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PubMed code 8676353

Compile data set for download or QSAR
Found 140 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM22541
PNG
(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1 |w:11.12|
Show InChI InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
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PubMed
 0.600n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051199
PNG
((4-Chloro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14ClN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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PubMed
 3.98n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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 4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051199
PNG
((4-Chloro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14ClN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 4.20n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051195
PNG
((2-ferrocenyl)-carbamic acid 3-(1H-imidazol-4-yl)-...)
Show SMILES O=C(NCC1=CC=CC1[Fe++]C1C=CC=C1)OCCCc1cnc[nH]1 |c:6,12,14,t:4|
Show InChI InChI=1S/C13H16N3O2.C5H5.Fe/c17-13(15-8-11-4-1-2-5-11)18-7-3-6-12-9-14-10-16-12;1-2-4-5-3-1;/h1-2,4-5,9-10H,3,6-8H2,(H,14,16)(H,15,17);1-5H;/q;;+2
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 5.80n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051202
PNG
((3-Trifluoromethyl-benzyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(CNC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C15H16F3N3O2/c16-15(17,18)12-4-1-3-11(7-12)8-20-14(22)23-6-2-5-13-9-19-10-21-13/h1,3-4,7,9-10H,2,5-6,8H2,(H,19,21)(H,20,22)
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 8.10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051196
PNG
(CHEMBL16056 | Cyclohexylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H23N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h10-12H,1-9H2,(H,15,17)(H,16,18)
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 10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051204
PNG
(CHEMBL274262 | Phenethyl-carbamic acid 3-(1H-imida...)
Show SMILES O=C(NCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c19-15(17-9-8-13-5-2-1-3-6-13)20-10-4-7-14-11-16-12-18-14/h1-3,5-6,11-12H,4,7-10H2,(H,16,18)(H,17,19)
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 10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051184
PNG
(Benzyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl e...)
Show SMILES O=C(NCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H17N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h1-3,5-6,10-11H,4,7-9H2,(H,15,17)(H,16,18)
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 10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051204
PNG
(CHEMBL274262 | Phenethyl-carbamic acid 3-(1H-imida...)
Show SMILES O=C(NCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c19-15(17-9-8-13-5-2-1-3-6-13)20-10-4-7-14-11-16-12-18-14/h1-3,5-6,11-12H,4,7-10H2,(H,16,18)(H,17,19)
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 10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051184
PNG
(Benzyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl e...)
Show SMILES O=C(NCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H17N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h1-3,5-6,10-11H,4,7-9H2,(H,15,17)(H,16,18)
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 11n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 11n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051196
PNG
(CHEMBL16056 | Cyclohexylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H23N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h10-12H,1-9H2,(H,15,17)(H,16,18)
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 11n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051188
PNG
(CHEMBL16348 | p-Tolyl-carbamic acid 3-(1H-imidazol...)
Show SMILES Cc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H17N3O2/c1-11-4-6-12(7-5-11)17-14(18)19-8-2-3-13-9-15-10-16-13/h4-7,9-10H,2-3,8H2,1H3,(H,15,16)(H,17,18)
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 11n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 12n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051221
PNG
((4-Trifluoromethyl-benzyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H16F3N3O2/c16-15(17,18)12-5-3-11(4-6-12)8-20-14(22)23-7-1-2-13-9-19-10-21-13/h3-6,9-10H,1-2,7-8H2,(H,19,21)(H,20,22)
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 12n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051203
PNG
((4-Chloro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16ClN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051217
PNG
(CHEMBL16142 | Phenyl-carbamic acid 3-(1H-imidazol-...)
Show SMILES O=C(Nc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H15N3O2/c17-13(16-11-5-2-1-3-6-11)18-8-4-7-12-9-14-10-15-12/h1-3,5-6,9-10H,4,7-8H2,(H,14,15)(H,16,17)
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 12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051193
PNG
((3-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(CNC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-6-2-4-12-9-15-10-17-12)16-8-11-3-1-5-13(7-11)18(20)21/h1,3,5,7,9-10H,2,4,6,8H2,(H,15,17)(H,16,19)
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 12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051211
PNG
(CHEMBL16957 | Cyclobutylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H19N3O2/c16-12(14-7-10-3-1-4-10)17-6-2-5-11-8-13-9-15-11/h8-10H,1-7H2,(H,13,15)(H,14,16)
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 12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051221
PNG
((4-Trifluoromethyl-benzyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H16F3N3O2/c16-15(17,18)12-5-3-11(4-6-12)8-20-14(22)23-7-1-2-13-9-19-10-21-13/h3-6,9-10H,1-2,7-8H2,(H,19,21)(H,20,22)
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 12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051193
PNG
((3-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(CNC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-6-2-4-12-9-15-10-17-12)16-8-11-3-1-5-13(7-11)18(20)21/h1,3,5,7,9-10H,2,4,6,8H2,(H,15,17)(H,16,19)
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 13n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051211
PNG
(CHEMBL16957 | Cyclobutylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H19N3O2/c16-12(14-7-10-3-1-4-10)17-6-2-5-11-8-13-9-15-11/h8-10H,1-7H2,(H,13,15)(H,14,16)
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 14n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051203
PNG
((4-Chloro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16ClN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 14n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051217
PNG
(CHEMBL16142 | Phenyl-carbamic acid 3-(1H-imidazol-...)
Show SMILES O=C(Nc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H15N3O2/c17-13(16-11-5-2-1-3-6-11)18-8-4-7-12-9-14-10-15-12/h1-3,5-6,9-10H,4,7-8H2,(H,14,15)(H,16,17)
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 14n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051185
PNG
((4-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-7-1-2-12-9-15-10-17-12)16-8-11-3-5-13(6-4-11)18(20)21/h3-6,9-10H,1-2,7-8H2,(H,15,17)(H,16,19)
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 15n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051206
PNG
((4-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-5-11(6-4-10)20-13(21)22-7-1-2-12-8-18-9-19-12/h3-6,8-9H,1-2,7H2,(H,18,19)(H,20,21)
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 15n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051185
PNG
((4-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-7-1-2-12-9-15-10-17-12)16-8-11-3-5-13(6-4-11)18(20)21/h3-6,9-10H,1-2,7-8H2,(H,15,17)(H,16,19)
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 15.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051206
PNG
((4-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-5-11(6-4-10)20-13(21)22-7-1-2-12-8-18-9-19-12/h3-6,8-9H,1-2,7H2,(H,18,19)(H,20,21)
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 15.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051198
PNG
((4-Bromo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Brc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14BrN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 18n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051213
PNG
(CHEMBL278025 | Thiophen-2-ylmethyl-carbamic acid 3...)
Show SMILES O=C(NCc1cccs1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H15N3O2S/c16-12(14-8-11-4-2-6-18-11)17-5-1-3-10-7-13-9-15-10/h2,4,6-7,9H,1,3,5,8H2,(H,13,15)(H,14,16)
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 18n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
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 19n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051192
PNG
((4-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-1-2-11-8-14-9-15-11)16-10-3-5-12(6-4-10)17(19)20/h3-6,8-9H,1-2,7H2,(H,14,15)(H,16,18)
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 19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
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 19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051215
PNG
((3-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-6-2-4-11-8-14-9-15-11)16-10-3-1-5-12(7-10)17(19)20/h1,3,5,7-9H,2,4,6H2,(H,14,15)(H,16,18)
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 19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051198
PNG
((4-Bromo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Brc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14BrN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051192
PNG
((4-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-1-2-11-8-14-9-15-11)16-10-3-5-12(6-4-10)17(19)20/h3-6,8-9H,1-2,7H2,(H,14,15)(H,16,18)
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 21n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051215
PNG
((3-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-6-2-4-11-8-14-9-15-11)16-10-3-1-5-12(7-10)17(19)20/h1,3,5,7-9H,2,4,6H2,(H,14,15)(H,16,18)
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 22n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051214
PNG
((4-Fluoro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16FN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 23n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051222
PNG
((4-Fluoro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14FN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 24n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051205
PNG
((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)
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 24n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051205
PNG
((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)
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 25.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051222
PNG
((4-Fluoro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14FN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 25.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051214
PNG
((4-Fluoro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16FN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 25.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051210
PNG
((3-Phenyl-propyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES O=C(NCCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c20-16(21-11-5-9-15-12-17-13-19-15)18-10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,17,19)(H,18,20)
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 25.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051210
PNG
((3-Phenyl-propyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES O=C(NCCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c20-16(21-11-5-9-15-12-17-13-19-15)18-10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,17,19)(H,18,20)
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 26n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051218
PNG
((4-Trifluoromethoxy-phenyl)-carbamic acid 3-(1H-im...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H14F3N3O3/c15-14(16,17)23-12-5-3-10(4-6-12)20-13(21)22-7-1-2-11-8-18-9-19-11/h3-6,8-9H,1-2,7H2,(H,18,19)(H,20,21)
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 26n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051212
PNG
((2-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-3-4-10-8-14-9-15-10)16-11-5-1-2-6-12(11)17(19)20/h1-2,5-6,8-9H,3-4,7H2,(H,14,15)(H,16,18)
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 30n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051212
PNG
((2-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-3-4-10-8-14-9-15-10)16-11-5-1-2-6-12(11)17(19)20/h1-2,5-6,8-9H,3-4,7H2,(H,14,15)(H,16,18)
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 31.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051224
PNG
(CHEMBL16407 | Cyclopentylmethyl-carbamic acid 3-(1...)
Show SMILES O=C(NCC1CCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H21N3O2/c17-13(15-8-11-4-1-2-5-11)18-7-3-6-12-9-14-10-16-12/h9-11H,1-8H2,(H,14,16)(H,15,17)
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 31.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051224
PNG
(CHEMBL16407 | Cyclopentylmethyl-carbamic acid 3-(1...)
Show SMILES O=C(NCC1CCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H21N3O2/c17-13(15-8-11-4-1-2-5-11)18-7-3-6-12-9-14-10-16-12/h9-11H,1-8H2,(H,14,16)(H,15,17)
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 32n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051223
PNG
((4-Dimethylamino-phenyl)-carbamic acid 3-(1H-imida...)
Show SMILES CN(C)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20N4O2/c1-19(2)14-7-5-12(6-8-14)18-15(20)21-9-3-4-13-10-16-11-17-13/h5-8,10-11H,3-4,9H2,1-2H3,(H,16,17)(H,18,20)
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 34n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051186
PNG
(CHEMBL16331 | Furan-2-ylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCc1ccco1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H15N3O3/c16-12(14-8-11-4-2-5-17-11)18-6-1-3-10-7-13-9-15-10/h2,4-5,7,9H,1,3,6,8H2,(H,13,15)(H,14,16)
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 39.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051187
PNG
(Benzyl-methyl-carbamic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES CN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c1-18(11-13-6-3-2-4-7-13)15(19)20-9-5-8-14-10-16-12-17-14/h2-4,6-7,10,12H,5,8-9,11H2,1H3,(H,16,17)
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 39.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051186
PNG
(CHEMBL16331 | Furan-2-ylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCc1ccco1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H15N3O3/c16-12(14-8-11-4-2-5-17-11)18-6-1-3-10-7-13-9-15-10/h2,4-5,7,9H,1,3,6,8H2,(H,13,15)(H,14,16)
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 42n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051187
PNG
(Benzyl-methyl-carbamic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES CN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c1-18(11-13-6-3-2-4-7-13)15(19)20-9-5-8-14-10-16-12-17-14/h2-4,6-7,10,12H,5,8-9,11H2,1H3,(H,16,17)
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 42n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051189
PNG
((1-Phenyl-ethyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES CC(NC(=O)OCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2/c1-12(13-6-3-2-4-7-13)18-15(19)20-9-5-8-14-10-16-11-17-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,16,17)(H,18,19)
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 49n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051194
PNG
((3-{[3-(1H-Imidazol-4-yl)-propoxycarbonylamino]-me...)
Show SMILES O=C(NCc1cccc(CNC(=O)OCCCc2cnc[nH]2)c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C22H28N6O4/c29-21(31-8-2-6-19-13-23-15-27-19)25-11-17-4-1-5-18(10-17)12-26-22(30)32-9-3-7-20-14-24-16-28-20/h1,4-5,10,13-16H,2-3,6-9,11-12H2,(H,23,27)(H,24,28)(H,25,29)(H,26,30)
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 50n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051194
PNG
((3-{[3-(1H-Imidazol-4-yl)-propoxycarbonylamino]-me...)
Show SMILES O=C(NCc1cccc(CNC(=O)OCCCc2cnc[nH]2)c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C22H28N6O4/c29-21(31-8-2-6-19-13-23-15-27-19)25-11-17-4-1-5-18(10-17)12-26-22(30)32-9-3-7-20-14-24-16-28-20/h1,4-5,10,13-16H,2-3,6-9,11-12H2,(H,23,27)(H,24,28)(H,25,29)(H,26,30)
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 50.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051209
PNG
(CHEMBL16524 | Cyclopropylmethyl-carbamic acid 3-(1...)
Show SMILES O=C(NCC1CC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C11H17N3O2/c15-11(13-6-9-3-4-9)16-5-1-2-10-7-12-8-14-10/h7-9H,1-6H2,(H,12,14)(H,13,15)
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 52n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051207
PNG
(CHEMBL15830 | Phenyl-thiocarbamic acid 3-(1H-imida...)
Show SMILES S=C(Nc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H15N3OS/c18-13(16-11-5-2-1-3-6-11)17-8-4-7-12-9-14-10-15-12/h1-3,5-6,9-10H,4,7-8H2,(H,14,15)(H,16,18)
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 56n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051225
PNG
(((R)-1-Phenyl-ethyl)-carbamic acid 3-(1H-imidazol-...)
Show SMILES C[C@@H](NC(=O)OCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2/c1-12(13-6-3-2-4-7-13)18-15(19)20-9-5-8-14-10-16-11-17-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,16,17)(H,18,19)/t12-/m1/s1
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 63.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051208
PNG
(Benzyl-ethyl-carbamic acid 3-(1H-imidazol-4-yl)-pr...)
Show SMILES CCN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c1-2-19(12-14-7-4-3-5-8-14)16(20)21-10-6-9-15-11-17-13-18-15/h3-5,7-8,11,13H,2,6,9-10,12H2,1H3,(H,17,18)
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 63.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051225
PNG
(((R)-1-Phenyl-ethyl)-carbamic acid 3-(1H-imidazol-...)
Show SMILES C[C@@H](NC(=O)OCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2/c1-12(13-6-3-2-4-7-13)18-15(19)20-9-5-8-14-10-16-11-17-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,16,17)(H,18,19)/t12-/m1/s1
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 64n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051208
PNG
(Benzyl-ethyl-carbamic acid 3-(1H-imidazol-4-yl)-pr...)
Show SMILES CCN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c1-2-19(12-14-7-4-3-5-8-14)16(20)21-10-6-9-15-11-17-13-18-15/h3-5,7-8,11,13H,2,6,9-10,12H2,1H3,(H,17,18)
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 69n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051182
PNG
(CHEMBL16593 | Cyclohexyl-carbamic acid 3-(1H-imida...)
Show SMILES O=C(NC1CCCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H21N3O2/c17-13(16-11-5-2-1-3-6-11)18-8-4-7-12-9-14-10-15-12/h9-11H,1-8H2,(H,14,15)(H,16,17)
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 69n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051201
PNG
(Benzoyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl ...)
Show SMILES O=C(NC(=O)c1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H15N3O3/c18-13(11-5-2-1-3-6-11)17-14(19)20-8-4-7-12-9-15-10-16-12/h1-3,5-6,9-10H,4,7-8H2,(H,15,16)(H,17,18,19)
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 95n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051191
PNG
(((S)-1-Phenyl-ethyl)-carbamic acid 3-(1H-imidazol-...)
Show SMILES C[C@H](NC(=O)OCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2/c1-12(13-6-3-2-4-7-13)18-15(19)20-9-5-8-14-10-16-11-17-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,16,17)(H,18,19)/t12-/m0/s1
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 95n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051220
PNG
((4-Phenyl-piperidin-1-yl)-carbamic acid 3-(1H-imid...)
Show SMILES O=C(NN1CCC(CC1)c1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C18H24N4O2/c23-18(24-12-4-7-17-13-19-14-20-17)21-22-10-8-16(9-11-22)15-5-2-1-3-6-15/h1-3,5-6,13-14,16H,4,7-12H2,(H,19,20)(H,21,23)
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 100n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051220
PNG
((4-Phenyl-piperidin-1-yl)-carbamic acid 3-(1H-imid...)
Show SMILES O=C(NN1CCC(CC1)c1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C18H24N4O2/c23-18(24-12-4-7-17-13-19-14-20-17)21-22-10-8-16(9-11-22)15-5-2-1-3-6-15/h1-3,5-6,13-14,16H,4,7-12H2,(H,19,20)(H,21,23)
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 105n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051200
PNG
(CHEMBL16274 | Naphthalen-2-yl-carbamic acid 3-(1H-...)
Show SMILES O=C(Nc1ccc2ccccc2c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C17H17N3O2/c21-17(22-9-3-6-16-11-18-12-19-16)20-15-8-7-13-4-1-2-5-14(13)10-15/h1-2,4-5,7-8,10-12H,3,6,9H2,(H,18,19)(H,20,21)
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 114n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051200
PNG
(CHEMBL16274 | Naphthalen-2-yl-carbamic acid 3-(1H-...)
Show SMILES O=C(Nc1ccc2ccccc2c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C17H17N3O2/c21-17(22-9-3-6-16-11-18-12-19-16)20-15-8-7-13-4-1-2-5-14(13)10-15/h1-2,4-5,7-8,10-12H,3,6,9H2,(H,18,19)(H,20,21)
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 126n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051197
PNG
(CHEMBL263071 | Diphenyl-carbamic acid 3-(1H-imidaz...)
Show SMILES O=C(OCCCc1cnc[nH]1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H19N3O2/c23-19(24-13-7-8-16-14-20-15-21-16)22(17-9-3-1-4-10-17)18-11-5-2-6-12-18/h1-6,9-12,14-15H,7-8,13H2,(H,20,21)
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 165n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051216
PNG
((4-Amino-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Nc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H16N4O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7,14H2,(H,15,16)(H,17,18)
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 355n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051219
PNG
((4-Amino-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Nc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H18N4O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8,15H2,(H,16,18)(H,17,19)
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 501n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50051219
PNG
((4-Amino-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Nc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H18N4O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8,15H2,(H,16,18)(H,17,19)
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 541n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051193
PNG
((3-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(CNC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-6-2-4-12-9-15-10-17-12)16-8-11-3-1-5-13(7-11)18(20)21/h1,3,5,7,9-10H,2,4,6,8H2,(H,15,17)(H,16,19)
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 1.00E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051220
PNG
((4-Phenyl-piperidin-1-yl)-carbamic acid 3-(1H-imid...)
Show SMILES O=C(NN1CCC(CC1)c1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C18H24N4O2/c23-18(24-12-4-7-17-13-19-14-20-17)21-22-10-8-16(9-11-22)15-5-2-1-3-6-15/h1-3,5-6,13-14,16H,4,7-12H2,(H,19,20)(H,21,23)
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 3.16E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051214
PNG
((4-Fluoro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16FN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 3.98E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 5.01E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 7.94E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051200
PNG
(CHEMBL16274 | Naphthalen-2-yl-carbamic acid 3-(1H-...)
Show SMILES O=C(Nc1ccc2ccccc2c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C17H17N3O2/c21-17(22-9-3-6-16-11-18-12-19-16)20-15-8-7-13-4-1-2-5-14(13)10-15/h1-2,4-5,7-8,10-12H,3,6,9H2,(H,18,19)(H,20,21)
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 7.94E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051200
PNG
(CHEMBL16274 | Naphthalen-2-yl-carbamic acid 3-(1H-...)
Show SMILES O=C(Nc1ccc2ccccc2c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C17H17N3O2/c21-17(22-9-3-6-16-11-18-12-19-16)20-15-8-7-13-4-1-2-5-14(13)10-15/h1-2,4-5,7-8,10-12H,3,6,9H2,(H,18,19)(H,20,21)
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 7.94E+3n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051217
PNG
(CHEMBL16142 | Phenyl-carbamic acid 3-(1H-imidazol-...)
Show SMILES O=C(Nc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H15N3O2/c17-13(16-11-5-2-1-3-6-11)18-8-4-7-12-9-14-10-15-12/h1-3,5-6,9-10H,4,7-8H2,(H,14,15)(H,16,17)
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 1.00E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051221
PNG
((4-Trifluoromethyl-benzyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H16F3N3O2/c16-15(17,18)12-5-3-11(4-6-12)8-20-14(22)23-7-1-2-13-9-19-10-21-13/h3-6,9-10H,1-2,7-8H2,(H,19,21)(H,20,22)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051215
PNG
((3-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-6-2-4-11-8-14-9-15-11)16-10-3-1-5-12(7-10)17(19)20/h1,3,5,7-9H,2,4,6H2,(H,14,15)(H,16,18)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051185
PNG
((4-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-7-1-2-12-9-15-10-17-12)16-8-11-3-5-13(6-4-11)18(20)21/h3-6,9-10H,1-2,7-8H2,(H,15,17)(H,16,19)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051192
PNG
((4-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-1-2-11-8-14-9-15-11)16-10-3-5-12(6-4-10)17(19)20/h3-6,8-9H,1-2,7H2,(H,14,15)(H,16,18)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051208
PNG
(Benzyl-ethyl-carbamic acid 3-(1H-imidazol-4-yl)-pr...)
Show SMILES CCN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c1-2-19(12-14-7-4-3-5-8-14)16(20)21-10-6-9-15-11-17-13-18-15/h3-5,7-8,11,13H,2,6,9-10,12H2,1H3,(H,17,18)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051215
PNG
((3-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-6-2-4-11-8-14-9-15-11)16-10-3-1-5-12(7-10)17(19)20/h1,3,5,7-9H,2,4,6H2,(H,14,15)(H,16,18)
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 1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051220
PNG
((4-Phenyl-piperidin-1-yl)-carbamic acid 3-(1H-imid...)
Show SMILES O=C(NN1CCC(CC1)c1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C18H24N4O2/c23-18(24-12-4-7-17-13-19-14-20-17)21-22-10-8-16(9-11-22)15-5-2-1-3-6-15/h1-3,5-6,13-14,16H,4,7-12H2,(H,19,20)(H,21,23)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051203
PNG
((4-Chloro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16ClN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051187
PNG
(Benzyl-methyl-carbamic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES CN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c1-18(11-13-6-3-2-4-7-13)15(19)20-9-5-8-14-10-16-12-17-14/h2-4,6-7,10,12H,5,8-9,11H2,1H3,(H,16,17)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051221
PNG
((4-Trifluoromethyl-benzyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H16F3N3O2/c16-15(17,18)12-5-3-11(4-6-12)8-20-14(22)23-7-1-2-13-9-19-10-21-13/h3-6,9-10H,1-2,7-8H2,(H,19,21)(H,20,22)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051184
PNG
(Benzyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl e...)
Show SMILES O=C(NCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H17N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h1-3,5-6,10-11H,4,7-9H2,(H,15,17)(H,16,18)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051198
PNG
((4-Bromo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Brc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14BrN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051206
PNG
((4-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-5-11(6-4-10)20-13(21)22-7-1-2-12-8-18-9-19-12/h3-6,8-9H,1-2,7H2,(H,18,19)(H,20,21)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051185
PNG
((4-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-7-1-2-12-9-15-10-17-12)16-8-11-3-5-13(6-4-11)18(20)21/h3-6,9-10H,1-2,7-8H2,(H,15,17)(H,16,19)
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 1.58E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051192
PNG
((4-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-1-2-11-8-14-9-15-11)16-10-3-5-12(6-4-10)17(19)20/h3-6,8-9H,1-2,7H2,(H,14,15)(H,16,18)
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 2.00E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051198
PNG
((4-Bromo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Brc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14BrN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 2.51E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 3.16E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051212
PNG
((2-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-3-4-10-8-14-9-15-10)16-11-5-1-2-6-12(11)17(19)20/h1-2,5-6,8-9H,3-4,7H2,(H,14,15)(H,16,18)
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 3.16E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051206
PNG
((4-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-5-11(6-4-10)20-13(21)22-7-1-2-12-8-18-9-19-12/h3-6,8-9H,1-2,7H2,(H,18,19)(H,20,21)
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 3.98E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 3.98E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051208
PNG
(Benzyl-ethyl-carbamic acid 3-(1H-imidazol-4-yl)-pr...)
Show SMILES CCN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c1-2-19(12-14-7-4-3-5-8-14)16(20)21-10-6-9-15-11-17-13-18-15/h3-5,7-8,11,13H,2,6,9-10,12H2,1H3,(H,17,18)
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 3.98E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051184
PNG
(Benzyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl e...)
Show SMILES O=C(NCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H17N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h1-3,5-6,10-11H,4,7-9H2,(H,15,17)(H,16,18)
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 3.98E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051205
PNG
((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)
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 3.98E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051214
PNG
((4-Fluoro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16FN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 5.01E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051225
PNG
(((R)-1-Phenyl-ethyl)-carbamic acid 3-(1H-imidazol-...)
Show SMILES C[C@@H](NC(=O)OCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2/c1-12(13-6-3-2-4-7-13)18-15(19)20-9-5-8-14-10-16-11-17-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,16,17)(H,18,19)/t12-/m1/s1
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 5.01E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051224
PNG
(CHEMBL16407 | Cyclopentylmethyl-carbamic acid 3-(1...)
Show SMILES O=C(NCC1CCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H21N3O2/c17-13(15-8-11-4-1-2-5-11)18-7-3-6-12-9-14-10-16-12/h9-11H,1-8H2,(H,14,16)(H,15,17)
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 5.01E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051193
PNG
((3-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1cccc(CNC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H16N4O4/c19-14(22-6-2-4-12-9-15-10-17-12)16-8-11-3-1-5-13(7-11)18(20)21/h1,3,5,7,9-10H,2,4,6,8H2,(H,15,17)(H,16,19)
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 5.01E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051212
PNG
((2-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14N4O4/c18-13(21-7-3-4-10-8-14-9-15-10)16-11-5-1-2-6-12(11)17(19)20/h1-2,5-6,8-9H,3-4,7H2,(H,14,15)(H,16,18)
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 5.01E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051199
PNG
((4-Chloro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14ClN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 6.31E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051196
PNG
(CHEMBL16056 | Cyclohexylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H23N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h10-12H,1-9H2,(H,15,17)(H,16,18)
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 6.31E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
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 6.31E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051204
PNG
(CHEMBL274262 | Phenethyl-carbamic acid 3-(1H-imida...)
Show SMILES O=C(NCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c19-15(17-9-8-13-5-2-1-3-6-13)20-10-4-7-14-11-16-12-18-14/h1-3,5-6,11-12H,4,7-10H2,(H,16,18)(H,17,19)
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 6.31E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051222
PNG
((4-Fluoro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14FN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 6.31E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051210
PNG
((3-Phenyl-propyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES O=C(NCCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c20-16(21-11-5-9-15-12-17-13-19-15)18-10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,17,19)(H,18,20)
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 7.94E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051222
PNG
((4-Fluoro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Fc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14FN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 7.94E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051203
PNG
((4-Chloro-benzyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16ClN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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 7.94E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051199
PNG
((4-Chloro-phenyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES Clc1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14ClN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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 7.94E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051210
PNG
((3-Phenyl-propyl)-carbamic acid 3-(1H-imidazol-4-y...)
Show SMILES O=C(NCCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O2/c20-16(21-11-5-9-15-12-17-13-19-15)18-10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,17,19)(H,18,20)
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 7.94E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051225
PNG
(((R)-1-Phenyl-ethyl)-carbamic acid 3-(1H-imidazol-...)
Show SMILES C[C@@H](NC(=O)OCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C15H19N3O2/c1-12(13-6-3-2-4-7-13)18-15(19)20-9-5-8-14-10-16-11-17-14/h2-4,6-7,10-12H,5,8-9H2,1H3,(H,16,17)(H,18,19)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051194
PNG
((3-{[3-(1H-Imidazol-4-yl)-propoxycarbonylamino]-me...)
Show SMILES O=C(NCc1cccc(CNC(=O)OCCCc2cnc[nH]2)c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C22H28N6O4/c29-21(31-8-2-6-19-13-23-15-27-19)25-11-17-4-1-5-18(10-17)12-26-22(30)32-9-3-7-20-14-24-16-28-20/h1,4-5,10,13-16H,2-3,6-9,11-12H2,(H,23,27)(H,24,28)(H,25,29)(H,26,30)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051187
PNG
(Benzyl-methyl-carbamic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES CN(Cc1ccccc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c1-18(11-13-6-3-2-4-7-13)15(19)20-9-5-8-14-10-16-12-17-14/h2-4,6-7,10,12H,5,8-9,11H2,1H3,(H,16,17)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051219
PNG
((4-Amino-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Nc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H18N4O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8,15H2,(H,16,18)(H,17,19)
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 1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051224
PNG
(CHEMBL16407 | Cyclopentylmethyl-carbamic acid 3-(1...)
Show SMILES O=C(NCC1CCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H21N3O2/c17-13(15-8-11-4-1-2-5-11)18-7-3-6-12-9-14-10-16-12/h9-11H,1-8H2,(H,14,16)(H,15,17)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051205
PNG
((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)
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 1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051211
PNG
(CHEMBL16957 | Cyclobutylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H19N3O2/c16-12(14-7-10-3-1-4-10)17-6-2-5-11-8-13-9-15-11/h8-10H,1-7H2,(H,13,15)(H,14,16)
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 1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051186
PNG
(CHEMBL16331 | Furan-2-ylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCc1ccco1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H15N3O3/c16-12(14-8-11-4-2-5-17-11)18-6-1-3-10-7-13-9-15-10/h2,4-5,7,9H,1,3,6,8H2,(H,13,15)(H,14,16)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051217
PNG
(CHEMBL16142 | Phenyl-carbamic acid 3-(1H-imidazol-...)
Show SMILES O=C(Nc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H15N3O2/c17-13(16-11-5-2-1-3-6-11)18-8-4-7-12-9-14-10-15-12/h1-3,5-6,9-10H,4,7-8H2,(H,14,15)(H,16,17)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051186
PNG
(CHEMBL16331 | Furan-2-ylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCc1ccco1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H15N3O3/c16-12(14-8-11-4-2-5-17-11)18-6-1-3-10-7-13-9-15-10/h2,4-5,7,9H,1,3,6,8H2,(H,13,15)(H,14,16)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051194
PNG
((3-{[3-(1H-Imidazol-4-yl)-propoxycarbonylamino]-me...)
Show SMILES O=C(NCc1cccc(CNC(=O)OCCCc2cnc[nH]2)c1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C22H28N6O4/c29-21(31-8-2-6-19-13-23-15-27-19)25-11-17-4-1-5-18(10-17)12-26-22(30)32-9-3-7-20-14-24-16-28-20/h1,4-5,10,13-16H,2-3,6-9,11-12H2,(H,23,27)(H,24,28)(H,25,29)(H,26,30)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051219
PNG
((4-Amino-benzyl)-carbamic acid 3-(1H-imidazol-4-yl...)
Show SMILES Nc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H18N4O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8,15H2,(H,16,18)(H,17,19)
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 1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051204
PNG
(CHEMBL274262 | Phenethyl-carbamic acid 3-(1H-imida...)
Show SMILES O=C(NCCc1ccccc1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O2/c19-15(17-9-8-13-5-2-1-3-6-13)20-10-4-7-14-11-16-12-18-14/h1-3,5-6,11-12H,4,7-10H2,(H,16,18)(H,17,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051211
PNG
(CHEMBL16957 | Cyclobutylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C12H19N3O2/c16-12(14-7-10-3-1-4-10)17-6-2-5-11-8-13-9-15-11/h8-10H,1-7H2,(H,13,15)(H,14,16)
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>1.00E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50051196
PNG
(CHEMBL16056 | Cyclohexylmethyl-carbamic acid 3-(1H...)
Show SMILES O=C(NCC1CCCCC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H23N3O2/c18-14(16-9-12-5-2-1-3-6-12)19-8-4-7-13-10-15-11-17-13/h10-12H,1-9H2,(H,15,17)(H,16,18)
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 1.26E+5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum

J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%