| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM561321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MAGL Inhibitory Activity |
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| IC50 | 42.0±n/a nM |
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| Citation |  Benz, J; Grether, U; Hornsperger, B; Kuhn, B; Richter, H; Kocer, B; O''Hara, F; Ritter, M; Tsuchiya, S; Collin, L; Johnson, SE; Bell, C Piperazine derivatives as MAGL inhibitors US Patent US11390610 Publication Date 7/19/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM561321 |
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| n/a |
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| Name | BDBM561321 |
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| Synonyms: | US11390610, Example 150 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20F4N4O3 |
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| Mol. Mass. | 512.4556 |
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| SMILES | Fc1cc(ccc1-c1cccc(OC(F)(F)F)c1)C(=O)N1CCN(CC1)c1nc2ccccc2c(=O)[nH]1 |
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| Structure | 
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