Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350851
(UNC2123A | US10004755, Compound UNC2123A | US97956...)Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12 |r,wU:7.7,wD:1.0,(5.85,-7.2,;5.45,-5.71,;6.54,-4.62,;6.14,-3.13,;4.66,-2.73,;3.57,-3.82,;3.97,-5.31,;4.26,-1.25,;5.16,,;4.26,1.25,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;3.57,3.82,;2.79,.77,;1.46,1.54,;.13,.77,;.13,-.77,;-1.21,-1.54,;-2.54,-.77,;-3.88,-1.54,;-5.21,-.77,;-6.54,,;-6.54,-1.54,;1.46,-1.54,;2.79,-.77,)| Show InChI InChI=1S/C23H28FN5/c24-17-5-3-16(4-6-17)21-14-29(19-9-7-18(25)8-10-19)22-20(21)13-27-23(28-22)26-12-11-15-1-2-15/h3-6,13-15,18-19H,1-2,7-12,25H2,(H,26,27,28)/t18-,19? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350861
(UNC2371A | US10004755, Compound UNC2371A | US97956...)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1 |r,wU:14.15,wD:18.19,(9.28,7.65,;7.79,7.25,;7.39,5.76,;5.9,5.36,;4.81,6.45,;3.33,6.05,;2.93,4.57,;4.02,3.48,;3.62,1.99,;2.13,1.59,;1.04,2.68,;1.44,4.17,;1.73,.1,;2.64,-1.14,;1.73,-2.39,;2.13,-3.88,;3.62,-4.27,;4.02,-5.76,;2.93,-6.85,;3.33,-8.34,;1.44,-6.45,;1.04,-4.96,;.27,-1.91,;-1.07,-2.68,;-2.4,-1.91,;-3.73,-2.68,;-5.07,-1.91,;-6.4,-2.68,;-7.74,-1.91,;-8.51,-.58,;-9.28,-1.91,;-2.4,-.37,;-1.07,.4,;.27,-.37,;5.21,7.94,;6.7,8.34,)| Show InChI InChI=1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350871
(UNC2433A | US9795606, D2)Show SMILES CCCCNc1ncc2n(cc(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 |r,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;2.48,5.66,;2.88,7.14,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C27H37N5O3S/c1-2-3-15-28-27-29-18-25-26(30-27)24(20-7-11-22(33)12-8-20)19-32(25)21-9-13-23(14-10-21)36(34,35)31-16-5-4-6-17-31/h9-10,13-14,18-20,22,33H,2-8,11-12,15-17H2,1H3,(H,28,29,30)/t20?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350842
(UNC1970A | US10004755, Compound UNC1970A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1 |r,wU:11.11,wD:15.15,(-6.54,-1.54,;-5.21,-.77,;-3.88,-1.54,;-2.54,-.77,;-1.21,-1.54,;.13,-.77,;.13,.77,;1.46,1.54,;2.79,.77,;4.26,1.25,;5.16,,;4.26,-1.25,;4.66,-2.73,;6.14,-3.13,;6.54,-4.62,;5.45,-5.71,;5.85,-7.2,;3.97,-5.31,;3.57,-3.82,;2.79,-.77,;1.46,-1.54,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;3.57,3.82,)| Show InChI InChI=1S/C22H28FN5/c1-2-3-12-25-22-26-13-19-20(15-4-6-16(23)7-5-15)14-28(21(19)27-22)18-10-8-17(24)9-11-18/h4-7,13-14,17-18H,2-3,8-12,24H2,1H3,(H,25,26,27)/t17-,18? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350844
(UNC1972A | US10004755, Compound UNC1972A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;2.48,6.45,;3.57,7.54,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C26H36N6O3S/c1-2-3-12-28-26-29-17-23-24(18-32(25(23)30-26)21-8-6-20(27)7-9-21)19-4-10-22(11-5-19)36(33,34)31-13-15-35-16-14-31/h4-5,10-11,17-18,20-21H,2-3,6-9,12-16,27H2,1H3,(H,28,29,30)/t20-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350866
(UNC1668A | US10004755, Compound UNC1668A | US97956...)Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1 |r,wU:12.11,wD:15.15,(-7.49,-2.83,;-6.15,-2.06,;-4.82,-2.83,;-3.48,-2.06,;-2.15,-2.83,;-.82,-2.06,;-.82,-.52,;.52,.25,;1.85,-.52,;3.31,-.04,;4.22,-1.29,;3.31,-2.53,;3.71,-4.02,;5.2,-4.42,;5.6,-5.91,;4.51,-7,;4.91,-8.48,;3.02,-6.6,;2.62,-5.11,;1.85,-2.06,;.52,-2.83,;3.71,1.45,;5.2,1.84,;5.6,3.33,;4.51,4.42,;4.91,5.91,;6.4,5.51,;7.49,6.6,;7.09,8.09,;5.6,8.48,;4.51,7.4,;3.02,4.02,;1.93,5.11,;2.62,2.53,)| Show InChI InChI=1S/C26H34FN5O2/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)31-11-13-34-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350868
(UNC1670A | US10004755, Compound UNC1670A | US97956...)Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1 |r,wU:12.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;.99,5.26,;1.68,2.68,;3.97,6.05,;2.43,6.05,;4.36,7.54,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C26H34FN5O4S/c1-2-3-10-28-26-29-16-21-22(17-32(25(21)30-26)19-5-7-20(33)8-6-19)18-4-9-24(23(27)15-18)37(34,35)31-11-13-36-14-12-31/h4,9,15-17,19-20,33H,2-3,5-8,10-14H2,1H3,(H,28,29,30)/t19-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350846
(UNC2026A | US10004755, Compound UNC2026A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;2.43,6.05,;3.57,7.54,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C27H36N4O4S/c1-2-3-14-28-27-29-17-24-25(18-31(26(24)30-27)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)23-12-15-35-16-13-23/h4-5,10-11,17-18,20-21,23,32H,2-3,6-9,12-16H2,1H3,(H,28,29,30)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350848
(UNC2078A | US10004755, Compound UNC2078A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;2.43,6.05,;3.2,7.39,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C27H37N5O3S/c1-2-3-15-28-27-29-18-24-25(19-32(26(24)30-27)21-9-11-22(33)12-10-21)20-7-13-23(14-8-20)36(34,35)31-16-5-4-6-17-31/h7-8,13-14,18-19,21-22,33H,2-6,9-12,15-17H2,1H3,(H,28,29,30)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350849
(UNC2094A | US10004755, Compound UNC2094A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(F)c(F)c1 |r,wU:11.11,wD:15.15,(-6.54,-1.54,;-5.21,-.77,;-3.88,-1.54,;-2.54,-.77,;-1.21,-1.54,;.13,-.77,;.13,.77,;1.46,1.54,;2.79,.77,;4.26,1.25,;5.16,,;4.26,-1.25,;4.66,-2.73,;6.14,-3.13,;6.54,-4.62,;5.45,-5.71,;5.85,-7.2,;3.97,-5.31,;3.57,-3.82,;2.79,-.77,;1.46,-1.54,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;2.88,6.4,;3.57,3.82,)| Show InChI InChI=1S/C22H26F2N4O/c1-2-3-10-25-22-26-12-17-18(14-4-9-19(23)20(24)11-14)13-28(21(17)27-22)15-5-7-16(29)8-6-15/h4,9,11-13,15-16,29H,2-3,5-8,10H2,1H3,(H,25,26,27)/t15?,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350852
(UNC2124A | US10004755, Compound UNC2124A | US97956...)Show SMILES N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCCCO)nc12 |r,wU:7.7,wD:1.0,(6.52,-7.2,;6.12,-5.71,;7.21,-4.62,;6.81,-3.13,;5.32,-2.73,;4.23,-3.82,;4.63,-5.31,;4.92,-1.25,;5.83,,;4.92,1.25,;5.32,2.73,;6.81,3.13,;7.21,4.62,;6.12,5.71,;6.52,7.2,;4.63,5.31,;4.23,3.82,;3.46,.77,;2.13,1.54,;.79,.77,;.79,-.77,;-.54,-1.54,;-1.87,-.77,;-3.21,-1.54,;-4.54,-.77,;-5.88,-1.54,;-7.21,-.77,;2.13,-1.54,;3.46,-.77,)| Show InChI InChI=1S/C22H28FN5O/c23-16-5-3-15(4-6-16)20-14-28(18-9-7-17(24)8-10-18)21-19(20)13-26-22(27-21)25-11-1-2-12-29/h3-6,13-14,17-18,29H,1-2,7-12,24H2,(H,25,26,27)/t17-,18? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350855
(UNC2143A | US10004755, Compound UNC2143A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCNCC2)cc1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;3.97,6.05,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,;2.08,4.17,;1.68,2.68,)| Show InChI InChI=1S/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(19-33(26(24)31-27)22-8-10-23(34)11-9-22)21-6-4-20(5-7-21)18-32-15-13-28-14-16-32/h4-7,17,19,22-23,28,34H,2-3,8-16,18H2,1H3,(H,29,30,31)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350839
(UNC1534A | US9795606, A3)Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1 |r,wU:13.12,wD:16.16,(-9.17,-3.77,;-7.84,-3,;-6.5,-3.77,;-5.17,-3,;-3.84,-3.77,;-2.5,-3,;-2.5,-1.46,;-1.17,-.69,;.16,-1.46,;1.63,-.99,;2.53,-2.23,;1.63,-3.48,;2.03,-4.96,;3.51,-5.36,;4.6,-4.27,;6.09,-4.67,;6.49,-6.16,;7.98,-6.56,;5.4,-7.25,;3.91,-6.85,;.16,-3,;-1.17,-3.77,;2.03,.5,;3.51,.9,;3.91,2.39,;2.82,3.48,;1.34,3.08,;.94,1.59,;3.22,4.96,;1.68,4.96,;3.22,6.5,;4.71,5.36,;5.8,4.27,;7.29,4.67,;7.68,6.16,;9.17,6.56,;6.6,7.25,;5.11,6.85,)| Show InChI InChI=1S/C28H41N7O2S/c1-3-4-13-30-28-31-18-25-26(20-34(27(25)32-28)19-21-5-9-23(29)10-6-21)22-7-11-24(12-8-22)38(36,37)35-16-14-33(2)15-17-35/h7-8,11-12,18,20-21,23H,3-6,9-10,13-17,19,29H2,1-2H3,(H,30,31,32)/t21-,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350841
(UNC1536A | US9795606, A5)Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1 |r,wU:13.12,wD:16.16,(-8.57,-3.77,;-7.24,-3,;-5.91,-3.77,;-4.57,-3,;-3.24,-3.77,;-1.91,-3,;-1.91,-1.46,;-.57,-.69,;.76,-1.46,;2.23,-.99,;3.13,-2.23,;2.23,-3.48,;2.62,-4.96,;4.11,-5.36,;5.2,-4.27,;6.69,-4.67,;7.09,-6.16,;8.57,-6.56,;6,-7.25,;4.51,-6.85,;.76,-3,;-.57,-3.77,;2.62,.5,;4.11,.9,;4.51,2.39,;3.42,3.48,;1.93,3.08,;.85,4.17,;1.54,1.59,;3.82,4.96,;2.28,4.96,;3.82,6.5,;5.31,5.36,;6.4,4.27,;7.88,4.67,;8.28,6.16,;7.19,7.25,;5.71,6.85,)| Show InChI InChI=1S/C27H37FN6O3S/c1-2-3-10-30-27-31-16-22-23(18-33(26(22)32-27)17-19-4-7-21(29)8-5-19)20-6-9-25(24(28)15-20)38(35,36)34-11-13-37-14-12-34/h6,9,15-16,18-19,21H,2-5,7-8,10-14,17,29H2,1H3,(H,30,31,32)/t19-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350850
(UNC2095A | US10004755, Compound UNC2095A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(F)(F)CC1 |r,wU:11.11,wD:15.15,(-9.17,-2.68,;-7.84,-1.91,;-6.5,-2.68,;-5.17,-1.91,;-3.84,-2.68,;-2.5,-1.91,;-2.5,-.37,;-1.17,.4,;.16,-.37,;1.63,.1,;2.53,-1.14,;1.63,-2.39,;2.03,-3.88,;3.51,-4.27,;3.91,-5.76,;2.82,-6.85,;3.22,-8.34,;1.34,-6.45,;.94,-4.96,;.16,-1.91,;-1.17,-2.68,;2.03,1.59,;3.51,1.99,;3.91,3.48,;2.82,4.57,;1.34,4.17,;.94,2.68,;3.22,6.05,;1.68,6.05,;2.45,7.39,;4.71,6.45,;5.8,5.36,;7.29,5.76,;7.68,7.25,;9.17,6.85,;8.77,8.34,;6.6,8.34,;5.11,7.94,)| Show InChI InChI=1S/C27H35F2N5O3S/c1-2-3-14-30-26-31-17-23-24(18-34(25(23)32-26)20-6-8-21(35)9-7-20)19-4-10-22(11-5-19)38(36,37)33-15-12-27(28,29)13-16-33/h4-5,10-11,17-18,20-21,35H,2-3,6-9,12-16H2,1H3,(H,30,31,32)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350854
(UNC2142A | US10004755, Compound UNC2142A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCOCC2)cc1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;3.97,6.05,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,;2.08,4.17,;1.68,2.68,)| Show InChI InChI=1S/C27H37N5O2/c1-2-3-12-28-27-29-17-24-25(19-32(26(24)30-27)22-8-10-23(33)11-9-22)21-6-4-20(5-7-21)18-31-13-15-34-16-14-31/h4-7,17,19,22-23,33H,2-3,8-16,18H2,1H3,(H,28,29,30)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350857
(UNC2253A | US10004755, Compound UNC2253A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;3.57,7.54,;2.48,6.45,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C29H39N5O2/c1-2-3-14-30-28-31-19-25-26(20-34(27(25)32-28)23-8-10-24(35)11-9-23)21-4-6-22(7-5-21)29(12-13-29)33-15-17-36-18-16-33/h4-7,19-20,23-24,35H,2-3,8-18H2,1H3,(H,30,31,32)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350862
(UNC1651A | US9795606, B23)Show SMILES CC(C)(C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1 |r,wU:12.11,wD:15.15,(-11.12,-1.16,;-9.79,-.39,;-9.79,1.15,;-9.79,-1.93,;-8.45,-1.16,;-7.12,-.39,;-7.12,1.15,;-5.79,1.92,;-4.45,1.15,;-2.99,1.63,;-2.08,.38,;-2.99,-.86,;-2.59,-2.35,;-1.1,-2.75,;-.7,-4.24,;-1.79,-5.33,;-1.39,-6.81,;-3.28,-4.93,;-3.68,-3.44,;-4.45,-.39,;-5.79,-1.16,;-2.22,2.96,;-.88,2.19,;.45,2.96,;.45,4.5,;-.88,5.27,;-.88,6.81,;-2.22,4.5,;1.78,5.27,;1.01,6.61,;2.55,6.61,;3.12,4.5,;3.12,2.96,;4.44,2.13,;5.84,2.94,;7.17,2.17,;8.51,2.94,;9.84,3.71,;9.28,1.61,;7.74,4.27,;5.83,4.55,;4.45,5.27,)| Show InChI InChI=1S/C28H36F4N6O3S/c1-27(2,3)35-26-33-15-21-22(16-38(25(21)34-26)19-5-7-20(39)8-6-19)18-4-9-24(23(29)14-18)42(40,41)37-12-10-36(11-13-37)17-28(30,31)32/h4,9,14-16,19-20,39H,5-8,10-13,17H2,1-3H3,(H,33,34,35)/t19-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350864
(UNC1666A | US10004755, Compound UNC1666A | US97956...)Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:12.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;2.43,6.05,;4.36,7.54,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C26H35N5O4S/c1-2-3-12-27-26-28-17-23-24(18-31(25(23)29-26)20-6-8-21(32)9-7-20)19-4-10-22(11-5-19)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17-18,20-21,32H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350865
(UNC1667A | US10004755, Compound UNC1667A | US97956...)Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1 |r,wU:12.11,wD:15.15,(-9.17,-2.68,;-7.84,-1.91,;-6.5,-2.68,;-5.17,-1.91,;-3.84,-2.68,;-2.5,-1.91,;-2.5,-.37,;-1.17,.4,;.16,-.37,;1.63,.1,;2.53,-1.14,;1.63,-2.39,;2.03,-3.88,;3.51,-4.27,;3.91,-5.76,;2.82,-6.85,;3.22,-8.34,;1.34,-6.45,;.94,-4.96,;.16,-1.91,;-1.17,-2.68,;2.03,1.59,;3.51,1.99,;3.91,3.48,;2.82,4.57,;1.34,4.17,;.94,2.68,;3.22,6.05,;1.68,6.05,;3.62,7.54,;4.71,6.45,;5.8,5.36,;7.29,5.76,;7.68,7.25,;9.17,7.65,;6.6,8.34,;5.11,7.94,)| Show InChI InChI=1S/C27H38N6O3S/c1-3-4-13-28-27-29-18-24-25(19-33(26(24)30-27)21-7-9-22(34)10-8-21)20-5-11-23(12-6-20)37(35,36)32-16-14-31(2)15-17-32/h5-6,11-12,18-19,21-22,34H,3-4,7-10,13-17H2,1-2H3,(H,28,29,30)/t21-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50055498
(CHEMBL3326004 | US10004755, Compound UNC1669A | US...)Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1 |r,wU:12.11,wD:15.15,(-3.17,-12.13,;-1.85,-11.36,;-.52,-12.13,;.83,-11.36,;2.16,-12.13,;3.49,-11.36,;3.49,-9.82,;4.82,-9.05,;6.15,-9.81,;7.63,-9.33,;8.54,-10.59,;7.63,-11.84,;8.11,-13.31,;9.61,-13.63,;10.08,-15.1,;9.05,-16.24,;9.52,-17.7,;7.54,-15.91,;7.07,-14.45,;6.16,-11.36,;4.82,-12.13,;8.11,-7.87,;9.62,-7.55,;10.09,-6.1,;9.07,-4.95,;7.56,-5.27,;6.54,-4.12,;7.08,-6.73,;9.55,-3.48,;8.06,-3.08,;9.15,-1.99,;11.06,-3.18,;12.07,-4.34,;13.57,-4.04,;14.07,-2.59,;15.58,-2.29,;13.05,-1.43,;11.54,-1.73,)| Show InChI InChI=1S/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350840
(UNC1535A | US9795606, A4)Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(N)(=O)=O |r,wU:13.12,wD:16.16,(-8.57,-3.4,;-7.24,-2.63,;-5.91,-3.4,;-4.57,-2.63,;-3.24,-3.4,;-1.91,-2.63,;-1.91,-1.09,;-.57,-.32,;.76,-1.09,;2.23,-.61,;3.13,-1.86,;2.23,-3.1,;2.62,-4.59,;4.11,-4.99,;5.2,-3.9,;6.69,-4.3,;7.09,-5.79,;8.57,-6.19,;6,-6.88,;4.51,-6.48,;.76,-2.63,;-.57,-3.4,;2.62,.87,;4.11,1.27,;4.51,2.76,;3.42,3.85,;1.93,3.45,;1.54,1.96,;3.82,5.34,;5.31,5.74,;2.28,5.34,;3.82,6.88,)| Show InChI InChI=1S/C23H32N6O2S/c1-2-3-12-26-23-27-13-20-21(17-6-10-19(11-7-17)32(25,30)31)15-29(22(20)28-23)14-16-4-8-18(24)9-5-16/h6-7,10-11,13,15-16,18H,2-5,8-9,12,14,24H2,1H3,(H2,25,30,31)(H,26,27,28)/t16-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350856
(UNC2146A | US10004755, Compound UNC2146A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CC(F)(F)C1 |r,wU:11.11,wD:15.15,(-8.74,-2.57,;-7.4,-1.8,;-6.07,-2.57,;-4.74,-1.8,;-3.4,-2.57,;-2.07,-1.8,;-2.07,-.26,;-.73,.51,;.6,-.26,;2.06,.22,;2.97,-1.03,;2.06,-2.27,;2.46,-3.76,;3.95,-4.16,;4.35,-5.65,;3.26,-6.73,;3.66,-8.22,;1.77,-6.34,;1.37,-4.85,;.6,-1.8,;-.73,-2.57,;2.46,1.71,;3.95,2.11,;4.35,3.59,;3.26,4.68,;1.77,4.28,;1.37,2.8,;3.66,6.17,;2.12,6.17,;2.89,7.5,;5.15,6.57,;6.48,5.8,;7.25,7.13,;8.34,8.22,;8.74,6.73,;5.92,7.9,)| Show InChI InChI=1S/C25H31F2N5O3S/c1-2-3-12-28-24-29-13-21-22(14-32(23(21)30-24)18-6-8-19(33)9-7-18)17-4-10-20(11-5-17)36(34,35)31-15-25(26,27)16-31/h4-5,10-11,13-14,18-19,33H,2-3,6-9,12,15-16H2,1H3,(H,28,29,30)/t18?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350858
(UNC2367A | US10004755, Compound UNC2367A | US97956...)Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn(C3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1 |r,wU:16.17,wD:20.21,(7.04,6.85,;8.53,7.25,;8.13,5.76,;6.65,5.36,;5.56,6.45,;5.96,7.94,;7.44,8.34,;4.07,6.05,;2.53,6.05,;3.3,7.39,;3.67,4.57,;4.76,3.48,;4.36,1.99,;2.87,1.59,;2.47,.1,;3.38,-1.14,;2.47,-2.39,;2.87,-3.88,;4.36,-4.27,;4.76,-5.76,;3.67,-6.85,;4.07,-8.34,;2.18,-6.45,;1.78,-4.96,;1.01,-1.91,;-.32,-2.68,;-1.66,-1.91,;-2.99,-2.68,;-4.32,-1.91,;-5.66,-2.68,;-6.99,-1.91,;-7.76,-.58,;-8.53,-1.91,;-1.66,-.37,;-.32,.4,;1.01,-.37,;1.78,2.68,;.3,2.28,;2.18,4.17,)| Show InChI InChI=1S/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350859
(UNC2368A | US10004755, Compound UNC2368A | US97956...)Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(cc2F)S(=O)(=O)N2CCOCC2)c2cnc(NCCC3CC3)nc12 |r,wU:7.7,wD:1.0,(4.07,-8.34,;3.67,-6.85,;4.76,-5.76,;4.36,-4.27,;2.87,-3.88,;1.78,-4.96,;2.18,-6.45,;2.47,-2.39,;3.38,-1.14,;2.47,.1,;2.87,1.59,;4.36,1.99,;4.76,3.48,;3.67,4.57,;2.18,4.17,;1.78,2.68,;.3,2.28,;4.07,6.05,;2.53,6.05,;3.3,7.39,;5.56,6.45,;6.65,5.36,;8.13,5.76,;8.53,7.25,;7.44,8.34,;5.96,7.94,;1.01,-.37,;-.32,.4,;-1.66,-.37,;-1.66,-1.91,;-2.99,-2.68,;-4.32,-1.91,;-5.66,-2.68,;-6.99,-1.91,;-7.76,-.58,;-8.53,-1.91,;-.32,-2.68,;1.01,-1.91,)| Show InChI InChI=1S/C27H34FN5O4S/c28-25-15-21(38(35,36)32-11-13-37-14-12-32)7-8-22(25)24-17-33(19-3-5-20(34)6-4-19)26-23(24)16-30-27(31-26)29-10-9-18-1-2-18/h7-8,15-20,34H,1-6,9-14H2,(H,29,30,31)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350863
(UNC1652A | US9795606, B24)Show SMILES CC(C)(C)Nc1ncc2c(cn([C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(CC(F)(F)F)CC1 |r,wD:12.11,15.15,(-11.12,-1.16,;-9.79,-.39,;-9.79,1.15,;-9.79,-1.93,;-8.45,-1.16,;-7.12,-.39,;-7.12,1.15,;-5.79,1.92,;-4.45,1.15,;-2.99,1.63,;-2.08,.38,;-2.99,-.86,;-2.59,-2.35,;-1.1,-2.75,;-.7,-4.24,;-1.79,-5.33,;-1.39,-6.81,;-3.28,-4.93,;-3.68,-3.44,;-4.45,-.39,;-5.79,-1.16,;-2.22,2.96,;-.88,2.19,;.45,2.96,;.45,4.5,;-.88,5.27,;-.88,6.81,;-2.22,4.5,;1.78,5.27,;1.01,6.61,;2.55,6.61,;3.12,4.5,;3.12,2.96,;4.44,2.13,;5.84,2.94,;7.17,2.17,;8.51,2.94,;9.84,3.71,;9.28,1.61,;7.74,4.27,;5.83,4.55,;4.45,5.27,)| Show InChI InChI=1S/C28H36F4N6O3S/c1-27(2,3)35-26-33-15-21-22(16-38(25(21)34-26)19-5-7-20(39)8-6-19)18-4-9-24(23(29)14-18)42(40,41)37-12-10-36(11-13-37)17-28(30,31)32/h4,9,14-16,19-20,39H,5-8,10-13,17H2,1-3H3,(H,33,34,35)/t19-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350837
(UNC1532A | US9795606, A1)Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCOCC1 |r,wU:13.12,wD:16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;5.2,-4.62,;6.69,-5.02,;7.09,-6.51,;8.57,-6.9,;6,-7.59,;4.51,-7.2,;.76,-3.35,;-.57,-4.12,;2.62,.16,;4.11,.56,;4.51,2.04,;3.42,3.13,;1.93,2.73,;1.54,1.25,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,)| Show InChI InChI=1S/C27H38N6O/c1-2-3-12-29-27-30-17-24-25(21-6-10-23(11-7-21)32-13-15-34-16-14-32)19-33(26(24)31-27)18-20-4-8-22(28)9-5-20/h6-7,10-11,17,19-20,22H,2-5,8-9,12-16,18,28H2,1H3,(H,29,30,31)/t20-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350838
(UNC1533A | US9795606, A2)Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1 |r,wU:13.12,wD:16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;5.2,-4.62,;6.69,-5.02,;7.09,-6.51,;8.57,-6.9,;6,-7.59,;4.51,-7.2,;.76,-3.35,;-.57,-4.12,;2.62,.16,;4.11,.56,;4.51,2.04,;3.42,3.13,;1.93,2.73,;1.54,1.25,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,)| Show InChI InChI=1S/C27H39N7/c1-2-3-12-30-27-31-17-24-25(21-6-10-23(11-7-21)33-15-13-29-14-16-33)19-34(26(24)32-27)18-20-4-8-22(28)9-5-20/h6-7,10-11,17,19-20,22,29H,2-5,8-9,12-16,18,28H2,1H3,(H,30,31,32)/t20-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350845
(UNC2025A | US10004755, Compound UNC2025A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wU:11.11,wD:15.15,(-9.17,-2.68,;-7.84,-1.91,;-6.5,-2.68,;-5.17,-1.91,;-3.84,-2.68,;-2.5,-1.91,;-2.5,-.37,;-1.17,.4,;.16,-.37,;1.63,.1,;2.53,-1.14,;1.63,-2.39,;2.03,-3.88,;3.51,-4.27,;3.91,-5.76,;2.82,-6.85,;3.22,-8.34,;1.34,-6.45,;.94,-4.96,;.16,-1.91,;-1.17,-2.68,;2.03,1.59,;3.51,1.99,;3.91,3.48,;2.82,4.57,;3.22,6.05,;4.71,6.45,;5.8,5.36,;7.29,5.76,;7.68,7.25,;9.17,7.65,;6.6,8.34,;5.11,7.94,;1.34,4.17,;.94,2.68,)| Show InChI InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350847
(UNC2087A | US10004755, Compound UNC2087A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)C1CCCC1 |r,wU:11.11,wD:15.15,(-8.23,-2.68,;-6.9,-1.91,;-5.56,-2.68,;-4.23,-1.91,;-2.89,-2.68,;-1.56,-1.91,;-1.56,-.37,;-.23,.4,;1.11,-.37,;2.57,.1,;3.48,-1.14,;2.57,-2.39,;2.97,-3.88,;4.46,-4.27,;4.86,-5.76,;3.77,-6.85,;4.17,-8.34,;2.28,-6.45,;1.88,-4.96,;1.11,-1.91,;-.23,-2.68,;2.97,1.59,;4.46,1.99,;4.86,3.48,;3.77,4.57,;2.28,4.17,;1.88,2.68,;4.17,6.05,;2.63,6.05,;3.4,7.39,;5.65,6.45,;6.05,7.94,;7.54,8.34,;8.23,5.76,;6.74,5.36,)| Show InChI InChI=1S/C27H36N4O3S/c1-2-3-16-28-27-29-17-24-25(18-31(26(24)30-27)20-10-12-21(32)13-11-20)19-8-14-23(15-9-19)35(33,34)22-6-4-5-7-22/h8-9,14-15,17-18,20-22,32H,2-7,10-13,16H2,1H3,(H,28,29,30)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350853
(UNC2125A | US10004755, Compound UNC2125A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(F)c(F)c1 |r,wU:11.11,wD:15.15,(-6.54,-1.54,;-5.21,-.77,;-3.88,-1.54,;-2.54,-.77,;-1.21,-1.54,;.13,-.77,;.13,.77,;1.46,1.54,;2.79,.77,;4.26,1.25,;5.16,,;4.26,-1.25,;4.66,-2.73,;6.14,-3.13,;6.54,-4.62,;5.45,-5.71,;5.85,-7.2,;3.97,-5.31,;3.57,-3.82,;2.79,-.77,;1.46,-1.54,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;2.88,6.4,;3.57,3.82,)| Show InChI InChI=1S/C22H27F2N5/c1-2-3-10-26-22-27-12-17-18(14-4-9-19(23)20(24)11-14)13-29(21(17)28-22)16-7-5-15(25)6-8-16/h4,9,11-13,15-16H,2-3,5-8,10,25H2,1H3,(H,26,27,28)/t15-,16? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350870
(UNC2421A | US9795606, D1)Show SMILES CCCCNc1ncc2n(cc(C3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wD:15.15,(-9.17,-2.68,;-7.84,-1.91,;-6.5,-2.68,;-5.17,-1.91,;-3.84,-2.68,;-2.5,-1.91,;-2.5,-.37,;-1.17,.4,;.16,-.37,;1.63,.1,;2.53,-1.14,;1.63,-2.39,;2.03,-3.88,;3.51,-4.27,;3.91,-5.76,;2.82,-6.85,;3.22,-8.34,;1.34,-6.45,;.94,-4.96,;.16,-1.91,;-1.17,-2.68,;2.03,1.59,;3.51,1.99,;3.91,3.48,;2.82,4.57,;3.22,6.05,;4.71,6.45,;5.8,5.36,;7.29,5.76,;7.68,7.25,;9.17,7.65,;6.6,8.34,;5.11,7.94,;1.34,4.17,;.94,2.68,)| Show InChI InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-26-27(31-28)25(22-7-11-24(35)12-8-22)20-34(26)23-9-5-21(6-10-23)19-33-16-14-32(2)15-17-33/h5-6,9-10,18,20,22,24,35H,3-4,7-8,11-17,19H2,1-2H3,(H,29,30,31)/t22?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350843
(UNC1971A | US10004755, Compound UNC1971A | US97956...)Show SMILES CCCCNc1ncc2c(cn(C3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;.99,5.26,;1.68,2.68,;3.97,6.05,;2.48,6.45,;3.57,7.54,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| Show InChI InChI=1S/C26H35FN6O3S/c1-2-3-10-29-26-30-16-21-22(17-33(25(21)31-26)20-7-5-19(28)6-8-20)18-4-9-24(23(27)15-18)37(34,35)32-11-13-36-14-12-32/h4,9,15-17,19-20H,2-3,5-8,10-14,28H2,1H3,(H,29,30,31)/t19-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350860
(UNC2370A | US10004755, Compound UNC2370A | US97956...)Show SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12 |r,wU:7.7,wD:1.0,(4.07,-8.34,;3.67,-6.85,;4.76,-5.76,;4.36,-4.27,;2.87,-3.88,;1.78,-4.96,;2.18,-6.45,;2.47,-2.39,;3.38,-1.14,;2.47,.1,;2.87,1.59,;4.36,1.99,;4.76,3.48,;3.67,4.57,;4.07,6.05,;5.56,6.45,;6.65,5.36,;8.13,5.76,;8.53,7.25,;7.44,8.34,;5.96,7.94,;2.18,4.17,;1.78,2.68,;1.01,-.37,;-.32,.4,;-1.66,-.37,;-1.66,-1.91,;-2.99,-2.68,;-4.32,-1.91,;-5.66,-2.68,;-6.99,-1.91,;-7.76,-.58,;-8.53,-1.91,;-.32,-2.68,;1.01,-1.91,)| Show InChI InChI=1S/C28H37N5O2/c34-24-9-7-23(8-10-24)33-19-26(22-5-3-21(4-6-22)18-32-13-15-35-16-14-32)25-17-30-28(31-27(25)33)29-12-11-20-1-2-20/h3-6,17,19-20,23-24,34H,1-2,7-16,18H2,(H,29,30,31)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <250 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM350869
(UNC2369A | US10004755, Compound UNC2369A | US97956...)Show SMILES CCCCN(C)c1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wU:13.12,wD:16.16,(-9.17,-2.68,;-7.84,-1.91,;-6.5,-2.68,;-5.17,-1.91,;-3.84,-2.68,;-3.84,-4.22,;-2.5,-1.91,;-2.5,-.37,;-1.17,.4,;.16,-.37,;1.63,.1,;2.53,-1.14,;1.63,-2.39,;2.03,-3.88,;3.51,-4.27,;3.91,-5.76,;2.82,-6.85,;3.22,-8.34,;1.34,-6.45,;.94,-4.96,;.16,-1.91,;-1.17,-2.68,;2.03,1.59,;3.51,1.99,;3.91,3.48,;2.82,4.57,;3.22,6.05,;4.71,6.45,;5.8,5.36,;7.29,5.76,;7.68,7.25,;9.17,7.65,;6.6,8.34,;5.11,7.94,;1.34,4.17,;.94,2.68,)| Show InChI InChI=1S/C29H42N6O/c1-4-5-14-33(3)29-30-19-26-27(21-35(28(26)31-29)24-10-12-25(36)13-11-24)23-8-6-22(7-9-23)20-34-17-15-32(2)16-18-34/h6-9,19,21,24-25,36H,4-5,10-18,20H2,1-3H3/t24-,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9795606 (2017)
BindingDB Entry DOI: 10.7270/Q2FB553D |
More data for this
Ligand-Target Pair | |
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