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USPatent US9675571

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168377
PNG
(US9675571, 36)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cc(no1)C(F)(F)F)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C23H29F3N4O4/c1-12(2)10-30(11-13(3)4)18-6-5-14(15-8-16(15)21(31)32)7-17(18)27-22(33)28-20-9-19(29-34-20)23(24,25)26/h5-7,9,12-13,15-16H,8,10-11H2,1-4H3,(H,31,32)(H2,27,28,33)/t15-,16-/m1/s1
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n/an/an/an/a 7n/an/an/a25



SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168360
PNG
(US9675571, 34)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cc(no1)C1CC1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C25H34N4O4/c1-14(2)12-29(13-15(3)4)22-8-7-17(18-10-19(18)24(30)31)9-21(22)26-25(32)27-23-11-20(28-33-23)16-5-6-16/h7-9,11,14-16,18-19H,5-6,10,12-13H2,1-4H3,(H,30,31)(H2,26,27,32)/t18-,19-/m1/s1
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US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168399
PNG
(US9675571, 60)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Cc1ccc(C)cc1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C27H36N2O3/c1-17(2)15-29(16-18(3)4)25-11-10-21(22-14-23(22)27(31)32)13-24(25)28-26(30)12-20-8-6-19(5)7-9-20/h6-11,13,17-18,22-23H,12,14-16H2,1-5H3,(H,28,30)(H,31,32)/t22-,23-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168413
PNG
(US9675571, 67)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cc(C)on1)C1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C23H32N4O4/c1-13(2)11-27(12-14(3)4)20-7-6-16(17-10-18(17)22(28)29)9-19(20)24-23(30)25-21-8-15(5)31-26-21/h6-9,13-14,17-18H,10-12H2,1-5H3,(H,28,29)(H2,24,25,26,30)/t17?,18-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168414
PNG
(US9675571, 71)
Show SMILES CCOC(=O)Nc1ccc(NC(=O)Nc2cc(ccc2N(CC(C)C)CC(C)C)[C@@H]2C[C@@H]2C(O)=O)cc1 |r|
Show InChI InChI=1S/C28H38N4O5/c1-6-37-28(36)30-21-10-8-20(9-11-21)29-27(35)31-24-13-19(22-14-23(22)26(33)34)7-12-25(24)32(15-17(2)3)16-18(4)5/h7-13,17-18,22-23H,6,14-16H2,1-5H3,(H,30,36)(H,33,34)(H2,29,31,35)/t22-,23-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168435
PNG
(US9675571, 129)
Show SMILES CC(C)CN(C1CCCCC1)c1ccc(cc1NC(=O)Nc1cc(C)no1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C25H34N4O4/c1-15(2)14-29(18-7-5-4-6-8-18)22-10-9-17(19-13-20(19)24(30)31)12-21(22)26-25(32)27-23-11-16(3)28-33-23/h9-12,15,18-20H,4-8,13-14H2,1-3H3,(H,30,31)(H2,26,27,32)/t19-,20-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168314
PNG
(US9675571, 1J)
Show SMILES COC(=O)[C@H]1C[C@H]1c1ccc(N(CC(C)C)CC(C)C)c(c1)[N+]([O-])=O |r|
Show InChI InChI=1S/C19H28N2O4/c1-12(2)10-20(11-13(3)4)17-7-6-14(8-18(17)21(23)24)15-9-16(15)19(22)25-5/h6-8,12-13,15-16H,9-11H2,1-5H3/t15-,16-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168320
PNG
(US9675571, 6)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(Cl)c(Cl)c1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C25H31Cl2N3O3/c1-14(2)12-30(13-15(3)4)23-8-5-16(18-11-19(18)24(31)32)9-22(23)29-25(33)28-17-6-7-20(26)21(27)10-17/h5-10,14-15,18-19H,11-13H2,1-4H3,(H,31,32)(H2,28,29,33)/t18-,19-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168396
PNG
(US9675571, 43)
Show SMILES COCCN(Cc1ccc(Cl)cc1)c1ccc(cc1NC(=O)Nc1ccc(C)cc1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C28H30ClN3O4/c1-18-3-10-22(11-4-18)30-28(35)31-25-15-20(23-16-24(23)27(33)34)7-12-26(25)32(13-14-36-2)17-19-5-8-21(29)9-6-19/h3-12,15,23-24H,13-14,16-17H2,1-2H3,(H,33,34)(H2,30,31,35)/t23-,24-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168431
PNG
(US9675571, 87)
Show SMILES OC(=O)[C@@H]1C[C@@H]1c1ccc(N(CCC(F)(F)F)C2CCCCC2)c(NC(=O)Nc2cncnc2)c1 |r|
Show InChI InChI=1S/C24H28F3N5O3/c25-24(26,27)8-9-32(17-4-2-1-3-5-17)21-7-6-15(18-11-19(18)22(33)34)10-20(21)31-23(35)30-16-12-28-14-29-13-16/h6-7,10,12-14,17-19H,1-5,8-9,11H2,(H,33,34)(H2,30,31,35)/t18-,19-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168315
PNG
(US9675571, ent-1J)
Show SMILES COC(=O)C1CC1c1ccc(N(CC(C)C)CC(C)C)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C19H28N2O4/c1-12(2)10-20(11-13(3)4)17-7-6-14(8-18(17)21(23)24)15-9-16(15)19(22)25-5/h6-8,12-13,15-16H,9-11H2,1-5H3
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US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168318
PNG
(US9675571, 5)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(cc1)C(F)(F)F)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C26H32F3N3O3/c1-15(2)13-32(14-16(3)4)23-10-5-17(20-12-21(20)24(33)34)11-22(23)31-25(35)30-19-8-6-18(7-9-19)26(27,28)29/h5-11,15-16,20-21H,12-14H2,1-4H3,(H,33,34)(H2,30,31,35)/t20-,21-/m1/s1
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US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168334
PNG
(US9675571, 20)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(cc1)C1CC1)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C28H37N3O3/c1-17(2)15-31(16-18(3)4)26-12-9-21(23-14-24(23)27(32)33)13-25(26)30-28(34)29-22-10-7-20(8-11-22)19-5-6-19/h7-13,17-19,23-24H,5-6,14-16H2,1-4H3,(H,32,33)(H2,29,30,34)/t23-,24-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168419
PNG
(US9675571, 73)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2N(CCCC(F)(F)F)C2CCCCC2)[C@H]2C[C@H]2C(O)=O)cc1 |r|
Show InChI InChI=1S/C28H34F3N3O3/c1-18-8-11-20(12-9-18)32-27(37)33-24-16-19(22-17-23(22)26(35)36)10-13-25(24)34(15-5-14-28(29,30)31)21-6-3-2-4-7-21/h8-13,16,21-23H,2-7,14-15,17H2,1H3,(H,35,36)(H2,32,33,37)/t22-,23-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168434
PNG
(US9675571, 118)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Cc1ccc(C)nc1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C26H35N3O3/c1-16(2)14-29(15-17(3)4)24-9-8-20(21-12-22(21)26(31)32)11-23(24)28-25(30)10-19-7-6-18(5)27-13-19/h6-9,11,13,16-17,21-22H,10,12,14-15H2,1-5H3,(H,28,30)(H,31,32)/t21-,22-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168326
PNG
(US9675571, 15)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(CC#C)cc1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C28H35N3O3/c1-6-7-20-8-11-22(12-9-20)29-28(34)30-25-14-21(23-15-24(23)27(32)33)10-13-26(25)31(16-18(2)3)17-19(4)5/h1,8-14,18-19,23-24H,7,15-17H2,2-5H3,(H,32,33)(H2,29,30,34)/t23-,24-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168337
PNG
(US9675571, 30)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cc(C)no1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C23H32N4O4/c1-13(2)11-27(12-14(3)4)20-7-6-16(17-10-18(17)22(28)29)9-19(20)24-23(30)25-21-8-15(5)26-31-21/h6-9,13-14,17-18H,10-12H2,1-5H3,(H,28,29)(H2,24,25,30)/t17-,18-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168417
PNG
(US9675571, 72)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(OCC(F)(F)F)cc1)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C27H34F3N3O4/c1-16(2)13-33(14-17(3)4)24-10-5-18(21-12-22(21)25(34)35)11-23(24)32-26(36)31-19-6-8-20(9-7-19)37-15-27(28,29)30/h5-11,16-17,21-22H,12-15H2,1-4H3,(H,34,35)(H2,31,32,36)/t21-,22-/m0/s1
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n/an/an/an/a 200n/an/an/a25



SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168433
PNG
(US9675571, 117)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Cc1ccc(F)cc1)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C26H33FN2O3/c1-16(2)14-29(15-17(3)4)24-10-7-19(21-13-22(21)26(31)32)12-23(24)28-25(30)11-18-5-8-20(27)9-6-18/h5-10,12,16-17,21-22H,11,13-15H2,1-4H3,(H,28,30)(H,31,32)/t21-,22-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168322
PNG
(US9675571, 9)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccccc1Cl)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C25H32ClN3O3/c1-15(2)13-29(14-16(3)4)23-10-9-17(18-12-19(18)24(30)31)11-22(23)28-25(32)27-21-8-6-5-7-20(21)26/h5-11,15-16,18-19H,12-14H2,1-4H3,(H,30,31)(H2,27,28,32)/t18-,19-/m1/s1
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n/an/an/an/a 97n/an/an/a25



SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168324
PNG
(US9675571, 14)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(C)cc1Cl)[C@H]1C[C@H]1C(O)=O |r|
Show InChI InChI=1S/C26H34ClN3O3/c1-15(2)13-30(14-16(3)4)24-9-7-18(19-12-20(19)25(31)32)11-23(24)29-26(33)28-22-8-6-17(5)10-21(22)27/h6-11,15-16,19-20H,12-14H2,1-5H3,(H,31,32)(H2,28,29,33)/t19-,20-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168329
PNG
(US9675571, 19)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cccc(C)c1)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C26H35N3O3/c1-16(2)14-29(15-17(3)4)24-10-9-19(21-13-22(21)25(30)31)12-23(24)28-26(32)27-20-8-6-7-18(5)11-20/h6-12,16-17,21-22H,13-15H2,1-5H3,(H,30,31)(H2,27,28,32)/t21-,22-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168400
PNG
(US9675571, 63)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Cc1cc(C)no1)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C24H33N3O4/c1-14(2)12-27(13-15(3)4)22-7-6-17(19-11-20(19)24(29)30)9-21(22)25-23(28)10-18-8-16(5)26-31-18/h6-9,14-15,19-20H,10-13H2,1-5H3,(H,25,28)(H,29,30)/t19-,20-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168424
PNG
(US9675571, 76)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2N(CCCC(F)(F)F)C2CCCCC2)[C@@H]2C[C@@H]2C(O)=O)cc1 |r|
Show InChI InChI=1S/C28H34F3N3O3/c1-18-8-11-20(12-9-18)32-27(37)33-24-16-19(22-17-23(22)26(35)36)10-13-25(24)34(15-5-14-28(29,30)31)21-6-3-2-4-7-21/h8-13,16,21-23H,2-7,14-15,17H2,1H3,(H,35,36)(H2,32,33,37)/t22-,23-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168430
PNG
(US9675571, 77)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cnc(C)nc1)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C24H33N5O3/c1-14(2)12-29(13-15(3)4)22-7-6-17(19-9-20(19)23(30)31)8-21(22)28-24(32)27-18-10-25-16(5)26-11-18/h6-8,10-11,14-15,19-20H,9,12-13H2,1-5H3,(H,30,31)(H2,27,28,32)/t19-,20-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168423
PNG
(US9675571, 75)
Show SMILES OC(=O)[C@@H]1C[C@@H]1c1ccc(N(CCCC(F)(F)F)C2CCCCC2)c(NC(=O)Nc2cncnc2)c1 |r|
Show InChI InChI=1S/C25H30F3N5O3/c26-25(27,28)9-4-10-33(18-5-2-1-3-6-18)22-8-7-16(19-12-20(19)23(34)35)11-21(22)32-24(36)31-17-13-29-15-30-14-17/h7-8,11,13-15,18-20H,1-6,9-10,12H2,(H,34,35)(H2,31,32,36)/t19-,20-/m1/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168358
PNG
(US9675571, 31)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cc(C)no1)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C23H32N4O4/c1-13(2)11-27(12-14(3)4)20-7-6-16(17-10-18(17)22(28)29)9-19(20)24-23(30)25-21-8-15(5)26-31-21/h6-9,13-14,17-18H,10-12H2,1-5H3,(H,28,29)(H2,24,25,30)/t17-,18-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))		BDBM168378
PNG
(US9675571, 37)
Show SMILES CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1cc(no1)C(F)(F)F)[C@@H]1C[C@@H]1C(O)=O |r|
Show InChI InChI=1S/C23H29F3N4O4/c1-12(2)10-30(11-13(3)4)18-6-5-14(15-8-16(15)21(31)32)7-17(18)27-22(33)28-20-9-19(29-34-20)23(24,25)26/h5-7,9,12-13,15-16H,8,10-11H2,1-4H3,(H,31,32)(H2,27,28,33)/t15-,16-/m0/s1
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SRMLSC

US Patent


Assay Description
Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...

US Patent US9675571 (2017)


BindingDB Entry DOI: 10.7270/Q2BK19HD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%