-2.35,;6.16,-3.12,;6.16,-4.67,)|
Show InChI InChI=1S/C14H17NO/c1-16-14-5-3-2-4-12(14)13-10-15-8-6-11(13)7-9-15/h2-5,10-11H,6-9H2,1H3
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 220n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036171
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octane | CHE...)
Show SMILES C1CN2CCC1C(C2)c1cc2ccccc2o1 |(14.72,-24.47,;13.78,-24.93,;14.4,-26.2,;13.08,-25.54,;13.08,-24,;14.4,-23.2,;15.74,-24,;15.74,-25.54,;17.23,-23.59,;17.7,-22.12,;19.25,-22.12,;20.28,-20.99,;21.77,-21.31,;22.26,-22.78,;21.21,-23.9,;19.71,-23.59,;18.47,-24.5,)|
Show InChI InChI=1S/C15H17NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9,11,13H,5-8,10H2
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 240n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1 |c:7,(17.86,-23.53,;17.86,-25.08,;19.19,-25.85,;19.95,-24.52,;18.46,-24.12,;19.19,-22.75,;20.54,-23.53,;20.54,-25.08,;21.87,-22.76,;23.27,-23.39,;24.3,-22.24,;25.83,-22.25,;26.6,-20.92,;25.83,-19.59,;24.3,-19.59,;23.54,-20.91,;22.03,-21.23,)|
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 270n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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 270n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036182
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1cccs1 |c:7,(9.06,-7.61,;10.56,-8.02,;9.8,-9.35,;8.45,-8.58,;8.45,-7.04,;9.8,-6.27,;11.13,-7.04,;11.13,-8.58,;12.46,-6.27,;12.62,-4.75,;14.1,-4.41,;14.9,-5.75,;13.87,-6.91,)|
Show InChI InChI=1S/C11H13NS/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 290n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036196
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccco1 |c:7,(9.06,-7.61,;10.56,-8.02,;9.8,-9.35,;8.45,-8.58,;8.45,-7.04,;9.8,-6.27,;11.13,-7.04,;11.13,-8.58,;12.46,-6.27,;12.62,-4.75,;14.1,-4.41,;14.9,-5.75,;13.87,-6.91,)|
Show InChI InChI=1S/C11H13NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 300n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036194
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-phenol | CHE...)
Show SMILES Oc1ccccc1C1=CN2CCC1CC2 |t:8,(10.48,-5.39,;11.15,-4.01,;12.7,-3.91,;13.38,-2.54,;12.53,-1.25,;10.99,-1.34,;10.31,-2.72,;8.84,-3.12,;8.84,-4.67,;7.49,-5.32,;6.87,-4.06,;7.81,-3.59,;7.5,-2.35,;6.17,-3.12,;6.17,-4.67,)|
Show InChI InChI=1S/C13H15NO/c15-13-4-2-1-3-11(13)12-9-14-7-5-10(12)6-8-14/h1-4,9-10,15H,5-8H2
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 330n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036175
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-aza-bicyclo[2.2....)
Show SMILES C1C(Oc2ccccc12)C1CN2CCC1CC2 |(11.53,-10.54,;11.06,-12,;12.31,-12.92,;13.55,-12,;15.05,-12.32,;16.1,-11.2,;15.62,-9.72,;14.12,-9.4,;13.08,-10.54,;9.56,-12.42,;9.56,-13.97,;8.22,-14.62,;7.61,-13.36,;8.54,-12.89,;8.22,-11.62,;6.9,-12.42,;6.9,-13.97,)|
Show InChI InChI=1S/C15H19NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,11,13,15H,5-10H2
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 340n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036163
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(=C2)c1cc2ccccc2o1 |c:8|
Show InChI InChI=1S/C16H18NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10-12H,6-9H2,1H3/q+1
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 360n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036194
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-phenol | CHE...)
Show SMILES Oc1ccccc1C1=CN2CCC1CC2 |t:8,(10.48,-5.39,;11.15,-4.01,;12.7,-3.91,;13.38,-2.54,;12.53,-1.25,;10.99,-1.34,;10.31,-2.72,;8.84,-3.12,;8.84,-4.67,;7.49,-5.32,;6.87,-4.06,;7.81,-3.59,;7.5,-2.35,;6.17,-3.12,;6.17,-4.67,)|
Show InChI InChI=1S/C13H15NO/c15-13-4-2-1-3-11(13)12-9-14-7-5-10(12)6-8-14/h1-4,9-10,15H,5-8H2
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 360n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036196
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccco1 |c:7,(9.06,-7.61,;10.56,-8.02,;9.8,-9.35,;8.45,-8.58,;8.45,-7.04,;9.8,-6.27,;11.13,-7.04,;11.13,-8.58,;12.46,-6.27,;12.62,-4.75,;14.1,-4.41,;14.9,-5.75,;13.87,-6.91,)|
Show InChI InChI=1S/C11H13NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 390n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036190
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene |...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2o1 |c:7,(-6.76,-24.05,;-7.7,-24.52,;-7.08,-25.79,;-8.4,-25.13,;-8.4,-23.58,;-7.08,-22.79,;-5.74,-23.58,;-5.74,-25.13,;-4.25,-23.17,;-3.77,-21.71,;-2.22,-21.71,;-1.19,-20.56,;.31,-20.88,;.8,-22.36,;-.25,-23.5,;-1.75,-23.17,;-3,-24.08,)|
Show InChI InChI=1S/C14H14N2O/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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 400n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036193
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]oct-2-ene...)
Show SMILES COc1ccccc1C1=CN2CCC1CC2 |t:9,(8.93,-5.49,;10.47,-5.39,;11.15,-4.01,;12.7,-3.91,;13.37,-2.54,;12.52,-1.25,;10.99,-1.34,;10.31,-2.72,;8.83,-3.12,;8.83,-4.67,;7.49,-5.32,;6.87,-4.06,;7.8,-3.59,;7.5,-2.35,;6.16,-3.12,;6.16,-4.67,)|
Show InChI InChI=1S/C14H17NO/c1-16-14-5-3-2-4-12(14)13-10-15-8-6-11(13)7-9-15/h2-5,10-11H,6-9H2,1H3
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 410n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036169
PNG
(3-Selenophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1ccc[se]1 |c:7,(25.63,-.73,;24.69,-1.2,;25.31,-2.46,;23.99,-1.81,;23.99,-.26,;25.31,.51,;26.64,-.26,;26.64,-1.81,;28.12,.14,;28.6,1.6,;30.14,1.6,;30.61,.13,;29.37,-.77,)|
Show InChI InChI=1S/C11H13NSe/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 410n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1 |c:7,(17.86,-23.53,;17.86,-25.08,;19.19,-25.85,;19.95,-24.52,;18.46,-24.12,;19.19,-22.75,;20.54,-23.53,;20.54,-25.08,;21.87,-22.76,;23.27,-23.39,;24.3,-22.24,;25.83,-22.25,;26.6,-20.92,;25.83,-19.59,;24.3,-19.59,;23.54,-20.91,;22.03,-21.23,)|
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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 420n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036163
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(=C2)c1cc2ccccc2o1 |c:8|
Show InChI InChI=1S/C16H18NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10-12H,6-9H2,1H3/q+1
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 460n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036192
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H20NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10,12,14H,6-9,11H2,1H3/q+1
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 520n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036191
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]octane | CHEMBL14...)
Show SMILES C1CN2CCC1C(C2)c1ccco1 |(-6.04,-3.11,;-6.04,-4.67,;-4.73,-5.45,;-4.12,-4.17,;-5.13,-3.83,;-4.73,-2.35,;-3.38,-3.11,;-3.38,-4.67,;-2.06,-2.33,;-1.37,-.95,;.19,-1.19,;.42,-2.7,;-.96,-3.42,)|
Show InChI InChI=1S/C11H15NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7,9-10H,3-6,8H2
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 540n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036170
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene ...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2s1 |c:7,(-2.89,-19.08,;-3.82,-19.55,;-3.21,-20.81,;-4.53,-20.16,;-4.53,-18.61,;-3.21,-17.82,;-1.87,-18.61,;-1.87,-20.16,;-.38,-18.19,;.1,-16.73,;1.65,-16.73,;2.68,-15.59,;4.18,-15.91,;4.67,-17.39,;3.62,-18.52,;2.12,-18.19,;.88,-19.11,)|
Show InChI InChI=1S/C14H14N2S/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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 600n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036182
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1cccs1 |c:7,(9.06,-7.61,;10.56,-8.02,;9.8,-9.35,;8.45,-8.58,;8.45,-7.04,;9.8,-6.27,;11.13,-7.04,;11.13,-8.58,;12.46,-6.27,;12.62,-4.75,;14.1,-4.41,;14.9,-5.75,;13.87,-6.91,)|
Show InChI InChI=1S/C11H13NS/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 620n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036165
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1ccsc1 |c:7,(21.51,-6.35,;20.56,-6.82,;21.19,-8.08,;19.86,-7.43,;19.86,-5.89,;21.19,-5.11,;22.52,-5.89,;22.52,-7.43,;24.01,-5.48,;24.48,-4.02,;26.02,-4.02,;26.49,-5.49,;25.25,-6.39,)|
Show InChI InChI=1S/C11H13NS/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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 710n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036190
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene |...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2o1 |c:7,(-6.76,-24.05,;-7.7,-24.52,;-7.08,-25.79,;-8.4,-25.13,;-8.4,-23.58,;-7.08,-22.79,;-5.74,-23.58,;-5.74,-25.13,;-4.25,-23.17,;-3.77,-21.71,;-2.22,-21.71,;-1.19,-20.56,;.31,-20.88,;.8,-22.36,;-.25,-23.5,;-1.75,-23.17,;-3,-24.08,)|
Show InChI InChI=1S/C14H14N2O/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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 720n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036193
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]oct-2-ene...)
Show SMILES COc1ccccc1C1=CN2CCC1CC2 |t:9,(8.93,-5.49,;10.47,-5.39,;11.15,-4.01,;12.7,-3.91,;13.37,-2.54,;12.52,-1.25,;10.99,-1.34,;10.31,-2.72,;8.83,-3.12,;8.83,-4.67,;7.49,-5.32,;6.87,-4.06,;7.8,-3.59,;7.5,-2.35,;6.16,-3.12,;6.16,-4.67,)|
Show InChI InChI=1S/C14H17NO/c1-16-14-5-3-2-4-12(14)13-10-15-8-6-11(13)7-9-15/h2-5,10-11H,6-9H2,1H3
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 740n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036177
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol |...)
Show SMILES OC1(CN2CCC1CC2)c1cc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.41,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.29,;8.38,-15.44,;6.88,-15.11,;5.63,-16.02,)|
Show InChI InChI=1S/C15H17NO2/c17-15(10-16-7-5-12(15)6-8-16)14-9-11-3-1-2-4-13(11)18-14/h1-4,9,12,17H,5-8,10H2
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 810n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036186
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-...)
Show SMILES OC1(CN2CCC1CC2)c1csc2ccccc12 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.31,-16.66,;5.76,-17.19,;6.72,-15.98,;8.25,-15.88,;8.94,-14.5,;8.07,-13.22,;6.55,-13.33,;5.87,-14.69,)|
Show InChI InChI=1S/C15H17NOS/c17-15(10-16-7-5-11(15)6-8-16)13-9-18-14-4-2-1-3-12(13)14/h1-4,9,11,17H,5-8,10H2
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 820n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036169
PNG
(3-Selenophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1ccc[se]1 |c:7,(25.63,-.73,;24.69,-1.2,;25.31,-2.46,;23.99,-1.81,;23.99,-.26,;25.31,.51,;26.64,-.26,;26.64,-1.81,;28.12,.14,;28.6,1.6,;30.14,1.6,;30.61,.13,;29.37,-.77,)|
Show InChI InChI=1S/C11H13NSe/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 990n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036180
PNG
(3-Benzo[b]thiophen-2-yl-1-aza-bicyclo[2.2.2]octan-...)
Show SMILES OC1(CN2CCC1CC2)c1cc2ccccc2s1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.41,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.29,;8.38,-15.44,;6.88,-15.11,;5.63,-16.02,)|
Show InChI InChI=1S/C15H17NOS/c17-15(10-16-7-5-12(15)6-8-16)14-9-11-3-1-2-4-13(11)18-14/h1-4,9,12,17H,5-8,10H2
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 1.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036169
PNG
(3-Selenophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | ...)
Show SMILES C1CN2CCC1C(=C2)c1ccc[se]1 |c:7,(25.63,-.73,;24.69,-1.2,;25.31,-2.46,;23.99,-1.81,;23.99,-.26,;25.31,.51,;26.64,-.26,;26.64,-1.81,;28.12,.14,;28.6,1.6,;30.14,1.6,;30.61,.13,;29.37,-.77,)|
Show InChI InChI=1S/C11H13NSe/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 1.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036196
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccco1 |c:7,(9.06,-7.61,;10.56,-8.02,;9.8,-9.35,;8.45,-8.58,;8.45,-7.04,;9.8,-6.27,;11.13,-7.04,;11.13,-8.58,;12.46,-6.27,;12.62,-4.75,;14.1,-4.41,;14.9,-5.75,;13.87,-6.91,)|
Show InChI InChI=1S/C11H13NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 1.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036192
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H20NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10,12,14H,6-9,11H2,1H3/q+1
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 1.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036170
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene ...)
Show SMILES C1CN2CCC1C(=C2)c1nc2ccccc2s1 |c:7,(-2.89,-19.08,;-3.82,-19.55,;-3.21,-20.81,;-4.53,-20.16,;-4.53,-18.61,;-3.21,-17.82,;-1.87,-18.61,;-1.87,-20.16,;-.38,-18.19,;.1,-16.73,;1.65,-16.73,;2.68,-15.59,;4.18,-15.91,;4.67,-17.39,;3.62,-18.52,;2.12,-18.19,;.88,-19.11,)|
Show InChI InChI=1S/C14H14N2S/c1-2-4-13-12(3-1)15-14(17-13)11-9-16-7-5-10(11)6-8-16/h1-4,9-10H,5-8H2
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 1.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036167
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol...)
Show SMILES OC1(CN2CCC1CC2)c1nc2ccccc2s1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Show InChI InChI=1S/C14H16N2OS/c17-14(9-16-7-5-10(14)6-8-16)13-15-11-3-1-2-4-12(11)18-13/h1-4,10,17H,5-9H2
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 1.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036179
PNG
(3-Pyridin-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHE...)
Show SMILES C1CN2CCC1C(=C2)c1ccccn1 |c:7,(-6.91,-10.64,;-7.86,-11.11,;-7.24,-12.38,;-8.56,-11.72,;-8.56,-10.17,;-7.22,-9.38,;-5.88,-10.17,;-5.88,-11.72,;-4.4,-9.76,;-3.72,-8.38,;-2.18,-8.28,;-1.31,-9.57,;-2,-10.94,;-3.54,-11.05,)|
Show InChI InChI=1S/C12H14N2/c1-2-6-13-12(3-1)11-9-14-7-4-10(11)5-8-14/h1-3,6,9-10H,4-5,7-8H2
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 1.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036182
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1cccs1 |c:7,(9.06,-7.61,;10.56,-8.02,;9.8,-9.35,;8.45,-8.58,;8.45,-7.04,;9.8,-6.27,;11.13,-7.04,;11.13,-8.58,;12.46,-6.27,;12.62,-4.75,;14.1,-4.41,;14.9,-5.75,;13.87,-6.91,)|
Show InChI InChI=1S/C11H13NS/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7-9H,3-6H2
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 1.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036163
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(=C2)c1cc2ccccc2o1 |c:8|
Show InChI InChI=1S/C16H18NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10-12H,6-9H2,1H3/q+1
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 1.30E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036194
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-phenol | CHE...)
Show SMILES Oc1ccccc1C1=CN2CCC1CC2 |t:8,(10.48,-5.39,;11.15,-4.01,;12.7,-3.91,;13.38,-2.54,;12.53,-1.25,;10.99,-1.34,;10.31,-2.72,;8.84,-3.12,;8.84,-4.67,;7.49,-5.32,;6.87,-4.06,;7.81,-3.59,;7.5,-2.35,;6.17,-3.12,;6.17,-4.67,)|
Show InChI InChI=1S/C13H15NO/c15-13-4-2-1-3-11(13)12-9-14-7-5-10(12)6-8-14/h1-4,9-10,15H,5-8H2
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 1.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036181
PNG
(3-Furan-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccoc1 |c:7,(23.48,-7.58,;22.54,-8.05,;23.16,-9.31,;21.84,-8.66,;21.84,-7.12,;23.17,-6.34,;24.5,-7.12,;24.5,-8.66,;25.98,-6.72,;26.47,-5.25,;28.01,-5.25,;28.48,-6.72,;27.22,-7.63,)|
Show InChI InChI=1S/C11H13NO/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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 1.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036191
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]octane | CHEMBL14...)
Show SMILES C1CN2CCC1C(C2)c1ccco1 |(-6.04,-3.11,;-6.04,-4.67,;-4.73,-5.45,;-4.12,-4.17,;-5.13,-3.83,;-4.73,-2.35,;-3.38,-3.11,;-3.38,-4.67,;-2.06,-2.33,;-1.37,-.95,;.19,-1.19,;.42,-2.7,;-.96,-3.42,)|
Show InChI InChI=1S/C11H15NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7,9-10H,3-6,8H2
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 1.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036176
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-methyl-1-azonia-...)
Show SMILES C[N+]12CCC(CC1)C(C2)C1Cc2ccccc2O1
Show InChI InChI=1S/C16H22NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,12,14,16H,6-11H2,1H3/q+1
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 1.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036181
PNG
(3-Furan-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccoc1 |c:7,(23.48,-7.58,;22.54,-8.05,;23.16,-9.31,;21.84,-8.66,;21.84,-7.12,;23.17,-6.34,;24.5,-7.12,;24.5,-8.66,;25.98,-6.72,;26.47,-5.25,;28.01,-5.25,;28.48,-6.72,;27.22,-7.63,)|
Show InChI InChI=1S/C11H13NO/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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 1.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036165
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1ccsc1 |c:7,(21.51,-6.35,;20.56,-6.82,;21.19,-8.08,;19.86,-7.43,;19.86,-5.89,;21.19,-5.11,;22.52,-5.89,;22.52,-7.43,;24.01,-5.48,;24.48,-4.02,;26.02,-4.02,;26.49,-5.49,;25.25,-6.39,)|
Show InChI InChI=1S/C11H13NS/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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 1.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036176
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-methyl-1-azonia-...)
Show SMILES C[N+]12CCC(CC1)C(C2)C1Cc2ccccc2O1
Show InChI InChI=1S/C16H22NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,12,14,16H,6-11H2,1H3/q+1
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 1.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036164
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol ...)
Show SMILES OC1(CN2CCC1CC2)c1nc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Show InChI InChI=1S/C14H16N2O2/c17-14(9-16-7-5-10(14)6-8-16)13-15-11-3-1-2-4-12(11)18-13/h1-4,10,17H,5-9H2
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 1.80E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036179
PNG
(3-Pyridin-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHE...)
Show SMILES C1CN2CCC1C(=C2)c1ccccn1 |c:7,(-6.91,-10.64,;-7.86,-11.11,;-7.24,-12.38,;-8.56,-11.72,;-8.56,-10.17,;-7.22,-9.38,;-5.88,-10.17,;-5.88,-11.72,;-4.4,-9.76,;-3.72,-8.38,;-2.18,-8.28,;-1.31,-9.57,;-2,-10.94,;-3.54,-11.05,)|
Show InChI InChI=1S/C12H14N2/c1-2-6-13-12(3-1)11-9-14-7-4-10(11)5-8-14/h1-3,6,9-10H,4-5,7-8H2
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 1.90E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036189
PNG
(3-(Tetrahydro-furan-2-yl)-1-aza-bicyclo[2.2.2]octa...)
Show SMILES C1COC(C1)C1CN2CCC1CC2 |(14.29,-9.92,;14.75,-11.39,;13.51,-12.3,;12.27,-11.39,;12.74,-9.92,;10.78,-11.79,;10.78,-13.33,;9.44,-13.98,;8.83,-12.72,;9.77,-12.25,;9.45,-11.02,;8.13,-11.79,;8.13,-13.33,)|
Show InChI InChI=1S/C11H19NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h9-11H,1-8H2
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 2.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036186
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-...)
Show SMILES OC1(CN2CCC1CC2)c1csc2ccccc12 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.31,-16.66,;5.76,-17.19,;6.72,-15.98,;8.25,-15.88,;8.94,-14.5,;8.07,-13.22,;6.55,-13.33,;5.87,-14.69,)|
Show InChI InChI=1S/C15H17NOS/c17-15(10-16-7-5-11(15)6-8-16)13-9-18-14-4-2-1-3-12(13)14/h1-4,9,11,17H,5-8,10H2
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 2.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036189
PNG
(3-(Tetrahydro-furan-2-yl)-1-aza-bicyclo[2.2.2]octa...)
Show SMILES C1COC(C1)C1CN2CCC1CC2 |(14.29,-9.92,;14.75,-11.39,;13.51,-12.3,;12.27,-11.39,;12.74,-9.92,;10.78,-11.79,;10.78,-13.33,;9.44,-13.98,;8.83,-12.72,;9.77,-12.25,;9.45,-11.02,;8.13,-11.79,;8.13,-13.33,)|
Show InChI InChI=1S/C11H19NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h9-11H,1-8H2
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 2.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036166
PNG
(3-(pyridin-3-yl)-1-azabicyclo[2.2.2]oct-2-ene | 3-...)
Show SMILES C1CN2CCC1C(=C2)c1cccnc1 |c:7,THB:8:6:4.3:0.1,(-3.23,-2.16,;-4,-3.38,;-2.35,-2.5,;-2.35,-1.13,;-1.52,-.29,;-1.51,-1.39,;.03,-2.32,;-.76,-3.46,;1.54,-2,;2.57,-3.14,;4.08,-2.83,;4.56,-1.36,;3.52,-.21,;2.01,-.52,)|
Show InChI InChI=1S/C12H14N2/c1-2-11(8-13-5-1)12-9-14-6-3-10(12)4-7-14/h1-2,5,8-10H,3-4,6-7H2
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 2.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036192
PNG
(3-Benzofuran-2-yl-1-methyl-1-azonia-bicyclo[2.2.2]...)
Show SMILES C[N+]12CCC(CC1)C(C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H20NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,10,12,14H,6-9,11H2,1H3/q+1
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 2.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036165
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Show SMILES C1CN2CCC1C(=C2)c1ccsc1 |c:7,(21.51,-6.35,;20.56,-6.82,;21.19,-8.08,;19.86,-7.43,;19.86,-5.89,;21.19,-5.11,;22.52,-5.89,;22.52,-7.43,;24.01,-5.48,;24.48,-4.02,;26.02,-4.02,;26.49,-5.49,;25.25,-6.39,)|
Show InChI InChI=1S/C11H13NS/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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 2.60E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036176
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-methyl-1-azonia-...)
Show SMILES C[N+]12CCC(CC1)C(C2)C1Cc2ccccc2O1
Show InChI InChI=1S/C16H22NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,12,14,16H,6-11H2,1H3/q+1
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 2.60E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036176
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-methyl-1-azonia-...)
Show SMILES C[N+]12CCC(CC1)C(C2)C1Cc2ccccc2O1
Show InChI InChI=1S/C16H22NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,12,14,16H,6-11H2,1H3/q+1
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 2.60E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036186
PNG
(3-Benzo[b]thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-...)
Show SMILES OC1(CN2CCC1CC2)c1csc2ccccc12 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.31,-16.66,;5.76,-17.19,;6.72,-15.98,;8.25,-15.88,;8.94,-14.5,;8.07,-13.22,;6.55,-13.33,;5.87,-14.69,)|
Show InChI InChI=1S/C15H17NOS/c17-15(10-16-7-5-11(15)6-8-16)13-9-18-14-4-2-1-3-12(13)14/h1-4,9,11,17H,5-8,10H2
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 2.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036177
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol |...)
Show SMILES OC1(CN2CCC1CC2)c1cc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.41,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.29,;8.38,-15.44,;6.88,-15.11,;5.63,-16.02,)|
Show InChI InChI=1S/C15H17NO2/c17-15(10-16-7-5-12(15)6-8-16)14-9-11-3-1-2-4-13(11)18-14/h1-4,9,12,17H,5-8,10H2
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 2.70E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036166
PNG
(3-(pyridin-3-yl)-1-azabicyclo[2.2.2]oct-2-ene | 3-...)
Show SMILES C1CN2CCC1C(=C2)c1cccnc1 |c:7,THB:8:6:4.3:0.1,(-3.23,-2.16,;-4,-3.38,;-2.35,-2.5,;-2.35,-1.13,;-1.52,-.29,;-1.51,-1.39,;.03,-2.32,;-.76,-3.46,;1.54,-2,;2.57,-3.14,;4.08,-2.83,;4.56,-1.36,;3.52,-.21,;2.01,-.52,)|
Show InChI InChI=1S/C12H14N2/c1-2-11(8-13-5-1)12-9-14-6-3-10(12)4-7-14/h1-2,5,8-10H,3-4,6-7H2
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 2.80E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036167
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol...)
Show SMILES OC1(CN2CCC1CC2)c1nc2ccccc2s1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Show InChI InChI=1S/C14H16N2OS/c17-14(9-16-7-5-10(14)6-8-16)13-15-11-3-1-2-4-12(11)18-13/h1-4,10,17H,5-9H2
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 3.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036191
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]octane | CHEMBL14...)
Show SMILES C1CN2CCC1C(C2)c1ccco1 |(-6.04,-3.11,;-6.04,-4.67,;-4.73,-5.45,;-4.12,-4.17,;-5.13,-3.83,;-4.73,-2.35,;-3.38,-3.11,;-3.38,-4.67,;-2.06,-2.33,;-1.37,-.95,;.19,-1.19,;.42,-2.7,;-.96,-3.42,)|
Show InChI InChI=1S/C11H15NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h1-2,7,9-10H,3-6,8H2
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 3.10E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036167
PNG
(3-Benzothiazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol...)
Show SMILES OC1(CN2CCC1CC2)c1nc2ccccc2s1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Show InChI InChI=1S/C14H16N2OS/c17-14(9-16-7-5-10(14)6-8-16)13-15-11-3-1-2-4-12(11)18-13/h1-4,10,17H,5-9H2
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 3.80E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036188
PNG
(3-Benzofuran-2-yl-3-hydroxy-1-methyl-1-azonia-bicy...)
Show SMILES C[N+]12CCC(CC1)C(O)(C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H20NO2/c1-17-8-6-13(7-9-17)16(18,11-17)15-10-12-4-2-3-5-14(12)19-15/h2-5,10,13,18H,6-9,11H2,1H3/q+1
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 3.80E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036179
PNG
(3-Pyridin-2-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHE...)
Show SMILES C1CN2CCC1C(=C2)c1ccccn1 |c:7,(-6.91,-10.64,;-7.86,-11.11,;-7.24,-12.38,;-8.56,-11.72,;-8.56,-10.17,;-7.22,-9.38,;-5.88,-10.17,;-5.88,-11.72,;-4.4,-9.76,;-3.72,-8.38,;-2.18,-8.28,;-1.31,-9.57,;-2,-10.94,;-3.54,-11.05,)|
Show InChI InChI=1S/C12H14N2/c1-2-6-13-12(3-1)11-9-14-7-4-10(11)5-8-14/h1-3,6,9-10H,4-5,7-8H2
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 4.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036180
PNG
(3-Benzo[b]thiophen-2-yl-1-aza-bicyclo[2.2.2]octan-...)
Show SMILES OC1(CN2CCC1CC2)c1cc2ccccc2s1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.41,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.29,;8.38,-15.44,;6.88,-15.11,;5.63,-16.02,)|
Show InChI InChI=1S/C15H17NOS/c17-15(10-16-7-5-12(15)6-8-16)14-9-11-3-1-2-4-13(11)18-14/h1-4,9,12,17H,5-8,10H2
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 4.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036177
PNG
(3-Benzofuran-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol |...)
Show SMILES OC1(CN2CCC1CC2)c1cc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.41,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.29,;8.38,-15.44,;6.88,-15.11,;5.63,-16.02,)|
Show InChI InChI=1S/C15H17NO2/c17-15(10-16-7-5-12(15)6-8-16)14-9-11-3-1-2-4-13(11)18-14/h1-4,9,12,17H,5-8,10H2
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 4.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036181
PNG
(3-Furan-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMB...)
Show SMILES C1CN2CCC1C(=C2)c1ccoc1 |c:7,(23.48,-7.58,;22.54,-8.05,;23.16,-9.31,;21.84,-8.66,;21.84,-7.12,;23.17,-6.34,;24.5,-7.12,;24.5,-8.66,;25.98,-6.72,;26.47,-5.25,;28.01,-5.25,;28.48,-6.72,;27.22,-7.63,)|
Show InChI InChI=1S/C11H13NO/c1-4-12-5-2-9(1)11(7-12)10-3-6-13-8-10/h3,6-9H,1-2,4-5H2
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 4.90E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036189
PNG
(3-(Tetrahydro-furan-2-yl)-1-aza-bicyclo[2.2.2]octa...)
Show SMILES C1COC(C1)C1CN2CCC1CC2 |(14.29,-9.92,;14.75,-11.39,;13.51,-12.3,;12.27,-11.39,;12.74,-9.92,;10.78,-11.79,;10.78,-13.33,;9.44,-13.98,;8.83,-12.72,;9.77,-12.25,;9.45,-11.02,;8.13,-11.79,;8.13,-13.33,)|
Show InChI InChI=1S/C11H19NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h9-11H,1-8H2
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 5.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036189
PNG
(3-(Tetrahydro-furan-2-yl)-1-aza-bicyclo[2.2.2]octa...)
Show SMILES C1COC(C1)C1CN2CCC1CC2 |(14.29,-9.92,;14.75,-11.39,;13.51,-12.3,;12.27,-11.39,;12.74,-9.92,;10.78,-11.79,;10.78,-13.33,;9.44,-13.98,;8.83,-12.72,;9.77,-12.25,;9.45,-11.02,;8.13,-11.79,;8.13,-13.33,)|
Show InChI InChI=1S/C11H19NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h9-11H,1-8H2
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 5.00E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036180
PNG
(3-Benzo[b]thiophen-2-yl-1-aza-bicyclo[2.2.2]octan-...)
Show SMILES OC1(CN2CCC1CC2)c1cc2ccccc2s1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.41,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.29,;8.38,-15.44,;6.88,-15.11,;5.63,-16.02,)|
Show InChI InChI=1S/C15H17NOS/c17-15(10-16-7-5-12(15)6-8-16)14-9-11-3-1-2-4-13(11)18-14/h1-4,9,12,17H,5-8,10H2
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 5.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036188
PNG
(3-Benzofuran-2-yl-3-hydroxy-1-methyl-1-azonia-bicy...)
Show SMILES C[N+]12CCC(CC1)C(O)(C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H20NO2/c1-17-8-6-13(7-9-17)16(18,11-17)15-10-12-4-2-3-5-14(12)19-15/h2-5,10,13,18H,6-9,11H2,1H3/q+1
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 5.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036166
PNG
(3-(pyridin-3-yl)-1-azabicyclo[2.2.2]oct-2-ene | 3-...)
Show SMILES C1CN2CCC1C(=C2)c1cccnc1 |c:7,THB:8:6:4.3:0.1,(-3.23,-2.16,;-4,-3.38,;-2.35,-2.5,;-2.35,-1.13,;-1.52,-.29,;-1.51,-1.39,;.03,-2.32,;-.76,-3.46,;1.54,-2,;2.57,-3.14,;4.08,-2.83,;4.56,-1.36,;3.52,-.21,;2.01,-.52,)|
Show InChI InChI=1S/C12H14N2/c1-2-11(8-13-5-1)12-9-14-6-3-10(12)4-7-14/h1-2,5,8-10H,3-4,6-7H2
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 5.90E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036178
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]octan-3-o...)
Show SMILES COc1ccccc1C1(O)CN2CCC1CC2 |(3,-17.89,;4.55,-17.8,;5.23,-16.42,;6.77,-16.32,;7.45,-14.94,;6.6,-13.66,;5.06,-13.75,;4.39,-15.13,;2.91,-15.53,;2.9,-13.98,;2.91,-17.07,;1.57,-17.73,;.24,-17.07,;.24,-15.53,;1.58,-14.76,;1.88,-16,;.94,-16.46,)|
Show InChI InChI=1S/C14H19NO2/c1-17-13-5-3-2-4-12(13)14(16)10-15-8-6-11(14)7-9-15/h2-5,11,16H,6-10H2,1H3
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 7.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036176
PNG
(3-(2,3-Dihydro-benzofuran-2-yl)-1-methyl-1-azonia-...)
Show SMILES C[N+]12CCC(CC1)C(C2)C1Cc2ccccc2O1
Show InChI InChI=1S/C16H22NO/c1-17-8-6-12(7-9-17)14(11-17)16-10-13-4-2-3-5-15(13)18-16/h2-5,12,14,16H,6-11H2,1H3/q+1
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 7.50E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036164
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol ...)
Show SMILES OC1(CN2CCC1CC2)c1nc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Show InChI InChI=1S/C14H16N2O2/c17-14(9-16-7-5-10(14)6-8-16)13-15-11-3-1-2-4-12(11)18-13/h1-4,10,17H,5-9H2
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 8.40E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036172
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Show SMILES OC1(CN2CCC1CC2)c1ccsc1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;8.03,-6.12,;8.97,-5.65,;8.66,-4.41,;7.33,-5.19,;7.33,-6.73,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NOS/c13-11(10-3-6-14-7-10)8-12-4-1-9(11)2-5-12/h3,6-7,9,13H,1-2,4-5,8H2
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 9.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036164
PNG
(3-Benzooxazol-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol ...)
Show SMILES OC1(CN2CCC1CC2)c1nc2ccccc2o1 |(2.9,-13.97,;2.91,-15.51,;2.91,-17.05,;1.57,-17.71,;.24,-17.05,;.24,-15.51,;1.57,-14.74,;1.88,-15.98,;.94,-16.45,;4.38,-15.11,;4.87,-13.64,;6.42,-13.64,;7.44,-12.52,;8.93,-12.82,;9.41,-14.3,;8.38,-15.44,;6.88,-15.11,;5.64,-16.03,)|
Show InChI InChI=1S/C14H16N2O2/c17-14(9-16-7-5-10(14)6-8-16)13-15-11-3-1-2-4-12(11)18-13/h1-4,10,17H,5-9H2
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 9.20E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036168
PNG
(3-Pyridin-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CH...)
Show SMILES OC1(CN2CCC1CC2)c1ccccn1 |(2.9,-13.98,;2.91,-15.53,;2.91,-17.07,;1.57,-17.73,;.24,-17.07,;.24,-15.53,;1.58,-14.76,;1.88,-16,;.94,-16.46,;4.39,-15.13,;5.06,-13.75,;6.6,-13.66,;7.45,-14.94,;6.77,-16.32,;5.23,-16.42,)|
Show InChI InChI=1S/C12H16N2O/c15-12(11-3-1-2-6-13-11)9-14-7-4-10(12)5-8-14/h1-3,6,10,15H,4-5,7-9H2
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 1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036184
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Show SMILES OC1(CN2CCC1CC2)c1cccs1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;7.33,-6.73,;7.33,-5.19,;8.66,-4.41,;8.97,-5.65,;8.03,-6.12,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NOS/c13-11(10-2-1-7-14-10)8-12-5-3-9(11)4-6-12/h1-2,7,9,13H,3-6,8H2
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 1.16E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036189
PNG
(3-(Tetrahydro-furan-2-yl)-1-aza-bicyclo[2.2.2]octa...)
Show SMILES C1COC(C1)C1CN2CCC1CC2 |(14.29,-9.92,;14.75,-11.39,;13.51,-12.3,;12.27,-11.39,;12.74,-9.92,;10.78,-11.79,;10.78,-13.33,;9.44,-13.98,;8.83,-12.72,;9.77,-12.25,;9.45,-11.02,;8.13,-11.79,;8.13,-13.33,)|
Show InChI InChI=1S/C11H19NO/c1-2-11(13-7-1)10-8-12-5-3-9(10)4-6-12/h9-11H,1-8H2
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 1.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036174
PNG
(3-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CH...)
Show SMILES OC1(CN2CCC1CC2)c1cccnc1 |(2.9,-13.98,;2.91,-15.53,;2.91,-17.07,;1.57,-17.73,;.94,-16.46,;1.88,-16,;1.58,-14.76,;.24,-15.53,;.24,-17.07,;4.39,-15.13,;5.06,-13.75,;6.6,-13.66,;7.45,-14.94,;6.77,-16.32,;5.23,-16.42,)|
Show InChI InChI=1S/C12H16N2O/c15-12(11-2-1-5-13-8-11)9-14-6-3-10(12)4-7-14/h1-2,5,8,10,15H,3-4,6-7,9H2
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 1.49E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036187
PNG
(3-Furan-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEM...)
Show SMILES OC1(CN2CCC1CC2)c1ccoc1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;8.03,-6.12,;8.97,-5.65,;8.66,-4.41,;7.33,-5.19,;7.33,-6.73,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NO2/c13-11(10-3-6-14-7-10)8-12-4-1-9(11)2-5-12/h3,6-7,9,13H,1-2,4-5,8H2
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>1.50E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036178
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]octan-3-o...)
Show SMILES COc1ccccc1C1(O)CN2CCC1CC2 |(3,-17.89,;4.55,-17.8,;5.23,-16.42,;6.77,-16.32,;7.45,-14.94,;6.6,-13.66,;5.06,-13.75,;4.39,-15.13,;2.91,-15.53,;2.9,-13.98,;2.91,-17.07,;1.57,-17.73,;.24,-17.07,;.24,-15.53,;1.58,-14.76,;1.88,-16,;.94,-16.46,)|
Show InChI InChI=1S/C14H19NO2/c1-17-13-5-3-2-4-12(13)14(16)10-15-8-6-11(14)7-9-15/h2-5,11,16H,6-10H2,1H3
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 1.59E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036188
PNG
(3-Benzofuran-2-yl-3-hydroxy-1-methyl-1-azonia-bicy...)
Show SMILES C[N+]12CCC(CC1)C(O)(C2)c1cc2ccccc2o1
Show InChI InChI=1S/C16H20NO2/c1-17-8-6-13(7-9-17)16(18,11-17)15-10-12-4-2-3-5-14(12)19-15/h2-5,10,13,18H,6-9,11H2,1H3/q+1
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 1.60E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036184
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Show SMILES OC1(CN2CCC1CC2)c1cccs1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;7.33,-6.73,;7.33,-5.19,;8.66,-4.41,;8.97,-5.65,;8.03,-6.12,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NOS/c13-11(10-2-1-7-14-10)8-12-5-3-9(11)4-6-12/h1-2,7,9,13H,3-6,8H2
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>1.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036172
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Show SMILES OC1(CN2CCC1CC2)c1ccsc1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;8.03,-6.12,;8.97,-5.65,;8.66,-4.41,;7.33,-5.19,;7.33,-6.73,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NOS/c13-11(10-3-6-14-7-10)8-12-4-1-9(11)2-5-12/h3,6-7,9,13H,1-2,4-5,8H2
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>1.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036168
PNG
(3-Pyridin-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CH...)
Show SMILES OC1(CN2CCC1CC2)c1ccccn1 |(2.9,-13.98,;2.91,-15.53,;2.91,-17.07,;1.57,-17.73,;.24,-17.07,;.24,-15.53,;1.58,-14.76,;1.88,-16,;.94,-16.46,;4.39,-15.13,;5.06,-13.75,;6.6,-13.66,;7.45,-14.94,;6.77,-16.32,;5.23,-16.42,)|
Show InChI InChI=1S/C12H16N2O/c15-12(11-3-1-2-6-13-11)9-14-7-4-10(12)5-8-14/h1-3,6,10,15H,4-5,7-9H2
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 2.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036174
PNG
(3-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CH...)
Show SMILES OC1(CN2CCC1CC2)c1cccnc1 |(2.9,-13.98,;2.91,-15.53,;2.91,-17.07,;1.57,-17.73,;.94,-16.46,;1.88,-16,;1.58,-14.76,;.24,-15.53,;.24,-17.07,;4.39,-15.13,;5.06,-13.75,;6.6,-13.66,;7.45,-14.94,;6.77,-16.32,;5.23,-16.42,)|
Show InChI InChI=1S/C12H16N2O/c15-12(11-2-1-5-13-8-11)9-14-6-3-10(12)4-7-14/h1-2,5,8,10,15H,3-4,6-7,9H2
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 2.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036178
PNG
(3-(2-Methoxy-phenyl)-1-aza-bicyclo[2.2.2]octan-3-o...)
Show SMILES COc1ccccc1C1(O)CN2CCC1CC2 |(3,-17.89,;4.55,-17.8,;5.23,-16.42,;6.77,-16.32,;7.45,-14.94,;6.6,-13.66,;5.06,-13.75,;4.39,-15.13,;2.91,-15.53,;2.9,-13.98,;2.91,-17.07,;1.57,-17.73,;.24,-17.07,;.24,-15.53,;1.58,-14.76,;1.88,-16,;.94,-16.46,)|
Show InChI InChI=1S/C14H19NO2/c1-17-13-5-3-2-4-12(13)14(16)10-15-8-6-11(14)7-9-15/h2-5,11,16H,6-10H2,1H3
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 2.99E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50036197
PNG
(3-Furan-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEM...)
Show SMILES OC1(CN2CCC1CC2)c1ccco1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;7.33,-6.73,;7.33,-5.19,;8.66,-4.41,;8.97,-5.65,;8.03,-6.12,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NO2/c13-11(10-2-1-7-14-10)8-12-5-3-9(11)4-6-12/h1-2,7,9,13H,3-6,8H2
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 3.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036172
PNG
(3-Thiophen-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Show SMILES OC1(CN2CCC1CC2)c1ccsc1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;8.03,-6.12,;8.97,-5.65,;8.66,-4.41,;7.33,-5.19,;7.33,-6.73,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NOS/c13-11(10-3-6-14-7-10)8-12-4-1-9(11)2-5-12/h3,6-7,9,13H,1-2,4-5,8H2
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 3.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036168
PNG
(3-Pyridin-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CH...)
Show SMILES OC1(CN2CCC1CC2)c1ccccn1 |(2.9,-13.98,;2.91,-15.53,;2.91,-17.07,;1.57,-17.73,;.24,-17.07,;.24,-15.53,;1.58,-14.76,;1.88,-16,;.94,-16.46,;4.39,-15.13,;5.06,-13.75,;6.6,-13.66,;7.45,-14.94,;6.77,-16.32,;5.23,-16.42,)|
Show InChI InChI=1S/C12H16N2O/c15-12(11-3-1-2-6-13-11)9-14-7-4-10(12)5-8-14/h1-3,6,10,15H,4-5,7-9H2
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 3.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036184
PNG
(3-Thiophen-2-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Show SMILES OC1(CN2CCC1CC2)c1cccs1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;7.33,-6.73,;7.33,-5.19,;8.66,-4.41,;8.97,-5.65,;8.03,-6.12,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NOS/c13-11(10-2-1-7-14-10)8-12-5-3-9(11)4-6-12/h1-2,7,9,13H,3-6,8H2
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 4.80E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50036187
PNG
(3-Furan-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEM...)
Show SMILES OC1(CN2CCC1CC2)c1ccoc1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;8.03,-6.12,;8.97,-5.65,;8.66,-4.41,;7.33,-5.19,;7.33,-6.73,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NO2/c13-11(10-3-6-14-7-10)8-12-4-1-9(11)2-5-12/h3,6-7,9,13H,1-2,4-5,8H2
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>5.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036187
PNG
(3-Furan-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEM...)
Show SMILES OC1(CN2CCC1CC2)c1ccoc1 |(9.99,-3.65,;9.99,-5.19,;9.99,-6.73,;8.66,-7.38,;8.03,-6.12,;8.97,-5.65,;8.66,-4.41,;7.33,-5.19,;7.33,-6.73,;11.46,-4.78,;11.95,-3.32,;13.49,-3.32,;13.96,-4.79,;12.72,-5.69,)|
Show InChI InChI=1S/C11H15NO2/c13-11(10-3-6-14-7-10)8-12-4-1-9(11)2-5-12/h3,6-7,9,13H,1-2,4-5,8H2
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>5.30E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Cavia porcellus)		BDBM50036174
PNG
(3-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | CH...)
Show SMILES OC1(CN2CCC1CC2)c1cccnc1 |(2.9,-13.98,;2.91,-15.53,;2.91,-17.07,;1.57,-17.73,;.94,-16.46,;1.88,-16,;1.58,-14.76,;.24,-15.53,;.24,-17.07,;4.39,-15.13,;5.06,-13.75,;6.6,-13.66,;7.45,-14.94,;6.77,-16.32,;5.23,-16.42,)|
Show InChI InChI=1S/C12H16N2O/c15-12(11-2-1-5-13-8-11)9-14-6-3-10(12)4-7-14/h1-2,5,8,10,15H,3-4,6-7,9H2
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 6.70E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland

J Med Chem 38: 473-87 (1995)


BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%